| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Jaime Herrera-Pérez, Alonso Fernández-Guasti, Lucía Martínez-Mot. Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution. Neuroscience journal. vol 2013. 2015-08-28. PMID:26317087. |
this last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. |
2015-08-28 |
2023-08-13 |
rat |
| Mika Senuma, Chisato Mori, Tetsuo Ogawa, Makiko Kuwagat. Prenatal sodium arsenite affects early development of serotonergic neurons in the fetal rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 38. 2015-08-21. PMID:25291237. |
however, reductions in the number of serotonin positive cells in the fetal median and dorsal raphe nuclei were observed following maternal treatment with 20mg/kg arsenite. |
2015-08-21 |
2023-08-13 |
rat |
| Yoshinori Suzuki, Emi Kiyokage, Jaerin Sohn, Hiroyuki Hioki, Kazunori Toid. Structural basis for serotonergic regulation of neural circuits in the mouse olfactory bulb. The Journal of comparative neurology. vol 523. issue 2. 2015-08-04. PMID:25234191. |
we accomplished this visualization by successfully labeling and reconstructing serotonin (5-hydroxytryptamine: 5-ht) neurons by infection with sindbis and adeno-associated virus into dorsal raphe nuclei (drn) of mice. |
2015-08-04 |
2023-08-13 |
mouse |
| Ling-Ling Fan, Zhi-Hong Hu, Yu-Dong Zhou, Qian-Qian Li, Yan-Ru Jia, Jin-Feng Wang, Chun-Wei Zha. [Intraventricular injection of 5,7-dihydroxytryptamine alters neuronal activity of neurons in the medial prefrontal cortex of rat]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 6. 2015-07-26. PMID:25516515. |
the results showed that the injection of 5,7-dht reduced the 5-hydroxytryptamine (5-ht) levels in the mpfc and dorsal raphe nucleus in the rats. |
2015-07-26 |
2023-08-13 |
rat |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
enhanced 5-ht1a receptor-dependent feedback control over dorsal raphe serotonin neurons in the sert knockout mouse. |
2015-07-24 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
since 5-ht1a receptors in the mpfc provide a key feedback regulation of the dorsal raphe nucleus (drn), we used a disinhibition strategy to examined endogenous feedback control of 5-ht neurons. |
2015-07-24 |
2023-08-13 |
mouse |
| Hélio Zangrossi, Frederico G Graef. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24657635. |
the evidence so far reported with the etm supports the above hypothesis and indicates that: (1) whereas 5-ht neurons located at the dorsal raphe nucleus are involved in the regulation of both inhibitory avoidance and escape, those of the median raphe nucleus are primarily implicated in the former task; (2) facilitation of 5-ht1a- and 5-ht2a-mediated neurotransmission in the dorsal periaqueductal gray (dpag) is likely to mediate the panicolytic drug action; (3) stimulation of 5-ht2c receptors in the basolateral amygdala increases anxiety and is implicated in the anxiogenesis caused by short-term administration of antidepressant drugs, and (4) 5-ht1a and the μ-opioid receptors work together in the dpag to modulate escape or panic attacks. |
2015-07-17 |
2023-08-12 |
rat |
| Evan D Paul, Philip L Johnson, Anantha Shekhar, Christopher A Lowr. The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24661986. |
evidence supporting this panic inhibition system comes from the following observations: (1) serotonergic neurons located in the 'ventrolateral dorsal raphe nucleus' (drvl) as well as the ventrolateral periaqueductal gray (vlpag) inhibit dorsal periaqueductal gray-elicited panic-like responses; (2) chronic, but not acute, antidepressant treatment potentiates serotonin's panicolytic effect; (3) contextual fear activates a central nucleus of the amygdala-drvl/vlpag circuit implicated in mediating freezing and inhibiting panic-like escape behaviors; (4) drvl/vlpag serotonergic neurons are central chemoreceptors and modulate the behavioral and cardiorespiratory response to panicogenic agents such as sodium lactate and co2. |
2015-07-17 |
2023-08-12 |
Not clear |
| Isabel M Quadros, Lara S Hwa, Akiko Shimamoto, Julia Carlson, Joseph F DeBold, Klaus A Micze. Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 12. 2015-07-10. PMID:24917195. |
the serotonin (5-ht) pathway from the dorsal raphe nucleus (drn) to the medial prefrontal cortex (mpfc) by crf-r1 was investigated as a possible target for the prevention of alcohol-heightened aggressive behavior. |
2015-07-10 |
2023-08-13 |
mouse |
| Hiroyuki Ito, Yuji Shimogawa, Daisuke Kohagura, Tetsuji Moriizumi, Korehito Yamanouch. Inhibitory role of the serotonergic system on estrogen receptor α expression in the female rat hypothalamus. Neuroscience letters. vol 583. 2015-06-05. PMID:25281790. |
the role of the serotonergic system in regulating the expression of estrogen receptor (er) α in the hypothalamus was investigated in ovariectomized rats by injecting a serotonin synthesis inhibitor, parachlorophenylalanine (pcpa), or by destroying the dorsal raphe nucleus (dr). |
