All Relations between cerebellum and cerebellum purkinje cell

Publication Sentence Publish Date Extraction Date Species
David J Herzfeld, Mati Joshua, Stephen G Lisberge. Rate versus synchrony codes for cerebellar control of motor behavior. Neuron. vol 111. issue 15. 2023-08-03. PMID:37536289. simultaneous recordings from purkinje cell pairs in the cerebellum of rhesus macaques reveal how these cells coordinate their activity to drive smooth pursuit eye movements. 2023-08-03 2023-08-14 Not clear
Silas E Busch, Christian Hanse. Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499000. canonically, each purkinje cell (pc) in the adult cerebellum receives only one climbing fiber (cf) from the inferior olive. 2023-07-27 2023-08-14 mouse
Mizuki Kato, Erik De Schutte. Models of Purkinje cell dendritic tree selection during early cerebellar development. PLoS computational biology. vol 19. issue 7. 2023-07-24. PMID:37486917. models of purkinje cell dendritic tree selection during early cerebellar development. 2023-07-24 2023-08-14 Not clear
Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kan. PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. Frontiers in molecular neuroscience. vol 16. 2023-07-10. PMID:37426069. ptpδ is a presynaptic organizer for the formation and maintenance of climbing fiber to purkinje cell synapses in the developing cerebellum. 2023-07-10 2023-08-14 mouse
Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kan. PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. Frontiers in molecular neuroscience. vol 16. 2023-07-10. PMID:37426069. in the cerebellum of neonatal rodents, each purkinje cell (pc) receives synaptic inputs from multiple (more than 4) climbing fibers (cfs). 2023-07-10 2023-08-14 mouse
Haoran Huang, Vikram G Shakkotta. Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374132. in this review, we propose that perturbations in cerebellar purkinje neuron intrinsic membrane excitability, a result of ion channel dysregulation, is a common pathophysiologic mechanism that drives motor impairment and vulnerability to degeneration in cerebellar ataxias of widely differing genetic etiologies. 2023-06-28 2023-08-14 Not clear
Micaela Lucarelli, Serena Camuso, Chiara Di Pietro, Francesco Bruno, Piergiorgio La Rosa, Daniela Marazziti, Maria Teresa Fiorenza, Sonia Canterin. Reduced Cerebellar BDNF Availability Affects Postnatal Differentiation and Maturation of Granule Cells in a Mouse Model of Cholesterol Dyshomeostasis. Molecular neurobiology. 2023-06-14. PMID:37314654. the prominent feature of the disorder is the progressive purkinje cell degeneration leading to ataxia.in a mouse model of npc1 disease, we have previously demonstrated that impaired sonic hedgehog signaling causes defective proliferation of granule cells (gcs) and abnormal cerebellar morphogenesis. 2023-06-14 2023-08-14 mouse
Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying She. cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning. eLife. vol 12. 2023-05-10. PMID:37159499. granule cell-specific blocking of epac-pkcε signaling abolishes presynaptic long-term potentiation at the parallel fiber to purkinje cell synapses and impairs basic performance and learning of cerebellar motor behavior. 2023-05-10 2023-08-14 mouse
Yang Liu, Li-Xin Cao, Wei-Yao Wang, Yong-Rui Piao, Jun-Ya Wang, Chun-Ping Chu, Yan-Hua Bing, De-Lai Qi. GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cell Frontiers in molecular neuroscience. vol 16. 2023-04-24. PMID:37089690. in the cerebellar cortex, glp-1 receptor is abundantly expressed in the molecular layer, purkinje cell (pc) layer and granular layer, indicating that glp-1 may modulate the cerebellar neuronal activity. 2023-04-24 2023-08-14 mouse
An Cheng, Ichiro Kawahata, Yifei Wang, Wenbin Jia, Wang Haoyang, Tomoki Sekimori, Yi Chen, Hiroyoshi Suzuki, Atsushi Takeda, Nadia Stefanova, David I Finkelstein, Wenbo Ma, Min Chen, Takuya Sasaki, Kohji Fukunag. Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain : a journal of neurology. 2023-04-21. PMID:37082980. lastly, aav5-dependent epsin-2 knock-down mice exhibited decreased levels of αsyn aggregate accumulation in purkinje neurons and oligodendrocytes, as well as improved myelin levels and purkinje neuron function in the cerebellum and motor performance. 2023-04-21 2023-08-14 mouse
