| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Zheng, Yue Du, Yubin Wu, Fuwei Li, Weiyue Gu, Chengguang Zha. COPA syndrome caused by a novel p.Arg227Cys COPA gene variant. Molecular genetics & genomic medicine. 2023-10-25. PMID:37877458. |
copa syndrome is a recently described and rare monogenic autosomal dominant disease caused by heterozygous missense mutations in the coatomer protein subunit alpha (copa) gene that encodes the alpha subunit of coat protein complex i (copi). |
2023-10-25 |
2023-11-08 |
Not clear |
| Letian Zhang, Minna Piipponen, Zhuang Liu, Dongqing Li, Xiaowei Bian, Guanglin Niu, Jennifer Geara, Maria A Toma, Pehr Sommar, Ning Xu Landé. Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport. Cell death and differentiation. 2023-03-03. PMID:36869179. |
moreover, rna pull-down assays followed by mass spectrometry and rna immunoprecipitation analysis revealed that mechanistically hoxc13-as sequestered the coat complex subunit alpha (copa) protein and interfered with golgi-to-endoplasmic reticulum (er) molecular transport, resulting in er stress and enhanced keratinocyte differentiation. |
2023-03-03 |
2023-08-14 |
human |
| HaiThuy N Nguyen, Rida Salman, Tiphanie P Vogel, Manuel Silva-Carmona, Marietta DeGuzman, R Paul Guillerma. Imaging findings of COPA Syndrome. Pediatric radiology. 2023-02-06. PMID:36746811. |
autosomal dominant mutations in the coatomer-associated protein alpha (copa) gene cause an immune dysregulation disorder associated with pulmonary hemorrhage, lymphoid hyperplasia, arthritis, and glomerulonephritis. |
2023-02-06 |
2023-08-14 |
Not clear |
| Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F Dagley, Michael J Mlodzianoski, Kelly L Rogers, Thomas Zillinger, Gunther Hartmann, Michael P Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L Master. Deficiency in coatomer complex I causes aberrant activation of STING signalling. Nature communications. vol 13. issue 1. 2022-04-28. PMID:35484149. |
deficiency in subunit alpha causes copa syndrome and is associated with type i ifn signalling, although the upstream innate immune sensor involved was unknown. |
2022-04-28 |
2023-08-13 |
Not clear |
| Sergio Ghirardo, Michele Mazzolai, Antonio Di Marco, Francesca Petreschi, Nicola Ullmann, Marta Lucia Ciofi Degli Atti, Renato Cutrer. Biological Treatments and Target Therapies for Pediatric Respiratory Medicine: Not Only Asthma. Frontiers in pediatrics. vol 10. 2022-03-04. PMID:35242725. |
we face these conditions in a cherry-picking fashion picturing savi (sting-associated vasculopathy with onset in infancy), candle (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature), and copa (coat proteins alpha syndrome) syndrome pulmonary involvement. |
2022-03-04 |
2023-08-13 |
Not clear |
| Tadashi Matsubayashi, Masaki Yamamoto, Saki Takayama, Yoshiro Otsuki, Ichiro Yamadori, Yoshitaka Honda, Kazushi Izawa, Ryuta Nishikomori, Takahiro Ot. Allograft Dysfunction After Lung Transplantation for COPA Syndrome: A Case Report and Literature Review. Modern rheumatology case reports. 2022-01-26. PMID:35079820. |
copa syndrome is caused by heterozygous loss-of-function mutations in the coatmer subunit alpha (copa) gene, encoding α subunit of coatmer protein complex i (cop-i) coated vesicles. |
2022-01-26 |
2023-08-13 |
Not clear |
| Takashi Kato, Masaki Yamamoto, Yoshitaka Honda, Takashi Orimo, Izumi Sasaki, Kohei Murakami, Hiroaki Hemmi, Yuri Fukuda-Ohta, Kyoichi Isono, Saki Takayama, Hidenori Nakamura, Yoshiro Otsuki, Toshiaki Miyamoto, Junko Takita, Takahiro Yasumi, Ryuta Nishikomori, Tadashi Matsubayashi, Kazushi Izawa, Tsuneyasu Kaish. Augmentation of Stimulator of Interferon Genes-Induced Type I Interferon Production in COPA Syndrome. Arthritis & rheumatology (Hoboken, N.J.). vol 73. issue 11. 2021-12-06. PMID:33982886. |
coatomer subunit alpha (copa) syndrome, also known as autoinflammatory interstitial lung, joint, and kidney disease, is caused by heterozygous mutations in copa. |
2021-12-06 |
2023-08-13 |
mouse |
| Marie-Louise Frémond, Nadia Natha. COPA syndrome, 5 years after: Where are we? Joint bone spine. vol 88. issue 2. 2021-06-25. PMID:32919065. |
heterozygous missense mutations in copa, encoding coatomer protein subunit alpha (copa), cause an interferonopathy mainly associating lung, joint and kidney involvement. |
2021-06-25 |
2023-08-13 |
Not clear |
| Brent Kerbel, Kimberly Badal, Lakshminarasimhan Sundarrajan, Ayelen Blanco, Suraj Unniappa. Xenin is a novel anorexigen in goldfish (Carassius auratus). PloS one. vol 13. issue 5. 2018-11-26. PMID:29791497. |
xenin, a highly conserved 25 amino acid peptide cleaved from the n-terminus of the coatomer protein alpha (copa), is emerging as a food intake regulator in mammals and birds. |
2018-11-26 |
2023-08-13 |
Not clear |
