| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Zhehan Chang, Qi Liu, Peijia Fan, Wenqiang Xu, Yabin Xie, Kerui Gong, Chunyang Zhang, Zhijun Zhao, Kai Sun, Guo Sha. Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo. Molecular biology reports. vol 51. issue 1. 2024-04-15. PMID:38622406. |
adult hippocampal neurogenesis has been associated with learning and memory. |
2024-04-15 |
2024-04-18 |
mouse |
| Zhehan Chang, Qi Liu, Peijia Fan, Wenqiang Xu, Yabin Xie, Kerui Gong, Chunyang Zhang, Zhijun Zhao, Kai Sun, Guo Sha. Hypoxia preconditioning increases Notch1 activity by regulating DNA methylation in vitro and in vivo. Molecular biology reports. vol 51. issue 1. 2024-04-15. PMID:38622406. |
the neurogenic locus notch homolog protein (notch) was involved in adult hippocampal neurogenesis, as well as in learning and memory. |
2024-04-15 |
2024-04-18 |
mouse |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |
| Jacob H Wilmot, Cassiano R A F Diniz, Ana P Crestani, Kyle R Puhger, Jacob Roshgadol, Lin Tian, Brian Joseph Wiltge. Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus. eLife. vol 12. 2024-04-09. PMID:38592773. |
locus coeruleus (lc) projections to the hippocampus play a critical role in learning and memory. |
2024-04-09 |
2024-04-11 |
mouse |
| Yongun Park, Yunn Me Me Paing, Namki Cho, Changyoun Kim, Jiho Yoo, Ji Woong Choi, Sung Hoon Le. Quinic Acid Alleviates Behavior Impairment by Reducing Neuroinflammation and MAPK Activation in LPS-Treated Mice. Biomolecules & therapeutics. 2024-04-08. PMID:38589292. |
in particular, the hippocampus is the central region for learning and memory and is highly susceptible to oxidative stress. |
2024-04-08 |
2024-04-11 |
mouse |
| Chu-Yun Teng, Ning-Jo Kao, Thi Kim Ngan Nguyen, Ching-I Lin, Tzu-Wen L Cross, Shyh-Hsiang Li. Effects of xylo-oligosaccharide on gut microbiota, brain protein expression, and lipid profile induced by high-fat diet. The Journal of nutritional biochemistry. 2024-04-07. PMID:38583497. |
additionally, xos elevated spatial learning and memory function, decreased amyloid plaques accumulation, increased brain-derived neurotrophic factor levels, and improved neuroinflammation status in hippocampus. |
2024-04-07 |
2024-04-10 |
mouse |
| Chu-Yun Teng, Ning-Jo Kao, Thi Kim Ngan Nguyen, Ching-I Lin, Tzu-Wen L Cross, Shyh-Hsiang Li. Effects of xylo-oligosaccharide on gut microbiota, brain protein expression, and lipid profile induced by high-fat diet. The Journal of nutritional biochemistry. 2024-04-07. PMID:38583497. |
in conclusion, xos improved gut dysbiosis and ameliorated spatial learning and memory dysfunction caused by hfd by decreasing cognitive decline-associated biomarkers and changing lipid composition in hippocampus. |
2024-04-07 |
2024-04-10 |
mouse |
| Norazirah Mat Nayan, Siti Hamimah Sheikh Abd Kadir, Andrean Husin, Rosfaiizah Sira. Neurodevelopmental Effects of Prenatal Bisphenol A Exposure on the Role of MicroRNA Regulating NMDA Receptor Subunits in the Male Rat Hippocampus. Physiology & behavior. 2024-04-07. PMID:38583549. |
this study investigates the effect of prenatal bpa exposure on the hippocampal mir-19a and mir-539, which are responsible for regulating nmda receptor subunits as well as learning and memory functions. |
2024-04-07 |
2024-04-10 |
rat |
| Weizhen Hua, Xuejingping Han, Fuping Li, Lu Lu, Yiqiong Sun, Hossein Hassanian-Moghaddam, Meiping Tian, Yanyang Lu, Qingyu Huan. Transgenerational Effects of Arsenic Exposure on Learning and Memory in Rats: Crosstalk between Arsenic Methylation, Hippocampal Metabolism, and Histone Modifications. Environmental science & technology. 2024-04-05. PMID:38578163. |
transgenerational effects of arsenic exposure on learning and memory in rats: crosstalk between arsenic methylation, hippocampal metabolism, and histone modifications. |
2024-04-05 |
2024-04-07 |
rat |
| Wu Lun, Guo Xingyu, Gao Yue, Yu Wenting, Qin Wen, Kuang Haixue, Su Yan. Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice. International journal of biological macromolecules. 2024-04-02. PMID:38565361. |
the results demonstrate that wscp exerts significant therapeutic effects on ad mice by enhancing learning and memory abilities, mitigating hippocampal neuronal damage, reducing abnormal amyloid-beta (aβ) deposition, and attenuating hyperphosphorylation of tau. |
2024-04-02 |
2024-04-05 |
mouse |
| Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Taiping Chen, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yan. Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing. Nature communications. vol 15. issue 1. 2024-04-01. PMID:38561334. |
knockout of prmt9 in hippocampal neurons causes alternative splicing of ~1900 genes, which likely accounts for the aberrant synapse development and impaired learning and memory in the prmt9 cko mice. |
2024-04-01 |
2024-04-04 |
mouse |
| Jing-Bo He, He Zhang, Hong-Xia Zheng, Jian-Xin Jia, Yi-Chi Zhang, Xu-Sheng Yan, Xiao-Xu Li, Kai-Wen Wei, Jun Mao, Hong Chen, Jing Li, He Wang, Ming Zhang, Zhi-Ying Zha. Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats. Journal of toxicology and environmental health. Part A. 2024-03-29. PMID:38551405. |
the results showed that sch b improved learning and memory function of rats with vd and exerted a protective effect on the hippocampus by inhibition of protein expression of hif-1α, trak2, and hummr factors. |
2024-03-29 |
2024-03-31 |
rat |
| Yunlin Feng, Jia Qin, Yanfei Lu, Mengdie Wang, Shengqiang Wang, Foquan Lu. Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy. PloS one. vol 19. issue 3. 2024-03-29. PMID:38551911. |
our results showed that maternal propofol exposure during middle pregnancy impaired the water-maze learning and memory of the offspring rats, increased the protein level of hdac2 and reduced the protein levels of p-creb, bdnf and p-trkb in the hippocampus of the offspring, and such effects were exacerbated by surgery. |
2024-03-29 |
2024-04-01 |
rat |
| Kushagra Nagori, Madhulika Pradhan, Mukesh Sharma, Ajazuddin, Hemant R Badwaik, Kartik T Nakhat. Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease. Current Alzheimer research. 2024-03-26. PMID:38529600. |
by modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ach plays a pivotal role in the regulation of learning and memory. |
2024-03-26 |
2024-03-28 |
Not clear |
| Zhiyuan Wang, Bin Han, Jianjiao Qi, Xuelei Cao, Huali Gu, Jinping Su. Chuanzhitongluo capsule improves cognitive impairment in mice with chronic cerebral hypoperfusion via the cholinergic anti-inflammatory pathway. Experimental gerontology. vol 189. 2024-03-24. PMID:38522309. |
results indicated that cztl significantly improved the spatial learning and memory abilities of cch mice, along with alterations in gene expression profiles in the hippocampus. |
2024-03-24 |
2024-03-27 |
mouse |
| Tegan A White, Suzanne L Miller, Amy E Sutherland, Beth J Allison, Emily J Cam. Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies. Pediatric research. 2024-03-23. PMID:38519794. |
the hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. |
2024-03-23 |
2024-03-26 |
human |
| Vaibhav Gupta, Rashmi Srivastav. Ashwagandha Diminishes Hippocampal Apoptosis Induced by Microwave Radiation by Acetylcholinesterase Dependent Neuro-Inflammatory Pathway in Male Coturnix coturnix Japonica. Neurochemical research. 2024-03-20. PMID:38506951. |
microwave radiation (mwr) has been linked to neurodegeneration by inducing oxidative stress in the hippocampus of brain responsible for learning and memory. |
2024-03-20 |
2024-03-23 |
cat |
| Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Kyle Wettschurack, Zhefu Que, Brody A Deming, Maria I Olivero-Acosta, Ningren Cui, Muriel Eaton, Yuanrui Zhao, Sophia M Li, Matthew Suzuki, Ian Chen, Tiange Xiao, Manasi S Halurkar, Purba Mandal, Chongli Yuan, Ranjie Xu, Wendy A Koss, Dongshu Du, Fuxue Chen, Long-Jun Wu, Yang Yan. Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids. Molecular psychiatry. 2024-03-19. PMID:38499656. |
here, we reported that scn2a-deficient mice have impaired learning and memory, accompanied by reduced synaptic transmission and lower spine density in neurons of the hippocampus. |
2024-03-19 |
2024-03-21 |
mouse |
| Haoxuan Gao, Mi Tian, Xiaozhe Geng, Ji Zhao, Yanan Song, Bing Wu, Xueyan Tian, Yong Yang, Wensi Ni, Huifang Yan. Cyfluthrin exposure during pregnancy causes neurotoxicity in offspring-Ca Ecotoxicology and environmental safety. vol 274. 2024-03-16. PMID:38492481. |
we found that gestational cy exposure affected pregnancy outcomes and fetal development, and that offspring showed impairments in anxiety as well as learning and memory, accompanied by impairments in hippocampal synaptic ultrastructure and synaptic plasticity. |
2024-03-16 |
2024-03-19 |
Not clear |