All Relations between cerebellum and cerebellum purkinje cell

Reference Sentence Publish Date Extraction Date Species
Hoda Ranjbar, Monavareh Soti, Kristi A Kohlmeier, Mahyar Janahmadi, Mohammad Shaban. Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP. BMC neuroscience vol 24 issue 1 2023 36869289 although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-ap exposure on purkinje cell electrophysiological properties. 2023-03-03 2023-03-06 Not clear
Felicity R Sterling, Jon D'Amico, Alexandria M Brumfield, Kara L Huegel, Patricia S Vaughan, Kathryn Morris, Shelby Schwarz, Michelle V Joyce, Bill Boggess, Matthew M Champion, Kevin Maciuba, Philip Allen, Eric Marasco, Grant Koch, Peter Gonzalez, Shannon Hodges, Shannon Leahy, Erica Gerstbauer, Edward H Hinchcliffe, Kevin T Vaugha. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival. Journal of cell science vol 136 issue 5 2023 36861884 the pathological accumulation of cholesterol is a signature feature of niemann-pick type c (npc) disease, in which excessive lipid levels induce purkinje cell death in the cerebellum. 2023-03-02 2023-03-06 mouse
David J Herzfeld, Mati Joshua, Stephen G Lisberge. Rate versus synchrony codes for cerebellar control of motor behavior. bioRxiv : the preprint server for biology vol issue 2023 36824885 simultaneous recordings from purkinje cell pairs in the cerebellar flocculus of rhesus macaques revealed how these cells coordinate their activity to drive smooth pursuit eye movements. 2023-02-24 2023-03-06 Not clear
Fabrice Faure, Lidia Yshii, Toufic Renno, Isabelle Coste, Bastien Joubert, Virginie Desestret, Roland Liblau, J\\xc3\\xa9r\\xc3\\xb4me Honnora. A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model. Cerebellum (London, England) vol issue 2023 36729270 ataxia and gait instability were assessed in treated mice as well as autoantibody levels, purkinje cell density, and immune infiltration in the cerebellum. 2023-02-02 2023-03-06 mouse
Audrey Bonnan, Ke Zhang, Michael A Gaffield, Jason M Christi. Expression of a form of cerebellar motor memory requires learned alterations to the activity of inhibitory molecular layer interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2023 36639897 procedural memories formed in the cerebellum in response to motor errors depend on changes to purkinje cell (pc) spiking patterns that correct movement when the erroneous context is repeated. 2023-01-14 2023-01-30 mouse
Ling-Ge Cui, Lin Liu, Mu-Zi Li, Yu Zhu, Xiang-Yu Ma, Xue-Nan Li, Jin-Long L. Phthalate induces mitochondrial injury in cerebellum through Sirt1-PGC-1\\xce\\xb1 and PINK1/Parkin-mediated signal pathways. Life sciences vol issue 2023 36623767 in present study, we set dehp-caused cerebellar injury models of quail and implied that dehp induced cerebellar dysplasia by abnormity of purkinje cell and reduction of cerebellar granule cell. 2023-01-09 2023-01-30 Not clear
Mireia Ortega, Ilario De Toma, \\xc3\\x81lvaro Fern\\xc3\\xa1ndez-Blanco, Anna Calder\\xc3\\xb3n, Luc\\xc3\\xada Barahona, Ram\\xc3\\xb3n Trull\\xc3\\xa0s, Eduard Sabid\\xc3\\xb3, Mara Diersse. Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene. Frontiers in molecular neuroscience vol 15 issue 2023 36590914 dyrk1a has also been implicated in cerebellar abnormalities observed in association with ds, and normalization of dyrk1a dosage rescues granular and purkinje cell densities in a trisomic ds mouse model. 2023-01-02 2023-01-30 mouse
Jonathan Mapelli, Giulia Maria Boiani, Egidio D'Angelo, Albertino Bigiani, Daniela Gandolf. Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer. Biomedicines vol 10 issue 12 2022 36551941 thus, akin with the expansion recoding process theoretically attributed to the cerebellum granular layer, ltp and ltd could implement selective filtering lines channeling information toward the molecular and purkinje cell layers for further processing. 2022-12-23 2023-01-30 Not clear
A Barri, M T Wiechert, M Jazayeri, D A DiGregori. Synaptic basis of a sub-second representation of time in a neural circuit model. Nature communications vol 13 issue 1 2022 36550115 a cerebellar circuit model equipped with dynamic synapses produced a diverse set of transient granule cell firing patterns that provided a temporal basis set for learning precisely timed pauses in purkinje cell activity during simulated delay eyelid conditioning and bayesian interval estimation. 2022-12-22 2023-01-30 Not clear
Asha Vijayan, Shyam Diwaka. A cerebellum inspired spiking neural network as a multi-model for pattern classification and robotic trajectory prediction. Frontiers in neuroscience vol 16 issue 2022 36518530 in the current work, a cerebellum-inspired spiking neural network with dynamics of cerebellar neurons and learning mechanisms attributed to the granular layer, purkinje cell (pc) layer, and cerebellar nuclei interconnected by excitatory and inhibitory synapses was implemented. 2022-12-15 2023-01-30 Not clear
Stijn Voerman, Bastiaan H A Urbanus, Martijn Schonewille, Joshua J White, Chris I De Zeeu. Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity. Communications biology vol 5 issue 1 2022 36463347 cerebellar learning is expressed as upbound or downbound changes in simple spike activity of purkinje cell subpopulations, but the underlying mechanism remains enigmatic. 2022-12-03 2023-01-30 mouse
