| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eloise Lemarchand, Alba Grayston, Raymond Wong, Miyako Rogers, Blake Ouvrier, Benjamin Llewellyn, Freddie Webb, Nikolett Lénárt, Adam Denes, David Brough, Stuart M Allan, Gregory Bix, Emmanuel Pinteau. Selective deletion of interleukin-1 alpha in microglia regulates neuronal responses and neurorepair processes after experimental ischemic stroke. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585834. |
rna sequencing analysis and subsequent pathway analysis on ipsilateral/contralateral cortex 4 h after stroke revealed a downregulation of the neuronal creb signaling pathway in microglial il-1α ko compared to wt mice. |
2024-04-08 |
2024-04-10 |
mouse |
| Carrie R Jonak, Samantha A Assad, Manbir S Sandhu, Terese A Garcia, Jeffrey A Rumschlag, Khaleel A Razak, Devin K Binde. Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice. Neurobiology of disease. 2024-04-06. PMID:38582333. |
third, we found hemispheric asymmetry of fast temporal processing in the mouse auditory cortex in wt but not fmr1 ko mice. |
2024-04-06 |
2024-04-10 |
mouse |
| Heleen M Van't Spijker, Joel D Richte. FMRP regulation of aggrecan mRNA translation controls perineuronal net development. Journal of neurochemistry. 2024-01-15. PMID:38225196. |
examination of pnns by wfa staining at p14 and p42 in the hippocampus, somatosensory cortex, and retrosplenial cortex shows that they were reduced in these brain regions at p14 but mostly less so at p42 in fmr1 ko mice. |
2024-01-15 |
2024-01-18 |
mouse |
| Alzahraa Fergany, Cai Zong, Frederick Adams Ekuban, Bin Wu, Satoshi Ueha, Shigeyuki Shichino, Kouji Matsushima, Yoichiro Iwakura, Sahoko Ichihara, Gaku Ichihar. Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1β-knockout mice. Archives of toxicology. 2023-11-16. PMID:37971544. |
c57bl/6 j wild-type and il-1β ko mice were exposed to acr at 0, 12.5, 25 mg/kg by oral gavage for 7 days/week for 4 weeks, followed by extraction of mrna from mice cerebral cortex for rna sequence analysis. |
2023-11-16 |
2023-11-20 |
mouse |
| Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. |
in rgs2 ko, serotonergic gene expression was sex-specifically changed (e.g., cortical htr2a, maoa increased in females but all serotonin targets unchanged or decreased in males); redox-related expression increased in paraventricular nucleus and aorta; and angiogenic gene expression was changed in male but not female cortex. |
2023-10-17 |
2023-11-08 |
mouse |
| Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. |
a hallmark of fxs patients and the fxs mouse model (fmr1 ko) is an overabundance of immature appearing dendritic spines in the cortex and hippocampus which is associated with behavioral deficits. |
2023-07-29 |
2023-08-14 |
mouse |
| Nazim Kourdougli, Anand Suresh, Benjamin Liu, Pablo Juarez, Ashley Lin, David T Chung, Anette Graven Sams, Michael J Gandal, Verónica Martínez-Cerdeño, Dean V Buonomano, Benjamin J Hall, Cédric Mombereau, Carlos Portera-Caillia. Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period. Neuron. 2023-07-14. PMID:37451263. |
using all-optical in vivo approaches, we find that parvalbumin (pv) ins and their immature precursors are hypoactive and transiently decoupled from excitatory neurons in postnatal mouse somatosensory cortex (s1) of fmr1 ko mice, a model of fragile x syndrome (fxs). |
2023-07-14 |
2023-08-14 |
mouse |
| Fabian Baalmann, Jana Brendler, Anne Butthof, Yulia Popkova, Kathrin M Engel, Jürgen Schiller, Karsten Winter, Vera Lede, Albert Ricken, Torsten Schöneberg, Angela Schul. Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250906. |
ko mice had a broader cortex relative to the total kidney area than wild-type (wt) mice. |
2023-05-30 |
2023-08-14 |
mouse |
| Soha Sohail, Gabriella Akkawi, Taylor Rechter, Maurice B Fluitt, Carolyn M Ecelbarge. Sex Modulates Response to Renal-Tubule-Targeted Insulin Receptor Deletion in Mice. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175762. |
western blotting of renal cortex homogenates showed decreased protein levels for the β and γ subunits of the epithelial sodium channel (enac) and the sodium-potassium-2-chloride cotransporter type 2 (nkcc2) in both sexes of ko mice; however, α-enac was upregulated in koms and downregulated in kofs. |
2023-05-14 |
2023-08-14 |
mouse |
| Jessica Cummings, Yijen L Wu, C Edward Dixon, Jeremy Henchir, J Marc Simard, Ashok Panigrahy, Patrick M Kochanek, Ruchira M Jha, Rajesh K Anej. Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis. Journal of neuroinflammation. vol 20. issue 1. 2023-01-21. PMID:36681815. |
abcc8 ko mice also had decreased microglial activation in the cerebral cortex vs. wt. |
2023-01-21 |
2023-08-14 |
mouse |
| Antonella Borreca, Mariassunta De Luca, Antonella Ferrante, Zaira Boussadia, Annabella Pignataro, Alberto Martire, Martine Ammassari-Teul. Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus. Scientific reports. vol 13. issue 1. 2023-01-14. PMID:36641518. |
