| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin vol issue 2023 36870621 |
investigation of the memory-associated gene pacap and its receptor pac1r revealed differential effects of hfd on their expression in the hippocampus and amygdala. |
2023-03-04 |
2023-03-06 |
rat |
| Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin vol issue 2023 36870621 |
specifically, hfd induced increased expression of pacap and pac1r in the hippocampus, whereas decreased pacap was observed in the amygdala. |
2023-03-04 |
2023-03-06 |
rat |
| Mariel P Seiglie, Lauren Lepeak, Clara Vel\\xc3\\xa1zquez-Sanchez, Antonio Ferragud, Teresa Le, Pietro Cottone, Valentina Sabin. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro vol 9 issue 5 2022 36566434 |
the pituitary adenylate cyclase-activating polypeptide (pacap) system of the central amygdala mediates the detrimental effects of chronic social defeat stress in rats. |
2022-12-25 |
2023-01-30 |
rat |
| Mariel P Seiglie, Lauren Lepeak, Clara Vel\\xc3\\xa1zquez-Sanchez, Antonio Ferragud, Teresa Le, Pietro Cottone, Valentina Sabin. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro vol 9 issue 5 2022 36566434 |
pituitary adenylate cyclase-activating polypeptide (pacap) and its receptor pac1r are highly expressed within the central amygdala (cea) and play a key role in stress regulation. |
2022-12-25 |
2023-01-30 |
rat |
| Keerthana Sureshkumar, Andrea Saenz, Syed M Ahmad, Kabirullah Lutf. The PACAP/PAC1 Receptor System and Feeding. Brain sciences vol 12 issue 1 2022 35053757 |
pacap and its receptors are expressed in the central and peripheral nervous systems with moderate to high expression in the hypothalamus, amygdala, and other limbic structures. |
2022-01-21 |
2023-01-26 |
Not clear |
| Melissa N Boucher, Victor May, Karen M Braas, Sayamwong E Hammac. PACAP orchestration of stress-related responses in neural circuits. Peptides vol 142 issue 2021 33865930 |
pacap can also influence both the consolidation and expression of fear memories, as demonstrated by studies in several fear-related areas, such as the amygdala, hippocampus, and prefrontal cortex. |
2021-11-17 |
2023-01-26 |
human |
| Abha K Rajbhandari, Christopher J Octeau, Sarah Gonzalez, Zachary T Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z Hong, Rachael L Neve, James Waschek, Baljit S Khakh, Michael S Fanselo. A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 41 issue 15 2021 33637560 |
the amygdala regulates fear, whereas pacap (pituitary adenylate activating peptide) and pac1 receptors are linked to ptsd symptom severity at genetic/epigenetic levels, with a strong link in females with ptsd. |
2021-08-20 |
2023-01-26 |
mouse |
| Abha K Rajbhandari, Christopher J Octeau, Sarah Gonzalez, Zachary T Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z Hong, Rachael L Neve, James Waschek, Baljit S Khakh, Michael S Fanselo. A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 41 issue 15 2021 33637560 |
a basomedial amygdala to intercalated cells microcircuit expressing pacap and its receptor pac1 regulates contextual fear. |
2021-08-20 |
2023-01-26 |
mouse |
| Antonio Ferragud, Clara Velazquez-Sanchez, Margaret A Minnig, Valentina Sabino, Pietro Cotton. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 46 issue 3 2021 33191400 |
during acute withdrawal, rats exposed to chronic intermittent ethanol vapor (ethanol-dependent) displayed a significant increase in pacap levels in the bed nucleus of the stria terminalis (bnst), a brain area within the extended amygdala critically involved in both stress and withdrawal. |
2021-06-23 |
2023-01-26 |
rat |
| Scheila Daiane Schmidt, Carolina Garrido Zinn, Jonny Anderson Kielbovicz Behling, Ana Fl\\xc3\\xa1via Furian, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Ivan Izquierd. Inhibition of PACAP/PAC1/VPAC2 signaling impairs the consolidation of social recognition memory and nitric oxide prevents this deficit. Neurobiology of learning and memory vol 180 issue 2021 33705861 |