Ella Borgenheimer, Katherine Hamel, Carrie Sheeler, Francisco Labrada Moncada, Kaelin Sbrocco, Ying Zhang, Marija Cvetanovi. Single nuclei RNA sequencing investigation of the Purkinje cell and glial changes in the cerebellum of transgenic Spinocerebellar ataxia type 1 mice. Frontiers in cellular neuroscience vol 16 issue 2022 36457352 single nuclei rna sequencing investigation of the purkinje cell and glial changes in the cerebellum of transgenic spinocerebellar ataxia type 1 mice. 2022-12-02 2023-01-30 mouse
Cheryl Brandenburg, Anthony J Griswold, Derek J Van Booven, Michaela B C Kilander, Jeannine A Frei, Michael W Nestor, Derek M Dykxhoorn, Margaret A Pericak-Vance, Gene J Blat. Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders. Frontiers in genetics vol 13 issue 2022 36437953 however, studies from human postmortem asd brains have consistently revealed disruptions in cerebellar circuitry, specifically reductions in purkinje cell (pc) number and size. 2022-11-28 2023-01-30 human
Ri Wang, Chao Liu, Wenyan Guo, Lixuan Wang, Siruan Chen, Jiaojiao Zhao, Xia Qin, Wanjun Bai, Zuxiao Yang, Dezhi Kong, Zhanfeng Jia, Shufeng Liu, Wei Zhan. Movement disorder caused by FRRS1L deficiency may be associated with morphological and functional disorders in Purkinje cells. Brain research bulletin vol 191 issue 2022 36330921 deletion also impairs purkinje cell dendritic spine formation and ampar expression in the cerebellum and damages the electrophysiological discharge rhythm of purkinje cells. 2022-11-04 2023-01-30 mouse
Deniz Yilmazer-Hanke, Najwa Ouali Alami, Lubin Fang, Sigried Klotz, Gabor G Kovacs, Helmut Pankratz, Joachim Weis, Istvan Katona, Angelika Scheuerle, Wolfgang J Streit, Kelly Del Tredic. Differential Glial Chitotriosidase 1 (CHIT1) and Chitinase 3-like protein 1 (CHI3L1) Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia. Neuroscience vol issue 2022 36332693 initial striatal cortical and cerebellar purkinje cell damage, detectable already 1/2 d after hibi, led to delayed neuronal death, whereas loss of cerebellar nfh-positive stellate and calr-positive granule cells was variable. 2022-11-04 2023-01-30 human
Sylvie Picker-Minh, Ilaria Luperi, Ethiraj Ravindran, Nadine Kraemer, Sami Zaqout, Gisela Stoltenburg-Didinger, Olaf Ninnemann, Luis R Hernandez-Miranda, Shyamala Mani, Angela M Kaind. PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients. Cerebellum (London, England) vol issue 2022 36219306 ptrh2 is necessary for purkinje cell differentiation and survival and its loss recapitulates progressive cerebellar atrophy and ataxia seen in imnepd patients. 2022-10-11 2023-01-30 Not clear
Deniz A Madencioglu, Karina A Kruth, Thomas H Wassink, Vincent A Magnotta, John A Wemmie, Aislinn J William. Modeling Human Cerebellar Development In Vitro in 2D Structure. Journal of visualized experiments : JoVE vol issue 187 2022 36190246 at 35 days of differentiation, ipsc-derived cerebellar cell cultures express cerebellar markers including atoh1, ptf1\xce\xb1, pax6, and kirrel2, suggesting that this protocol generates glutamatergic and gabaergic cerebellar neuronal precursors, as well as purkinje cell progenitors. 2022-10-03 2023-01-30 human
Elizabeth J Apsley, Esther B E Becke. Purkinje Cell Patterning-Insights from Single-Cell Sequencing. Cells vol 11 issue 18 2022 36139493 traditional methods have characterized cerebellar development and cell types, including purkinje cell subtypes, based on knowledge of selected markers. 2022-09-23 2023-01-30 mouse
Singla Rubal, Mishra Abhishek, Joshi Rupa, Sarma Phulen, Rajput Kumar, Gurjeet Kaur, Sarma AmitRaj, Ashish Jain, Ajay Prakash, Bhatia Alka, Medhi Bikas. Homotaurine ameriolates the core ASD symptomatology in VPA rats through GABAergic signalling: Role of GAD67. Brain research bulletin vol issue 2022 36113682 the offspring of the vpa exposed group exhibited significant (p<0.05) developmental delays, behavioral deficits [decreased sociability and social novelty (three-chamber sociability test), spatial memory (morris water maze), increased stereotypy (self-grooming)], increased oxidative stress (decreased gsh, sod, catalase, and increased mda), increased pro-inflammatory (il-1\xce\xb2, 6, tnf-\xce\xb1) and decreased anti-inflammatory (il-10) cytokines, purkinje cell loss in the cerebellum and pyknosis in pfc (h/e, nissil staining) and decreased gad67 expression in the cerebellum (rt-pcr & immunohistochemistry). 2022-09-16 2023-01-30 rat
Singla Rubal, Mishra Abhishek, Joshi Rupa, Sarma Phulen, Rajput Kumar, Gurjeet Kaur, Sarma AmitRaj, Ashish Jain, Ajay Prakash, Bhatia Alka, Medhi Bikas. Homotaurine ameriolates the core ASD symptomatology in VPA rats through GABAergic signalling: Role of GAD67. Brain research bulletin vol issue 2022 36113682 compared to the dc, ht treatment (50mg/kg) was able to ameliorate the aberrant core behavioral deficits, decreased oxidative stress, decreased pro-inflammatory and increased anti-inflammatory cytokine profile with preservation of the purkinje cell density in the cerebellum, decreased pyknosis in the prefrontal cortex and normalised the expression of gad67. 2022-09-16 2023-01-30 rat