| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paola Rodríguez-Quintero, Moisés Rubio-Osornio, Eric Uribe, Wilhelm Moreno, Luis A Marín-Castañeda, Zayra Morales, Alonso Portila, David Vázquez, Carmen Rubi. Exposure to Ozone Downregulates Bcl-2 and Increases Executing Caspases-3 and -8 in the Hippocampus, Frontal Cortex, and Cerebellum of Rats. Cureus. vol 16. issue 2. 2024-03-22. PMID:38516464. |
conclusions this study demonstrates that acute exposure to 1 ppm of ozone can trigger neuronal apoptosis in the frontal cortex, hippocampus, and cerebellum of rats, primarily through the activation of the extrinsic apoptosis pathway via caspase-8 and caspase-3. |
2024-03-22 |
2024-03-24 |
rat |
| Diego Iacono, Erin K Murphy, Cheryl D Stimpson, Daniel P Perl, Regina M Da. Low-dose brain radiation: lowering hyperphosphorylated-tau without increasing DNA damage or oncogenic activation. Scientific reports. vol 13. issue 1. 2023-11-30. PMID:38036591. |
quantitative analyses demonstrated reduced levels of at8 and 3r-tau in hippocampus (h) and striatum (str), increased levels of synaptophysin and psd-95 in frontal cortex (fctx), and reduced levels of nf-l in cerebellum (crb) of rad versus sh swine. |
2023-11-30 |
2023-12-10 |
Not clear |
| Zsolt Kristóf Bali, Lili Veronika Nagy, Nóra Bruszt, Kornélia Bodó, Péter Engelmann, Zsófia Hernádi, Kitti Göntér, Sai Ambika Tadepalli, István Hernád. Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment. GeroScience. 2023-11-23. PMID:37994990. |
at the end of the behavioral experiments, mrna and protein expression of alpha7 nachrs, cytokines, and brain-derived neurotrophic factor (bdnf) were quantitatively measured in the hippocampus, frontal cortex, striatum, and cerebellum. |
2023-11-23 |
2023-11-29 |
human |
| O A Solovieva, M A Gruden, V S Kudrin, N P Mikhailova, V B Narkevich, V V Sherstnev, Z I Storozhev. Motor and Cognitive Functions in Aging C57BL/6 Mice: Association with Activity of the Monoaminergic Systems in the Cerebellum and Frontal Cortex. Bulletin of experimental biology and medicine. 2023-11-17. PMID:37978148. |
the levels of norepinephrine, dopamine, serotonin, and their metabolites were determined in the cerebellum and frontal cortex. |
2023-11-17 |
2023-11-20 |
mouse |
| A S Oreshko, A Ya Rodnyy, D V Bazovkina, V S Naumenk. Effects of central administration of the human Tau protein on the Bdnf, Trkb, p75, Mapt, Bax and Bcl-2 genes expression in the mouse brain. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 4. 2023-07-19. PMID:37465194. |
thus, central administration of aggregating human tau protein decreases the expression of the bdnf gene in the frontal cortex and the mapt gene encoding endogenous mouse tau protein in the cerebellum of c57bl/6j mice. |
2023-07-19 |
2023-08-14 |
mouse |
| Sophie A Barton, Marc Kent, Erin E Hech. Neuroanatomical asymmetry in the canine brain. Brain structure & function. 2023-07-12. PMID:37436502. |
volumetrically asymmetric regions of gray matter included portions of the temporal and frontal cortex, in addition to portions of the cerebellum, brainstem, and other subcortical regions. |
2023-07-12 |
2023-08-14 |
Not clear |
| Kuaikuai Duan, Jiayu Chen, Vince D Calhoun, Wenhao Jiang, Kelly Rootes-Murdy, Gido Schoenmacker, Rogers F Silva, Barbara Franke, Jan K Buitelaar, Martine Hoogman, Jaap Oosterlaan, Pieter J Hoekstra, Dirk Heslenfeld, Catharina A Hartman, Emma Sprooten, Alejandro Arias-Vasquez, Jessica A Turner, Jingyu Li. Genomic patterns linked to gray matter alterations underlying working memory deficits in adults and adolescents with attention-deficit/hyperactivity disorder. Translational psychiatry. vol 13. issue 1. 2023-02-11. PMID:36774336. |
