| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter T Nelson, David W Fardo, Xian Wu, Khine Zin Aung, Matthew D Cykowski, Yuriko Katsumat. Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis. Journal of neuropathology and experimental neurology. 2024-04-13. PMID:38613823. |
although "pure" late-nc is not rare, late-nc often coexists in the same brains with alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (artag). |
2024-04-13 |
2024-04-16 |
human |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
the strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of l1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. |
2024-04-12 |
2024-04-14 |
mouse |
| Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Patcharapong Pantiya, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways. Molecular neurobiology. 2024-04-03. PMID:38568417. |
dox insult also mediated hyperphosphorylation of tau and simultaneously induced various pcd, including apoptosis, necroptosis, and pyroptosis in the hippocampus. |
2024-04-03 |
2024-04-05 |
rat |
| Fanglin Qin, Yiming Yan, Ningxi Yang, Yarong Ha. Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2024-04-03. PMID:38569512. |
in db/db mice, ech alleviates diabetes symptoms, memory loss, and hippocampal neuronal damage.following the step, we found cd44 and phosphorylated tau expression upregulated in diabetic mice. |
2024-04-03 |
2024-04-06 |
mouse |
| Wu Lun, Guo Xingyu, Gao Yue, Yu Wenting, Qin Wen, Kuang Haixue, Su Yan. Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice. International journal of biological macromolecules. 2024-04-02. PMID:38565361. |
the results demonstrate that wscp exerts significant therapeutic effects on ad mice by enhancing learning and memory abilities, mitigating hippocampal neuronal damage, reducing abnormal amyloid-beta (aβ) deposition, and attenuating hyperphosphorylation of tau. |
2024-04-02 |
2024-04-05 |
mouse |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
importantly, arc protein was upregulated in the hippocampus of tau knockout (tau ko) mice and dendrites of tau ko primary hippocampal neurons. |
2024-03-29 |
2024-04-01 |
mouse |
| Tuancheng Feng, Huan Du, Cha Yang, Ya Wang, Fenghua H. Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice. Acta neuropathologica. vol 147. issue 1. 2024-03-25. PMID:38526799. |
here we show that loss of tmem106b enhances the accumulation of pathological tau, especially in the neuronal soma in the hippocampus, resulting in severe neuronal loss in the ps19 tau transgenic mice. |
2024-03-25 |
2024-03-28 |
mouse |
| Katharina Schindowsk. Differential Regulation of Neurotrophic Factors During Pathogenic Tau-Aggregation in a Tau Transgenic Mouse Model for Alzheimer's Disease: A Protocol for Double-Labeling mRNA by In Situ Hybridization and Protein Epitopes by Immunohistochemistry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512677. |
interestingly, both, the mrna and protein levels of nerve growth factor (ngf) were significantly increased in hippocampal neurons in the tau models as demonstrated by ish, immunofluorescence, and western blotting. |
2024-03-21 |
2024-03-24 |
mouse |
| Sarah Buchholz, Michael Bell-Simons, Natja Haag, Hans Zempe. Tracking Tau in Neurons: How to Grow, Fix, and Stain Primary Neurons for the Investigation of Tau in All Developmental Stages. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512686. |
here, we describe (i) a relatively cheap and easy cell culture procedure for the cultivation of forebrain neurons from embryonic mice (e13.5) based on a commercially available neuronal supplement (ns21), (ii) a protocol for the cultivation of hippocampal and cortical neurons from postnatal (p0-p3) animals, and (iii) basic fixation and immunofluorescence techniques for the staining of neuronal markers and endogenous tau. |
2024-03-21 |
2024-03-24 |
mouse |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
brain regions in alzheimer's (ad) exhibit distinct vulnerability to the disease's hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. |
2024-03-18 |
2024-03-20 |
Not clear |
| Julian D Dallmeier, Ryan Gober, Regina T Vontell, Ayled Barreda, Daniel A Dorfsman, David A Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P Garamszegi, Connor M Wander, Todd Cohen, William K Scot. Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-03-15. PMID:38486969. |
corpora amylacea negatively correlate with hippocampal tau pathology in alzheimer's disease. |
2024-03-15 |
2024-03-17 |
Not clear |
| Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming H. Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice. Experimental gerontology. 2024-03-14. PMID:38484904. |
immunohistochemistry and western blot assessments unveiled elevated levels of hyperphosphorylated tau in the cortex and hippocampus of mice treated with ad-omvs. |
2024-03-14 |
2024-03-17 |
mouse |
| Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yan. Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss. Military Medical Research. vol 11. issue 1. 2024-03-11. PMID:38462603. |
episodic memory loss is a prominent clinical manifestation of alzheimer's disease (ad), which is closely related to tau pathology and hippocampal impairment. |
2024-03-11 |
2024-03-14 |
mouse |
| Hao Chen, Kaitlyn Hinz, Chen Zhang, Yssa Rodriguez, Sha Neisha Williams, Mengwei Niu, Xiaowen Ma, Xiaojuan Chao, Alexandria L Frazier, Kenneth E McCarson, Xiaowan Wang, Zheyun Peng, Wanqing Liu, Hong-Min Ni, Jianhua Zhang, Russell H Swerdlow, Wen-Xing Din. Late-Life Alcohol Exposure Does Not Exacerbate Age-Dependent Reductions in Mouse Spatial Memory and Brain TFEB Activity. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38464149. |
in young mice, alcohol decreased hippocampal nuclear tfeb staining but increased sqstm1/p62, lc3-ii, ubiquitinated proteins, and phosphorylated tau. |
2024-03-11 |
2024-03-14 |
mouse |
| Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Pau. Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine. vol 221. issue 4. 2024-03-05. PMID:38442267. |
here, we show that in the absence of ch25h and the resultant reduction in 25-hc, there is strikingly reduced age-dependent neurodegeneration and neuroinflammation in the hippocampus and entorhinal/piriform cortex of ps19 mice, which express the p301s mutant human tau transgene. |
2024-03-05 |
2024-03-08 |
mouse |
| Ayane Ninomiya, Izuki Amano, Hiraku Suzuki, Yuki Fujiwara, Asahi Haijima, Noriyuki Koibuch. Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice. The journal of physiological sciences : JPS. vol 74. issue 1. 2024-03-05. PMID:38443820. |
in the hippocampus, the expression of tau protein was significantly increased. |
2024-03-05 |
2024-03-08 |
mouse |
| Foad Feizolahi, Ehsan Arabzadeh, Amir Sarshin, Farshad Falahi, Zahra Dehghannayeri, Ali Ali Askari, Alexei Wong, Fariba Aghaei, Mehdi Zargan. Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats. Neurotoxicity research. vol 42. issue 2. 2024-03-05. PMID:38441819. |
effects of exercise training and l-arginine loaded chitosan nanoparticles on hippocampus histopathology, β-secretase enzyme function, app, tau, iba1and apoe-4 mrna in aging rats. |
2024-03-05 |
2024-03-07 |
rat |
| Foad Feizolahi, Ehsan Arabzadeh, Amir Sarshin, Farshad Falahi, Zahra Dehghannayeri, Ali Ali Askari, Alexei Wong, Fariba Aghaei, Mehdi Zargan. Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats. Neurotoxicity research. vol 42. issue 2. 2024-03-05. PMID:38441819. |
the objective of this study was to evaluate the combined and independent effects of exercise training and l-arginine loaded chitosan nanoparticles (la cnps) supplementation on hippocampal tau, app, iba1, and apoe gene expression, oxidative stress, β-secretase enzyme activity, and hippocampus histopathology in aging rats. |
2024-03-05 |
2024-03-07 |
rat |
| Julia Eisenhardt de Mello, Fernanda Cardoso Teixeira, Alessandra Dos Santos, Karina Luduvico, Mayara Sandrielly Soares de Aguiar, William Borges Domingues, Vinicius Farias Campos, Rejane Giacomelli Tavares, Augusto Schneider, Francieli Moro Stefanello, Roselia Maria Spanevell. Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling. Molecular neurobiology. 2024-03-02. PMID:38430352. |
in animals of group ii, an increase in acetylcholinesterase activity, phosphorylated tau protein, il-6, oxidative damage, and gene expression of gsk-3β and nrf2 was observed in the hippocampus. |
2024-03-02 |
2024-03-04 |
rat |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl J Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan L Bedard, Esther Buendia, Eunice Chung, Amanda Denning, María Del Mar Arroyo-Jiménez, Emilio Artacho-Pérula, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, María Del Pilar Marcos-Rabal, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Carlos de la Rosa Prieto, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. Hippocampus. 2024-02-28. PMID:38415962. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2024-02-28 |
2024-03-01 |
human |