| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suzannah De Almeida, Gregory Sarto. BET proteins as novel epigenetic targets for the treatment of Opioid Use Disorder. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555955. |
to assess a potential role for bet proteins in oud, we measured time-dependent changes in bet mrna expression in the prefrontal cortex (pfc), nucleus accumbens (nac), and dorsal striatum (ds), following oral oxycodone self-administration. |
2022-05-13 |
2023-08-13 |
mouse |
| Atul P Daiwile, Patricia Sullivan, Subramaniam Jayanthi, David S Goldstein, Jean Lud Cade. Sex-Specific Alterations in Dopamine Metabolism in the Brain after Methamphetamine Self-Administration. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457170. |
dopamine and its metabolites were measured in the prefrontal cortex (pfc), nucleus accumbens (nac), dorsal striatum (dstr), and hippocampus (hip). |
2022-04-23 |
2023-08-13 |
rat |
| Anne Almey, Teresa A Milner, Wayne G Brak. Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons. The Journal of comparative neurology. 2022-04-09. PMID:35397175. |
prior studies demonstrated membrane-associated ers in the dorsal striatum; these experiments extend those findings to the nac core and shell. |
2022-04-09 |
2023-08-13 |
rat |
| Martyna Bayassi-Jakowicka, Grazyna Lietzau, Ewelina Czuba, Cesare Patrone, Przemysław Kowiańsk. More than Addiction-The Nucleus Accumbens Contribution to Development of Mental Disorders and Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 5. 2022-03-10. PMID:35269761. |
interestingly, changes in the nac often have a different character and intensity compared to the changes observed in the other parts of the basal ganglia, in particular the dorsal striatum. |
2022-03-10 |
2023-08-13 |
Not clear |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
microinjections of tfb-tboa into the nac, but not the ventral tegmental area (vta), or dorsal striatum (ds), dose-dependently inhibited cocaine self-administration under fixed-ratio and progressive-ratio reinforcement schedules, shifted the cocaine dose-response curve downward, and inhibited intracranial brain-stimulation reward. |
2022-01-29 |
2023-08-13 |
rat |
| Scott Edwards, Chelsea N Callicoatte, Angela E Barattini, Jessica A Cucinello-Ragland, Alex Melain, Kimberly N Edwards, Nicholas W Gilpin, Elizabeth M Avegno, Amanda R Pahn. Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain. Neuropharmacology. 2022-01-27. PMID:35085583. |
we also examined the effects of pramipexole treatment on glutamatergic and presynaptic signaling in pain- and reward-related brain regions including the nucleus accumbens (nac), dorsal striatum (ds), ventral tegmental area (vta), cingulate cortex (cc), central amygdala (cea), and periaqueductal gray (pag). |
2022-01-27 |
2023-08-13 |
rat |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
here, we investigated changes in the total neuronal density and relative concentration of d2r-expressing neurons in the medial prefrontal cortex (mpfc), dorsal striatum (dstr), nucleus accumbens (nac), and ventral tegmental area (vta) in both male and female mice passively exposed to cocaine for two weeks. |
2021-12-12 |
2023-08-13 |
mouse |
| Nurul H M Yusoff, Zurina Hassan, Vikneswaran Murugaiyah, Christian P Mülle. The effect of mitragynine on extracellular activity of brain dopamine and its metabolites. Brain research bulletin. vol 178. 2021-12-09. PMID:34774992. |
affects extracellular activity of dopamine (da) and its metabolites, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the prefrontal cortex (pfc), nucleus accumbens (nac) and caudate putamen (cpu) of the brain, compared to morphine (mor; 10 mg/kg, i.p.) |
2021-12-09 |
2023-08-13 |
rat |
| Mijung Yeom, Sora Ahn, Ju-Young Oh, Song-Yi Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Par. Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31743694. |
in the nucleus accumbens (nac), dorsal striatum (ds) and ventral tegmental area (vta), protein levels of dopamine- and plasticity-related signaling molecules were determined by western immunoblotting assay. |
2021-11-22 |
2023-08-13 |
mouse |
| Ethan M Anderson, Marcelo F Lopez, Abigail Kastner, Patrick J Mulholland, Howard C Becker, Christopher W Cowa. The histone methyltransferase G9a mediates stress-regulated alcohol drinking. Addiction biology. 2021-11-21. PMID:34013595. |
we show here that chronic intermittent ethanol (cie) exposure in male mice reduced both g9a and h3k9me2 levels in the adult nac, but not dorsal striatum. |
2021-11-21 |
2023-08-13 |
mouse |
