| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Kushagra Nagori, Madhulika Pradhan, Mukesh Sharma, Ajazuddin, Hemant R Badwaik, Kartik T Nakhat. Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease. Current Alzheimer research. 2024-03-26. PMID:38529600. |
by modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ach plays a pivotal role in the regulation of learning and memory. |
2024-03-26 |
2024-03-28 |
Not clear |
| Qingquan Li, Xiaokui Gan, Ming Zhang, Guangmin Zhang, Yingbin Li, Liang Ga. Erianin promotes endogenous neurogenesis in traumatic brain injury rats. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374284. |
additionally, there was an increase in neuronal regeneration in the cortex and hippocampus, inhibition of pro-inflammatory microglial cell transformation in the cortex, improvement in learning and memory function in tbi rats, and simultaneous inhibition of the activation of the erk1/c-jun signal pathway. |
2024-02-19 |
2024-02-22 |
rat |
| Pia Kruse, Gudrun Brandes, Hanna Hemeling, Zhong Huang, Christoph Wrede, Jan Hegermann, Andreas Vlachos, Maximilian Len. Synaptopodin Regulates Denervation-Induced Plasticity at Hippocampal Mossy Fiber Synapses. Cells. vol 13. issue 2. 2024-01-22. PMID:38247806. |
in order to address this issue, we performed an entorhinal cortex lesion (ecl) in mouse organotypic entorhino-hippocampal tissue cultures of both sexes and studied denervation-induced plasticity of mossy fiber synapses, which connect dentate granule cells (dgcs) with ca3 pyramidal cells (ca3-pcs) and play important roles in learning and memory formation. |
2024-01-22 |
2024-01-24 |
mouse |
| Xi Zhang, Hong Zheng, Zhitao Ni, Yuyin Shen, Die Wang, Wenqing Li, Liangcai Zhao, Chen Li, Hongchang Ga. Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline. Cerebral cortex (New York, N.Y. : 1991). 2024-01-14. PMID:38220573. |
results revealed that i.c.v fgf21 infusion effectively improved learning and memory performance of dicd mice; neuron loss and apoptosis in hippocampus and cortex were significantly blocked, suggesting a potential neuroprotective role of fgf21 in dicd. |
2024-01-14 |
2024-01-17 |
mouse |
| Jingjing Ge, Xiaoling Jiao, Hui L. MicroRNA-126-3P targets PIK3R2 to ameliorate autophagy and apoptosis of cortex in hypoxia-reoxygenation treated neonatal rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063094. |
injection of mir-126-3p mimic raised the learning and memory abilities through down-regulating the cerebral ischemic area, improving pathological damage of the cortex, reducing the neurons apoptosis of the cortex and down-regulating the autophagy-related and apoptosis-related proteins. |
2023-12-08 |
2023-12-17 |
rat |
| Clark W Bird, Stefanie S Mayfield, Katalina M Lopez, Brooke R Dunn, Angela Feng, Bryce T Roberts, Roberto N Almeida, Glenna J Chavez, C Fernando Valenzuel. Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice. Neuropharmacology. 2023-10-01. PMID:37778437. |
ethanol (etoh) exposure during late pregnancy leads to enduring impairments in learning and memory that may stem from damage to components of the posterior limbic memory system, including the retrosplenial cortex (rsc) and anterior thalamic nuclei (atn). |
2023-10-01 |
2023-10-07 |
mouse |
| Qihui Zhao, Junli Chen, Mengjun Wu, Xiaoli Yin, Qiaoying Jiang, Hongchang Gao, Hong Zhen. Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice. Chemico-biological interactions. 2023-07-20. PMID:37473910. |
the results demonstrate that fmt from healthy mice effectively improved the learning and memory abilities in t1d mice, and significantly reduced neuroinflammation and neuron injury in the cortex and hippocampus. |
2023-07-20 |
2023-08-14 |
mouse |
| Qingxi Zhang, Qingrui Duan, Yuyuan Gao, Peikun He, Rui Huang, Haifeng Huang, Yanyi Li, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wan. Cerebral Microvascular Injury Induced by Lag3-Dependent α-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α-Synucleinopathies. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-06-29. PMID:37381656. |
here, it is reported that combined injection of α-syn preformed fibrils (pffs) in the unilateral substantia nigra pars compacta, hippocampus, and cerebral cortex results in impaired spatial learning and memory abilities at 6 months post-injection and that this cognitive decline is related to cerebral microvascular injury. |
2023-06-29 |
2023-08-14 |
mouse |
| Shogo Soma, Shinya Ohara, Satoshi Nonomura, Naofumi Suematsu, Junichi Yoshida, Eva Pastalkova, Yutaka Sakai, Ken-Ichiro Tsutsui, Yoshikazu Isomur. Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex. Communications biology. vol 6. issue 1. 2023-05-31. PMID:37258700. |
the hippocampus and entorhinal cortex are deeply involved in learning and memory. |
2023-05-31 |
2023-08-14 |
rat |
| Priyanka De, Kunal Ro. Computational modeling of PET imaging agents for vesicular acetylcholine transporter (VAChT) protein binding affinity: application of 2D-QSAR modeling and molecular docking techniques. In silico pharmacology. vol 11. issue 1. 2023-04-10. PMID:37035236. |
