| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.) vol 165 issue 2023 36869551 |
in hypothalamus and hippocampus, clock (bmal1 and clock) and tight junction (ocln and tjp2) genes were improved by prebiotics, and corticotropin-releasing hormone receptor genes, crf1 and crf2, were also significantly regulated for mitigation of depression and anxiety caused by sleep deprivation. |
2023-03-04 |
2023-03-06 |
mouse |
| Hao Wu, Yong Liu, Lishuo Liu, Qiang Meng, Changwang Du, Kuo Li, Shan Dong, Yong Zhang, Huanfa Li, Hua Zhan. Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy. Molecular brain vol 14 issue 1 2021 34261484 |
we first investigated the levels of bmal1 and other clock proteins in the hippocampus of subjects with epilepsy to define the function of bmal1. |
2021-08-12 |
2023-01-26 |
human |
| Hao Wu, Yong Liu, Lishuo Liu, Qiang Meng, Changwang Du, Kuo Li, Shan Dong, Yong Zhang, Huanfa Li, Hua Zhan. Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy. Molecular brain vol 14 issue 1 2021 34261484 |
knockout of bmal1 in hippocampal dentate gyrus (dg) neurons of bmal1 |
2021-08-12 |
2023-01-26 |
human |
| Shunpei Moriya, Hitoshi Takahashi, Daiki Masukawa, Makiko Yamada, Jun Ishigooka, Katsuji Nishimur. Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice. Journal of pharmacological sciences vol 144 issue 1 2020 32624301 |
zip significantly increased per1, per2, and bmal1 mrna 2\xc2\xa0h after the lights were turned off (zt14) in the hippocampus, but not in the amygdala. |
2020-10-29 |
2023-01-26 |
mouse |
| Xiao Wu, Xuguang Liu, Zhongkun Jing, Yang Chen, Huahui Liu, Wenbin M. Moxibustion benignantly regulates circadian rhythm of REV-ERB\\xce\\xb1 in RA rats. American journal of translational research vol 12 issue 5 2020 32509155 |
rt-pcr was used to measure the relatively expression quantity of rev-erb\xce\xb1, clock, bmal1, and per2 in hypothalamus, hippocampus, and adrenal gland. |
2020-09-28 |
2023-01-26 |
rat |
| Shunsuke Hasegawa, Hotaka Fukushima, Hiroshi Hosoda, Tatsurou Serita, Rie Ishikawa, Tomohiro Rokukawa, Ryouka Kawahara-Miki, Yue Zhang, Miho Ohta, Shintaro Okada, Toshiyuki Tanimizu, Sheena A Josselyn, Paul W Frankland, Satoshi Kid. Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation. Nature communications vol 10 issue 1 2020 31852900 |
here, we show that hippocampal clock controlled by the circadian-dependent transcription factor bmal1 regulates time-of-day retrieval profile. |
2020-04-02 |
2023-01-26 |
mouse |
| Shunsuke Hasegawa, Hotaka Fukushima, Hiroshi Hosoda, Tatsurou Serita, Rie Ishikawa, Tomohiro Rokukawa, Ryouka Kawahara-Miki, Yue Zhang, Miho Ohta, Shintaro Okada, Toshiyuki Tanimizu, Sheena A Josselyn, Paul W Frankland, Satoshi Kid. Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation. Nature communications vol 10 issue 1 2020 31852900 |
inducible transgenic dominant negative bmal1 (dnbmal1) expression in mouse forebrain or hippocampus disrupted retrieval of hippocampal memories at zeitgeber time 8-12, independently of retention delay, encoding time and zeitgeber entrainment cue. |
2020-04-02 |
2023-01-26 |
mouse |
| Jiabao Hou, Qianni Shen, Xing Wan, Bo Zhao, Yang Wu, Zhongyuan Xi. REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. Behavioural brain research vol 364 issue 2020 30779975 |
western blot analysis revealed that sleep deprivation inhibited hippocampal bmal1 and egr1 expression for more than 7 days after sevoflurane inhalation. |
2020-03-09 |
2023-01-26 |
rat |
| Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiu. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PloS one vol 12 issue 11 2017 29108016 |
finally, modifications to expression of 12 genes (adora2a, app, aqp4, bdnf, bmal1, clock, cry, gfap, orx1, orx2, per, tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed. |
2017-11-28 |
2023-01-26 |
rat |
| Korey Stevanovic, Amara Yunus, Aurelie Joly-Amado, Marcia Gordon, David Morgan, Danielle Gulick, Joshua Gamsb. Disruption of normal circadian clock function in a mouse model of tauopathy. Experimental neurology vol 294 issue 2017 28461004 |
finally, disruption of the cyclic expression of per2 and bmal1, another core circadian clock protein, is evident in the tg4510 hippocampus. |
2017-08-17 |
2023-01-26 |
mouse |
| Shunpei Moriya, Yu Tahara, Hiroyuki Sasaki, Jun Ishigooka, Shigenobu Shibat. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice. Neuroscience research vol 99 issue 2016 26026603 |
housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes per1, per2, and bmal1 in the amygdala and hippocampus of mice. |
2016-08-19 |
