| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C'iana P Cooper, Liam H Cheng, Jafar A Bhatti, Edward L Rivera, Derek Huell, Cristina Banuelos, Evelyn J Perez, Jeffrey M Long, Peter R Rap. Cerebellum Purkinje cell vulnerability in aged rats with memory impairment. The Journal of comparative neurology. vol 532. issue 4. 2024-04-12. PMID:38605461. |
parallel biochemical analysis of pc-specific protein levels in whole cerebellum additionally revealed that calbindin-d28k and purkinje cell protein-2 (pcp-2) levels were lower selectively in aged rats with spatial memory impairment compared to both young animals and aged rats with intact memory. |
2024-04-12 |
2024-04-14 |
rat |
| Melike Doğan Ünlü, Sanem Aşçı, Orhan İmeci, Adem Milletsever, Özlem Özmen, Serdar Sezer, Serpil Demirc. A novel insight into the neuroprotective effects of cannabidiol: maintained apelin/dopamine synthesis, NRF2 signaling, and AKT/CREB/BDNF gene expressions. Acta neurobiologiae experimentalis. vol 84. issue 1. 2024-04-08. PMID:38587319. |
additionally, purkinje cell loss in the cerebellum, as well as neuronal loss in the cerebral cortex and hippocampus, were found throughout the lps group. |
2024-04-08 |
2024-04-10 |
rat |
| Gabriella Sekerková, Sümeyra Kiliç, Yen-Hsin Cheng, Natalie Fredrick, Anne Osmani, Haram Kim, Puneet Opal, Marco Martin. Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia. Neurobiology of disease. 2024-04-04. PMID:38575093. |
cerebellar pathology is characterized by early and almost complete loss of unipolar brush cells as well as slowly progressive, moderate loss of purkinje cell (pcs). |
2024-04-04 |
2024-04-07 |
mouse |
| N Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L Pritchett, Megan R Care. Climbing fibers provide essential instructive signals for associative learning. Nature neuroscience. 2024-04-02. PMID:38565684. |
however, recent studies have shown that purkinje cell stimulation can also drive cerebellar learning and the relative importance of these two neuron types in providing instructive signals for cerebellum-dependent behaviors remains unresolved. |
2024-04-02 |
2024-04-05 |
mouse |
| N Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L Pritchett, Megan R Care. Climbing fibers provide essential instructive signals for associative learning. Nature neuroscience. 2024-04-02. PMID:38565684. |
we conclude that cfs and corresponding purkinje cell complex spike events provide essential instructive signals for associative cerebellar learning. |
2024-04-02 |
2024-04-05 |
mouse |
| Luis E Salazar Leon, Amanda M Brown, Heet Kaku, Roy V Sillito. Purkinje cell dysfunction causes disrupted sleep in ataxic mice. Disease models & mechanisms. 2024-04-02. PMID:38563553. |
here, we used an ataxic mouse model generated by silencing purkinje cell neurotransmission (l7cre;vgatfx/fx) to better understand how cerebellar dysfunction impacts sleep physiology. |
2024-04-02 |
2024-04-04 |
mouse |
| Shilin Song, Yuanyuan Li, Lin Lv, Mengqi Dong, Zhanfen Qi. Tetrabromobisphenol A exerts thyroid disrupting effects but has little overt impact on postnatal brain development and neurobehaviors in mice. Journal of environmental sciences (China). vol 142. 2024-03-25. PMID:38527875. |
the highest dose of tbbpa also caused thyroid histological alteration but had no effects on cerebellar development in terms of purkinje cell morphology and the thickness of the internal granular layer and the molecular layer of the cerebellum. |
2024-03-25 |
2024-03-28 |
mouse |
| Valérie Quinot, Romana Höftberge. Pathogenesis and immunopathology of paraneoplastic disorders. Handbook of clinical neurology. vol 200. 2024-03-17. PMID:38494287. |
by contrast, the neuropathology of cell surface antibody-mediated pns strongly depends on the targeted antigen and varies from b cell/plasma cell-dominated inflammation and well-preserved neurons together with a reduced expression of the target antigen in anti-nmdar encephalitis to irreversible purkinje cell loss in anti-p/q-type vgcc antibody-associated paraneoplastic cerebellar degeneration. |
2024-03-17 |
2024-03-20 |
Not clear |
| Elise Peter, Jérôme Honnorat, Virginie Desestre. Paraneoplastic neurologic syndrome associated with gynecologic and breast malignancies. Handbook of clinical neurology. vol 200. 2024-03-17. PMID:38494293. |
gynecologic and breast malignancies are the cancers most commonly associated with paraneoplastic neurologic syndromes, of which the foremost is yo [purkinje cell antibody, type 1 (pca-1)] paraneoplastic cerebellar degeneration. |
2024-03-17 |
2024-03-20 |
Not clear |
| Christopher Douthwaite, Christoph Tietje, XiaoQian Ye, Sabine Liebsche. Probing cerebellar circuit dysfunction in rodent models of spinocerebellar ataxia by means of in vivo two-photon calcium imaging. STAR protocols. vol 5. issue 1. 2024-02-27. PMID:38412102. |
purkinje neuron degeneration characterizes spinocerebellar ataxia type 1, yet the comprehension of the impact on the broader cerebellar circuit remains incomplete. |