the neurotransmitter acetylcholine (ach) plays a ubiquitous role in cognitive functions including learning and memory with widespread innervation in the cortex, subcortical structures, and the cerebellum. |
2023-04-10 |
2023-08-14 |
Not clear |
| Bente Jacobsen, Heidi Kleven, Wairimu Gatome, Liora Las, Nachum Ulanovsky, Menno P Witte. Organization of projections from the entorhinal cortex to the hippocampal formation of the Egyptian fruit bat Rousettus aegyptiacus. Hippocampus. 2023-03-04. PMID:36869437. |
the hippocampal formation and entorhinal cortex are crucially involved in learning and memory as well as in spatial navigation. |
2023-03-04 |
2023-08-14 |
Not clear |
| Yoshiaki Shinohara, Keigo Kohar. Projections of hippocampal CA2 pyramidal neurons: Distinct innervation patterns of CA2 compared to CA3 in rodents. Hippocampus. 2023-03-01. PMID:36855258. |
for decades, the trisynaptic circuit (entorhinal cortex layer ii-dentate gyrus - ca3-ca1) has been considered the neural network substrate responsible for learning and memory. |
2023-03-01 |
2023-08-14 |
Not clear |
| E B Engler-Chiurazzi, A E Russell, J M Povroznik, K O McDonald, K N Porter, D S Wang, J Hammock, B K Billig, C C Felton, A Yilmaz, B G Schreurs, J D O'Callaghan, K J Zwezdaryk, J W Simpkin. Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice. Brain, behavior, and immunity. vol 108. 2023-01-23. PMID:36549577. |
though there was limited evidence for an ongoing inflammatory state in cortex and hippocampus, we observed impaired learning and memory and a disruption of hippocampal long-term potentiation. |
2023-01-23 |
2023-08-16 |
mouse |
| Andrew N Bubak, Laetitia Merle, Christy S Niemeyer, B Dnate' Baxter, Arianna Gentile Polese, Vijay Ramakrishnan, Johana Gomez, Lucia Madrigal, Andres Villegas-Lanau, Francisco Lopera, Wendy Macklin, Seth Frietze, Maria A Nagel, Diego Restrep. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease. Neurobiology of aging. vol 123. 2023-01-13. PMID:36638683. |
in fad samples, rna sequencing showed: (1) viral infection in the ob; (2) inflammation in the ot that carries information via entorhinal cortex from the ob to hippocampus, a brain region essential for learning and memory; and (3) decreased oligodendrocyte deconvolved transcripts. |
2023-01-13 |
2023-08-14 |
Not clear |
| Farimah Beheshti, Masoumeh Gholami, Zahra Ghane, Seyedeh Elnaz Nazari, Maryam Salari, Sadegh Shabab, Mahmoud Hossein. PPARγ activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats. Physiological reports. vol 10. issue 24. 2022-12-21. PMID:36541251. |
pparγ activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats. |
2022-12-21 |
2023-08-14 |
rat |
| Farimah Beheshti, Masoumeh Gholami, Zahra Ghane, Seyedeh Elnaz Nazari, Maryam Salari, Sadegh Shabab, Mahmoud Hossein. PPARγ activation improved learning and memory and attenuated oxidative stress in the hippocampus and cortex of aged rats. Physiological reports. vol 10. issue 24. 2022-12-21. PMID:36541251. |
it is concluded that pparγ activation by pio as an agonist improved learning and memory in aged rats probably by attenuating oxidative stress in the hippocampus and cortex. |
2022-12-21 |
2023-08-14 |
rat |
| Qianwen Zang, Sanrong Wang, Yinqiang Qi, Lei Zhang, Chunxia Huang, Yun Xiu, Chunni Zhou, Yanmin Luo, Gongwei Jia, Shuangyu Li, Yi Zhang, Yong Tan. Running exercise improves spatial learning and memory ability and enhances angiogenesis in the cerebral cortex via endogenous nitric oxide. Behavioural brain research. 2022-12-03. PMID:36462674. |
running exercise improves spatial learning and memory ability and enhances angiogenesis in the cerebral cortex via endogenous nitric oxide. |
2022-12-03 |
2023-08-14 |
Not clear |
| Muhan Li, Qiaoyu Shi, Xueyi Jiang, Xuanyi Liu, Wei Han, Xiuqin Fan, Ping Li, Kemin Q. Paternal preconceptional diet enriched with n-3 polyunsaturated fatty acids affects offspring brain function in mice. Frontiers in nutrition. vol 9. 2022-11-17. PMID:36386900. |
the results showed that paternal n-3 pufa supplementation in preconception reduced the anxiety- and depressive-like behavior, and improved sociability, learning and memory in the offspring, along with increased synaptic number, upregulated expressions of neuron specific enolase, myelin basic protein, glial fibrillary acidic protein, brain-derived neurotrophic factor in the hippocampus and cerebral cortex, and altered expressions of genes associated with mitochondria biogenesis, fusion, fission and autophagy. |
2022-11-17 |
2023-08-14 |
mouse |
| Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Pen. Hippocampus-prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture. CNS neuroscience & therapeutics. 2022-11-15. PMID:36377471. |
hippocampus-prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture. |
2022-11-15 |
2023-08-14 |
mouse |