2015-06-05 |
2023-08-13 |
rat |
| Kayoko W Miyazaki, Katsuhiko Miyazaki, Kenji F Tanaka, Akihiro Yamanaka, Aki Takahashi, Sawako Tabuchi, Kenji Doy. Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. Current biology : CB. vol 24. issue 17. 2015-05-20. PMID:25155504. |
optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. |
2015-05-20 |
2023-08-13 |
mouse |
| Kayoko W Miyazaki, Katsuhiko Miyazaki, Kenji F Tanaka, Akihiro Yamanaka, Aki Takahashi, Sawako Tabuchi, Kenji Doy. Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. Current biology : CB. vol 24. issue 17. 2015-05-20. PMID:25155504. |
previous recording studies of the midbrain dorsal raphe nucleus (drn) revealed that the activation of putative serotonin neurons correlates with the levels of behavioral arousal [1], rhythmic motor outputs [2], salient sensory stimuli [3-6], reward, and conditioned cues [5-8]. |
2015-05-20 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Kathryn G Common. Unraveling the architecture of the dorsal raphe synaptic neuropil using high-resolution neuroanatomy. Frontiers in neural circuits. vol 8. 2015-05-15. PMID:25206323. |
the dorsal raphe nucleus (drn), representing the main source of brain's serotonin, is implicated in the pathophysiology and therapeutics of several mental disorders that can be debilitating and life-long including depression, anxiety and autism. |
2015-05-15 |
2023-08-13 |
Not clear |
| C Lanteri, E L Doucet, S J Hernández Vallejo, G Godeheu, A-C Bobadilla, L Salomon, L Lanfumey, J-P Tassi. Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons. Molecular psychiatry. vol 19. issue 7. 2015-04-15. PMID:23958955. |
finally, molecular analysis including radiolabeling, western blot and quantitative reverse transcription-polymerase chain reaction reveals that mice repeatedly treated with mdma exhibit normal α(2a)-adrenergic and 5-ht(1a) receptor binding, but a long-lasting downregulation of gαi proteins expression in both locus coeruleus and dorsal raphe nucleus. |
2015-04-15 |
2023-08-12 |
mouse |
| Naoya Nishitani, Kazuki Nagayasu, Nozomi Asaoka, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24852262. |
a subcutaneous administration of ketamine (5 and 25 mg/kg) significantly increased the prefrontal 5-ht level in a dose-dependent manner, which was attenuated by local injection of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampar) antagonists into the dorsal raphe nucleus (drn). |
2015-04-14 |
2023-08-13 |
rat |
| Helene Bach, Victoria Arango, Suham A Kassir, Tea Tsaava, Andrew J Dwork, J John Mann, Mark D Underwoo. Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei. Alcoholism, clinical and experimental research. vol 38. issue 7. 2015-04-14. PMID:24942188. |
chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-ht]), yet we previously found more tryptophan hydroxylase 2 (tph2), the rate-limiting biosynthetic enzyme for 5-ht, in the dorsal raphe nucleus (drn) of alcoholics. |
2015-04-14 |
2023-08-13 |
Not clear |
| Jingfeng Zhou, Chunying Jia, Qiru Feng, Junhong Bao, Minmin Lu. Prospective coding of dorsal raphe reward signals by the orbitofrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 6. 2015-04-13. PMID:25673861. |
the ofc is interconnected with the dorsal raphe nucleus (drn), which is a major serotonin (5-ht) center of the brain. |
2015-04-13 |
2023-08-13 |
mouse |
| Hind Benammi, Omar El Hiba, Abderrahmane Romane, Halima Gamran. A blunted anxiolytic like effect of curcumin against acute lead induced anxiety in rat: involvement of serotonin. Acta histochemica. vol 116. issue 5. 2015-04-03. PMID:24721902. |
using immunohistochemistry and anxiety assessment tests (dark light box and elevated plus maze), we evaluated, respectively, the expression of serotonin (5ht) in the dorsal raphe nucleus (drn) and the anxiety state in our animals. |
2015-04-03 |
2023-08-13 |
rat |
| Tae Woon Kim, Baek Vin Lim, Dongjin Baek, Dong-Soo Ryu, Jin Hee Se. Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in Rats. International neurourology journal. vol 19. issue 1. 2015-04-02. PMID:25833478. |
in the present study, we investigated the effect of treadmill exercise on stress-induced depression while focusing on the expression of 5-ht 1a (5-h1a) receptors in the dorsal raphe. |
2015-04-02 |
2023-08-13 |
rat |
| Tae-Woon Kim, Eun-Sang Ji, Tae-Wook Kim, Sang-Won Lee, Choong-Yeol Lee, Sam-Jun Le. Postnatal treadmill exercise attenuates prenatal stress-induced apoptosis through enhancing serotonin expression in aged-offspring rats. Journal of exercise rehabilitation. vol 11. issue 1. 2015-04-01. PMID:25830139. |
in the present results, offspring exposed to prenatal stress exhibited lower bcl-2 level and higher bax level in the hippocampus, lower 5-hydroxytryptamine (5-ht) and tryptophan hydroxylase (tph) expression in the dorsal raphe, and higher c-fos expression in the locus coeruleus compared to age-matched control rats. |
2015-04-01 |
2023-08-13 |
rat |