| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Chen, Mengge Pan, Lanxin Chen, Miaoxin Peng, Zhenyu Liu, Yiran Fang, Ying Du, Yonggong Yang, Peipei X. Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia. Annals of hematology. 2024-01-31. PMID:38294534. |
acute promyelocytic leukemia (apl) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (pml) gene with the retinoic acid receptor alpha (rara). |
2024-01-31 |
2024-02-02 |
Not clear |
| Shatha Mallah, Fahed Owda, Hamza Hamayel, Ahmad Enaya, Osama Mallah, Dina Abugaber, Razan Ode. Successful Management of Acute Promyelocytic Leukemia in a Patient Who Presented With Acute Ischemic Stroke on Top of Subdural Hematoma. Cureus. vol 15. issue 9. 2023-10-16. PMID:37842379. |
the subsequent bone marrow biopsy confirmed the diagnosis of apl, displaying the characteristic positive promyelocytic leukemia (pml)-retinoic acid receptor alpha (rara) t(15;17) translocation. |
2023-10-16 |
2023-11-08 |
Not clear |
| Jonathan M Tsai, Jacob D Aguirre, Yen-Der Li, Jared Brown, Vivian Focht, Lukas Kater, Georg Kempf, Brittany Sandoval, Stefan Schmitt, Justine C Rutter, Pius Galli, Colby R Sandate, Jevon A Cutler, Charles Zou, Katherine A Donovan, Ryan J Lumpkin, Simone Cavadini, Paul M C Park, Quinlan Sievers, Charlie Hatton, Elizabeth Ener, Brandon D Regalado, Micah T Sperling, Mikołaj Słabicki, Jeonghyeon Kim, Rebecca Zon, Zinan Zhang, Peter G Miller, Roger Belizaire, Adam S Sperling, Eric S Fischer, Rafael Irizarry, Scott A Armstrong, Nicolas H Thomä, Benjamin L Eber. UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Molecular cell. 2023-07-21. PMID:37478846. |
here, we demonstrate the ubiquitin ligase ubr5 drives degradation of multiple agonist-bound nrs, including the retinoic acid receptor alpha (rara), retinoid x receptor alpha (rxra), glucocorticoid, estrogen, liver-x, progesterone, and vitamin d receptors. |
2023-07-21 |
2023-08-14 |
human |
| Eman Shreteh, Susannah Boulet, Melody L Milliron, Christopher Karn. An Emergency Department Patient With Pharyngitis and Final Diagnosis of Rare T-cell Acute Lymphoblastic Leukemia With a Copy of Retinoic Acid Receptor Alpha Gene. Cureus. vol 15. issue 5. 2023-06-28. PMID:37378217. |
the patient also had an extra copy of the retinoic acid receptor alpha (rara) gene. |
2023-06-28 |
2023-08-14 |
Not clear |
| Shujie Zhang, Laibo Song, Bo Liu, Yuan-Di Zhao, Wei Che. Poly(ethylene glycol) diacrylate based hydrogel filled micropore with enhanced sensing capability. Analytica chimica acta. vol 1251. 2023-03-17. PMID:36925308. |
the promyelocytic leukemia (pml)/retinoic acid receptor alpha (rara) fusion genes and adenosine triphosphate (atp) were respectively used as model analytes and the measured detection limits of 0.1 pm were achieved. |
2023-03-17 |
2023-08-14 |
Not clear |
| Ellis G Jaffray, Michael H Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T Ha. The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA. The Journal of cell biology. vol 222. issue 4. 2023-03-07. PMID:36880596. |
acute promyelocytic leukemia is caused by expression of the oncogenic promyelocytic leukemia (pml)-retinoic acid receptor alpha (rara) fusion protein. |
2023-03-07 |
2023-08-14 |
Not clear |
| Wenjing Ding, Guangyang Weng, Zheng Wang, Yusha Guo, Man Wang, Hongjie Shen, Suning Chen, Xin Du, Lijun We. Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement. Frontiers in oncology. vol 12. 2023-01-30. PMID:36713535. |
