| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Zhang, Yanling Tang, Wanjing Xu, Zeyu Hu, Shangzhi Xu, Qiang Ni. Fluoride-Induced Cortical Toxicity in Rats: the Role of Excessive Endoplasmic Reticulum Stress and Its Mediated Defective Autophagy. Biological trace element research. 2022-11-03. PMID:36327065. |
the cerebral cortex is closely associated with learning and memory, and fluoride is capable of inducing cortical toxicity, but its mechanism is unclear. |
2022-11-03 |
2023-08-14 |
rat |
| Bolu Zhou, Kristin E Claflin, Kyle H Flippo, Andrew I Sullivan, Arvand Asghari, Satya M Tadinada, Sharon O Jensen-Cody, Ted Abel, Matthew J Potthof. Central FGF21 production regulates memory but not peripheral metabolism. Cell reports. vol 40. issue 8. 2022-08-24. PMID:36001982. |
using a mouse model that drives cre recombinase in fgf21-expressing cells, we demonstrate that fgf21 is not expressed in the hypothalamus, but instead is produced from the retrosplenial cortex (rsc), an essential brain region for spatial learning and memory. |
2022-08-24 |
2023-08-14 |
mouse |
| Callum Walsh, Thomas Ridler, Gabriella Margetts-Smith, Maria Garcia Garrido, Jonathan Witton, Andrew D Randall, Jonathan T Brow. Beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-04. PMID:35927034. |
the retrosplenial cortex (rsc) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of alzheimer's disease. |
2022-08-04 |
2023-08-14 |
mouse |
| Peirong Liu, Juan Wang, Sheng Peng, Dan Zhang, Lin Zhuang, Chunliang Liu, Yu Zhang, Xiaowei Sh. Suppression of phosphodiesterase IV enzyme by Roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anesthesia via PKA-CREB and MEK/ERK pathways. The European journal of neuroscience. 2022-06-29. PMID:35767003. |
after treatment with rf, rats had better learning and memory function, and the activity of neurons in hippocampus and cortex was improved. |
2022-06-29 |
2023-08-14 |
rat |
| Stephanie V Koebele, Mallori L Poisson, Justin M Palmer, Claire Berns-Leone, Steven N Northup-Smith, Veronica L Peña, Isabel M Strouse, Haidyn L Bulen, Shruti Patel, Corissa Croft, Heather A Bimonte-Nelso. Evaluating the Cognitive Impacts of Drospirenone, a Spironolactone-Derived Progestin, Independently and in Combination With Ethinyl Estradiol in Ovariectomized Adult Rats. Frontiers in neuroscience. vol 16. 2022-06-13. PMID:35692432. |
the hippocampus, entorhinal cortex, and perirhinal cortex were then probed for proteins known to elicit estrogen- and progestin- mediated effects on learning and memory, including glutamate decarboxylase (gad)65, gad67, and insulin-like growth factor receptor protein expression, using western blot. |
2022-06-13 |
2023-08-14 |
rat |
| Goran Šimić, Željka Krsnik, Vinka Knezović, Zlatko Kelović, Mathias Lysholt Mathiasen, Alisa Junaković, Milan Radoš, Damir Mulc, Ena Španić, Giulia Quattrocolo, Vanessa Jane Hall, Laszlo Zaborszky, Mario Vukšić, Francisco Olucha Bordonau, Ivica Kostović, Menno P Witter, Patrick R Ho. Prenatal development of the human entorhinal cortex. The Journal of comparative neurology. 2022-05-23. PMID:35603771. |
little is known about the development of the human entorhinal cortex (ec), a major hub in a widespread network for learning and memory, spatial navigation, high-order processing of object information, multimodal integration, attention and awareness, emotion, motivation, and perception of time. |
2022-05-23 |
2023-08-13 |
human |