2023-01-25 |
mouse |
| Lauren E Chun, Elizabeth R Woodruff, Sarah Morton, Laura R Hinds, Robert L Spence. Variations in Phase and Amplitude of Rhythmic Clock Gene Expression across Prefrontal Cortex, Hippocampus, Amygdala, and Hypothalamic Paraventricular and Suprachiasmatic Nuclei of Male and Female Rats. Journal of biological rhythms vol 30 issue 5 2016 26271538 |
this study examined basal clock gene expression (per1, per2, bmal1 mrna) in the scn, prefrontal cortex (pfc), rostral agranular insula, hypothalamic paraventricular nucleus (pvn), amygdala, and hippocampus of male and female rats at 4-h intervals throughout a 12:12 h light:dark cycle. |
2016-06-15 |
2023-01-25 |
rat |
| Lauren E Chun, Elizabeth R Woodruff, Sarah Morton, Laura R Hinds, Robert L Spence. Variations in Phase and Amplitude of Rhythmic Clock Gene Expression across Prefrontal Cortex, Hippocampus, Amygdala, and Hypothalamic Paraventricular and Suprachiasmatic Nuclei of Male and Female Rats. Journal of biological rhythms vol 30 issue 5 2016 26271538 |
there was a significant rhythm of per1, per2, and bmal1 in the scn, pfc, insula, pvn, subregions of the hippocampus, and amygdala with a 24-h period, suggesting the importance of an oscillating molecular clock in extra-scn brain regions. |
2016-06-15 |
2023-01-25 |
rat |
| Evelin Antonieli da Silva Santos, Thalita Ewellyn Batista Sales Marques, Helo\\xc3\\xadsa de Carvalho Matos, Jo\\xc3\\xa3o Pereira Leite, Norberto Garcia-Cairasco, Maria Luisa Pa\\xc3\\xa7\\xc3\\xb3-Larson, Daniel Leite G\\xc3\\xb3es Gita\\xc3\\xa. Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy. PloS one vol 10 issue 10 2016 26473354 |
for this, we have selected six core clock genes (per1, per3, bmal1, clock, cry1 and cry2), whose rhythmic expression pattern in hippocampus had been previously reported. |
2016-06-10 |
2023-01-25 |
rat |
| Evelin Antonieli da Silva Santos, Thalita Ewellyn Batista Sales Marques, Helo\\xc3\\xadsa de Carvalho Matos, Jo\\xc3\\xa3o Pereira Leite, Norberto Garcia-Cairasco, Maria Luisa Pa\\xc3\\xa7\\xc3\\xb3-Larson, Daniel Leite G\\xc3\\xb3es Gita\\xc3\\xa. Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy. PloS one vol 10 issue 10 2016 26473354 |
next, we confirmed the temporal profiling of per1, per3, bmal1, cry1 and cry2 mrna levels in the hippocampus of naive rats by both acrophase and circwave statistical tests for circadian analysis. |
2016-06-10 |
2023-01-25 |
rat |
| Amira A H Ali, Beryl Schwarz-Herzke, Anna Stahr, Timour Prozorovski, Orhan Aktas, Charlotte von Gal. Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice. Aging vol 7 issue 6 2016 26142744 |
as proliferation of neuronal progenitor/precursor cells (npcs) is enhanced in young bmal1(-/-) mice, we tested the hypothesis that this results in premature aging of hippocampal neurogenic niche in adult bmal1(-/-) mice as compared to wildtype littermates. |
2016-04-06 |
2023-01-25 |
mouse |
| Tomoko Ikeno, Randy J Nelso. Acute melatonin treatment alters dendritic morphology and circadian clock gene expression in the hippocampus of Siberian hamsters. Hippocampus vol 25 issue 2 2015 25160468 |
however, melatonin treatment increased both period1 and bmal1 expression in the hippocampus, suggesting that melatonin affected molecular oscillations in the hippocampus. |
2015-09-16 |
2023-01-25 |
Not clear |
| Brooke D Rakai, Michael J Chrusch, Simon C Spanswick, Richard H Dyck, Michael C Antl. Survival of adult generated hippocampal neurons is altered in circadian arrhythmic mice. PloS one vol 9 issue 6 2015 24941219 |
in the present study, neurogenesis in the hippocampal subgranular zone was examined in arrhythmic bmal1 knockout (-ko) mice and their rhythmic heterozygous and wildtype littermates. |
2015-07-03 |
2023-01-25 |
mouse |
| Sarah M Wardlaw, Trongha X Phan, Amit Saraf, Xuanmao Chen, Daniel R Stor. Genetic disruption of the core circadian clock impairs hippocampus-dependent memory. Learning & memory (Cold Spring Harbor, N.Y.) vol 21 issue 8 2015 25034823 |
we conclude that critical signaling events in the hippocampus required for memory depend on bmal1. |
2015-05-12 |
2023-01-25 |
mouse |
| Shunpei Moriya, Yu Tahara, Hiroyuki Sasaki, Yutaro Hamaguchi, Daisuke Kuriki, Ryosuke Ishikawa, Jun Ishigooka, Shigenobu Shibat. Effect of quetiapine on Per1, Per2, and Bmal1 clock gene expression in the mouse amygdala and hippocampus. Journal of pharmacological sciences vol 125 issue 3 2015 24965164 |
effect of quetiapine on per1, per2, and bmal1 clock gene expression in the mouse amygdala and hippocampus. |
2015-02-23 |
2023-01-25 |
mouse |