| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oliver D Howes, Bernard R Bukala, Katherine Bec. Schizophrenia: from neurochemistry to circuits, symptoms and treatments. Nature reviews. Neurology. 2023-12-19. PMID:38110704. |
this evidence demonstrates regionally specific neurotransmitter alterations, including higher glutamate and dopamine measures in the basal ganglia, and lower glutamate, dopamine and γ-aminobutyric acid (gaba) levels in cortical regions, particularly the frontal cortex, relative to healthy individuals. |
2023-12-19 |
2023-12-21 |
Not clear |
| Robertas Guzulaitis, Lucy M Palme. A thalamocortical pathway controlling impulsive behavior. Trends in neurosciences. 2023-10-01. PMID:37778915. |
historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal ganglia. |
2023-10-01 |
2023-10-07 |
mouse |
| Shino Magaki, Zesheng Chen, Alyscia Severance, Christopher K Williams, Ramiro Diaz, Chuo Fang, Negar Khanlou, William H Yong, Annlia Paganini-Hill, Rajesh N Kalaria, Harry V Vinters, Mark Fishe. Neuropathology of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Journal of neuropathology and experimental neurology. 2023-01-30. PMID:36715085. |
in this study, we characterized findings relevant to cmbs in autopsy brain tissue of 8 patients with genetically confirmed cadasil and 10 controls within the age range of the cadasil patients by assessing the distribution and extent of hemosiderin/iron deposits including perivascular hemosiderin leakage (pvh), capillary hemosiderin deposits, and parenchymal iron deposits (pid) in the frontal cortex and white matter, basal ganglia and cerebellum. |
2023-01-30 |
2023-08-14 |
human |
| Elliot J Teo, Kirat K Chand, Stephanie M Miller, Julie A Wixey, Paul B Colditz, S Tracey Bjorkma. Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain. Scientific reports. vol 13. issue 1. 2023-01-07. PMID:36609414. |
brain tissue from the frontal cortex and basal ganglia was harvested for assessment of glial cell activation profiles and transcription levels of inflammatory markers in hi piglets with comparison to a control group of newborn piglets. |
2023-01-07 |
2023-08-14 |
Not clear |
| Irene Sintini, Kenton Kaufman, Hugo Botha, Peter R Martin, Stacy R Loushin, Matthew L Senjem, Robert I Reid, Christopher G Schwarz, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwell, Farwa Al. Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34655905. |
progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex. |
2021-11-17 |
2023-08-13 |
Not clear |
| George F Koo. Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development. Pharmacological reviews. vol 73. issue 1. 2021-10-28. PMID:33318153. |
compulsive drug seeking that is associated with addiction is hypothesized to follow a heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation) and three domains of dysfunction (incentive salience/pathologic habits, negative emotional states, and executive function, respectively) via changes in the basal ganglia, extended amygdala/habenula, and frontal cortex, respectively. |
2021-10-28 |
2023-08-13 |
Not clear |
| Ariana Z Turk, Mahsa Lotfi Marchoubeh, Ingrid Fritsch, Gerald A Maguire, Shahriar SheikhBahae. Dopamine, vocalization, and astrocytes. Brain and language. vol 219. 2021-10-25. PMID:34098250. |
dopamine, the main catecholamine neurotransmitter in the brain, is predominately produced in the basal ganglia and released to various brain regions including the frontal cortex, midbrain and brainstem. |
2021-10-25 |
2023-08-13 |
Not clear |
| Laura Biagi, Sara Lenzi, Emilio Cipriano, Simona Fiori, Paolo Bosco, Paola Cristofani, Guia Astrea, Antonella Pini, Giovanni Cioni, Eugenio Mercuri, Michela Tosetti, Roberta Battin. Neural substrates of neuropsychological profiles in dystrophynopathies: A pilot study of diffusion tractography imaging. PloS one. vol 16. issue 5. 2021-10-07. PMID:33939732. |
the current study aims to: 1) analyze the neuropsychological profile of a group of dmd and bmd boys without cognitive impairment with an assessment of their executive functions; 2) explore the structural connectivity in dmd, bmd, and age-matched controls focusing on cortico-subcortical tracts that connect frontal cortex, basal ganglia, and cerebellum via the thalamus; 3) explore possible correlations between altered structural connectivity and clinical neuropsychological measures. |
2021-10-07 |
2023-08-13 |
Not clear |
| Xueqiu Jian, Tamar Sofer, Wassim Tarraf, Jan Bressler, Jessica D Faul, Wei Zhao, Scott M Ratliff, Melissa Lamar, Lenore J Launer, Cathy C Laurie, Neil Schneiderman, David R Weir, Clinton B Wright, Kristine Yaffe, Donglin Zeng, Charles DeCarli, Thomas H Mosley, Jennifer A Smith, Hector M González, Myriam Fornag. Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32699239. |
by applying tissue-specific gene expression prediction models to our genotype data, additional genes highly expressed in brain showed suggestive associations with cognitive measures possibly indicating novel biological mechanisms, including ift122 in the hippocampus for sis, snx31 in the basal ganglia for b-sevlt, rps6kb2 in the frontal cortex for wft, and cspg5 in the hypothalamus for dsst. |
2021-06-18 |
2023-08-13 |
Not clear |
| Farhan Augustine, Shreenath Rajendran, Harvey S Singe. Cortical endogenous opioids and their role in facilitating repetitive behaviors in deer mice. Behavioural brain research. vol 379. 2021-04-30. PMID:31676208. |
