| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Liu, Jie Wu, Changlin Zhang, Tong Cao, Yongli Lu, Zhi He, Zicheng L. Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice. Brain research. 2024-04-11. PMID:38604556. |
(2) the endoplasmic reticulum stress-related proteins in the lateral habenula (lhb) but not in the nucleus accumbens (nac), ventral pallidum (vp), basolateral amygdala (bla) and ca1 of hippocampus was upregulated by morphine withdrawal, upregulation of endoplasmic reticulum stress-related proteins in the lateral habenula induced by morphine withdrawal was inhibited by 4-pba. |
2024-04-11 |
2024-04-14 |
mouse |
| Shahrzad Nazari, Mitra-Sadat Sadat-Shirazi, Ali Shahbazi, Kamran Ghaffari, Nasim Vousoogh. The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain. Acta neurobiologiae experimentalis. vol 84. issue 1. 2024-04-08. PMID:38587320. |
the mrna level of the glun3b subunit of the nmda receptor in the striatum, hippocampus, and nucleus accumbens (nac) was measured by real‑time pcr. |
2024-04-08 |
2024-04-10 |
rat |
| Pu Zhao, Quan Yuan, Chen Liang, Yilu Ma, Xiaoying Zhu, Xueqin Hao, Xinyu Li, Jian Shi, Qizhi Fu, Hua Fan, Dongmei Wan. GPX4 degradation contributes to fluoride-induced neuronal ferroptosis and cognitive impairment via mtROS-chaperone-mediated autophagy. The Science of the total environment. 2024-04-06. PMID:38582117. |
notably, the ferroptosis-specific inhibitor ferrostatin-1 (fer-1) or the ros scavenger n-acetyl-l-cysteine (nac) alleviated fluoride-evoked hippocampal neuronal death and synaptic injury as well as cognitive deficits in mice. |
2024-04-06 |
2024-04-10 |
mouse |
| Pan Zhang, Yangke Mao, Liangchao Gao, Zilei Tian, Ruirui Sun, Yuqi He, Peihong Ma, Beihong Dou, Yuan Chen, Xiabing Zhang, Zhaoxuan He, Tao Yin, Fang Zen. Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome. Appetite. vol 197. 2024-03-29. PMID:38552365. |
the results demonstrated that the patients with pds manifested strengthened fc between nac and the caudate, putamen, pallidum, amygdala, hippocampus, thalamus, anterior cingulate cortex (acc), and insula. |
2024-03-29 |
2024-04-01 |
Not clear |
| Pan Zhang, Yangke Mao, Liangchao Gao, Zilei Tian, Ruirui Sun, Yuqi He, Peihong Ma, Beihong Dou, Yuan Chen, Xiabing Zhang, Zhaoxuan He, Tao Yin, Fang Zen. Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome. Appetite. vol 197. 2024-03-29. PMID:38552365. |
moreover, the fc between nac and acc, insula, thalamus, and hippocampus exhibited significant positive associations with symptom severity. |
2024-03-29 |
2024-04-01 |
Not clear |
| Pan Zhang, Yangke Mao, Liangchao Gao, Zilei Tian, Ruirui Sun, Yuqi He, Peihong Ma, Beihong Dou, Yuan Chen, Xiabing Zhang, Zhaoxuan He, Tao Yin, Fang Zen. Abnormal functional connectivity of the reward circuit associated with early satiety in patients with postprandial distress syndrome. Appetite. vol 197. 2024-03-29. PMID:38552365. |
more importantly, the strengthened fc between nac and the acc, insula, amygdala, and hippocampus were found associated with the early satiety symptom of patients with pds. |
2024-03-29 |
2024-04-01 |
Not clear |
| Tsun Hay Jason Ng, Mohammed H Sarikahya, Roger Hudson, Hanna J Szkudlarek, Enzo Pérez-Valenzuela, Taygun C Uzuneser, Emma Proud, Dana Gummerson, Miray Youssef, Madeline Machado, Kuralay Zhaksylyk, Marieka V DeVuono, Chaochao Chen, Ken K-C Yeung, Walter J Rushlow, Steven R Laviolett. Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-24. PMID:38521861. |
specifically, brain regions such as the medial prefrontal cortex (mpfc), the ventral tegmental area (vta), nucleus accumbens (nac) and hippocampus, are implicated in both nicotine dependence and pathological phenotypes linked to mood and anxiety disorders. |
2024-03-24 |
2024-03-26 |
rat |
| Tong Jiang, Shuyu Liang, Xiaohan Zhang, Shasha Dong, HaiFang Zhu, Ying Wang, Yanping Su. Parvalbumin neurons in the nucleus accumbens shell modulate seizure in temporal lobe epilepsy. Neurobiology of disease. 2024-03-24. PMID:38522590. |
ruby-virus mapping results identified that the hippocampus (ventral and dorsal) is one of the projection targets of nac shell pv neurons. |
2024-03-24 |
2024-03-27 |
Not clear |
| Kaili Du, Qianwen Shi, Xiuya Zhou, Lifei Zhang, Hongliang Su, Chao Zhang, Zhiwen Wei, Ting Liu, Li Wang, Xiaohui Wang, Bin Cong, Keming Yu. Melatonin attenuates fentanyl - induced behavioral sensitization and circadian rhythm disorders in mice. Physiology & behavior. 2024-03-16. PMID:38492912. |
the accompanying changes in the expression of brain and muscle arnt-like (bmal1), tyrosine hydroxylase (th), and monoamine oxidase a (mao-a) in relevant brain regions including the suprachiasmatic nucleus (scn), nucleus accumbens (nac), prefrontal cortex (pfc), and hippocampus (hip) were investigated by western blot assays to dissect the mechanism by which melatonin modulates fentanyl - induced behavioral sensitization and circadian rhythm disorders. |
