| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior vol issue 2023 36870422 |
the present study demonstrated for the first time that acute as well as subchronic (4\xe2\x80\xafdays) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3\xe2\x80\xafmg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the \xce\xb2-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). |
2023-03-04 |
2023-03-06 |
rat |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior vol issue 2023 36870422 |
furthermore, following the methamphetamine intravenous self-administration in rats, the 3\xe2\x80\xafmg/kg jmv2959 pretreatment significantly reduced or prevented the methamphetamine-induced significant decrease of hippocampal \xce\xb2-actin and c-fos as well as it prevented the significant decrease of creb in the nac and mpfc. |
2023-03-04 |
2023-03-06 |
rat |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior vol issue 2023 36870422 |
these results imply, that the ghs-r1a antagonist/jmv2959 might reduce/prevent some of the memory-linked molecular changes elicited by methamphetamine addiction within brain structures associated with memory (hipp), reward (nac), and motivation (mpfc), which may contribute to the previously observed significant jmv2959-induced reduction of the methamphetamine self-administration and drug-seeking behavior in the same animals. |
2023-03-04 |
2023-03-06 |
rat |
| Ji-Eun Kim, Hana Park, Tae-Cheon Kan. Peroxiredoxin 6 Regulates Glutathione Peroxidase 1-Medited Glutamine Synthase Preservation in the Hippocampus of Chronic Epilepsy Rats. Antioxidants (Basel, Switzerland) vol 12 issue 1 2023 36671018 |
to elucidate this, the present study was designed to investigate whether nac affects astroglial glutamine synthase (gs) expression mediated by gsh peroxidase 1 (gpx1) and/or peroxiredoxin 6 (prdx6) in the epileptic hippocampus. |
2023-01-21 |
2023-01-30 |
rat |
| Xiao-Bo Wu, Qian Zhu, Ming-Hui Gao, Sheng-Xiang Yan, Pan-Yang Gu, Peng-Fei Zhang, Meng-Lin Xu, Yong-Jing Ga. Excitatory projections from the prefrontal cortex to nucleus accumbens core D1-MSNs and kappa opioid receptor modulate itch-related scratching behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2023 36653189 |
excitatory afferents from the medial prefrontal cortex (mpfc), amygdala, and hippocampus are crucial in tuning the activity of dopamine receptor d1- and d2-expressing medium spiny neurons (drd1- and drd2-msns) in the nac. |
2023-01-18 |
2023-01-30 |
mouse |
| Ekram Mohammadi, Farnaz Nikbakht, Somayeh Vazifekhah, Javad Fahanik Babae, Mohamad Taghi Jogatae. Evaluation the cognition-improvement effects of N-acetyl cysteine in experimental temporal lobe epilepsy in rat. Behavioural brain research vol issue 2022 36563904 |
histological analysis showed that nac significantly increased the number of intact neurons in ca3 and hilar areas of the hippocampus following the induction of epilepsy. |
2022-12-23 |
2023-01-30 |
rat |
| Shane A Perrine, Walid F Alsharif, Arman Harutyunyan, Swatabdi Kamal, Nerissa T Viola, Juri G Gelovan. Low- and high-cocaine intake affects the spatial and temporal dynamics of class IIa HDAC expression-activity in the nucleus accumbens and hippocampus of male rats as measured by [18F]TFAHA PET/CT neuroimaging. Addiction neuroscience vol 4 issue 2022 36540409 |
repeated cocaine alters neuronal function in the nucleus accumbens (nac), a brain region involved in cocaine taking, and in hippocampus (hc), known for contextual and associative learning. |
2022-12-21 |
2023-01-30 |
rat |
| K\\xc4\\xb1ymet K\\xc3\\xbcbra T\\xc3\\xbcfekci, Elfide Gizem Bakirhan, Funda Terz. A Maternal High-Fat Diet Causes Anxiety-Related Behaviors by Altering Neuropeptide Y1 Receptor and Hippocampal Volumes in Rat Offspring: the Potential Effect of N-Acetylcysteine. Molecular neurobiology vol issue 2022 36502431 |
the study results show that nac attenuated anxiety-like behaviors and npy1r expression and also protected hippocampal volume against maternal obesity. |
2022-12-11 |
2023-01-30 |
rat |
| K\\xc4\\xb1ymet K\\xc3\\xbcbra T\\xc3\\xbcfekci, Elfide Gizem Bakirhan, Funda Terz. A Maternal High-Fat Diet Causes Anxiety-Related Behaviors by Altering Neuropeptide Y1 Receptor and Hippocampal Volumes in Rat Offspring: the Potential Effect of N-Acetylcysteine. Molecular neurobiology vol issue 2022 36502431 |
additionally, although there is no direct evidence, maintenance of npy1r expression by nac may be critical for regulating maternal obesity-induced anxiety-related behaviors and hippocampal structure. |
2022-12-11 |
2023-01-30 |
rat |
