| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmet H Kaya, Rinske Vlamings, Sonny Tan, Lee Wei Lim, Peter J Magill, Harry W M Steinbusch, Veerle Visser-Vandewalle, Trevor Sharp, Yasin Teme. Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats. Brain research. vol 1221. 2008-10-20. PMID:18565496. |
serotonin (5-ht) containing neurons in the dorsal raphe nucleus (drn) may play important roles in parkinson's disease (pd). |
2008-10-20 |
2023-08-12 |
rat |
| Andrew K Evans, Niels Reinders, Katie A Ashford, Isabel N Christie, Jonathan B Wakerley, Christopher A Lowr. Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18577382. |
we describe the effects of perfusion of living rat brain slices with tryptophan on both 1) tissue concentrations of serotonin metabolites and 2) neuronal firing rates within the dorsal raphe nucleus. |
2008-10-14 |
2023-08-12 |
rat |
| Andrew K Evans, Niels Reinders, Katie A Ashford, Isabel N Christie, Jonathan B Wakerley, Christopher A Lowr. Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18577382. |
tryptophan resulted in time-dependent and concentration-dependent increases in serotonin and serotonin metabolites, effects that were correlated with restoration of tonic autoinhibition of dorsal raphe nucleus neuronal firing rates. |
2008-10-14 |
2023-08-12 |
rat |
| Renato Leonardo Freitas, Gabriel Shimizu Bassi, Ana Maria de Oliveira, Norberto Cysne Coimbr. Serotonergic neurotransmission in the dorsal raphe nucleus recruits in situ 5-HT(2A/2C) receptors to modulate the post-ictal antinociception. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18671968. |
serotonergic neurotransmission in the dorsal raphe nucleus recruits in situ 5-ht(2a/2c) receptors to modulate the post-ictal antinociception. |
2008-10-08 |
2023-08-12 |
rat |
| Bruno P Guiard, Mostafa El Mansari, Zul Merali, Pierre Blie. Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions. The international journal of neuropsychopharmacology. vol 11. issue 5. 2008-09-24. PMID:18205979. |
the selective lesion of da neurons elicited by 6-hydroxydopamine (6-ohda) decreased the spontaneous firing activity of dorsal raphe (dr) nucleus 5-ht neurons by 60%, thus revealing the excitatory effect of the da input on these 5-ht neurons. |
2008-09-24 |
2023-08-12 |
rat |
| Jaime M Monti, Marcello Leopoldo, Héctor Janto. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behavioural brain research. vol 191. issue 2. 2008-09-24. PMID:18466985. |
the serotonin 5-ht7 receptor agonist lp-44 microinjected into the dorsal raphe nucleus suppresses rem sleep in the rat. |
2008-09-24 |
2023-08-12 |
rat |
| Y Tokuyama, A P Reddy, C L Bethe. Neuroprotective actions of ovarian hormones without insult in the raphe region of rhesus macaques. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18486349. |
using a nonhuman primate model of surgical menopause, our laboratory has shown that ovarian hormone treatment (ht) improves 5-ht neural function in the dorsal raphe nucleus (drn). |
2008-08-29 |
2023-08-12 |
monkey |
| Kathryn G Common. Evidence for topographically organized endogenous 5-HT-1A receptor-dependent feedback inhibition of the ascending serotonin system. The European journal of neuroscience. vol 27. issue 10. 2008-08-20. PMID:18513318. |
this was done by testing the effect of systemic blockade of 5-ht-1a receptors on fos expression in 5-ht neurons in the dorsal raphe (dr) and median raphe (mr). |
2008-08-20 |
2023-08-12 |
rat |
| Igor Sibon, Chawki Benkelfat, Paul Gravel, Nicolas Aznavour, Nicolas Costes, Shadrek Mzengeza, Linda Booij, Glen Baker, Jean-Paul Soucy, Luc Zimmer, Laurent Descarrie. Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a single oral dose of fluoxetine: a positron-emission tomography study in healthy volunteers. Biological psychiatry. vol 63. issue 12. 2008-08-15. PMID:18191817. |
this positron-emission tomography (pet) study tested the hypothesis that 5-ht(1a) autoreceptor internalization might be indexed in vivo by a decrease in the specific binding of the 5-ht(1a) radioligand, 4-[18f]fluoro-n-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-n-2-pyridinyl-benzamide ([(18)f]mppf), in the dorsal raphe nucleus (drn) of healthy adult men administered a single oral dose of the selective serotonin reuptake inhibitor, fluoxetine. |
2008-08-15 |
2023-08-12 |
human |