our previous work has identified that across adults and adolescents with adhd, gray matter volume (gmv) alteration in the frontal cortex was consistently associated with working memory underperformance, and gmv alteration in the cerebellum was associated with inattention. |
2023-02-11 |
2023-08-14 |
human |
| Shino Magaki, Zesheng Chen, Alyscia Severance, Christopher K Williams, Ramiro Diaz, Chuo Fang, Negar Khanlou, William H Yong, Annlia Paganini-Hill, Rajesh N Kalaria, Harry V Vinters, Mark Fishe. Neuropathology of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Journal of neuropathology and experimental neurology. 2023-01-30. PMID:36715085. |
in this study, we characterized findings relevant to cmbs in autopsy brain tissue of 8 patients with genetically confirmed cadasil and 10 controls within the age range of the cadasil patients by assessing the distribution and extent of hemosiderin/iron deposits including perivascular hemosiderin leakage (pvh), capillary hemosiderin deposits, and parenchymal iron deposits (pid) in the frontal cortex and white matter, basal ganglia and cerebellum. |
2023-01-30 |
2023-08-14 |
human |
| Zhaofei Yang, Ying Wang, Min Wei, Song Li, Congcong Jia, Cheng Cheng, Murad Al-Nusaif, Jun Zhang, Cong Liu, Weidong L. Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain. Cell death & disease. vol 14. issue 1. 2023-01-05. PMID:36604420. |
strikingly, such an injection induced dopaminergic neurodegeneration and α-syn depositions in the striatum, substantia nigra, and other brain regions, including the frontal cortex, somatosensory cortex, hypothalamus, brain stem, and cerebellum. |
2023-01-05 |
2023-08-14 |
rat |
| Marta Moya, Berta Escudero, Elena Gómez-Blázquez, Ana Belen Rebolledo-Poves, Meritxell López-Gallardo, Carmen Guerrero, Eva M Marco, Laura Ori. Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke's encephalopathy: Findings in preclinical models and in a postmortem human case. Frontiers in pharmacology. vol 13. 2022-10-13. PMID:36225571. |
in addition, we characterized for the first time the tlr4 and its coreceptor myd88 signature, along with other markers of this proinflammatory signaling such as phospo-nfκb p65 and iκbα, in the postmortem human frontal cortex and cerebellum (gray and white matter) of an alcohol-induced we patient, comparing it with negative (no disease) and positive (aged brain with alzheimer's disease) control subjects for neuroinflammation. |
2022-10-13 |
2023-08-14 |
human |
| Jerel Adam Fields, Mary Swinton, Erin E Sundermann, Nicholas Scrivens, Kaylie-Anna Juliette Vallee, David J Moor. Complement component 3 and complement factor H protein levels are altered in brain tissues from people with human immunodeficiency virus: A pilot study. Frontiers in aging neuroscience. vol 14. 2022-09-19. PMID:36118688. |
we analyzed by immunoblot c3 and cfh protein levels in frontal cortex (fc) and cerebellum (cb) brain specimens from pwh previously characterized for aβ plaque deposition. |
2022-09-19 |
2023-08-14 |
human |
| Barbara B Shih, Sarah M Brown, Jack Barrington, Lucas Lefevre, Neil A Mabbott, Josef Priller, Gerard Thompson, Alistair B Lawrence, Barry W McCol. Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia. Glia. 2022-09-19. PMID:36120803. |
we isolated pig hippocampal tissue and microglia from frontal cortex, hippocampus, and cerebellum, as well as alveolar macrophages from the lungs and conducted rna-sequencing (rnaseq). |
2022-09-19 |
2023-08-14 |
mouse |
| Niti Sharma, Kanishk Luhach, Lalit K Golani, Bhagwat Singh, Bhupesh Sharm. Vinpocetine a PDE1 modulator regulates markers of cerebral health, inflammation, and oxidative stress in a rat model of prenatal alcohol-induced experimental attention deficit hyperactivity disorder. Alcohol (Fayetteville, N.Y.). 2022-08-22. PMID:35995260. |
protein markers of cerebral health (synapsin-iia, bdnf, pcreb), inflammation (il-6, il-10 and tnf-α), and oxidative stress (tbars, gsh, sod) were analyzed in three brain regions (frontal cortex, striatum, and cerebellum). |