| Vimal Kumar Dubey, Ung Gyu Lee, Deok Ho Kwon, Si Hyeock Le. Agroinfiltration-based expression of hairpin RNA in soybean plants for RNA interference against Tetranychus urticae. Pesticide biochemistry and physiology. vol 142. 2018-01-26. PMID:29107247. |
the coatomer subunit alpha (copa) and aquaporin 9 (aq9) genes from the two-spotted spider mite, tetranychus urticae, were previously determined to exhibit rna interference (rnai)-based lethality when their double-stranded rnas were systemically delivered via multi-unit chambers (kwon et al., 2016 [8]). |
2018-01-26 |
2023-08-13 |
spider |
| Brynjar O Jensson, Sif Hansdottir, Gudny A Arnadottir, Gerald Sulem, Ragnar P Kristjansson, Asmundur Oddsson, Stefania Benonisdottir, Hakon Jonsson, Agnar Helgason, Jona Saemundsdottir, Olafur T Magnusson, Gisli Masson, Gudmundur A Thorisson, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Ingileif Jonsdottir, Vigdis Petursdottir, Jon R Kristinsson, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Reynir Arngrimsson, Patrick Sulem, Gunnar Gudmundsson, Kari Stefansso. COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA. BMC medical genetics. vol 18. issue 1. 2017-11-29. PMID:29137621. |
rare missense mutations in the gene encoding coatomer subunit alpha (copa) have recently been shown to cause autoimmune interstitial lung, joint and kidney disease, also known as copa syndrome, under a dominant mode of inheritance. |
2017-11-29 |
2023-08-13 |
Not clear |
| Timothy J Vece, Levi B Watkin, Sarah Nicholas, Debra Canter, Michael C Braun, R Paul Guillerman, Karen W Eldin, Grant Bertolet, Scott McKinley, Marietta de Guzman, Lisa Forbes, Ivan Chinn, Jordan S Orang. Copa Syndrome: a Novel Autosomal Dominant Immune Dysregulatory Disease. Journal of clinical immunology. vol 36. issue 4. 2017-10-18. PMID:27048656. |
copa syndrome is named for the gene mutated in the disease, which encodes the alpha subunit of the coatomer complex-i that, in aggregate, is devoted to transiting molecular cargo from the golgi complex to the endoplasmic reticulum (er). |
2017-10-18 |
2023-08-13 |
Not clear |
| Ben Dorshorst, Corneliu Henegar, Xiaoping Liao, Markus Sällman Almén, Carl-Johan Rubin, Shosuke Ito, Kazumasa Wakamatsu, Paul Stothard, Brian Van Doormaal, Graham Plastow, Gregory S Barsh, Leif Andersso. Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Protein Complex, Subunit Alpha (COPA) Gene. PloS one. vol 10. issue 6. 2016-05-10. PMID:26042826. |
dominant red coat color in holstein cattle is associated with a missense mutation in the coatomer protein complex, subunit alpha (copa) gene. |
2016-05-10 |
2023-08-13 |
cattle |
| Ben Dorshorst, Corneliu Henegar, Xiaoping Liao, Markus Sällman Almén, Carl-Johan Rubin, Shosuke Ito, Kazumasa Wakamatsu, Paul Stothard, Brian Van Doormaal, Graham Plastow, Gregory S Barsh, Leif Andersso. Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Protein Complex, Subunit Alpha (COPA) Gene. PloS one. vol 10. issue 6. 2016-05-10. PMID:26042826. |
here we show that a missense mutation in the coatomer protein complex, subunit alpha (copa), a gene with previously no known role in pigmentation synthesis, is completely associated with dominant red in holstein dairy cattle. |
2016-05-10 |
2023-08-13 |
cattle |
| S Maas, C P Godfried Sie, I Stoev, D E Dupuis, J Latona, A M Porman, B Evans, P Rekawek, V Kluempers, M Mutter, W M Gommans, D Loprest. Genome-wide evaluation and discovery of vertebrate A-to-I RNA editing sites. Biochemical and biophysical research communications. vol 412. issue 3. 2011-11-21. PMID:21835166. |
we experimentally validate recoding-type a-to-i rna editing in a number of human genes with high scoring positions including the coatomer protein complex subunit alpha (copa) as well as cyclin dependent kinase cdk13. |
2011-11-21 |
2023-08-12 |
mouse |
| Kohji Nagano, Takashi Shinkawa, Hironori Mutoh, Osamu Kondoh, Sayuri Morimoto, Noriyuki Inomata, Motooki Ashihara, Nobuya Ishii, Yuko Aoki, Masayuki Haramur. Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment. Proteomics. vol 9. issue 10. 2009-08-26. PMID:19415658. |
in spite of the complex changes observed in the phosphorylation of many of the proteins, possible common features induced by nocodazole were found, including phosphorylation of nucleophosmin (npm) s254 and coatomer protein complex, subunit alpha (copa) s173, suggesting that the events are not cell-type specific but events generally occurring in mitosis or induced by a microtubule-interfering agent. |
2009-08-26 |
2023-08-12 |
Not clear |
| V T Chow, H H Que. Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. Annals of human genetics. vol 61. issue Pt 4. 1997-12-10. PMID:9365789. |
alpha coat protein copa (hep-cop): presence of an alu repeat in cdna and identity of the amino terminus to xenin. |
1997-12-10 |
2023-08-12 |
human |