| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Yoshino, Takeaki Miyamae, Gwenn Hansen, Brian Zambrowicz, Michael Flynn, Donna Pedicord, Yuval Blat, Ryan S Westphal, Robert Zaczek, David A Lewis, Guillermo Gonzalez-Burgo. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. The Journal of physiology. vol 589. issue Pt 20. 2012-02-07. PMID:21807615. |
here we studied endocannabinoid signalling in the prefrontal cortex (pfc), where several components of the endocannabinoid system have been identified, but endocannabinoid signalling remains largely unexplored. |
2012-02-07 |
2023-08-12 |
mouse |
| Allyn C Howlett, Patricia H Reggio, Steven R Childers, Robert E Hampson, Nadine M Ulloa, Dale G Deutsc. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21545414. |
considering that endocannabinoid signalling to cb receptors is a much more likely scenario than is receptor activation in the absence of agonist ligands, researchers are advised to refrain from assuming constitutive activity except for experimental models known to be devoid of endocannabinoid ligands. |
2012-01-18 |
2023-08-12 |
Not clear |
| Maria-Paz Viveros, Eva M Marco, Meritxell López-Gallardo, Luis Miguel Garcia-Segura, Edward J Wagne. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neuroscience and biobehavioral reviews. vol 35. issue 8. 2011-12-01. PMID:20869396. |
given the extensive precedence of sex differences in cannabinoid-regulated biology, we then focus on the disparities within the endogenous cannabinoid system, as well as those observed with exogenously administered cannabinoids. |
2011-12-01 |
2023-08-12 |
Not clear |
| Claudio Zanettini, Leigh V Panlilio, Mano Alicki, Steven R Goldberg, József Haller, Sevil Yasa. Effects of endocannabinoid system modulation on cognitive and emotional behavior. Frontiers in behavioral neuroscience. vol 5. 2011-11-10. PMID:21949506. |
research has shown that cannabinoid drugs produce these effects by driving the brain's endogenous cannabinoid system and that this system plays a modulatory role in many cognitive and emotional processes. |
2011-11-10 |
2023-08-12 |
Not clear |
| Hendrika H van Hell, Matthijs G Bossong, Gerry Jager, René S Kahn, Nick F Ramse. Methods of the pharmacological imaging of the cannabinoid system (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition. International journal of methods in psychiatric research. vol 20. issue 1. 2011-09-30. PMID:21574207. |
methods of the pharmacological imaging of the cannabinoid system (phics) study: towards understanding the role of the brain endocannabinoid system in human cognition. |
2011-09-30 |
2023-08-12 |
human |
| Hendrika H van Hell, Matthijs G Bossong, Gerry Jager, René S Kahn, Nick F Ramse. Methods of the pharmacological imaging of the cannabinoid system (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition. International journal of methods in psychiatric research. vol 20. issue 1. 2011-09-30. PMID:21574207. |
in the pharmacological imaging of the cannabinoid system (phics) study, the involvement of the endocannabinoid system in cognitive brain function is assessed by comparing acute effects of the cannabinoid agonist Δ9-tetrahydrocannabinol (thc) on brain function between healthy controls and groups of psychiatric patients showing cognitive dysfunction. |
2011-09-30 |
2023-08-12 |
human |
| Ljiljana Sokolic, Leonora E Long, Glenn E Hunt, Jonathon C Arnold, Iain S McGrego. Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. Behavioural pharmacology. vol 22. issue 3. 2011-08-16. PMID:21512341. |
these results confirm impairment of cognitive flexibility (reversal learning) by cannabinoids and show remarkable sensitivity of auditory discrimination performance to Δ⁹-thc and the augmented endocannabinoid signalling produced by urb-597. |
2011-08-16 |
2023-08-12 |
rat |
| Hila Abush, Irit Akira. Cannabinoids modulate hippocampal memory and plasticity. Hippocampus. vol 20. issue 10. 2011-06-28. PMID:19830813. |
administration of win55,212-2 (0.5 mg/kg), am404 (10 mg/kg), and am251 (2 mg/kg) impaired ltp in the schaffer collateral-ca1 projection, whereas am404 facilitated ltd. our findings suggest diverse effects of the cannabinoid system on ca1 memory and plasticity that cannot be categorized simply into an impairing or an enhancing effect of cannabinoid activation and deactivation, respectively. |
2011-06-28 |
2023-08-12 |
Not clear |
| Eric J Downe. Cannabinoids and innate immunity: taking a toll on neuroinflammation. TheScientificWorldJournal. vol 11. 2011-06-27. PMID:21479354. |
cannabinoids influence immune function in both the peripheral and the central nervous system (cns), and the components of the cannabinoid system, the cannabinoid receptors and their endogenous ligands (endocannabinoids), have been detected on immune cells as well as in brain glia. |
2011-06-27 |
2023-08-12 |
Not clear |
| D Matthew Walentiny, Thomas F Gamage, Jonathan A Warner, Thanh K Nguyen, Darren B Grainger, Jenny L Wiley, Robert E Van. The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. European journal of pharmacology. vol 656. issue 1-3. 2011-06-13. PMID:21300050. |
the endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (thc). |
2011-06-13 |
2023-08-12 |
mouse |