rars have three isoforms: retinoic acid receptor alpha (rara), retinoic acid receptor beta (rarb) and retinoic acid receptor gamma (rarg). |
2023-01-30 |
2023-08-14 |
Not clear |
| Stéphane de Botton, Thomas Cluzeau, Carlos Enrique Vigil, Rachel Cook, Philippe Rousselot, David A Rizzieri, Jane L Liesveld, Pierre Fenaux, Thorsten Braun, Anne Banos, Joseph G Jurcic, Mikkael A Sekeres, Michael R Savona, Gail J Roboz, Dale Bixby, Kate Madigan, Angela Volkert, Kristin Stephens, Qing Kang-Fortner, Kristen Baker, Sofia Paul, Michael Robert McKeown, John P Carulli, Matthew Lucas Eaton, Graeme Hodgson, Christopher Fiore, Michael Kelly, David A Roth, Eytan M Stei. Targeting RARA Overexpression with Tamibarotene, a Potent and Selective RARα Agonist, is a Novel Approach in AML. Blood advances. 2022-12-08. PMID:36477975. |
a super-enhancer at the retinoic acid receptor alpha (rara) gene is associated with rara mrna overexpression in approximately 30% of non-acute promyelocytic leukemia (non apl) acute myeloid leukemia (aml) and in approximately 50% of myelodysplastic syndromes (mds). |
2022-12-08 |
2023-08-14 |
Not clear |
| Victoria Korsos, Wilson H Mille. How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy. Journal of molecular endocrinology. vol 69. issue 4. 2022-10-12. PMID:36112505. |
this t(15;17) results in a fusion transcript of promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) genes and the expression of a functional pml/rara protein. |
2022-10-12 |
2023-08-16 |
Not clear |
| Diana Condrea, Sirine Souali-Crespo, Betty Féret, Muriel Klopfenstein, Sylvain Faisan, Manuel Mark, Norbert B Ghyselinck, Nadège Verne. Retinoic Acid Receptor Alpha Is Essential in Postnatal Sertoli Cells but Not in Germ Cells. Cells. vol 11. issue 5. 2022-03-10. PMID:35269513. |
it is known that loss of retinoic acid nuclear receptor alpha (rara) induces male sterility due to seminiferous epithelium degeneration. |
2022-03-10 |
2023-08-13 |
Not clear |
| Monika W Perez, Oscar Sias-Garcia, Alfred Daramola, Helen Wei, Maci Terrell, Raushan Rashid, Woojun D Park, Kevin Duong, Terzah M Horton, Feng Li, Nikitha Cherayil, Jost Vrabic Koren, Vincent U Gant, Jacob J Junco, Choladda V Curry, Alexandra M Stevens, Charles Y Lin, Joanna S Y. Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency. Blood advances. vol 5. issue 23. 2021-11-25. PMID:34543389. |
the retinoic acid receptor alpha (rara) gene was differentially regulated in our cohort, and a rara-associated se was detected in 64% of the study cohort across all cytogenetic and molecular subtypes tested. |
2021-11-25 |
2023-08-13 |
mouse |
| Jhansi Rani Arumugam, B K Karthik Bommannan, Jayachandran Perumal Kalaiyarasi, Shirley Sundersing. Cytogenetics and FISH negative cryptic acute promyelocytic leukemia with CD56 expression. Indian journal of pathology & microbiology. vol 64. issue 2. 2021-10-06. PMID:33851647. |
however, rare cases of apl show a cryptic insertion of retinoic acid receptor alpha (rara) gene into promyelocytic leukemia (pml) gene which is negative both by fluorescence in situ hybridization (fish) and conventional cytogenetics (cc). |
2021-10-06 |
2023-08-13 |
Not clear |
| Md Abdullah Al Noman, Jillian L Kyzer, Sanny S W Chung, Debra J Wolgemuth, Gunda I Geor. Retinoic acid receptor antagonists for male contraception: current status†. Biology of reproduction. vol 103. issue 2. 2021-09-24. PMID:32671394. |