2022-08-22 |
2023-08-14 |
rat |
| Grace A H Nguyen, Christopher Liang, Jogeshwar Mukherje. [ Molecules (Basel, Switzerland). vol 27. issue 14. 2022-07-28. PMID:35889425. |
the in vitro binding of [125i]ibeta and [124i]ibeta in transgenic 5 × fad mouse model for aβ plaques was high in the frontal cortex, anterior cingulate, thalamus, and hippocampus, which are regions of high aβ accumulation, with very little binding in the cerebellum (ratio of brain regions to cerebellum was >5). |
2022-07-28 |
2023-08-16 |
mouse |
| Kanishk Luhach, Giriraj T Kulkarni, Vijay P Singh, Bhupesh Sharm. Vinpocetine ameliorates developmental hyperserotonemia induced behavioral and biochemical changes: role of neuronal function, inflammation, and oxidative stress. Acta neurobiologiae experimentalis. vol 82. issue 1. 2022-04-22. PMID:35451422. |
also, effects on biochemical markers related with neuronal function brain derived neurotrophic factor (bdnf) and phosphorylated camp response element binding protein (pcreb), inflammation interleukins (il‑6 and il‑10) and tumor necrosis factor-alpha (tnf‑α), and oxidative stress (tbars and gsh) were studied in important brain areas (frontal cortex, cerebellum, hippocampus, and striatum). |
2022-04-22 |
2023-08-13 |
rat |
| Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M Van Deerlin, John Q Trojanowski, Edward B Lee, Fenghua H. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta neuropathologica communications. vol 10. issue 1. 2022-03-15. PMID:35287730. |
interestingly, tmem106b deficiency causes distinct lysosomal phenotypes in different types of neurons and glia in the cerebellum and frontal cortex. |
2022-03-15 |
2023-08-13 |
mouse |
| Bryony N Thorne, Bart A Ellenbroek, Darren J Da. The serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner. Journal of neuroscience research. 2022-01-19. PMID:35043462. |
the serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner. |
2022-01-19 |
2023-08-13 |
human |
| Kenji Sakai, Chiho Ishida, Koji Hayashi, Naotaka Tsuji, Takayuki Kannon, Kazuyoshi Hosomichi, Nobuyuki Takei, Akiyoshi Kakita, Atsushi Tajima, Masahito Yamad. Familial idiopathic basal ganglia calcification with a heterozygous missense variant (c.902C>T/p.P307L) in SLC20A2 showing widespread cerebrovascular lesions. Neuropathology : official journal of the Japanese Society of Neuropathology. 2022-01-13. PMID:35026865. |
moreover, western blot analysis identified preserved pit-2 immunoreactivity signals in the frontal cortex and cerebellum. |
2022-01-13 |
2023-08-13 |
Not clear |
| Natalie Grima, Lyndal Henden, Owen Watson, Ian P Blair, Kelly L William. Simultaneous Isolation of High-Quality RNA and DNA From Postmortem Human Central Nervous System Tissues for Omics Studies. Journal of neuropathology and experimental neurology. 2021-12-23. PMID:34939123. |
motor cortex, frontal cortex, hippocampus, occipital cortex, anterior cingulate cortex, cerebellum, and spinal cord tissues were obtained from 22 individuals diagnosed with motor neuron disease (mnd) and 13 neurologically normal controls (n = 245 tissues). |
2021-12-23 |
2023-08-13 |
human |
| Freek Nieuwhof, Ivan Toni, Michiel F Dirkx, Cecile Gallea, Marie Vidailhet, Arthur W G Buijink, Anne-Fleur van Rootselaar, Bart P C van de Warrenburg, Rick C Helmic. Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor. NeuroImage. Clinical. vol 33. 2021-12-20. PMID:34929584. |
we found tremor-related activity in sensorimotor regions of the bilateral cerebellum, contralateral posterior and anterior ventral lateral nuclei of the thalamus (vlp and vla), contralateral primary motor cortex (hand area), contralateral pallidum, and the bilateral frontal cortex (laterality with respect to the tremor). |
2021-12-20 |
2023-08-13 |
Not clear |