| Lucia Carboni, Laura Rullo, Francesca Felicia Caputi, Serena Stamatakos, Sanzio Candeletti, Patrizia Romuald. Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy. International journal of molecular sciences vol 23 issue 22 2022 36430520 |
mrna expression of growth factor and circadian rhythm genes was evaluated by qpcr in the prefrontal cortex (pfcx), hippocampus, nucleus accumbens (nac), amygdala, and hypothalamus. |
2022-11-26 |
2023-01-30 |
rat |
| Lucia Carboni, Laura Rullo, Francesca Felicia Caputi, Serena Stamatakos, Sanzio Candeletti, Patrizia Romuald. Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy. International journal of molecular sciences vol 23 issue 22 2022 36430520 |
bdnf levels were significantly increased in pfcx and hippocampus by trazodone and in the nac and hypothalamus by citalopram. |
2022-11-26 |
2023-01-30 |
rat |
| Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience vol 16 issue 2022 36338879 |
the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), \xce\xb1-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). |
2022-11-07 |
2023-01-30 |
rat |
| Blake L Elliott, Kimberlee D'Ardenne, Vishnu P Murty, Gene A Brewer, Samuel M McClur. Midbrain-Hippocampus Structural Connectivity Selectively Predicts Motivated Memory Encoding. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 36332978 |
functional mri studies show that interactions between the dopaminergic midbrain (sn/vta), hippocampus, and nucleus accumbens (nac) are critical for motivated memory encoding. |
2022-11-04 |
2023-01-30 |
human |
| William C Griffin, Marcelo F Lopez, John J Woodward, Howard C Becke. Alcohol Dependence and the Ventral Hippocampal Influence on Alcohol Drinking in Male Mice. Alcohol (Fayetteville, N.Y.) vol issue 2022 36328184 |
facilitated by its connectivity with other parts of the brain such as the nucleus accumbens (nac), the ventral hippocampus (vhc) supports many behaviors, including those related to reward seeking and addiction. |
2022-11-03 |
2023-01-30 |
mouse |
| Ashley J McFalls, Christopher Jenney, Rachel S Stanford, Emma Woodward, Andras Hajnal, Patricia S Grigson, Kent E Vran. Greater Avoidance of a Saccharin Cue Paired with Passive Delivery of Heroin is Associated with a Select Increase in Expression of CRFR2 and CRFbp in the Hippocampus in Rats. Brain research bulletin vol issue 2022 36228871 |
we then assessed gene expression for components of the crf pathway in the mpfc, hipp, vta, amygdala, and nucleus accumbens (nac). |
2022-10-13 |
2023-01-30 |
rat |
| Ezio Carboni, Anna R Cart. BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression. Journal of integrative neuroscience vol 21 issue 5 2022 36137960 |
in this review we have examined the role of several brain areas: namely, the hippocampus, the medial prefrontal cortex (mpfc), the nucleus accumbens (nac), the lateral habenula (lhb), the amygdala and the bed nucleus of stria terminalis (bnst). |
2022-09-22 |
2023-01-30 |
Not clear |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology vol 13 issue 2022 35903343 |
analyses of markers involved in the inflammatory response, such as astrocytes (glial fibrillary acid protein, gfap) and microglia (binding adapter molecule 1, iba1), and parvalbumin (pv) positive gabaergic, were conducted in the prefrontal cortex [pfc, medial orbital cortex (mo) and prelimbic cortex (prl)] and dorsal and ventral hippocampus [ca1, ca2, ca3, and dentate gyrus (dg)] in rats under chronic treatment with nac. |
2022-07-29 |
2023-01-30 |
rat |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology vol 13 issue 2022 35903343 |
nac increased the density of iba1 cells at pfc and of pv cells at mo and ca1 of the ventral hippocampus. |
2022-07-29 |
2023-01-30 |
rat |
| L Stan Leung, Jingyi M. Medial Septum Modulates Consciousness and Psychosis-Related Behaviors Through Hippocampal Gamma Activity. Frontiers in neural circuits vol 16 issue 2022 35874429 |
glutamatergic projection of the hippocampus to the nucleus accumbens (nac) and dopaminergic transmission in nac is necessary for abnormal behaviors. |
2022-07-25 |
2023-01-30 |
rat |
| L Stan Leung, Jingyi M. Medial Septum Modulates Consciousness and Psychosis-Related Behaviors Through Hippocampal Gamma Activity. Frontiers in neural circuits vol 16 issue 2022 35874429 |
local inactivation or lesion of the medial septum, nac, and brain areas connected to the septohippocampal-nac system attenuates the increase in hippocampal gamma and associated behavioral disruptions induced by hippocampal seizure or pcp/ketamine. |
2022-07-25 |
2023-01-30 |
rat |