in the present work, we investigate the effect of the infusion of pacap-38 (endogenous neuropeptide and potent stimulator of adenylyl cyclase), pacap 6-38 (pac1/vpac2 receptors antagonist) and s-nitroso-n-acetyl-dl-penicillamine (snap, no donor) in the ca1 region of the hippocampus and in the basolateral amygdala (bla) on the consolidation of srm. |
2021-06-18 |
2023-01-26 |
rat |
| F P Varodayan, M A Minnig, M Q Steinman, C S Oleata, M W Riley, V Sabino, M Robert. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology vol 168 issue 2021 31476352 |
despite this behavioral evidence, pacap's effects on neuronal activity within the medial subdivision of the cea (cem, the major output nucleus for the entire amygdala complex) during basal conditions and after psychological stress remain unknown. |
2021-05-27 |
2023-01-26 |
rat |
| F P Varodayan, M A Minnig, M Q Steinman, C S Oleata, M W Riley, V Sabino, M Robert. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology vol 168 issue 2021 31476352 |
pacap regulation of central amygdala gabaergic synapses is altered by restraint stress. |
2021-05-27 |
2023-01-26 |
rat |
| F P Varodayan, M A Minnig, M Q Steinman, C S Oleata, M W Riley, V Sabino, M Robert. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology vol 168 issue 2021 31476352 |
the neuropeptide pacap and its main receptor pac1 are expressed in the rodent central amygdala (cea), a brain region critical in negative emotional processing, and cea pacapergic signaling drives anxiogenic and stress coping behaviors. |
2021-05-27 |
2023-01-26 |
rat |
| Mariel P Seiglie, Lillian Huang, Pietro Cottone, Valentina Sabin. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology vol 160 issue 2020 31493466 |
pituitary adenylate cyclase-activating polypeptide (pacap) is a neuropeptide highly expressed in the extended amygdala, a brain macrostructure involved in the response to threat that includes the central nucleus of the amygdala (cea) and the bed nucleus of the stria terminalis (bnst). |
2020-07-08 |
2023-01-26 |
rat |
| Mariel P Seiglie, Lillian Huang, Pietro Cottone, Valentina Sabin. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology vol 160 issue 2020 31493466 |
altogether, these data show that the pacap system of the extended amygdala contributes to stress-induced hyperarousal and suggest it as a potential novel target for the treatment of stress-related disorders. |
2020-07-08 |
2023-01-26 |
rat |
| Mariel P Seiglie, Lillian Huang, Pietro Cottone, Valentina Sabin. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology vol 160 issue 2020 31493466 |
role of the pacap system of the extended amygdala in the acoustic startle response in rats. |
2020-07-08 |
2023-01-26 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory vol 157 issue 2019 30458282 |
pacap can alter synaptic plasticity and has direct actions on neurons in the amygdala and hippocampus that could contribute to its acute and persistent effects on the consolidation and expression of conditioned fear. |
2019-11-25 |
2023-01-26 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory vol 157 issue 2019 30458282 |
pacap increases arc/arg 3.1 expression within the extended amygdala after fear conditioning in rats. |
2019-11-25 |
2023-01-26 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory vol 157 issue 2019 30458282 |
we recently demonstrated that intracerebroventricular (icv) infusion of pacap prior to fear conditioning (fc) results in initial amnestic-like effects followed by hyper-expression of conditioned freezing with repeated testing, and analyses of immediate-early gene c-fos expression suggested that the central nucleus of the amygdala (cea), but not the lateral/basolateral amygdala (la/bla) or hippocampus, are involved in these pacap effects. |
2019-11-25 |
2023-01-26 |
rat |
| Lee E Eiden, Andrew C Emery, Limei Zhang, Corey B Smit. PACAP signaling in stress: insights from the chromaffin cell. Pflugers Archiv : European journal of physiology vol 470 issue 1 2018 28965274 |
pacap is a neurotransmitter important in stress transduction in the central nervous system as well, and is found at stress-transduction nuclei in brain including the paraventricular nucleus of hypothalamus, the amygdala and extended amygdalar nuclei, and the prefrontal cortex. |
2018-07-27 |
2023-01-26 |
Not clear |