| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meilun Shen, Mengjuan Shang, Ruofei Tian, Yang Hu, Qian Han, Junfeng Hu, Guangzhou An, Bingxia Wang, Zhi Cao, Xiaoyu Lin, Hao Yang, Junling Xin. Single Cell Molecular Alterations Reveal Target Cells and Pathways of Conditioned Fear Memory. Brain research vol issue 2023 36870465 |
recent evidence indicates that hippocampus is important for conditioned fear memory (cfm). |
2023-03-04 |
2023-03-06 |
Not clear |
| Thays Brenner Santos, Juliana Carlota Kramer-Soares, Maria Gabriela Menezes Oliveir. Contextual fear conditioning with a time interval induces CREB phosphorylation in the dorsal hippocampus and amygdala nuclei that depend on prelimbic cortex activity. Hippocampus vol issue 2023 36847108 |
for this, we observed in wistar rats the effect of pre-training pl inactivation by muscimol in creb (camp response element-binding protein) phosphorylation, which is essential for memory consolidation, in subdivisions of the medial prefrontal cortex (mpfc), hippocampus, and amygdala 3\xc2\xa0h after the training in the contextual fear conditioning (cfc) or cfc with 5-s interval (cfc-5s), fear associations without or with an interval between the cs and us, respectively. |
2023-02-27 |
2023-03-06 |
rat |
| Yu Qu, Nan Zhou, Xia Zhang, Yan Li, Xu-Feng X. Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice. Neuroscience bulletin vol issue 2023 36807260 |
using proteomics analysis, we found protein expression changes in the hippocampal dentate gyrus (dg) after the knockdown of smarca5 during contextual fear conditioning (cfc) memory maintenance in mice. |
2023-02-22 |
2023-03-06 |
mouse |
| Subhajit Jana, Monica Dines, Maya Lalzar, Raphael Lamprech. Fear Conditioning Leads to Enduring Alterations in RNA Transcripts in Hippocampal Neuropil that are Dependent on EphB2 Forward Signaling. Molecular neurobiology vol issue 2023 36637747 |
fear conditioning leads to enduring alterations in rna transcripts in hippocampal neuropil that are dependent on ephb2 forward signaling. |
2023-01-13 |
2023-01-30 |
Not clear |
| Subhajit Jana, Monica Dines, Maya Lalzar, Raphael Lamprech. Fear Conditioning Leads to Enduring Alterations in RNA Transcripts in Hippocampal Neuropil that are Dependent on EphB2 Forward Signaling. Molecular neurobiology vol issue 2023 36637747 |
we wanted to examine if fear conditioning causes long-term changes in transcriptome profiles in the basolateral amygdala (bla) and hippocampus using rna-seq and laser microdissection microscopy. |
2023-01-13 |
2023-01-30 |
Not clear |
| Pedro Correia, Korn\\xc3\\xa9l Demeter, J\\xc3\\xa1nos Varga, Eszter Urb\\xc3\\xa1n, Bibi\\xc3\\xa1na T\\xc3\\xb6r\\xc3\\xb6k, Di\\xc3\\xa1na Bal\\xc3\\xa1zsfi, Nikolett Bakos, J\\xc3\\xb3zsef Haller, D\\xc3\\xb3ra Zelen. The effectiveness of extinction training in male rats: temporal considerations and brain mechanisms. Behavioural brain research vol issue 2023 36610549 |
by contrast, the activation of the basolateral amygdala and the entire hippocampus decreased by the last training session when extinction started 28 days after fear conditioning. |
2023-01-07 |
2023-01-30 |
rat |
| Carolina Montanez-Miranda, Sara N Bramlett, John R Heple. RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease. Hippocampus vol issue 2022 36541898 |
in this review, we discuss the signaling functions of rgs14 and its role in postsynaptic strength (long-term potentiation) and spine structural plasticity in ca2 hippocampal neurons, and how rgs14 suppression of plasticity impacts linked behaviors such as spatial learning, object memory, and fear conditioning. |
2022-12-21 |
2023-01-30 |
human |
