| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Somoday Hazra, Joyeeta Dutta Hazra, Rani Amit Bar-On, Yanhong Duan, Shahaf Edut, Xiaohua Cao, Gal Richter-Levi. The role of hippocampal CaMKII in resilience to trauma-related psychopathology. Neurobiology of stress. vol 21. 2022-12-19. PMID:36532378. |
in light of the established role of hippocampal synaptic plasticity in stress and the essential role of ca2+/calmodulin-dependent protein kinase ii (camkii) in hippocampal based synaptic plasticity, we pharmacologically inhibited camkii or knocked-down (kd) αcamkii (in two separate experiments) in the dorsal dentate gyrus of the hippocampus (ddg) following exposure to the same trauma paradigm. |
2022-12-19 |
2023-08-14 |
rat |
| Zheng-Mao Li, Xiu-Xiu Liu, Chen Li, Zhao-Cong Wei, Yi Shi, Heng-Yi Song, Xiang Chen, Yu Zhang, Jia-Wei Li, Rui-Fang Zhu, Ben-Hui Hu, Wei-Feng Ye, Da Huo, Guo-Jun Jiang, Takuya Sasaki, Li Zhang, Feng Han, Ying-Mei L. Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelial MedComm. vol 3. issue 3. 2022-06-30. PMID:35770064. |
moreover, the persistent epileptic seizures induce aberrant changes in phosphorylation of camkii protein in the hippocampus of spontaneous epileptic mice. |
2022-06-30 |
2023-08-14 |
mouse |
| Zhilu Zou, Jiaru Huang, Qingqing Yang, Yuxuan Zhang, Bo Xu, Ping Wang, Gang Che. Repeated Yueju, But Not Fluoxetine, Induced Sustained Antidepressant Activity in a Mouse Model of Chronic Learned Helplessness: Involvement of CaMKII Signaling in the Hippocampus. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-07. PMID:35251201. |
repeated yueju, but not fluoxetine, induced sustained antidepressant activity in a mouse model of chronic learned helplessness: involvement of camkii signaling in the hippocampus. |
2022-03-07 |
2023-08-13 |
mouse |
| Xiaoli Cui, Ruijin Zhang, Ye Yang, Erzhong Wu, Yiheng Tang, Zhihua Zhao, Chao Li, Lei Yang, Xueyi Teng, Yanzhen Ye, Ya Cui, Feng Xu, Zewen Su, Dongpeng Wang, Dongdong Zhang, Yan Yang, Jianyuan Sun, Jianjun Luo, Shuli Zhang, Runsheng Chen, Jianzhong Jeff X. Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory. Cell reports. vol 38. issue 8. 2022-02-23. PMID:35196493. |
recent studies have shown that a variety of modulators interact with the subunits of camkii to regulate the long-term potentiation (ltp) of hippocampal neurons. |
2022-02-23 |
2023-08-13 |
mouse |
| Nikita Zernov, Ilya Bezprozvanny, Elena Popugaev. CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines. IBRO neuroscience reports. vol 12. 2022-01-26. PMID:35079728. |
in the present study, we demonstrated that inhibition of kinase activity of camkii by kn-62 decreases nsoce amplitude in soma of primary hippocampal neurons. |
2022-01-26 |
2023-08-13 |
Not clear |
| Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yua. Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. Neurochemistry international. vol 152. 2021-12-11. PMID:34743016. |
importantly, our data demonstrated strongly enhanced expression of nlrp3, asc and caspase-1 in the hippocampus of aged rats as well as decreased ampa receptor and phosphorylated levels of camkii and creb in the hippocampus of natural aging rats. |
2021-12-11 |
2023-08-13 |
rat |
| Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yua. Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. Neurochemistry international. vol 152. 2021-12-11. PMID:34743016. |
furthermore, nlrp3 inflammasome inhibitor elevated the surface expression of ampa receptor and the phosphorylated levels of camkii, creb in hippocampus, and finally contributed to the attenuation of hippocampal long-term potentiation (ltp) deficits and the improvement of cognitive decline of natural aging rats. |
2021-12-11 |
2023-08-13 |
rat |
| Inci Turan, Hale Sayan Ozacmak, V Haktan Ozacmak, Meryem Ergenc, Taner Bayraktaroğl. The effects of glucagon-like peptide 1 receptor agonist (exenatide) on memory impairment, and anxiety- and depression-like behavior induced by REM sleep deprivation. Brain research bulletin. vol 174. 2021-12-10. PMID:34146656. |
the levels of ca2+/calmodulin-dependent protein kinase ii (camkii) and postsynaptic density proteins 95 (psd95) were measured in tissues of hippocampus and prefrontal cortex. |
2021-12-10 |
2023-08-13 |
rat |
| Inci Turan, Hale Sayan Ozacmak, V Haktan Ozacmak, Meryem Ergenc, Taner Bayraktaroğl. The effects of glucagon-like peptide 1 receptor agonist (exenatide) on memory impairment, and anxiety- and depression-like behavior induced by REM sleep deprivation. Brain research bulletin. vol 174. 2021-12-10. PMID:34146656. |
contents of camkii and psd95 decreased in hippocampus of sd rats. |
2021-12-10 |
2023-08-13 |
rat |
| Inci Turan, Hale Sayan Ozacmak, V Haktan Ozacmak, Meryem Ergenc, Taner Bayraktaroğl. The effects of glucagon-like peptide 1 receptor agonist (exenatide) on memory impairment, and anxiety- and depression-like behavior induced by REM sleep deprivation. Brain research bulletin. vol 174. 2021-12-10. PMID:34146656. |
exenatide treatment improved the impaired memory of sd rats and increased camkii content in hippocampus there was no difference in mda and gsh levels among groups. |
2021-12-10 |
2023-08-13 |
rat |