in this study, we pursue the mechanism of repetitive behaviors by performing stereological analyses and liquid chromatography/ mass spectrometry (lc-ms/ms) measurements of glutamate (glut), gaba, 3,4-dihydroxyphenylacetic acid (dopac), dopamine (da), leu-enkephalin (leu-enk), and dynorphin-a (dyn-a) in frontal cortex (fc), prefrontal cortex (pfc), and basal ganglia. |
2021-04-30 |
2023-08-13 |
mouse |
| Yasin Hasan Balcioglu, Mehmet Dogan, Ipek Incı, Mustafa Solma. Sexual Behavioral Disinhibition Associated with Nucleus Lentiformis Lesion: A Forensic Neuroscience Perspective Through a Case. Journal of forensic sciences. vol 65. issue 5. 2021-03-29. PMID:32525581. |
organic brain disturbances particularly related to frontal cortex structures and subcortical areas including the basal ganglia may play a role in behavioral disinhibition disorders. |
2021-03-29 |
2023-08-13 |
Not clear |
| Marco Pozzi, Silvana Bertella, Erika Gatti, Gabriëlla G A M Peeters, Carla Carnovale, Stefania Zambrano, Maria Nobil. Emerging drugs for the treatment of attention-deficit hyperactivity disorder (ADHD). Expert opinion on emerging drugs. vol 25. issue 4. 2021-03-16. PMID:32938246. |
current pharmacological treatments for adhd are based on stimulant or non-stimulant medications, targeting dopaminergic and noradrenergic systems in the frontal cortex and dopaminergic system in the basal ganglia. |
2021-03-16 |
2023-08-13 |
Not clear |
| Bon-Mi Gu, Robert Schmidt, Joshua D Berk. Globus pallidus dynamics reveal covert strategies for behavioral inhibition. eLife. vol 9. 2021-03-15. PMID:32519952. |
this behavioral inhibition critically relies on frontal cortex - basal ganglia circuits. |
2021-03-15 |
2023-08-13 |
rat |
| George F Koob, Ian M Colrai. Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 1. 2020-12-16. PMID:31234199. |
these three heuristic stages map onto the dysregulation of functional domains of incentive salience/habits, negative emotional states, and executive function, mediated by the basal ganglia, extended amygdala, and frontal cortex, respectively. |
2020-12-16 |
2023-08-13 |
Not clear |
| Maria Rogdaki, Pamela Hathway, Maria Gudbrandsen, Robert A McCutcheon, Sameer Jauhar, Eileen Daly, Oliver Howe. Glutamatergic function in a genetic high-risk group for psychosis: A proton magnetic resonance spectroscopy study in individuals with 22q11.2 deletion. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 12. 2020-09-08. PMID:31648854. |
meta-analysis of magnetic resonance spectroscopy studies in schizophrenia shows increased levels of glutamate and glutamine (glx) in the medial frontal cortex and basal ganglia in clinical high-risk groups for psychosis and increased glutamine levels in the thalamus, but it is unclear if this is also the case in people at genetic high risk for psychosis. |
2020-09-08 |
2023-08-13 |
human |
| Fulong Xiao, Chao Lu, Dianjiang Zhao, Qihong Zou, Liyue Xu, Jing Li, Jun Zhang, Fang Ha. Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy. Neuroscience bulletin. vol 35. issue 4. 2020-02-18. PMID:30421271. |
the altered brain areas in nodal topological properties between groups were mainly in the inferior frontal cortex, basal ganglia, anterior cingulate, sensory cortex, supplementary motor cortex, and visual cortex. |
2020-02-18 |
2023-08-13 |
Not clear |
| Mohammad Sharaf. Comparison of Classical and Clozapine Treatment on Schizophrenia Using Positive and Negative Syndrome Scale of Schizophrenia (PANSS) and SPECT Imaging. International journal of medical sciences. vol 2. issue 2. 2019-11-20. PMID:15968344. |
many neuroimaging studies of schizophrenia have shown abnormalities in the frontal cortex, limbic system, basal ganglia, temporal and parietal lobes. |
2019-11-20 |
2023-08-12 |
Not clear |
| Zade R Holloway, Timothy G Freels, Josiah F Comstock, Hunter G Nolen, Helen J Sable, Deranda B Leste. Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex. Synapse (New York, N.Y.). 2019-11-20. PMID:30317673. |
midbrain dopaminergic neurons project to and modulate multiple highly interconnected modules of the basal ganglia, limbic system, and frontal cortex. |
2019-11-20 |
2023-08-13 |
mouse |
| Davide Nardo, Rachel Holland, Alexander P Leff, Cathy J Price, Jennifer T Crinio. Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients. Brain : a journal of neurology. vol 140. issue 11. 2019-05-23. PMID:29053773. |
processing of whole word cues was associated with increased activity in the right angular gyrus; whereas partial word cues (initial and final phonemes) recruited the left supplementary motor area, and right anterior insula, inferior frontal cortex, and basal ganglia. |
2019-05-23 |
2023-08-13 |
Not clear |
| Selwyn A Headley, Luciano A Pimentel, Mariana Z Michelazzo, Hugo S Toma, Lucienne G Pretto-Giordano, Rogério A Marcasso, Alexandre M Amude, Thalita E Oliveira, Marcelo D Santos, Mark Krockenberge. Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 31. issue 1. 2019-04-11. PMID:30541419. |
grossly, there was a large space-occupying gelatinous mass (cryptococcoma) in the left lung and smaller masses in the cerebral temporal and frontal cortex, thalamus, hippocampus, basal nuclei, and mesencephalon with consequent internal hydrocephalus. |
2019-04-11 |
2023-08-13 |
Not clear |