| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward G Meloni, William A Carlezon, Vadim Y Bolshako. Association between social dominance hierarchy and PACAP expression in the extended amygdala, corticosterone, and behavior in C57BL/6 male mice. Scientific reports. vol 14. issue 1. 2024-04-18. PMID:38637645. |
association between social dominance hierarchy and pacap expression in the extended amygdala, corticosterone, and behavior in c57bl/6 male mice. |
2024-04-18 |
2024-04-21 |
mouse |
| Steven J Granger, Victor May, Sayamwong E Hammack, Eylül Akman, Sydney A Jobson, Elizabeth A Olson, Cameron D Pernia, Nikos P Daskalakis, Caitlin Ravichandran, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. medRxiv : the preprint server for health sciences. 2023-09-11. PMID:37693514. |
in ptsd, pacap is associated with higher activity of the amygdala to threat stimuli and lower functional connectivity of the amygdala and hippocampus. |
2023-09-11 |
2023-10-07 |
Not clear |
| Steven J Granger, Victor May, Sayamwong E Hammack, Eylül Akman, Sydney A Jobson, Elizabeth A Olson, Cameron D Pernia, Nikos P Daskalakis, Caitlin Ravichandran, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. medRxiv : the preprint server for health sciences. 2023-09-11. PMID:37693514. |
here, we examined whether peripheral pacap levels were associated with neuronal morphology of the amygdala and hippocampus (primary analysis), and ec (secondary analysis) using neurite orientation dispersion and density imaging. |
2023-09-11 |
2023-10-07 |
Not clear |
| Sarah Thomas Broome, Mawj Mandwie, Catherine A Gorrie, Giuseppe Musumeci, Rubina Marzagalli, Alessandro Castorin. Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury. Journal of molecular neuroscience : MN. 2023-08-30. PMID:37646964. |
in sci rats, pacap expression was increased in the hypothalamus (104-141% vs sham) and amygdala (138-350%), but downregulated in the thalamus (35-95%) and periaqueductal gray (58-68%). |
2023-08-30 |
2023-09-07 |
rat |
| Mariel P Seiglie, Lauren Lepeak, Sophia Miracle, Pietro Cottone, Valentina Sabin. Stimulation of lateral parabrachial (LPB) to central amygdala (CeA) pituitary adenylate cyclase-activating polypeptide (PACAP) neurons induces anxiety-like behavior and mechanical allodynia. Pharmacology, biochemistry, and behavior. 2023-07-27. PMID:37499765. |
stimulation of lateral parabrachial (lpb) to central amygdala (cea) pituitary adenylate cyclase-activating polypeptide (pacap) neurons induces anxiety-like behavior and mechanical allodynia. |
2023-07-27 |
2023-08-14 |
Not clear |
| Edward G Meloni, William A Carlezon, Vadim Y Bolshako. Impact of social dominance hierarchy on PACAP expression in the extended amygdala, corticosterone, and behavior in C57BL/6 male mice. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205328. |
impact of social dominance hierarchy on pacap expression in the extended amygdala, corticosterone, and behavior in c57bl/6 male mice. |
2023-05-19 |
2023-08-14 |
mouse |
| Edward G Meloni, William A Carlezon, Vadim Y Bolshako. Impact of social dominance hierarchy on PACAP expression in the extended amygdala, corticosterone, and behavior in C57BL/6 male mice. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205328. |
here, we examined the impact of social dominance hierarchies established within cages of group-housed laboratory mice on expression of the stress peptide pituitary adenylate cyclase-activating polypeptide (pacap) in areas of the extended amygdala comprising the bed nucleus of the stria terminalis (bnst) and central nucleus of the amygdala (cea). |
2023-05-19 |
2023-08-14 |
mouse |
| Kevin J Clancy, Quentin Devignes, Poornima Kumar, Victor May, Sayamwong E Hammack, Eylül Akman, Emily J Casteen, Cameron D Pernia, Sydney A Jobson, Michael W Lewis, Nikolaos P Daskalakis, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-05-10. PMID:37161077. |
while the influence of pacap on amygdala reactivity has been described, its association with intrinsic amygdala connectivity remains unknown. |
2023-05-10 |
2023-08-14 |
human |
| Kevin J Clancy, Quentin Devignes, Poornima Kumar, Victor May, Sayamwong E Hammack, Eylül Akman, Emily J Casteen, Cameron D Pernia, Sydney A Jobson, Michael W Lewis, Nikolaos P Daskalakis, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-05-10. PMID:37161077. |
higher circulating pacap levels were associated with increased amygdala connectivity with posterior dmn regions, including the posterior cingulate cortex/precuneus (pcc/precun) and left angular gyrus (lang). |
2023-05-10 |
2023-08-14 |
human |
| Kevin J Clancy, Quentin Devignes, Poornima Kumar, Victor May, Sayamwong E Hammack, Eylül Akman, Emily J Casteen, Cameron D Pernia, Sydney A Jobson, Michael W Lewis, Nikolaos P Daskalakis, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-05-10. PMID:37161077. |
