| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F P Varodayan, M A Minnig, M Q Steinman, C S Oleata, M W Riley, V Sabino, M Robert. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology. vol 168. 2021-05-27. PMID:31476352. |
pacap regulation of central amygdala gabaergic synapses is altered by restraint stress. |
2021-05-27 |
2023-08-13 |
rat |
| F P Varodayan, M A Minnig, M Q Steinman, C S Oleata, M W Riley, V Sabino, M Robert. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology. vol 168. 2021-05-27. PMID:31476352. |
the neuropeptide pacap and its main receptor pac1 are expressed in the rodent central amygdala (cea), a brain region critical in negative emotional processing, and cea pacapergic signaling drives anxiogenic and stress coping behaviors. |
2021-05-27 |
2023-08-13 |
rat |
| F P Varodayan, M A Minnig, M Q Steinman, C S Oleata, M W Riley, V Sabino, M Robert. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology. vol 168. 2021-05-27. PMID:31476352. |
despite this behavioral evidence, pacap's effects on neuronal activity within the medial subdivision of the cea (cem, the major output nucleus for the entire amygdala complex) during basal conditions and after psychological stress remain unknown. |
2021-05-27 |
2023-08-13 |
rat |
| Mariel P Seiglie, Lillian Huang, Pietro Cottone, Valentina Sabin. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology. vol 160. 2020-07-08. PMID:31493466. |
role of the pacap system of the extended amygdala in the acoustic startle response in rats. |
2020-07-08 |
2023-08-13 |
rat |
| Mariel P Seiglie, Lillian Huang, Pietro Cottone, Valentina Sabin. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology. vol 160. 2020-07-08. PMID:31493466. |
pituitary adenylate cyclase-activating polypeptide (pacap) is a neuropeptide highly expressed in the extended amygdala, a brain macrostructure involved in the response to threat that includes the central nucleus of the amygdala (cea) and the bed nucleus of the stria terminalis (bnst). |
2020-07-08 |
2023-08-13 |
rat |
| Mariel P Seiglie, Lillian Huang, Pietro Cottone, Valentina Sabin. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology. vol 160. 2020-07-08. PMID:31493466. |
altogether, these data show that the pacap system of the extended amygdala contributes to stress-induced hyperarousal and suggest it as a potential novel target for the treatment of stress-related disorders. |
2020-07-08 |
2023-08-13 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. |
pacap increases arc/arg 3.1 expression within the extended amygdala after fear conditioning in rats. |
2019-11-25 |
2023-08-13 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. |
pacap can alter synaptic plasticity and has direct actions on neurons in the amygdala and hippocampus that could contribute to its acute and persistent effects on the consolidation and expression of conditioned fear. |
2019-11-25 |
2023-08-13 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. |
we recently demonstrated that intracerebroventricular (icv) infusion of pacap prior to fear conditioning (fc) results in initial amnestic-like effects followed by hyper-expression of conditioned freezing with repeated testing, and analyses of immediate-early gene c-fos expression suggested that the central nucleus of the amygdala (cea), but not the lateral/basolateral amygdala (la/bla) or hippocampus, are involved in these pacap effects. |
2019-11-25 |
2023-08-13 |
rat |
| Lee E Eiden, Andrew C Emery, Limei Zhang, Corey B Smit. PACAP signaling in stress: insights from the chromaffin cell. Pflugers Archiv : European journal of physiology. vol 470. issue 1. 2018-07-27. PMID:28965274. |
pacap is a neurotransmitter important in stress transduction in the central nervous system as well, and is found at stress-transduction nuclei in brain including the paraventricular nucleus of hypothalamus, the amygdala and extended amygdalar nuclei, and the prefrontal cortex. |
2018-07-27 |
2023-08-13 |
Not clear |
| Attilio Iemolo, Antonio Ferragud, Pietro Cottone, Valentina Sabin. Pituitary Adenylate Cyclase-Activating Peptide in the Central Amygdala Causes Anorexia and Body Weight Loss via the Melanocortin and the TrkB Systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25649277. |
intra-cea (but not intra-basolateral amygdala) pacap dose-dependently induced anorexia and body weight loss without affecting locomotor activity. |