| Ting Jin, Ranran Wang, Shiqiao Peng, Xin Liu, Hanyi Zhang, Xue He, Weiping Teng, Xiaochun Ten. Developmental Hypothyroidism Influences the Development of the Entorhinal-Dentate Gyrus Pathway of Rat Offspring. Endocrinology and metabolism (Seoul, Korea). 2022-04-07. PMID:35390249. |
developmental hypothyroidism impairs learning and memory in offspring, which depend on extensive neuronal circuits in the entorhinal cortex, together with the hippocampus and neocortex. |
2022-04-07 |
2023-08-13 |
rat |
| Lingli Chen, Yuye Liu, Penghuan Jia, Hongli Zhang, Zhihong Yin, Dongfang Hu, Hongmei Ning, Yaming G. Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells. Environmental science and pollution research international. 2022-04-04. PMID:35377123. |
lead (pb) is a widespread environmental heavy metal that can damage the cerebral cortex and hippocampus, and reduce the learning and memory ability in humans and animals. |
2022-04-04 |
2023-08-13 |
mouse |
| Luting Yu, Shixi Liu, Ruixi Zhou, Hao Sun, Xiaojuan Su, Qian Liu, Shiping Li, Junjie Ying, Fengyan Zhao, Dezhi Mu, Yi Q. Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 4. 2022-03-18. PMID:35303316. |
in vivo, atorvastatin reduced cerebral infarction, improved learning and memory ability, decreased the number of tunel-positive neurons, inhibited the expression of cleaved caspase-3 and bax/bcl2, and activated the camp/pka/p-creb/bdnf pathway in the cerebral cortex after hibd. |
2022-03-18 |
2023-08-13 |
rat |
| Jiamou Ren, Shuli Zhang, Xiaoling Wang, Yuxin Deng, Yi Zhao, Yan Xiao, Jian Liu, Liangzhao Chu, Xiaolan Q. MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer's disease and. Acta biochimica et biophysica Sinica. vol 54. issue 1. 2022-02-07. PMID:35130621. |
in addition, knockdown of enhances the generation and aggregation of aβ in the cortex of app/ps1_dt mice, reduces the expression of synaptic proteins, exacerbates the ability of learning and memory of app/ps1_dt mice, damages the structure of mitochondria, increases the oxidative stress (os) level, and inhibits the expression levels of members of the nrf2-are signal pathway. |
2022-02-07 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, John H Anneken, Donald M Kuh. The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders. Journal of psychiatry and psychiatric disorders. vol 1. issue 5. 2022-01-31. PMID:35098038. |
bdnf is highly expressed in limbic structures and cerebral cortex, making it a crucial factor in the regulation of learning and memory, affective behaviors and reward processes. |
2022-01-31 |
2023-08-13 |
human |
| Xiaoyan Du, Lianzhong Luo, Qingyu Huang, Jie Zhan. Cortex metabolome and proteome analysis reveals chronic arsenic exposure via drinking water induces developmental neurotoxicity through hnRNP L mediated mitochondrial dysfunction in male rats. The Science of the total environment. 2022-01-25. PMID:35074374. |
thus, this study aimed to explore the molecular mechanisms of arsenic-induced learning and memory function impairments through the integrative proteome and metabolome analysis of cortex in rats. |
2022-01-25 |
2023-08-13 |
rat |
| Hyunha Kim, Min Jae Kim, Young Woo Kwon, Sangheon Jeon, Seo-Yeon Lee, Chang-Seok Kim, Byung Tae Choi, Yong-Il Shin, Suck Won Hong, Hwa Kyoung Shi. Benefits of a Skull-Interfaced Flexible and Implantable Multilight Emitting Diode Array for Photobiomodulation in Ischemic Stroke. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022-01-25. PMID:35076161. |
moreover, the pbm with 630 nm led array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates aim2 inflammasome activation and inflammasome-mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. |
2022-01-25 |
2023-08-13 |