taken together, our findings converge with previously demonstrated effects of pacap on amygdala activity in ptsd-related processes and offer novel evidence for an association between pacap and intrinsic amygdala connectivity patterns in ptsd. |
2023-05-10 |
2023-08-14 |
human |
| Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin. 2023-03-04. PMID:36870621. |
investigation of the memory-associated gene pacap and its receptor pac1r revealed differential effects of hfd on their expression in the hippocampus and amygdala. |
2023-03-04 |
2023-08-14 |
rat |
| Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin. 2023-03-04. PMID:36870621. |
specifically, hfd induced increased expression of pacap and pac1r in the hippocampus, whereas decreased pacap was observed in the amygdala. |
2023-03-04 |
2023-08-14 |
rat |
| Mariel P Seiglie, Lauren Lepeak, Clara Velázquez-Sanchez, Antonio Ferragud, Teresa Le, Pietro Cottone, Valentina Sabin. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro. vol 9. issue 5. 2022-12-25. PMID:36566434. |
the pituitary adenylate cyclase-activating polypeptide (pacap) system of the central amygdala mediates the detrimental effects of chronic social defeat stress in rats. |
2022-12-25 |
2023-08-14 |
rat |
| Mariel P Seiglie, Lauren Lepeak, Clara Velázquez-Sanchez, Antonio Ferragud, Teresa Le, Pietro Cottone, Valentina Sabin. The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro. vol 9. issue 5. 2022-12-25. PMID:36566434. |
pituitary adenylate cyclase-activating polypeptide (pacap) and its receptor pac1r are highly expressed within the central amygdala (cea) and play a key role in stress regulation. |
2022-12-25 |
2023-08-14 |
rat |
| Keerthana Sureshkumar, Andrea Saenz, Syed M Ahmad, Kabirullah Lutf. The PACAP/PAC1 Receptor System and Feeding. Brain sciences. vol 12. issue 1. 2022-01-21. PMID:35053757. |
pacap and its receptors are expressed in the central and peripheral nervous systems with moderate to high expression in the hypothalamus, amygdala, and other limbic structures. |
2022-01-21 |
2023-08-13 |
Not clear |
| Melissa N Boucher, Victor May, Karen M Braas, Sayamwong E Hammac. PACAP orchestration of stress-related responses in neural circuits. Peptides. vol 142. 2021-11-17. PMID:33865930. |
pacap can also influence both the consolidation and expression of fear memories, as demonstrated by studies in several fear-related areas, such as the amygdala, hippocampus, and prefrontal cortex. |
2021-11-17 |
2023-08-13 |
human |
| Abha K Rajbhandari, Christopher J Octeau, Sarah Gonzalez, Zachary T Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z Hong, Rachael L Neve, James Waschek, Baljit S Khakh, Michael S Fanselo. A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 15. 2021-08-20. PMID:33637560. |
a basomedial amygdala to intercalated cells microcircuit expressing pacap and its receptor pac1 regulates contextual fear. |
2021-08-20 |
2023-08-13 |
mouse |
| Abha K Rajbhandari, Christopher J Octeau, Sarah Gonzalez, Zachary T Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z Hong, Rachael L Neve, James Waschek, Baljit S Khakh, Michael S Fanselo. A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 15. 2021-08-20. PMID:33637560. |
the amygdala regulates fear, whereas pacap (pituitary adenylate activating peptide) and pac1 receptors are linked to ptsd symptom severity at genetic/epigenetic levels, with a strong link in females with ptsd. |
2021-08-20 |
2023-08-13 |
mouse |
| Antonio Ferragud, Clara Velazquez-Sanchez, Margaret A Minnig, Valentina Sabino, Pietro Cotton. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 3. 2021-06-23. PMID:33191400. |
during acute withdrawal, rats exposed to chronic intermittent ethanol vapor (ethanol-dependent) displayed a significant increase in pacap levels in the bed nucleus of the stria terminalis (bnst), a brain area within the extended amygdala critically involved in both stress and withdrawal. |
2021-06-23 |
2023-08-13 |
rat |
| Scheila Daiane Schmidt, Carolina Garrido Zinn, Jonny Anderson Kielbovicz Behling, Ana Flávia Furian, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Ivan Izquierd. Inhibition of PACAP/PAC1/VPAC2 signaling impairs the consolidation of social recognition memory and nitric oxide prevents this deficit. Neurobiology of learning and memory. vol 180. 2021-06-18. PMID:33705861. |
in the present work, we investigate the effect of the infusion of pacap-38 (endogenous neuropeptide and potent stimulator of adenylyl cyclase), pacap 6-38 (pac1/vpac2 receptors antagonist) and s-nitroso-n-acetyl-dl-penicillamine (snap, no donor) in the ca1 region of the hippocampus and in the basolateral amygdala (bla) on the consolidation of srm. |
2021-06-18 |
2023-08-13 |
rat |