2024-02-27 |
2024-03-01 |
mouse |
| Michalina Hanzel, Kayla Fernando, Susan E Maloney, Shioaching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull, Mary E Hatte. Mice lacking bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405978. |
mice lacking astrotactin 2 (astn2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar purkinje cell (pc) synaptic activity. |
2024-02-26 |
2024-02-28 |
mouse |
| Ping He, Shuting Zhong, Shuaijun Lin, Zhiyan Xia, Liqing Wang, Yuhe Han, Di Xu, Shuping Hu, Xiaokun Li, Peijun Li, Cong Wan. FGF9 is required for Purkinje cell development and function in the cerebellum. iScience. vol 27. issue 2. 2024-02-14. PMID:38352230. |
fgf9 is required for purkinje cell development and function in the cerebellum. |
2024-02-14 |
2024-02-16 |
Not clear |
| Ping He, Shuting Zhong, Shuaijun Lin, Zhiyan Xia, Liqing Wang, Yuhe Han, Di Xu, Shuping Hu, Xiaokun Li, Peijun Li, Cong Wan. FGF9 is required for Purkinje cell development and function in the cerebellum. iScience. vol 27. issue 2. 2024-02-14. PMID:38352230. |
it has been reported that deletion of fgf9 leads to defects in cerebellum development, including purkinje cell defect. |
2024-02-14 |
2024-02-16 |
Not clear |
| Smathorn Thakolwiboon, Jenny Linnoila, Sean J Pittock, Divyanshu Dubey, Anastasia Zekerido. Cerebellar leptomeningeal enhancement: An imaging finding of rapidly progressive Purkinje cell cytoplasmic autoantibody type 1 paraneoplastic cerebellar syndrome. Journal of neuroimmunology. vol 387. 2024-01-24. PMID:38266443. |
cerebellar leptomeningeal enhancement: an imaging finding of rapidly progressive purkinje cell cytoplasmic autoantibody type 1 paraneoplastic cerebellar syndrome. |
2024-01-24 |
2024-01-27 |
Not clear |
| Smathorn Thakolwiboon, Jenny Linnoila, Sean J Pittock, Divyanshu Dubey, Anastasia Zekerido. Cerebellar leptomeningeal enhancement: An imaging finding of rapidly progressive Purkinje cell cytoplasmic autoantibody type 1 paraneoplastic cerebellar syndrome. Journal of neuroimmunology. vol 387. 2024-01-24. PMID:38266443. |
purkinje cell cytoplasmic autoantibody type 1 (pca1), also known as anti-yo, is a 'high-risk' paraneoplastic antibody, associated with rapidly progressive cerebellar syndrome. |
2024-01-24 |
2024-01-27 |
Not clear |
| Samar M Ez Elarab, Mohamed A M Alsafy, Samir A A El-Gendy, Neveen E R El-Bakary, Ahmed Elsayed Noreldin, Ahmed M Rashwa. Investigating the role of Purkinje fibers and synaptic connectivity in balance regulation through comprehensive ultrastructural and immunohistochemical analysis of the donkey's (Equus asinus) cerebellum. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2024-01-17. PMID:38229259. |
the purkinje cells were situated in the intermediate zone of the cerebellum cortex, known as the purkinje cell layer. |
2024-01-17 |
2024-01-19 |
Not clear |
| Sara A Hosny, Alshaymaa M Abdelmenem, Taha Azouz, Samaa S Kamar, Asmaa M ShamsEldeen, Asmaa A El-Shafe. Beneficial Effect of Erythropoietin on Ameliorating Propionic Acid-Induced Autistic-Like Features in Young Rats. Acta histochemica et cytochemica. vol 56. issue 5. 2023-11-16. PMID:37970239. |
epo protected cerebellar structure, increased purkinje cell count, improved neuronal morphology, reduced ppa-induced autistic-like features, alleviated neuronal oxidative stress, increased intercellular antioxidant levels, and suppressed inflammation. |
2023-11-16 |
2023-11-20 |
rat |
| Christopher H Chen, Leannah N Newman, Amanda P Stark, Katherine E Bond, Dawei Zhang, Stefano Nardone, Charles R Vanderburg, Naeem M Nadaf, Zhiyi Yao, Kefiloe Mutume, Isabella Flaquer, Bradford B Lowell, Evan Z Macosko, Wade G Regeh. A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain. Nature neuroscience. vol 26. issue 11. 2023-11-03. PMID:37919612. |
a purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain. |
2023-11-03 |
2023-11-08 |
Not clear |
| Lan Zhang, Kun Yang, Xiao Tan, Yazhu Cai, Haie Ding, Rui Li, Yiyang Zhang, Manlin Zhou, Zuli Ben, Qian Zhang, Zilin Qia. Analysis of age-related differences in hypoxia-related factors in yak brain tissue. Folia morphologica. 2023-10-12. PMID:37822067. |
immunohistochemical results showed that hif-1α, epo, vegf, and vcam were expressed in the pyramidal cell layer of the yak cerebrum, and distributed in the cerebellum granulose cell layer, purkinje cell layer and medulla layer, and were mainly positive in purkinje cells and medulla. |
2023-10-12 |
2023-10-15 |
Not clear |
| Seth A Ament, Marcia Cortes-Gutierrez, Brian R Herb, Evelina Mocci, Carlo Colantuoni, Margaret M McCarth. A single-cell genomic atlas for maturation of the human cerebellum during early childhood. Science translational medicine. 2023-10-12. PMID:37824600. |
immunohistochemical analysis of a subset of these postmortem cerebellar samples revealed no change to purkinje neuron soma size but evidence for increased activation of microglia in those children who had experienced inflammation. |
2023-10-12 |
2023-10-15 |
human |