mouse |
| Sydney Trask, Fred J Helmstette. Unique Roles for the Anterior and Posterior Retrosplenial Cortices in Encoding and Retrieval of Memory for Context. Cerebral cortex (New York, N.Y. : 1991). 2022-01-14. PMID:35029643. |
the rat retrosplenial cortex (rsc) makes critical contributions to learning and memory but these contributions may not be uniform along its rostro-caudal axis. |
2022-01-14 |
2023-08-13 |
rat |
| Vivek Verma, Ruchika Kumari, Muniyandi Singarave. Chronic altered light-dark cycle differentially affects hippocampal CA1 and DG neuronal arborization in diurnal and nocturnal rodents. Chronobiology international. 2022-01-05. PMID:34983277. |
the hippocampus, an extension of the temporal part of the cerebral cortex, plays a crucial role in learning and memory. |
2022-01-05 |
2023-08-13 |
Not clear |
| Weifeng Shan, Yini Wu, Xin Han, Qin Chen, Jimin W. The mechanism of sevoflurane post-treatment alleviating hypoxic-ischemic encephalopathy by affecting histone methyltransferase G9a in rats. Bioengineered. vol 12. issue 2. 2021-12-08. PMID:34672892. |
after sf post-treatment, the neurons in cerebral cortex, the learning and memory skills and the contents of ngf/bdnf were increased, while the apoptosis and g9a/h3k9me2 levels were reduced. |
2021-12-08 |
2023-08-13 |
rat |
| Susan Zhou, Zhengping Ji. Disruption of PAK3 Signaling in Social Interaction Induced cFos Positive Cells Impairs Social Recognition Memory. Cells. vol 10. issue 11. 2021-12-08. PMID:34831234. |
we show that the expression of mpak3-gfp proteins was in cfos-expressing excitatory and inhibitory neurons in various brain regions, such as the cortex and hippocampus, commonly activated during learning and memory. |
2021-12-08 |
2023-08-13 |
mouse |
| Bo-Wen Chen, Kai-Wen Zhang, Si-Jia Chen, Chun Yang, Peng-Gao L. Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice. Frontiers in aging neuroscience. vol 13. 2021-11-19. PMID:34790112. |
our results show that vad aggravated the behavioral learning and memory deficits, reduced the retinol concentration in the liver and the serum, decreased the transcription of vitamin a (va)-related receptors and va-related enzymes in the cortex, increased amyloid-β peptides (aβ40 and aβ42) in the brain and gut, upregulate the translation of beta-site app-cleaving enzyme 1 (bace1) and phosphorylated tau in the cortex, and downregulate the expression of brain-derived neurotrophic factor (bdnf) and γ-aminobutyric acid (gaba) receptors in the cortex. |
2021-11-19 |
2023-08-13 |
mouse |
| Dylan C Sarver, Cheng Xu, Yi Cheng, Chantelle E Terrillion, G William Won. CTRP4 ablation impairs associative learning and memory. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 11. 2021-11-12. PMID:34610176. |
this deficit is sex-dependent, affects only female mice, and is associated with altered expression of learning and memory genes (arc, c-fos, and pde4d) in the hippocampus and cortex. |
2021-11-12 |
2023-08-13 |
mouse |
| Clare R Quirk, Ipshita Zutshi, Sunandha Srikanth, Maylin L Fu, Naomie Devico Marciano, Morgan K Wright, Darian F Parsey, Stanley Liu, Rachel E Siretskiy, Tiffany L Huynh, Jill K Leutgeb, Stefan Leutge. Precisely timed theta oscillations are selectively required during the encoding phase of memory. Nature neuroscience. vol 24. issue 11. 2021-11-10. PMID:34608335. |
the entorhinal cortex and hippocampus are necessary for learning and memory and exhibit prominent theta oscillations (6-9 hz), which are controlled by pacemaker cells in the medial septal area. |
2021-11-10 |
2023-08-13 |
mouse |