2024-03-16 |
2024-03-19 |
mouse |
| Amira A Kamel, Ahmed Y Nassar, Fatma Y Meligy, Yomna A Omar, Gamal A Y Nassar, Ghada M Ezza. Acetylated oligopeptide and N-acetylcysteine protect against iron overload-induced dentate gyrus hippocampal degeneration through upregulation of Nestin and Nrf2/HO-1 and downregulation of MMP-9/TIMP-1 and GFAP. Cell biochemistry and function. vol 42. issue 2. 2024-02-24. PMID:38396357. |
we examined the preventive effects of acetylated oligopeptides (aop) from whey protein on iron-induced hippocampal damage compared to n-acetyl cysteine (nac). |
2024-02-24 |
2024-02-26 |
rat |
| Amira A Kamel, Ahmed Y Nassar, Fatma Y Meligy, Yomna A Omar, Gamal A Y Nassar, Ghada M Ezza. Acetylated oligopeptide and N-acetylcysteine protect against iron overload-induced dentate gyrus hippocampal degeneration through upregulation of Nestin and Nrf2/HO-1 and downregulation of MMP-9/TIMP-1 and GFAP. Cell biochemistry and function. vol 42. issue 2. 2024-02-24. PMID:38396357. |
we found that aop and nac can protect the brain hippocampus from iron overload, improve bbb disruption, and provide neuroprotection with mostly no significant difference from healthy controls. |
2024-02-24 |
2024-02-26 |
rat |
| Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Takashi Asano, Atsumi Nitt. Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice. Journal of pharmacological sciences. vol 154. issue 3. 2024-02-23. PMID:38395513. |
mice with meth (nac) exhibited cognitive dysfunction in behavioral analyses and decreased long-term potentiation in the hippocampus, with nac activation confirmed by expression of fosb, a neuronal activity marker. |
2024-02-23 |
2024-02-26 |
mouse |
| Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Takashi Asano, Atsumi Nitt. Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice. Journal of pharmacological sciences. vol 154. issue 3. 2024-02-23. PMID:38395513. |
in the hippocampus of mice with meth (nac), activated microglia, but not astroglia, and upregulated microglia-related genes, il1b and c1qa were observed. |
2024-02-23 |
2024-02-26 |
mouse |
| Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Takashi Asano, Atsumi Nitt. Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice. Journal of pharmacological sciences. vol 154. issue 3. 2024-02-23. PMID:38395513. |
finally, administration of minocycline, a tetracycline antibiotic with suppressive effect on microglial activation, to mice with meth (nac) ameliorated cognitive impairment and synaptic dysfunction by suppressing the increased expression of il1b and c1qa in the hippocampus. |
2024-02-23 |
2024-02-26 |
mouse |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. |
2024-02-20 |
2024-02-23 |
rat |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
our findings demonstrate that a brief ee exposure induces metaplastic changes in glutamatergic mpfc, nac and hipp. |
2024-02-20 |
2024-02-23 |
rat |
| Robin Nguyen, Sanghavy Sivakumaran, Evelyn K Lambe, Jun Chul Ki. Ventral hippocampal cholecystokinin interneurons gate contextual reward memory. iScience. vol 27. issue 2. 2024-02-02. PMID:38303709. |
here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vhpc) to nucleus accumbens (nac) circuit that is gated by cholecystokinin (cck) interneurons. |
2024-02-02 |
2024-02-04 |
Not clear |
| Ashley E Copenhaver, Tara A LeGate. Sex-specific mechanisms underlie long-term potentiation at hippocampus-nucleus accumbens synapses. bioRxiv : the preprint server for biology. 2024-01-31. PMID:38293132. |
the connection between the hippocampus (hipp) and nucleus accumbens (nac) is a crucial site where modulation of neuronal activity mediates reward-related behavior. |
2024-01-31 |
2024-02-02 |
mouse |
| Diego Romero-Miguel, Marta Casquero-Veiga, Nicolás Lamanna-Rama, Sonia Torres-Sánchez, Karina S MacDowell, José A García-Partida, Cristina Santa-Marta, Esther Berrocoso, Juan C Leza, Manuel Desco, María Luisa Soto-Montenegr. N-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia. Translational psychiatry. vol 14. issue 1. 2024-01-08. PMID:38191622. |
moreover, nac treatments during pregnancy not only replicated the beneficial outcomes reported by the treatment in periadolescence, but also prevented some neuroanatomical deficits, including reductions in hippocampal and corpus callosum volumes. |
2024-01-08 |
2024-01-10 |
rat |
| Madalyn Hafenbreidel, Surya Pandey, Sherri B Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D Cameron, Gavin Rumbaugh, Courtney A Mille. Basolateral Amygdala Corticotropin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory in Males. Neurobiology of learning and memory. 2023-11-23. PMID:37995804. |
the effect is highly selective, as nmii inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dphc], nucleus accumbens [nac]), nor does it interfere with associations for other aversive or appetitive stimuli, including cocaine (coc). |
2023-11-23 |
2023-11-29 |
mouse |