| Muhammad Zahid Khan, Yong-Bo Zheng, Kai Yuan, Ying Han, Lin L. Extracellular zinc regulates contextual fear memory formation in male rats through MMP-BDNF-TrkB pathway in dorsal hippocampus and basolateral amygdala. Behavioural brain research vol issue 2022 36442645 |
male sprague dawley rats were trained for fear conditioning followed by in vivo microdialysis for collection of microdialysate samples from ca1 and ca3 regions of hippocampus and basolateral amygdala (bla). |
2022-11-28 |
2023-01-30 |
rat |
| Chelsey C Damphousse, Noam Miller, Diano F Marron. Functional dissociation along the rostrocaudal axis of Japanese quail hippocampus. PloS one vol 17 issue 11 2022 36374865 |
using japanese quail (coturnix japonica), we report that bilateral lesions of the rostral hippocampus (rhp) produce robust deficits in a spatial y-maze discrimination (ymd) test while sparing performance during contextual fear conditioning (cfc), comparable to results from lesions to homologous regions in mammals. |
2022-11-14 |
2023-01-30 |
Not clear |
| Elizabeth P Baue. Sex differences in fear responses: Neural circuits. Neuropharmacology vol issue 2022 36328063 |
however, there is greater evidence of differential activation of the hippocampus, amygdalar nuclei and the prefrontal cortical regions in male and female rodents during context and cued fear conditioning. |
2022-11-03 |
2023-01-30 |
Not clear |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-\\xce\\xbaB Pathway. Neurotoxicity research vol issue 2022 36308704 |
besides, the morris water maze (mwm) and fear conditioning test were used to evaluate the learning and memory ability of rats; western blot to detect the expression levels of neurotrophic factors (brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf)) as well as nf-\xce\xbab pathway-related proteins (p65 and p-p65) in rat hippocampal tissues or pc-12 cells; qrt-pcr to assess the expression levels of mir-182-5p and bdnf in rat plasma, plasma exosomes, hippocampal tissues, and pc-12 cells; elisa to evaluate the levels of tumor necrosis factor (tnf)-\xce\xb1, interleukin (il)-6, and il-1\xce\xb2 in rat hippocampal tissues; and dual-luciferase reporter assay to verify the targeting relationship between mir-182-5p and bdnf. |
2022-10-29 |
2023-01-30 |
rat |
| Wataru Ito, Alexander J Palmer, Alexei Morozo. Social Synchronization of Conditioned Fear in Mice Requires Ventral Hippocampus Input to the Amygdala. Biological psychiatry vol issue 2022 36244803 |
social synchronization of conditioned fear in mice requires ventral hippocampus input to the amygdala. |
2022-10-16 |
2023-01-30 |
mouse |
| Yufang Yang, Xiaoshuang Zhang, Dongxue Li, Rong Fang, Zishan Wang, Di Yun, Mo Wang, Jinghui Wang, Hongtian Dong, Zhaoliang Fei, Qing Li, Zhaolin Liu, Chenye Shen, Jian Fei, Mei Yu, Thomas Behnisch, Fang Huan. NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters ad-like pathology. Human molecular genetics vol issue 2022 36229920 |
here we show that conditional nrsf/rest knockout either in the dorsal telencephalon or specially in neurons induced an age-dependently diminished retrieval performance in spatial or fear conditioning memory tasks and altered hippocampal synaptic transmission and activity-dependent synaptic plasticity. |
2022-10-14 |
2023-01-30 |
mouse |
| Ilse Delint-Ramirez, Lahiri Konada, Lance Heady, Richard Rueda, Alvaro Sebastian Vaca Jacome, Eric Marlin, Charlotte Marchioni, Amir Segev, Oleg Kritskiy, Satoko Yamakawa, Andrew H Reiter, Li-Huei Tsai, Ram Madabhush. Calcineurin dephosphorylates topoisomerase II\\xce\\xb2 and regulates the formation of neuronal-activity-induced DNA breaks. Molecular cell vol issue 2022 36206766 |