| Benoit Forget, Elena Martin Garcia, Arthur Godino, Laura Domingo Rodriguez, Vincent Kappes, Pierre Poirier, Andry Andrianarivelo, Eric Senabre Marchan, Marie-Charlotte Allichon, Mélanie Marias, Peter Vanhoutte, Jean-Antoine Girault, Rafael Maldonado, Jocelyne Caboch. Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons. Molecular psychiatry. 2021-11-17. PMID:34785784. |
here, we evaluated the expression of a subset of mirnas proposed to modulate cocaine effects in the nucleus accumbens (nac) and dorsal striatum (ds) upon sustained cocaine exposure in mice and showed that these selected mirnas were preferentially upregulated in the nac. |
2021-11-17 |
2023-08-13 |
mouse |
| Dinesh Y Gawande, Gajanan P Shelkar, Jinxu Liu, Anna D Ayala, Ratnamala Pavuluri, Diane Choi, Yoland Smith, Shashank M Dravi. Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors. Molecular neurobiology. vol 58. issue 10. 2021-10-27. PMID:34173171. |
loss of glud1 leads to reduced excitatory neurotransmission in medium spiny neurons (msns) in the dorsal striatum, but not in the ventral striatum (both core and shell of the nucleus accumbens (nac)). |
2021-10-27 |
2023-08-13 |
Not clear |
| Dinesh Y Gawande, Gajanan P Shelkar, Jinxu Liu, Anna D Ayala, Ratnamala Pavuluri, Diane Choi, Yoland Smith, Shashank M Dravi. Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors. Molecular neurobiology. vol 58. issue 10. 2021-10-27. PMID:34173171. |
when glud1 was ablated from the dorsal striatum, several behavioral phenotypes were altered in opposite manner compared to glud1 ablation from nac. |
2021-10-27 |
2023-08-13 |
Not clear |
| Barbara Ziółkowsk. The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain. Brain sciences. vol 11. issue 10. 2021-10-26. PMID:34679376. |
the first part of the present article reviews the evidence indicating that dopamine exerts analgesic effects during persistent pain by stimulating the d2 receptors in the dorsal striatum and nucleus accumbens (nac). |
2021-10-26 |
2023-08-13 |
Not clear |
| Elaheh Soleimanpour, Jorge R Bergado Acosta, Peter Landgraf, Dana Mayer, Evelyn Dankert, Daniela C Dieterich, Markus Fend. Regulation of CREB Phosphorylation in Nucleus Accumbens after Relief Conditioning. Cells. vol 10. issue 2. 2021-10-12. PMID:33530478. |
forty-five minutes or 6 h after conditioning, samples of five different brain regions, namely the prefrontal cortex, nucleus accumbens (nac), dorsal striatum, dorsal hippocampus, and amygdala, were collected. |
2021-10-12 |
2023-08-13 |
rat |
| Qing Shang, Jing Xiao, Baoyao Gao, Min Liang, Jing Wang, Hongyan Qian, Zhijia Xi, Tao Li, Xinshe Li. D1R/PP2A/p-CaMKIIα signaling in the caudate putamen is involved in acute methamphetamine-induced hyperlocomotion. Neuroscience letters. vol 760. 2021-08-17. PMID:34237414. |
the protein levels of methylated pp2a-c (m-pp2a-c, leucine [leu] 309), phosphorylated pp2a-c (p-pp2a-c, tyrosine [tyr] 307), pp2a-c, p-camkiiα (thr 286), and camkiiα in the prefrontal cortex (pfc), nucleus accumbens (nac), and caudate putamen (cpu) were measured. |
2021-08-17 |
2023-08-13 |
mouse |
| Caroline E Strong, Mohamed Kabba. Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder. Frontiers in behavioral neuroscience. vol 14. 2021-07-08. PMID:33362485. |
to do this, the focus will be on reward-related brain regions such as the nucleus accumbens (nac), dorsal striatum, prefrontal cortex (pfc), hippocampus, and ventral tegmental area (vta) to understand how acute vs. chronic exposure will alter reward signaling over time. |
2021-07-08 |
2023-08-13 |
human |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nic females showed hyperphagia, preference for a high-sucrose diet, increased anxiety-like behavior, lower tyrosine hydroxylase (th), lower dopamine transporter and higher dopamine receptor (drd2) in nac; lower drd1 in prefrontal cortex and lower th in dorsal striatum (ds). |
2021-06-24 |
2023-08-13 |
rat |
| Jerome A J Becker, Lucie P Pellissier, Yannick Corde, Thibaut Laboute, Audrey Léauté, Jorge Gandía, Julie Le Merre. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 7. 2021-06-23. PMID:33349673. |
among these markers, grm4, encoding mglur4, displayed down-regulated expression in the caudate putamen and nac of morphine, but not cocaine, abstinent mice. |
2021-06-23 |
2023-08-13 |
mouse |
| Kaili Du, Zhuoyi Wang, Huimin Zhang, Yaofang Zhang, Hongliang Su, Zhiwen Wei, Chao Zhang, Keming Yun, Bin Con. Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice. Neuroscience letters. vol 756. 2021-06-22. PMID:34029649. |
western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (erk) and camp response element binding protein (creb) in related brain regions, including the hippocampus (hip), caudate putamen (cpu), prefrontal cortex (pfc), and nucleus accumbens (nac), which may mediate the effects of l-thp on fentanyl-induced cpp. |
2021-06-22 |
2023-08-13 |
mouse |