retinoic acid receptor alpha (rara), a nuclear receptor protein, has been validated as a target for male contraception by gene knockout studies and also pharmacologically using a pan-retinoic acid receptor antagonist. |
2021-09-24 |
2023-08-13 |
Not clear |
| Sanny S W Chung, Nika Vizcarra, Debra J Wolgemut. Filamentous actin disorganization and absence of apical ectoplasmic specialization disassembly during spermiation upon interference with retinoid signaling†. Biology of reproduction. vol 103. issue 2. 2021-09-24. PMID:32678439. |
we have observed spermiation defects, including abnormalities in spermatid orientation, translocation and release, in mice deficient in the retinoic acid receptor alpha (rara) and upon treatment with a pan-rar antagonist. |
2021-09-24 |
2023-08-13 |
mouse |
| Yuka Nagata, Takeshi Yamamoto, Makoto Kadowak. Ginger Increases ALDH1A1 Expression and Enhances Retinoic Acid Signaling in a Human Colonic Epithelial Cell Line. Journal of nutritional science and vitaminology. vol 66. issue 5. 2021-08-25. PMID:33132350. |
in addition, ginger significantly upregulated the gene expression of retinoic acid receptor (rar) alpha (rara), thereby enhancing ra signaling. |
2021-08-25 |
2023-08-13 |
mouse |
| Musa Yilmaz, Hagop Kantarjian, Farhad Ravand. Acute promyelocytic leukemia current treatment algorithms. Blood cancer journal. vol 11. issue 6. 2021-07-21. PMID:34193815. |
apl, accounting for 10-15% of the newly diagnosed aml cases, results from a balanced translocation, t(15;17) (q22;q12-21), which leads to the fusion of the promyelocytic leukemia (pml) gene with the retinoic acid receptor alpha (rara) gene. |
2021-07-21 |
2023-08-13 |
Not clear |
| Gui-Shuan Wang, Ajuan Liang, Yu-Bing Dai, Xiao-Long Wu, Fei Su. Expression and localization of retinoid receptors in the testis of normal and infertile men. Molecular reproduction and development. vol 87. issue 9. 2021-07-20. PMID:32770619. |
ra activates downstream pathways through its receptors (retinoic acid receptor alpha [rara], retinoic acid receptor beta, and retinoic acid receptor gamma [rarg]) and retinoid x receptors (retinoid x receptor alpha [rxra], retinoid x receptor beta [rxrb], and retinoid x receptor gamma [rxrg]). |
2021-07-20 |
2023-08-13 |
human |
| Shandong Tao, Lixiao Song, Yuan Deng, Yue Chen, Yuye Shi, Yimin Gan, Zhikui Deng, Banghe Ding, Zhengmei He, Chunling Wang, Liang Y. Acute Myeloid Leukemia with OncoTargets and therapy. vol 13. 2020-10-30. PMID:33116634. |
acute myeloid leukemia with retinoic acid receptor gamma (rarg) belongs to the nuclear receptor superfamily and has 90% homology to rar alpha (rara) and rar beta. |
2020-10-30 |
2023-08-13 |
Not clear |
| Yiping Liu, Fang Xu, Hong Hu, Jingjing Wen, Jing Su, Qiaolin Zhou, Wen Q. A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review. OncoTargets and therapy. vol 12. 2020-09-29. PMID:31447564. |
acute promyelocytic leukemia (apl) is commonly characterized by the fusion of retinoic acid receptor alpha (rara) with promyelocytic leukemia (pml). |
2020-09-29 |
2023-08-13 |
Not clear |
| Orsola di Martino, John S Welc. Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy. Cancers. vol 11. issue 12. 2020-09-28. PMID:31805753. |
all-trans retinoic acid (atra) is the principal endogenous ligand for the retinoic acid receptor alpha (rara) and is produced by the enzymatic oxidation of dietary vitamin a, whose deficiency is associated with several pathological conditions. |
2020-09-28 |
2023-08-13 |
Not clear |