| Christopher J Fowler, Sofia B Gustafsson, Sui Chu Chung, Emma Persson, Stig O P Jacobsson, Anders Berg. Targeting the endocannabinoid system for the treatment of cancer--a practical view. Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370711. |
in the present review, the potential of targeting the cannabinoid system for the treatment of cancer is considered from a practical, rather than a mechanistic viewpoint, addressing questions such as whether human tumour cells express cb receptors; whether the potencies of action of cannabinoids in vitro match the potencies expected on the base of receptor theory; what is known about the in vivo effects of cannabinoids and cancer, and how relevant the experiments undertaken are to the clinical situation; and finally, what approaches can be taken to minimise unwanted effects of cannabinoid treatment. |
2011-05-02 |
2023-08-12 |
human |
| Christopher J Fowler, Sofia B Gustafsson, Sui Chu Chung, Emma Persson, Stig O P Jacobsson, Anders Berg. Targeting the endocannabinoid system for the treatment of cancer--a practical view. Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370711. |
it is concluded that cannabinoids (or agents modulating the endogenous cannabinoid system) are an attractive target for drug development in the cancer area, but that more in vivo studies, particularly those investigating the potential of cannabinoids as an addition to current treatment strategies, are needed. |
2011-05-02 |
2023-08-12 |
human |
| Qiang Li, Haidun Yan, Wilkie A Wilson, H Scott Swartzwelde. Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells. Brain research. vol 1342. 2011-01-18. PMID:20420813. |
although the endogenous cannabinoid system modulates a variety of physiological and pharmacological processes, the specific role of cannabinoid cb1 receptors in the modulation of glutamatergic neurotransmission and neural plasticity is not well understood. |
2011-01-18 |
2023-08-12 |
rat |
| Aron H Lichtman, Jacqueline L Blankman, Benjamin F Cravat. Endocannabinoid overload. Molecular pharmacology. vol 78. issue 6. 2010-12-17. PMID:20952498. |
these findings highlight the central role that magl plays in endocannabinoid metabolism in vivo and reveal that excessive 2-ag signaling can lead to functional antagonism of the brain cannabinoid system. |
2010-12-17 |
2023-08-12 |
Not clear |
| Elodie Fino, Vincent Paille, Yihui Cui, Teresa Morera-Herreras, Jean-Michel Deniau, Laurent Venanc. Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. The Journal of physiology. vol 588. issue Pt 16. 2010-12-07. PMID:20603333. |
activation of plcbeta and ip3rs leads to robust retrograde endocannabinoid signalling mediated by 2-arachidonoyl-glycerol and cannabinoid cb1 receptors. |
2010-12-07 |
2023-08-12 |
Not clear |
| Robert A Battisti, Steven Roodenrys, Stuart J Johnstone, Colleen Respondek, Daniel F Hermens, Nadia Solowi. Chronic use of cannabis and poor neural efficiency in verbal memory ability. Psychopharmacology. vol 209. issue 4. 2010-07-08. PMID:20217055. |
the endogenous cannabinoid system is sensitive to the introduction of exogenous cannabinoids such as delta-9-tetrahydrocannabinol, which are known to impact upon memory functioning. |
2010-07-08 |
2023-08-12 |
Not clear |
| Palmiero Monteleone, Maurizio Bifulco, Giuseppe Maina, Alfonso Tortorella, Patrizia Gazzerro, Maria Chiara Proto, Carmela Di Filippo, Francesco Monteleone, Benedetta Canestrelli, Giovanna Buonerba, Filippo Bogetto, Mario Ma. Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacological research. vol 61. issue 5. 2010-07-05. PMID:20080186. |
experimental data suggest that the endogenous cannabinoid system is involved in mood regulation, but no study has been performed so far to investigate the role of endocannabinoid genes in the susceptibility to major depression (md) and/or bipolar disorder (bd). |
2010-07-05 |
2023-08-12 |
human |
| Julie Desroches, Pierre Beaulie. Opioids and cannabinoids interactions: involvement in pain management. Current drug targets. vol 11. issue 4. 2010-06-10. PMID:20017728. |
further studies have demonstrated that the endogenous opioid system could be involved in cannabinoid antinociception and recent data have also provided evidence for a role of the endogenous cannabinoid system in opioid antinociception. |
2010-06-10 |
2023-08-12 |
Not clear |
| Stefania Petrosino, Vincenzo Di Marz. FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 1. 2010-03-23. PMID:20047159. |
following the identification of receptors for thc - the cannabinoid cb1 and cb2 receptors - in mammals, various pharmaceutical strategies have attempted to exploit the properties of the cannabinoid system while minimizing psychotropic side effects. |
2010-03-23 |
2023-08-12 |
Not clear |
| Tonia Luca, Giulia Di Benedetto, Mariagrazia Rita Scuderi, Marco Palumbo, Silvia Clementi, Renato Bernardini, Giuseppina Cantarell. The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitro. European journal of pharmacology. vol 616. issue 1-3. 2009-10-19. PMID:19539619. |
in view of the antiproliferative effects of cannabinoids on ks-imm cells, one could envision the cannabinoid system as a potential target for pharmacological treatment of kaposi's sarcoma. |
2009-10-19 |
2023-08-12 |
human |