| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takehiro Takahashi, Milan Stoiljkovic, Eric Song, Xiao-Bing Gao, Yuki Yasumoto, Eriko Kudo, Fernando Carvalho, Yong Kong, Annsea Park, Marya Shanabrough, Klara Szigeti-Buck, Zhong-Wu Liu, Ashley Kristant, Yalan Zhang, Parker Sulkowski, Peter M Glazer, Leonard K Kaczmarek, Tamas L Horvath, Akiko Iwasak. LINE-1 activation in the cerebellum drives ataxia. Neuron. 2022-09-07. PMID:36070749. |
we demonstrated that l1 activation in the cerebellum led to purkinje cell dysfunctions and degeneration and was sufficient to cause ataxia. |
2022-09-07 |
2023-08-14 |
mouse |
| Ilknur Özen, Hongcheng Mai, Alessandro De Maio, Karsten Ruscher, Georgios Michalettos, Fredrik Clausen, Michael Gottschalk, Saema Ansar, Sertan Arkan, Ali Erturk, Niklas Marklun. Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits. Acta neuropathologica communications. vol 10. issue 1. 2022-09-05. PMID:36064443. |
despite a lack of direct input from the injury site to the cerebellum, these findings argue for novel long-range mechanisms causing purkinje cell injury that likely contribute to cerebellar dysfunction after tbi. |
2022-09-05 |
2023-08-14 |
mouse |
| Justine H Liang, Jonathan Alevy, Viktor Akhanov, Ryan Seo, Cory A Massey, Danye Jiang, Joy Zhou, Roy V Sillitoe, Jeffrey L Noebels, Melanie A Samue. Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Disease models & mechanisms. 2022-08-16. PMID:35972048. |
we also show that kctd7 is required for purkinje cell survival in the cerebellum and that selective degeneration of these neurons is accompanied by defects in cerebellar brain microvascular organization and patterning. |
2022-08-16 |
2023-08-14 |
mouse |
| Deiweson Souza-Monteiro, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Walessa Alana Bragança Aragão, Igor Gonçalves de Oliveira, Cristiane Socorro Ferraz Maia, Marco Aurelio M Freire, Fatemeh Vida Zohoori, Marília Afonso Rabelo Buzalaf, Rafael Rodrigues Lim. Intrauterine and Postnatal Exposure to High Levels of Fluoride Is Associated with Motor Impairments, Oxidative Stress, and Morphological Damage in the Cerebellum of Offspring Rats. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955690. |
the results pointed out that 50 mg f/l exposure during the intrauterine and lactational period of rats is capable of promoting oxidative stress in the cerebellum with a decrease in purkinje cell density and myelin basic protein compromise, which could be associated with functional motor impairments. |
2022-08-12 |
2023-08-14 |
human |
| Timothy Hua, Chang Liu, Sonia Kiran, Kelly Gray, Sunghoon Jung, David G Meckes, Yan Li, Qing-Xiang Amy San. Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids. Scientific reports. vol 12. issue 1. 2022-07-27. PMID:35896708. |
however, the expression of cerebellar genes for the molecular layer (bhle22), the granule cell layer (gabrb2, pax6, tmem266, kcnip4), the bergmann glial cells (qk1, dao), and the purkinje cell layer (arhgef33, kit, mx1, myh10, ppp1r17, scgn) was significantly higher in the rcp condition than the control. |
2022-07-27 |
2023-08-14 |
human |
| John E Greenlee, H Robert Brashea. The Discovery of Anti-Yo (Anti-PCA1) Antibody in Patients with Paraneoplastic Cerebellar Degeneration: Opening a Window into Autoimmune Neurological Disease. Cerebellum (London, England). 2022-07-26. PMID:35881322. |
although the role of anti-yo antibody in cerebellar injury has not been established in living animals, in vitro studies have demonstrated that anti-yo antibody causes purkinje cell death in the absence of t lymphocytes. |
2022-07-26 |
2023-08-14 |
human |
| Tabita Kreko-Pierce, Jason R Pug. Altered Synaptic Transmission and Excitability of Cerebellar Nuclear Neurons in a Mouse Model of Duchenne Muscular Dystrophy. Frontiers in cellular neuroscience. vol 16. 2022-07-22. PMID:35865113. |
in this work, we investigate potential dysfunction in the output of the cerebellum, downstream of purkinje cell (pc) activity. |
2022-07-22 |
2023-08-14 |
mouse |
| Yuning Liu, Hong Xing, Alexis F Ernst, Canna Liu, Christian Maugee, Fumiaki Yokoi, Madepalli Lakshmana, Yuqing L. Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice. Molecular and cellular neurosciences. 2022-07-17. PMID:35843530. |
manipulating the purkinje cell firing or cerebellar output may contribute to c9orf72-associated als/ftd treatment. |
2022-07-17 |
2023-08-14 |
mouse |
| Victor Olmos, Neha Gogia, Kimberly Luttik, Fatema Haidery, Janghoo Li. The extra-cerebellar effects of spinocerebellar ataxia type 1 (SCA1): looking beyond the cerebellum. Cellular and molecular life sciences : CMLS. vol 79. issue 8. 2022-07-08. PMID:35802260. |
however, until recently, sca1 research has primarily centered on the cerebellum, given the characteristic cerebellar purkinje cell loss observed in patients, as well as the progressive motor deficits, including gait and limb incoordination, that sca1 patients present with. |
2022-07-08 |
2023-08-14 |
mouse |
| David D Bushart, Vikram G Shakkotta. Vulnerability of Human Cerebellar Neurons to Degeneration in Ataxia-Causing Channelopathies. Frontiers in systems neuroscience. vol 16. 2022-06-27. PMID:35757096. |