2016-03-08 |
2023-08-13 |
rat |
| S D Schmidt, J C Myskiw, C R G Furini, B E Schmidt, L E Cavalcante, I Izquierd. PACAP modulates the consolidation and extinction of the contextual fear conditioning through NMDA receptors. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25490058. |
thus, in the current study we investigated in the ca1 region of hippocampus and in the basolateral amygdala (bla) the role of pacap in the consolidation and extinction of contextual fear conditioning (cfc) and the interaction between pacap and nmda receptors. |
2015-11-10 |
2023-08-13 |
rat |
| Galen Missig, Carolyn W Roman, Margaret A Vizzard, Karen M Braas, Sayamwong E Hammack, Victor Ma. Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of pain. Neuropharmacology. vol 86. 2015-07-14. PMID:24998751. |
parabrachial nucleus (pbn) pituitary adenylate cyclase activating polypeptide (pacap) signaling in the amygdala: implication for the sensory and behavioral effects of pain. |
2015-07-14 |
2023-08-13 |
Not clear |
| Jennifer Strafford Stevens, Lynn M Almli, Negar Fani, David A Gutman, Bekh Bradley, Seth D Norrholm, Emily Reiser, Timothy D Ely, Rahim Dhanani, Ebony M Glover, Tanja Jovanovic, Kerry J Ressle. PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 8. 2014-04-22. PMID:24516127. |
pacap receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. |
2014-04-22 |
2023-08-12 |
Not clear |
| Jennifer Strafford Stevens, Lynn M Almli, Negar Fani, David A Gutman, Bekh Bradley, Seth D Norrholm, Emily Reiser, Timothy D Ely, Rahim Dhanani, Ebony M Glover, Tanja Jovanovic, Kerry J Ressle. PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 8. 2014-04-22. PMID:24516127. |
analyses focused on the amygdala and hippocampus, regions that play central roles in the pathophysiology of ptsd and are known to have high densities of pacap receptors. |
2014-04-22 |
2023-08-12 |
Not clear |
| Jon M Resch, Brian Maunze, Adriana K Gerhardt, Samuel K Magnuson, Kailynn A Phillips, SuJean Cho. Intrahypothalamic pituitary adenylate cyclase-activating polypeptide regulates energy balance via site-specific actions on feeding and metabolism. American journal of physiology. Endocrinology and metabolism. vol 305. issue 12. 2014-02-26. PMID:24148346. |
ctb signal from pvn injections was colocalized with pacap mrna in the medial anterior bed nucleus of the stria terminalis, vmn, and lateral parabrachial nucleus (lpb), whereas ctb signal from vmn injections was highly colocalized with pacap mrna in the medial amygdala and lpb. |
2014-02-26 |
2023-08-12 |
Not clear |
| Jun-Hyeong Cho, Ko Zushida, Gleb P Shumyatsky, William A Carlezon, Edward G Meloni, Vadim Y Bolshako. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 41. 2013-01-03. PMID:23055486. |
pacap is highly expressed in the amygdala, a subcortical brain area involved in both innate and learned fear, suggesting a role for pacap-mediated signaling in fear-related behaviors. |
2013-01-03 |
2023-08-12 |
rat |
| Jun-Hyeong Cho, Ko Zushida, Gleb P Shumyatsky, William A Carlezon, Edward G Meloni, Vadim Y Bolshako. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 41. 2013-01-03. PMID:23055486. |
it remains unknown, however, whether and how pacap affects neuronal and synaptic functions in the amygdala. |
2013-01-03 |
2023-08-12 |
rat |
| Tamás Kozicz, Akira Arimur. Dopamine- and cyclic AMP-regulated phosphoprotein-immunoreactive neurons activated by acute stress are innervated by fiber terminals immunopositive for pituitary adenylate cyclase-activating polypeptide in the extended amygdala in the rat. Regulatory peptides. vol 109. issue 1-3. 2003-06-24. PMID:12409216. |
the oval nucleus of the bst and the central amygdala exhibit a dense network of pituitary adenylate cyclase-activating polypeptide (pacap)-immunoreactive (ir) fiber terminals. |
2003-06-24 |
2023-08-12 |
rat |
| K Peeters, H H Gerets, L Arckens, F Vandesand. Distribution of pituitary adenylate cyclase-activating polypeptide and pituitary adenylate cyclase-activating polypeptide type I receptor mRNA in the chicken brain. The Journal of comparative neurology. vol 423. issue 1. 2000-08-07. PMID:10861537. |
the telencephalic areas where the most intense signals for pacap mrna were found included the hyperstriatum accessorium, the hippocampus, and the archistriatum. |
2000-08-07 |
2023-08-12 |
chicken |