exposing mice to a fear conditioning paradigm also triggers top2b dephosphorylation at s1509 and s1511 in the hippocampus, indicating that calcineurin also regulates top2b-mediated dsb formation following physiological neuronal activity. |
2022-10-07 |
2023-01-30 |
mouse |
| Holly DeRosa, Salvatore G Caradonna, Hieu Tran, Jordan Marrocco, Amanda C Kentne. Got milk? Maternal immune activation during the mid-lactational period affects nutritional milk quality and adolescent offspring sensory processing in male and female rats. Molecular psychiatry vol issue 2022 36056174 |
however, this did not protect against disrupted neonatal huddling or later-life alterations in sensorimotor gating, conditioned fear, mechanical allodynia, or reductions in hippocampal parvalbumin expression in mia offspring. |
2022-09-02 |
2023-01-30 |
rat |
| Yosif Zaki, William Mau, Christine Cincotta, Amy Monasterio, Emma Odom, Emily Doucette, Stephanie L Grella, Emily Merfeld, Monika Shpokayte, Steve Ramire. Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol issue 2022 35941286 |
here, we demonstrate that, in male mice, cells active during fear conditioning in the dentate gyrus of hippocampus exhibit decreased activity during extinction and are re-engaged after contextual fear relapse. |
2022-08-08 |
2023-01-30 |
mouse |
| Yosif Zaki, William Mau, Christine Cincotta, Amy Monasterio, Emma Odom, Emily Doucette, Stephanie L Grella, Emily Merfeld, Monika Shpokayte, Steve Ramire. Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol issue 2022 35941286 |
finally, we find that optogenetic inactivation of neuronal ensembles active during fear conditioning in either the hippocampus or amygdala is sufficient to disrupt fear expression after relapse, while optogenetic stimulation of these same ensembles after extinction is insufficient to artificially mimic fear relapse. |
2022-08-08 |
2023-01-30 |
mouse |
| Desi C Alexander, Tanya Corman, Mariel Mendoza, Andrew Glass, Tal Belity, Ranran Wu, Rianne R Campbell, Joseph Han, Ashley A Keiser, Jeffrey Winkler, Marcelo A Wood, Thomas Kim, Benjamin A Garcia, Hagit Cohen, Philipp Mews, Gabor Egervari, Shelley L Berge. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation. Proceedings of the National Academy of Sciences of the United States of America vol 119 issue 32 2022 35921439 |
loss of acss2 leads to reductions in both histone acetylation and expression of critical learning and memory-related genes in the dorsal hippocampus, specifically following fear conditioning. |
2022-08-03 |
2023-01-30 |
rat |
| Emma N Fikse, Jianhua Zhang, Mritunjay Pandey, Glenda Smerin, Adam Awe, Nicole Lue, Claire Kittock, Weiping Chen, Yanqin Yang, Poorni Adikaram, Nirmal Jacob, Emily Greenfest-Allen, Rachel Thomas, Laura Bomeny, Xiaowen Wang, Yulong Li, William F Simond. Association of Mouse Vulnerability to Alzheimer's Disease Pathology with Mutations of Gnb5: A Modulator of G-protein Coupled Receptor Signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35560642 |
for this project, we demonstrated through fear conditioning behavioral tasks involving hippocampus and amygdala function that learning and memory deficits existed in mice heterozygous for gnb5. |
2022-05-13 |
2023-01-27 |
mouse |
| Andie Dodge, Nicole Morrill, Edwin J Weeber, Kevin R Nas. Recovery of Angelman syndrome rat deficits with UBE3A protein supplementation. Molecular and cellular neurosciences vol issue 2022 35367589 |
furthermore, injection of recombinant ube3a protein into the hippocampus of the as rat can rescue the associative learning and memory deficits seen in the fear conditioning task. |
2022-04-03 |
2023-01-27 |
rat |