| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong W Kan. Central Nervous System Associated With Light Perception and Physiological Responses of Birds. Frontiers in physiology. vol 12. 2021-11-10. PMID:34744764. |
although further research is required to establish the functional role of opn4 in the ventral tegmental area (vta), dorsal raphe nucleus, and caudal raphe nucleus in the light perception and physiological responses of birds, it is an exciting prospect because the previous results in birds support this hypothesis that opn4 in the midbrain da and serotonin neurons may play significant roles on the light-induced welfare of birds. |
2021-11-10 |
2023-08-13 |
Not clear |
| Chen Li, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun L. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31980728. |
here we show that adiponectin receptor 1 (adipor1) is expressed in the dorsal raphe nucleus (drn) and colocalized with tryptophan hydroxylase 2 (tph2), a marker of serotonin (5-ht) neurons. |
2021-11-02 |
2023-08-13 |
mouse |
| Aki Takahashi, Hossein Aleyasin, Mihaela A Stavarache, Long Li, Flurin Cathomas, Lyonna F Parise, Hsiao-Yun Lin, C Joseph Burnett, Antonio Aubry, Meghan E Flanigan, Anna Brancato, Caroline Menard, Madeline L Pfau, Veronika Kana, Jun Wang, Georgia E Hodes, Tetsuya Sasaki, Michael G Kaplitt, Sonoko Ogawa, Bruce S McEwen, Scott J Russ. Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Molecular psychiatry. 2021-11-02. PMID:33931727. |
we found that nonaggressive mice exhibit higher levels of il-1β in the dorsal raphe nucleus (drn), the major source of forebrain serotonin (5-ht), compared to aggressive mice. |
2021-11-02 |
2023-08-13 |
mouse |
| Manuel A Giannoni-Guzmán, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Douglas G McMaho. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. Journal of pineal research. vol 70. issue 2. 2021-11-01. PMID:33210730. |
we then quantified kcnk2 mrna levels specifically in dorsal raphe 5-ht neurons using triple-label rnascope. |
2021-11-01 |
2023-08-13 |
mouse |
| Manuel A Giannoni-Guzmán, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Douglas G McMaho. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. Journal of pineal research. vol 70. issue 2. 2021-11-01. PMID:33210730. |
photoperiodic effects on the function and expression of trek-1 were blocked in melatonin 1 receptor knockout (mt-1ko) mice, consistent with previous findings that mt-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-ht neurons. |
2021-11-01 |
2023-08-13 |
mouse |
| Manuel A Giannoni-Guzmán, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Douglas G McMaho. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. Journal of pineal research. vol 70. issue 2. 2021-11-01. PMID:33210730. |
taken together these results indicate that photoperiodic regulation of trek-1 expression and function plays a key role in photoperiodic programming the excitability of dorsal raphe 5-ht neurons. |
2021-11-01 |
2023-08-13 |
mouse |
| Omar Hernández-González, Andrea Mondragón-García, Salvador Hernández-López, Diego E Castillo-Rolon, Gabina Arenas-López, Dagoberto Tapia, Stefan Mihailesc. Mechanisms of stimulatory effects of mecamylamine on the dorsal raphe neurons. Brain research bulletin. vol 164. 2021-10-29. PMID:32910991. |
previous studies showed that mecamylamine a noncompetitive and nonspecific blocker of nicotinic acetylcholine receptors (nachrs), stimulates the activity of the dorsal raphe nucleus (drn) serotonergic neurons and drn serotonin (5-ht) release. |
2021-10-29 |
2023-08-13 |
rat |
| Laifu Li, Li-Zi Zhang, Zhi-Xiong He, Huan Ma, Yu-Ting Zhang, Yu-Feng Xun, Wei Yuan, Wen-Juan Hou, Yi-Tong Li, Zi-Jian Lv, Rui Jia, Fa-Dao Ta. Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability. eLife. vol 10. 2021-10-19. PMID:34080539. |
by using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-htergic neurons in the dorsal raphe nucleus (dr) or optogenetic inhibition of serotonin (5-ht) terminals in the anterior cingulate cortex (acc) significantly decreased allogrooming time in the consolation test and reduced sociability in the three-chamber test. |
2021-10-19 |
2023-08-13 |
Not clear |