at the 1 h-interval, ko mice failed to discriminate the novel object, showed a collapse of spines in the lateral entorhinal cortex (lec), and of long-term potentiation (ltp) in the lateral perforant path (lpp), but a normal increase in hippocampal spines. |
2023-01-14 |
2023-08-14 |
mouse |
| Arezoo Dadashzadeh, Saeid Moghassemi, Monika Grubliauskaité, Hanne Vlieghe, Davide Brusa, Christiani A Amori. Medium supplementation can influence the human ovarian cells in vitro. Journal of ovarian research. vol 15. issue 1. 2022-12-26. PMID:36572931. |
to this end, we have in vitro cultured cells isolated from the menopausal ovarian cortex using different additives: knockout serum replacement (ko), fetal bovine serum (fbs), human serum albumin (hsa), and platelet lysate (pl). |
2022-12-26 |
2023-08-14 |
human |
| Robin Scharrenberg, Melanie Richter, Ole Johanns, Durga Praveen Meka, Tabitha Rücker, Nadeem Murtaza, Zsuzsa Lindenmaier, Jacob Ellegood, Anne Naumann, Bing Zhao, Birgit Schwanke, Jan Sedlacik, Jens Fiehler, Ileana L Hanganu-Opatz, Jason P Lerch, Karun K Singh, Froylan Calderon de And. TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model. Molecular psychiatry. 2022-09-19. PMID:36123424. |
finally, we report that the brains of the taok2 ko and 16p11.2 del het mouse models show striking anatomical similarities and that the heterozygous 16p11.2 microdeletion mouse model displayed reduced levels of phosphorylated jnk1 and neuronal migration deficits, which were ameliorated upon the introduction of taok2α in cortical neurons and in the developing cortex of those mice. |
2022-09-19 |
2023-08-14 |
mouse |
| J Sánchez-Ventura, C Canal, J Hidalgo, C Penas, X Navarro, A Torres-Espin, K Fouad, E Udin. Aberrant perineuronal nets alter spinal circuits, impair motor function, and increase plasticity. Experimental neurology. 2022-09-05. PMID:36064003. |
crtl1 ko mice showed disorganized pnns with an altered proportion of their components in both motor cortex and spinal cord. |
2022-09-05 |
2023-08-14 |
mouse |
| Jahangir Iqbal, Manuel D Suarez, Pradeep K Yadav, Meghan T Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M Brickman, José A Luchsinger, Kezhi Dai, Herman Moreno, M Mahmood Hussai. ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. The Journal of biological chemistry. 2022-08-25. PMID:36007616. |
we found anomalies in synaptic plasticity at the intracortical layer ii/iii lateral entorhinal cortex synapse but not in the hippocampal synapses in ko mice. |
2022-08-25 |
2023-08-14 |
mouse |
| Tingting Liu, Xiaolei Zhu, Chaoli Huang, Jiang Chen, Shu Shu, Guiquan Chen, Yun Xu, Yimin H. ERK inhibition reduces neuronal death and ameliorates inflammatory responses in forebrain-specific Ppp2cα knockout mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 9. 2022-08-23. PMID:35997299. |
we show that ppp2cα ko mice display robust neuronal apoptosis and inflammatory responses in the postnatal cortex. |
2022-08-23 |
2023-08-14 |
mouse |
| Tingting Liu, Xiaolei Zhu, Chaoli Huang, Jiang Chen, Shu Shu, Guiquan Chen, Yun Xu, Yimin H. ERK inhibition reduces neuronal death and ameliorates inflammatory responses in forebrain-specific Ppp2cα knockout mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 9. 2022-08-23. PMID:35997299. |
we demonstrated that the total number of cleaved caspase3 positive (+) cells in the cortex was significantly reduced in ppp2cα ko mice treated with pd98059 compared with those without pd98059 treatment. |
2022-08-23 |
2023-08-14 |
mouse |
| Tingting Liu, Xiaolei Zhu, Chaoli Huang, Jiang Chen, Shu Shu, Guiquan Chen, Yun Xu, Yimin H. ERK inhibition reduces neuronal death and ameliorates inflammatory responses in forebrain-specific Ppp2cα knockout mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 9. 2022-08-23. PMID:35997299. |
we observed that the total number of iba1+ cells in the cortex was significantly decreased in ppp2cα ko mice treated with pd98059. |
2022-08-23 |
2023-08-14 |
mouse |
| Patrick A Cody, Thanos Tzounopoulo. Neuromodulatory Mechanisms Underlying Contrast Gain Control in Mouse Auditory Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 42. issue 28. 2022-08-23. PMID:35998293. |
to study these mechanisms in male and female mice, we used a 2-photon calcium imaging preparation in layer 2/3 neurons of primary auditory cortex (a1), along with pharmacological and genetic ko approaches. |
2022-08-23 |
2023-08-14 |
mouse |
| Patricia M Horvath, Michelle K Piazza, Ege T Kavalali, Lisa M Monteggi. MeCP2 loss-of-function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance. Hippocampus. 2022-07-19. PMID:35851733. |
two mirnas, mir-101a and mir-203, were identified and confirmed as upregulated in mecp2 ko mice in the hippocampus and cortex, respectively. |
2022-07-19 |
2023-08-14 |
mouse |