| Inci Turan, Hale Sayan Ozacmak, V Haktan Ozacmak, Meryem Ergenc, Taner Bayraktaroğl. The effects of glucagon-like peptide 1 receptor agonist (exenatide) on memory impairment, and anxiety- and depression-like behavior induced by REM sleep deprivation. Brain research bulletin. vol 174. 2021-12-10. PMID:34146656. |
in conclusion, treatment with exenatide, at least in part, prevented from these cognitive and behavioral changes possibly through normalizing camkii levels in the hippocampus. |
2021-12-10 |
2023-08-13 |
rat |
| Andressa Radiske, Maria Carolina Gonzalez, Janine I Rossato, Gênedy Apolinário, João R de Oliveira, Lia R M Bevilaqua, Martín Cammarot. Avoidance memory requires CaMKII activity to persist after recall. Molecular brain. vol 14. issue 1. 2021-12-10. PMID:34775982. |
using pharmacological, electrophysiological and optogenetic tools, we found that in adult male wistar rats hippocampal camkii is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via camkii inhibition erases learned avoidance responses. |
2021-12-10 |
2023-08-13 |
rat |
| V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology. 2021-11-09. PMID:34751792. |
statistically significant increments in the protein expression of tau and camkii were observed both in cortical and hippocampal neurons treated with subtherapeutic doses of lithium. |
2021-11-09 |
2023-08-13 |
Not clear |
| Chang-Hai Fu, Xue-Yan Han, Lei Tong, Peng-Yin Nie, Yue-Dong Hu, Li-Li J. miR-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pCaMKII and BAI3 in the hippocampus of APP/PS1 transgenic mice. Behavioural brain research. vol 414. 2021-11-04. PMID:34302879. |
in addition, the reduction of phosphorylation of synapsin i and calcium/calmodulin-dependent protein kinase ii (camkii), as well as the expression of psd-95 in the hippocampus of app/ps1 transgenic mice, were significantly restored by inhibiting mir-142. |
2021-11-04 |
2023-08-13 |
mouse |
| Roman Sloutsky, Noelle Dziedzic, Matthew J Dunn, Rachel M Bates, Ana P Torres-Ocampo, Sivakumar Boopathy, Brendan Page, John G Weeks, Luke H Chao, Margaret M Stratto. Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Science signaling. vol 13. issue 641. 2021-11-01. PMID:32694170. |
heterogeneity in human hippocampal camkii transcripts reveals allosteric hub-dependent regulation. |
2021-11-01 |
2023-08-13 |
human |
| ManKin Choy, Ehsan Dadgar-Kiani, Greg O Cron, Ben A Duffy, Florian Schmid, Bradley J Edelman, Mazen Asaad, Russell W Chan, Shahabeddin Vahdat, Jin Hyung Le. Repeated hippocampal seizures lead to brain-wide reorganization of circuits and seizure propagation pathways. Neuron. 2021-10-27. PMID:34706219. |
here, we developed an optogenetic kindling model through repeated stimulation of ventral hippocampal camkii neurons in adult rats. |
2021-10-27 |
2023-08-13 |
rat |
| Jannike M Andersen, Siri H Opdal, Christian P Müller, Fernando Boi. CaMKII is activated in opioid induced conditioned place preference, but αCaMKII Thr286 autophosphorylation is not necessary for its establishment. Behavioural brain research. vol 390. 2021-10-25. PMID:32407818. |
to study the contribution of camkii in opioid induced conditioned learning, we examined how establishment of conditioned place preference (cpp) induced by 10 or 30 μmol/kg morphine or its active metabolite morphine-6-glucuronide (m6g) affects the levels and thr286 autophosphorylation of the α- and β-isoforms of camkii, as well as β-actin levels, in dorsal and ventral striatum and in hippocampus of mice. |
2021-10-25 |
2023-08-13 |
mouse |
| Jannike M Andersen, Siri H Opdal, Christian P Müller, Fernando Boi. CaMKII is activated in opioid induced conditioned place preference, but αCaMKII Thr286 autophosphorylation is not necessary for its establishment. Behavioural brain research. vol 390. 2021-10-25. PMID:32407818. |
whereas an acute single administration of morphine or m6g caused increases in camkii levels and phosphorylation at thr286 and β-actin in striatal areas, cpp induced by these opioids was accompanied primarily by an increase in the protein levels of both camkii isoforms and β-actin in dorsal striatum and hippocampus. |
2021-10-25 |
2023-08-13 |
mouse |
| Jinxin Wang, Dongfan Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Yumin He, Chaoqi Liu, Chengfu Yuan, Ding Yuan, Ting Wan. Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors. Neurochemistry international. vol 148. 2021-09-08. PMID:34129896. |
our results showed that hfd-fed mice caused behavioral disorders, neuronal degeneration as well as elevated neuroinflammation, which was partly involved in nlrp3 inflammasome that finally resulted in decreased protein levels of ampa receptors and down-regulated phosphorylated levels of camkii and creb in cortex and hippocampus. |
2021-09-08 |
2023-08-13 |
mouse |
| Yuangui Zhang, Qingqing Sun, Aixia Fan, Guimin Don. Isoflurane triggers the acute cognitive impairment of aged rats by damaging hippocampal neurons via the NR2B/CaMKII/CREB pathway. Behavioural brain research. vol 405. 2021-09-02. PMID:33636236. |
isoflurane jeopardized hippocampal neurons by directly inactivating the nr2b/camkii/creb pathway and its harmful effects could be ameliorated by adding camkii activator cdcl |
2021-09-02 |
2023-08-13 |
rat |