| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon Taraku, Roger P Woods, Michael Boucher, Randall Espinoza, Mayank Jog, Noor Al-Sharif, Katherine L Narr, Artemis Zavaliangos-Petropul. Changes in white matter microstructure following serial ketamine infusions in treatment resistant depression. Human brain mapping. 2023-01-30. PMID:36715291. |
ski leads to significant changes in the microstructural features of neurites within occipitotemporal tracts, and changes in neurite density within tracts connecting the basal ganglia, thalamus, and cortex relate to improvements in anhedonia. |
2023-01-30 |
2023-08-14 |
Not clear |
| Xiangchuan Chen, Diana J Beltran, Valeriya D Tsygankova, Bobbi J Woolwine, Trusharth Patel, Wendy Baer, Jennifer C Felger, Andrew H Miller, Ebrahim Haroo. Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34482366. |
we measured markers of glial dysfunction and distress including glutamate (glu) and myo-inositol in the left basal ganglia using magnetic resonance spectroscopy (mrs); metrics of local activity coherence (regional homogeneity, reho) and functional connectivity from resting-state functional mri measures; and anhedonia from the inventory for depressive symptoms-self report version (ids-sr). |
2021-10-11 |
2023-08-13 |
human |
| Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Rodrigo B Mansur, Roger C Ho, Samantha J Yim, Roger S McIntyr. Anti-cytokine agents for anhedonia: targeting inflammation and the immune system to treat dimensional disturbances in depression. Therapeutic advances in psychopharmacology. vol 8. issue 12. 2020-09-30. PMID:30524702. |
three ongoing clinical trials aim to investigate the effects of anti-tnf-alpha biologic infliximab on measures of anhedonia [clinicaltrials.gov identifier: nct02363738], motivational behavior and circuitry [clinicaltrials.gov identifier: nct03006393], and glutamatergic changes in the basal ganglia [clinicaltrials.gov identifier: nct03004443] in clinical populations with unipolar or bipolar depression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bei Zhang, Pan Lin, Huqing Shi, Dost Öngür, Randy P Auerbach, Xiaosheng Wang, Shuqiao Yao, Xiang Wan. Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis. Brain imaging and behavior. vol 10. issue 3. 2017-10-16. PMID:26487590. |
ale results revealed that consummatory anhedonia was associated with decreased activation in ventral basal ganglia areas, while anticipatory anhedonia was associated with more substrates in frontal-striatal networks except the ventral striatum, which included the dorsal anterior cingulate, middle frontal gyrus and medial frontal gyrus. |
2017-10-16 |
2023-08-13 |
Not clear |
| E Haroon, C C Fleischer, J C Felger, X Chen, B J Woolwine, T Patel, X P Hu, A H Mille. Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Molecular psychiatry. vol 21. issue 10. 2017-09-05. PMID:26754953. |
in turn, log left basal ganglia glutamate was associated with anhedonia and psychomotor slowing measured by the finger-tapping test, simple reaction time task and the digit symbol substitution task. |
2017-09-05 |
2023-08-13 |
Not clear |
| Ebrahim Haroon, Andrew H Mille. Inflammation Effects on Brain Glutamate in Depression: Mechanistic Considerations and Treatment Implications. Current topics in behavioral neurosciences. vol 31. 2017-06-20. PMID:27830574. |
moreover, mrs studies in patients with major depressive disorder have revealed that increased markers of inflammation including c-reactive protein correlate with increased basal ganglia glutamate, which in turn was associated with anhedonia and psychomotor retardation. |
2017-06-20 |
2023-08-13 |
human |
| Yu Sun Chung, Deanna Barc. Anhedonia is associated with reduced incentive cue related activation in the basal ganglia. Cognitive, affective & behavioral neuroscience. vol 15. issue 4. 2016-08-15. PMID:26105776. |
anhedonia is associated with reduced incentive cue related activation in the basal ganglia. |
2016-08-15 |
2023-08-13 |
human |
| Jennifer C Felger, Andrew H Mille. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Frontiers in neuroendocrinology. vol 33. issue 3. 2013-04-05. PMID:23000204. |
however, chronic inflammation and exposure to inflammatory cytokines appears to lead to persisting alterations in the basal ganglia and dopamine function reflected by anhedonia, fatigue, and psychomotor slowing. |
2013-04-05 |
2023-08-12 |
Not clear |
| Daniel G Dillon, Ryan Bogdan, Jesen Fagerness, Avram J Holmes, Roy H Perlis, Diego A Pizzagall. Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Human brain mapping. vol 31. issue 2. 2010-03-22. PMID:19621370. |
trek1 genetic variations did not affect basal ganglia volume, and fmri group differences were confirmed when accounting for self-report measures of anhedonia. |
2010-03-22 |
2023-08-12 |
Not clear |
| P-O Harvey, J Pruessner, Y Czechowska, M Lepag. Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects. Molecular psychiatry. vol 12. issue 8. 2007-09-25. PMID:17505465. |
these findings may reflect a specific kind of vulnerability for the development of psychiatric affective disorders and suggest that trait anhedonia may be linked to a volumetric reduction in the basal ganglia and to a prefrontal functional abnormality during hedonic processing. |
2007-09-25 |
2023-08-12 |
human |