| Nashat Abumaria, Adema Ribic, Christoph Anacker, Eberhard Fuchs, Gabriele Flügg. Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18197473. |
we show here that in the rat dorsal raphe nucleus (drn), the nucleus that contains the highest number of 5-ht neurons in the brain, tph1 mrna reveals a low level of expression but is detectable both by quantitative real-time pcr and in situ hybridization whereas in the pineal gland (pig), tph1 mrna is strongly expressed. |
2008-08-11 |
2023-08-12 |
rat |
| E Fiske, C M Portas, J Grønli, E Sørensen, B Bjorvatn, A A Bjørkum, R Ursi. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta physiologica (Oxford, England). vol 193. issue 1. 2008-08-01. PMID:18081887. |
increased extracellular 5-ht but no change in sleep after perfusion of a 5-ht1a antagonist into the dorsal raphe nucleus of rats. |
2008-08-01 |
2023-08-12 |
rat |
| E Fiske, C M Portas, J Grønli, E Sørensen, B Bjorvatn, A A Bjørkum, R Ursi. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta physiologica (Oxford, England). vol 193. issue 1. 2008-08-01. PMID:18081887. |
the 5-ht(1a) receptor antagonist 4-iodo-n-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-benzamide hydrochloride (p-mppi) (10 microm) was perfused into the dorsal raphe nucleus (drn) to study simultaneously the effects of the drug on the drn and frontal cortex extracellular serotonin (5-hydroxytryptamine, 5-ht) levels and concurring behavioural states. |
2008-08-01 |
2023-08-12 |
rat |
| Jaime M Monti, Héctor Janto. Activation of the serotonin 5-HT3 receptor in the dorsal raphe nucleus suppresses REM sleep in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18295951. |
activation of the serotonin 5-ht3 receptor in the dorsal raphe nucleus suppresses rem sleep in the rat. |
2008-07-22 |
2023-08-12 |
rat |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
5-ht immunostaining revealed no difference between sert(+/+) and sert(-/-) rats in the dorsal raphe nuclei, in both males and females. |
2008-07-21 |
2023-08-12 |
human |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
paradoxically, in the dorsal raphe nucleus (drn) there are more serotonin neurons and more neuronal tryptophan hydroxylase-2 (tph2) expression postmortem in depressed suicides. |
2008-07-03 |
2023-08-12 |
Not clear |
| Kae Nakamura, Masayuki Matsumoto, Okihide Hikosak. Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 20. 2008-06-19. PMID:18480289. |
to elucidate the functional relationship between serotonin neurons and dopamine neurons, we performed single-unit recording in the dorsal raphe nucleus (drn), a major source of serotonin, and the substantia nigra pars compacta, a major source of dopamine, while monkeys performed saccade tasks in which the position of the target indicated the size of an upcoming reward. |
2008-06-19 |
2023-08-12 |
monkey |
| Dania V Rossi, Teresa F Burke, Melissa McCasland, Julie G Hensle. Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18182050. |
serotonin-1a receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline. |
2008-06-06 |
2023-08-12 |
rat |
| Dania V Rossi, Teresa F Burke, Melissa McCasland, Julie G Hensle. Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18182050. |
serotonin-1a (5-ht(1a) receptors in the dorsal raphe nucleus (drn) function as somatodendritic autoreceptors, and therefore play a critical role in controlling serotonergic cell firing and serotonergic neurotransmission. |
2008-06-06 |
2023-08-12 |
rat |
| Cynthia L Bethea, Arubala P Redd. Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18182058. |
we sought the effect of estradiol (e) and progesterone (p) on survival gene expression in laser captured serotonin neurons and in the dorsal raphe region of monkeys with cdna array analysis. |
2008-06-06 |
2023-08-12 |
monkey |
| Dania V Rossi, Teresa F Burke, Julie G Hensle. Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram. European journal of pharmacology. vol 583. issue 1. 2008-05-27. PMID:18289523. |
as the binding and action of escitalopram is limited by the inactive enantiomer r-citalopram present in racemic citalopram, we propose that the regulation of 5-ht1a receptor function in the dorsal raphe nucleus at the level of receptor-g protein interaction may be a result of greater inhibition of the serotonin transporter by escitalopram. |
2008-05-27 |
2023-08-12 |
Not clear |