All Relations between dorsal striatum and medial prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Jayapriya Chandrasekaran, Kevin K Caldwell, Jonathan L Brigma. Dynamic regulation of corticostriatal glutamatergic synaptic expression during reversal learning in male mice. Neurobiology of learning and memory. 2024-01-19. PMID:38242226. following training to well-established stages of discrimination and reversal learning on a touchscreen visual task, lateral orbitofrontal cortex (ofc), dorsal striatum (ds) as well as medial prefrontal cortex (mpfc), basolateral amygdala (bla) and piriform cortex (pir) were micro dissected from male mouse brain and the expression of glutamatergic receptor subunits in the synaptic fraction were measured via immunoblotting. 2024-01-19 2024-01-22 mouse
Cameron J Davidson, John H Hannigan, Shane A Perrine, Scott E Bowe. Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice. Neurotoxicology and teratology. 2024-01-10. PMID:38199311. analysis of monoamines and their metabolites using high pressure liquid chromatography (hplc) within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum (dstr), and ventral tegmental area (vta) revealed subtle effects on monoamine or metabolite levels following cumulative dosing that varied by drug (cocaine and ethanol) and abstinence duration. 2024-01-10 2024-01-13 mouse
Rachel Aruldas, Laura Buczek Orenstein, Sade Spence. Metformin Prevents Cocaine Sensitization: Involvement of Adenosine Monophosphate-Activated Protein Kinase Trafficking between Subcellular Compartments in the Corticostriatal Reward Circuit. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069180. here, our objective was to quantify changes in phosphorylated (active) and total ampk in the cytosol and synaptosome of the medial prefrontal cortex, nucleus accumbens, and dorsal striatum following acute or sensitizing cocaine injections. 2023-12-09 2023-12-17 rat
E Schreuders, M van Buuren, R J Walsh, H Sijtsma, M Hollarek, N C Lee, L Krabbenda. Learning whom not to trust across early and middle adolescence: A longitudinal neuroimaging study to trusting behavior involving an uncooperative other. Child development. 2023-08-16. PMID:37583272. neural regions of interest (rois) included the medial prefrontal cortex (mpfc), dorsal anterior cingulate cortex (dacc), left anterior insula (ai), bilateral ventral striatum (vs), and right dorsal striatum (ds). 2023-08-16 2023-09-07 human
Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-Xiang Liu, Cheng Lon. Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice. Stress (Amsterdam, Netherlands). vol 26. issue 1. 2023-07-03. PMID:37395260. here we report that cyld deficiency leads to an unexpected reaction to ars in mice, and is accompanied by significant neuronal activation of brain regions including the medial prefrontal cortex (mpfc), dorsal striatum (ds), nucleus accumbens (nac), and basal lateral amygdala (bla), but not ventral hippocampus (vhpc). 2023-07-03 2023-08-14 mouse
Diogo Rodrigues, Clara Monteiro, Helder Cardoso-Cruz, Vasco Galhard. Altered Brain Expression of DNA Methylation and Hydroxymethylation Epigenetic Enzymes in a Rat Model of Neuropathic Pain. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108466. in a spared nerve injury rat model of neuropathic pain, 21 days after surgery, we found increased tet1 expression in the medial prefrontal cortex and decreased expression in the caudate-putamen and the amygdala; tet2 was upregulated in the medial thalamus; tet3 mrna levels were reduced in the medial prefrontal cortex and the caudate-putamen; and dnmt1 was downregulated in the caudate-putamen and the medial thalamus. 2023-04-28 2023-08-14 rat
Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. the present study demonstrated for the first time that acute as well as subchronic (4 days) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3 mg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the β-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). 2023-03-04 2023-08-14 rat
Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), α-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). 2022-11-07 2023-08-14 rat
Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaned. A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice. Behavioural brain research. 2022-07-01. PMID:35777550. immunohistochemical analyses revealed that the number of c-fos (a neuronal activity marker)-positive cells increased in the medial prefrontal cortex (mpfc), core and shell of the nucleus accumbens (nac), dorsal striatum (str), and lateral septum (ls) at day 1, day 9, and days 20-24, in a time-dependent manner. 2022-07-01 2023-08-14 mouse
Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huan. Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683439. the c-fos expression analysis showed that the medial prefrontal cortex (i.e., cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), nucleus accumbens (nac), basolateral amygdala (bla), ventral tegmental area (vta), caudate-putamen (cpu), and hippocampus (i.e., ca1, ca3, and dentate gyrus (dg)) contributed to mamph-induced behavioral sensitization. 2022-06-10 2023-08-14 mouse
Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Sumiyoshi Kiguch. Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside-induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission. Clinical and experimental pharmacology & physiology. 2022-05-31. PMID:35637550. moreover, rovatirelin significantly increased acetylcholine (ach) levels in the medial prefrontal cortex (mpfc) and dopamine (da) levels in the nucleus accumbens (nac) at ≥3 mg/kg and significantly increased da levels in the dorsal striatum at ≥10 mg/kg in normal rats. 2022-05-31 2023-08-13 mouse
Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. here, we investigated changes in the total neuronal density and relative concentration of d2r-expressing neurons in the medial prefrontal cortex (mpfc), dorsal striatum (dstr), nucleus accumbens (nac), and ventral tegmental area (vta) in both male and female mice passively exposed to cocaine for two weeks. 2021-12-12 2023-08-13 mouse
Maria Vrettou, Liying Yan, Kent W Nilsson, Åsa Wallén-Mackenzie, Ingrid Nylander, Erika Comasc. DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34321562. the present study aimed to investigate whether dna methylation of the vesicular glutamate transporters (vglut)1-3 is related to previously observed vglut1-3 transcriptional differences in the ventral tegmental area (vta), nucleus accumbens (acb), dorsal striatum (dstr) and medial prefrontal cortex (mpfc) of adult rats exposed to els, modelled by maternal separation, and voluntary ethanol consumption. 2021-11-08 2023-08-13 rat
Anna Solarz, Iwona Majcher-Maślanka, Agnieszka Chocy. Effects of early-life stress and sex on blood-brain barrier permeability and integrity in juvenile and adult rats. Developmental neurobiology. vol 81. issue 7. 2021-10-15. PMID:34320279. we used the maternal separation (ms) procedure in rats to model els and evaluated bbb permeability and gene expression of selected tight junction (tj) proteins, glucose transporter type 1 (slc2a1) and aquaporin 4 (aqp4) in the medial prefrontal cortex (mpfc), dorsal striatum (dstr) and hippocampus of juvenile and adult rats. 2021-10-15 2023-08-13 rat
Adrienne N Santiago, Emily A Makowicz, Muzi Du, Chiye Aok. Food Restriction Engages Prefrontal Corticostriatal Cells and Local Microcircuitry to Drive the Decision to Run versus Conserve Energy. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 6. 2021-10-11. PMID:33497440. here, we demonstrate that chemogenetic activation of either the general medial prefrontal cortex (mpfc) pyramidal cell population, or the subpopulation projecting to dorsal striatum (ds) drives running specifically during hours preceding limited food availability, and not during ad libitum food availability. 2021-10-11 2023-08-13 human
Christina Strauch, Thu-Huong Hoang, Frank Angenstein, Denise Manahan-Vaugha. Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination. Cerebral cortex (New York, N.Y. : 1991). 2021-08-11. PMID:34379749. we detected bold signal increases in the anterior olfactory nucleus (aon), pc and entorhinal cortex, nucleus accumbens, dorsal striatum, ventral diagonal band of broca, prelimbic-infralimbic cortex (prl-il), dorsal medial prefrontal cortex, and basolateral amygdala. 2021-08-11 2023-08-13 Not clear
Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. here, we report that extracellular steady-state levels of da are reduced in the medial prefrontal cortex (mpfc; -65%), hippocampus (-53%) and nucleus accumbens (nac; -35%), but are elevated in the dorsal striatum (+25%) of erbb4 knock-out mice (erbb4 kos) relative to wild-type controls. 2021-06-18 2023-08-13 mouse
Jakub Kraus, Robert Roman, Lenka Jurkovičová, Radek Mareček, Michal Mikl, Milan Brázdil, Andreas Fric. Social support modulates subjective and neural responses to sad mental imagery. Behavioural brain research. vol 380. 2021-05-03. PMID:31843658. we found that mental imagery of a recently deceased loved one was associated with increased reactivity in the dorsal striatum, medial prefrontal cortex, anterior and posterior cingulate cortex, thalamus and cerebellum. 2021-05-03 2023-08-13 Not clear
Camilla d'Angelo, Dawn M Eagle, Cristina-M Coman, Trevor W Robbin. Role of the medial prefrontal cortex and nucleus accumbens in an operant model of checking behaviour and uncertainty. Brain and neuroscience advances. vol 1. 2021-03-04. PMID:29900415. the present study used the observing response task to investigate checking behaviour following excitotoxic lesions of the medial prefrontal cortex, nucleus accumbens core and dorsal striatum, brain regions considered to be of relevance to obsessive-compulsive disorder. 2021-03-04 2023-08-13 rat
A Sánchez-González, I Oliveras, C Río-Álamos, M A Piludu, C Gerbolés, C Tapias-Espinosa, A Tobeña, S Aznar, A Fernández-Terue. Dissociation between schizophrenia-relevant behavioral profiles and volumetric brain measures after long-lasting social isolation in Roman rats. Neuroscience research. vol 155. 2021-02-23. PMID:31306676. the aim here was to further investigate the neuroanatomical effects of the isolation rearing, estimated through volume differences in medial prefrontal cortex (mpfc), dorsal striatum (dst) and hippocampus (hpc). 2021-02-23 2023-08-13 rat