Yaroslav Kolinko, Milena Kralickova, Jan Cendeli. Reduction of Microvessel Number and Length in the Cerebellum of Purkinje Cell Degeneration Mice. Cerebellum (London, England). 2023-04-18. PMID:37071329. reduction of microvessel number and length in the cerebellum of purkinje cell degeneration mice. 2023-04-18 2023-08-14 mouse
Yaroslav Kolinko, Milena Kralickova, Jan Cendeli. Reduction of Microvessel Number and Length in the Cerebellum of Purkinje Cell Degeneration Mice. Cerebellum (London, England). 2023-04-18. PMID:37071329. in this study, we compared the vascularity of the individual cerebellar components of 3-month-old wild-type mice (n = 8) and purkinje cell degeneration (pcd) mutant mice, which represent a model of hereditary cerebellar degeneration (n = 8). 2023-04-18 2023-08-14 mouse
Sol Pose-Méndez, Paul Schramm, Barbara Winter, Jochen C Meier, Konstantinos Ampatzis, Reinhard W Köste. Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish. eLife. vol 12. 2023-04-12. PMID:37042514. however, regeneration of the principal neuron of the evolutionary conserved cerebellum, the purkinje cell (pc), is believed to be limited to developmental stages based on invasive lesions. 2023-04-12 2023-08-14 zebrafish
Sarmad Hayder Weli Weli, Ahmad Yahyazade. Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide. Journal of chemical neuroanatomy. vol 130. 2023-03-29. PMID:36989922. in the sk + gb group, the total number purkinje cell, and granular cells, as well as the mean volumes of molecular layer, granular layer, white matter, and cerebellum were significantly increased than the sk group (p < 0.05). 2023-03-29 2023-08-14 rat
Hoda Ranjbar, Monavareh Soti, Kristi A Kohlmeier, Mahyar Janahmadi, Mohammad Shaban. Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP. BMC neuroscience. vol 24. issue 1. 2023-03-03. PMID:36869289. although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-ap exposure on purkinje cell electrophysiological properties. 2023-03-03 2023-08-14 Not clear
Felicity R Sterling, Jon D'Amico, Alexandria M Brumfield, Kara L Huegel, Patricia S Vaughan, Kathryn Morris, Shelby Schwarz, Michelle V Joyce, Bill Boggess, Matthew M Champion, Kevin Maciuba, Philip Allen, Eric Marasco, Grant Koch, Peter Gonzalez, Shannon Hodges, Shannon Leahy, Erica Gerstbauer, Edward H Hinchcliffe, Kevin T Vaugha. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival. Journal of cell science. vol 136. issue 5. 2023-03-02. PMID:36861884. the pathological accumulation of cholesterol is a signature feature of niemann-pick type c (npc) disease, in which excessive lipid levels induce purkinje cell death in the cerebellum. 2023-03-02 2023-08-14 mouse
David J Herzfeld, Mati Joshua, Stephen G Lisberge. Rate versus synchrony codes for cerebellar control of motor behavior. bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824885. simultaneous recordings from purkinje cell pairs in the cerebellar flocculus of rhesus macaques revealed how these cells coordinate their activity to drive smooth pursuit eye movements. 2023-02-24 2023-08-14 Not clear
Fabrice Faure, Lidia Yshii, Toufic Renno, Isabelle Coste, Bastien Joubert, Virginie Desestret, Roland Liblau, Jérôme Honnora. A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model. Cerebellum (London, England). 2023-02-02. PMID:36729270. ataxia and gait instability were assessed in treated mice as well as autoantibody levels, purkinje cell density, and immune infiltration in the cerebellum. 2023-02-02 2023-08-14 mouse
Audrey Bonnan, Ke Zhang, Michael A Gaffield, Jason M Christi. Expression of a form of cerebellar motor memory requires learned alterations to the activity of inhibitory molecular layer interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-01-14. PMID:36639897. procedural memories formed in the cerebellum in response to motor errors depend on changes to purkinje cell (pc) spiking patterns that correct movement when the erroneous context is repeated. 2023-01-14 2023-08-14 mouse
Ling-Ge Cui, Lin Liu, Mu-Zi Li, Yu Zhu, Xiang-Yu Ma, Xue-Nan Li, Jin-Long L. Phthalate induces mitochondrial injury in cerebellum through Sirt1-PGC-1α and PINK1/Parkin-mediated signal pathways. Life sciences. 2023-01-09. PMID:36623767. in present study, we set dehp-caused cerebellar injury models of quail and implied that dehp induced cerebellar dysplasia by abnormity of purkinje cell and reduction of cerebellar granule cell. 2023-01-09 2023-08-14 Not clear