| Charline Jansch, Georg C Ziegler, Andrea Forero, Sina Gredy, Sina Wäldchen, Maria Rosaria Vitale, Evgeniy Svirin, Johanna E M Zöller, Jonas Waider, Katharina Günther, Frank Edenhofer, Markus Sauer, Erhard Wischmeyer, Klaus-Peter Lesc. Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 2. 2021-10-15. PMID:33560471. |
among the high percentage of 5-ht specific neurons (~ 42%), a subpopulation of cdh13 + cells presumably designates dorsal raphe neurons. |
2021-10-15 |
2023-08-13 |
human |
| Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspa. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727585. |
dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. |
2021-10-14 |
2023-08-13 |
mouse |
| Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspa. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727585. |
this nursing defect is due to acute rather constitutive 5-ht depletion, as it is reproduced by adult knockdown of tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. |
2021-10-14 |
2023-08-13 |
mouse |
| Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspa. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727585. |
we conclude that 5-ht innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. |
2021-10-14 |
2023-08-13 |
mouse |
| Luanne H Hale, Maria C Tickerhoof, Adam S Smit. Chronic intranasal oxytocin reverses stress-induced social avoidance in female prairie voles. Neuropharmacology. vol 198. 2021-10-14. PMID:34461067. |
in males, serotonin 1a receptor binding was decreased in the basolateral amygdala and dorsal raphe nucleus starting at one week and four weeks post-defeat, respectively. |
2021-10-14 |
2023-08-13 |
Not clear |
| Emilio Garro-Martínez, Maria Neus Fullana, Eva Florensa-Zanuy, Julia Senserrich, Verónica Paz, Esther Ruiz-Bronchal, Albert Adell, Elena Castro, Álvaro Díaz, Ángel Pazos, Analía Bortolozzi, Fuencisla Pilar-Cuélla. mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse. International journal of molecular sciences. vol 22. issue 16. 2021-09-15. PMID:34445375. |
in parallel, decreased brain-derived neurotrophic factor (bdnf) expression was found bilaterally in both il and prl cortices along with a dysregulation of serotonin (5-ht) and glutamate (glu) release in the dorsal raphe nucleus (drn). |
2021-09-15 |
2023-08-13 |
mouse |
| Hye Jin Yang, Mi Jung Kim, Sung Soo Kim, Young-Wuk Ch. Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 25. issue 5. 2021-09-08. PMID:34448462. |
the dorsal raphe nucleus (drn) secretes 5-hydroxytryptamine (5-ht, serotonin), promoting wakefulness. |
2021-09-08 |
2023-08-13 |
rat |
| Jung Eun Kim, Sujin Chae, Sungsoo Kim, Yeon-Joo Jung, Myoung-Goo Kang, Won Do Heo, Daesoo Ki. Cerebellar 5HT-2A receptor mediates stress-induced onset of dystonia. Science advances. vol 7. issue 10. 2021-08-26. PMID:33658190. |
here, we reveal that 5ht neurons in the dorsal raphe nuclei (drn) send projections to the fastigial deep cerebellar nuclei (fdcn) and that photostimulation of 5ht-fdcn induces dystonia in wild-type mice. |
2021-08-26 |
2023-08-13 |
mouse |
| Burak Yaman, Ramazan Ba. Serotonin hyperpolarizes the dorsal raphe nucleus neurons of mice by activating G protein-coupled inward rectifier potassium channels. Neuroreport. vol 31. issue 12. 2021-08-13. PMID:32576771. |
serotonin hyperpolarizes the dorsal raphe nucleus neurons of mice by activating g protein-coupled inward rectifier potassium channels. |
2021-08-13 |
2023-08-13 |
mouse |
| Mauricio Sepulveda, Elizabeth E Manning, Andrea Gogos, Matthew Hale, Maarten van den Buus. Long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: Role of brain-derived neurotrophic factor. Brain research. vol 1762. 2021-08-11. PMID:33737066. |
long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: role of brain-derived neurotrophic factor. |
2021-08-11 |
2023-08-13 |
mouse |
| Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. |
maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. |
2021-08-06 |
2023-08-13 |
Not clear |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
obesity, a condition of chronic mild inflammation including obesity-induced neuroinflammation, is proposed to contribute to decreases in synaptic concentrations of neurotransmitters like serotonin (5ht) by decreasing 5ht synthesis in the dorsal raphe nucleus (drn) and/or affecting 5ht reuptake in drn target regions like the hippocampus. |
2021-08-06 |
2023-08-13 |
human |