human ataxia-causing channelopathies that result in even haploinsufficiency can result in cerebellar atrophy and cerebellar purkinje neuron loss. |
2022-06-27 |
2023-08-14 |
mouse |
| Eric J Lang, Adrian Handfort. Is the inferior olive central to essential tremor? Yes. International review of neurobiology. vol 163. 2022-06-24. PMID:35750361. |
much evidence shows that the olivocerebellar system is the main system capable of generating the widespread synchronous oscillatory purkinje cell (pc) complex spike (cs) activity across the cerebellar cortex that would be capable of generating the type of bursting cerebellar output from the deep cerebellar nuclei (dcn) that could underlie tremor. |
2022-06-24 |
2023-08-14 |
mouse |
| Steven Bellows, Joohi Jimenez-Shahe. Is essential tremor a disorder of GABA dysfunction? No. International review of neurobiology. vol 163. 2022-06-24. PMID:35750366. |
hypersynchrony of purkinje cell activity may account for excessive oscillatory cerebellar output, with potential contributions along multiple sites of the olivocerebellar loop. |
2022-06-24 |
2023-08-14 |
mouse |
| Phyllis L Faus. Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder. International review of neurobiology. vol 163. 2022-06-24. PMID:35750370. |
most of these pathological changes are centered on the purkinje cell and connected neuronal populations, which can result in partial loss of purkinje cells and circuitry reorganizations that would disturb cerebellar function. |
2022-06-24 |
2023-08-14 |
Not clear |
| Kazuyuki Miyamoto, Motoyasu Nakamura, Hirokazu Ohtaki, Keisuke Suzuki, Hiroki Yamaga, Kaoru Yanagisawa, Atsuo Maeda, Masaharu Yagi, Munetaka Hayashi, Kazuho Honda, Kenji Doh. Heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, Purkinje cell degeneration, and synaptic impairment in the cerebellum. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732789. |
heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, purkinje cell degeneration, and synaptic impairment in the cerebellum. |
2022-06-22 |
2023-08-14 |
mouse |
| Harry T Or. Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway. Cerebellum (London, England). 2022-06-22. PMID:35733029. |
this is a summary of the virtual presentation given at the 2021 meeting of the society for research on the cerebellum and ataxias, https://www.meetings.be/srca2021/ , where the therapeutic potential of the cck-cck1r pathway for treating diseases involving purkinje cell degeneration was presented. |
2022-06-22 |
2023-08-14 |
mouse |
| Andrea Pirone, Chiara Magliaro, Carlo Cantile, Carla Lenzi, Alessandra Coli, Vincenzo Miragliott. Comparative and quantitative morphology of the pig and wild boar cerebellum for identifying possible effects of domestication. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022-06-01. PMID:35644466. |
our results showed that: (i) the foliation index, expressing the rate of cerebellar cortical folding, and the number of granular cells were not significantly different between pigs and wild boars; (ii) area of the granular layer and the molecular layer, and area of white matter were lower in pigs; (iii) the fraction area, grey matter/white matter, was higher in pigs; (iv) the purkinje cell linear density and their soma area were higher in wild boars. |
2022-06-01 |
2023-08-13 |
human |
| Xiu-Xiu Liu, Xing-Hui Chen, Zhi-Wei Zheng, Qin Jiang, Chen Li, Lin Yang, Xiang Chen, Xing-Feng Mao, Hao-Yang Yuan, Li-Li Feng, Quan Jiang, Wei-Xing Shi, Takuya Sasaki, Kohji Fukunaga, Zhong Chen, Feng Han, Ying-Mei L. BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination. Signal transduction and targeted therapy. vol 7. issue 1. 2022-05-31. PMID:35641478. |
through cell-type-specific manipulations, we discovered a novel gabaergic purkinje cell (pc) circuit in the cerebellar iv/v lobe that projected to camkiiα |
2022-05-31 |
2023-08-13 |
Not clear |
| Eric Avila, Nico A Flierman, Peter J Holland, Pieter R Roelfsema, Maarten A Frens, Aleksandra Badura, Chris I De Zeeu. Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques. Frontiers in cellular neuroscience. vol 16. 2022-05-16. PMID:35573834. |
purkinje cell activity in the medial and lateral cerebellum during suppression of voluntary eye movements in rhesus macaques. |
2022-05-16 |
2023-08-13 |
Not clear |
| Eric Avila, Nico A Flierman, Peter J Holland, Pieter R Roelfsema, Maarten A Frens, Aleksandra Badura, Chris I De Zeeu. Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques. Frontiers in cellular neuroscience. vol 16. 2022-05-16. PMID:35573834. |
here, we measured purkinje cell (pc) responses in the medial and lateral cerebellum in two rhesus macaques during pro- and anti-saccade tasks. |
2022-05-16 |
2023-08-13 |
Not clear |
| Xiaofan Yang, Hongqiang Yin, Xiaojing Wang, Yueqing Sun, Xianli Bian, Gaorui Zhang, Anning Li, Aihua Cao, Baomin Li, Darius Ebrahimi-Fakhari, Zhuo Yang, Miriam H Meisler, Qiji Li. Social Deficits and Cerebellar Degeneration in Purkinje Cell Frontiers in molecular neuroscience. vol 15. 2022-05-13. PMID:35557557. |
social deficits and cerebellar degeneration in purkinje cell mutations in the |
2022-05-13 |
2023-08-13 |
Not clear |