| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Yuan Zhang, Cui-Mei Zhao, Chang-Shui Wang, Xin Xie, Yu-Qi Li, Bei-Bei Chen, Lei Feng, Pei Jian. Methylglyoxal accumulation contributes to accelerated brain aging in spontaneously hypertensive rats. Free radical biology & medicine. 2023-11-20. PMID:37984752. |
nac decreased iba-1 immunofluorescence, inhibited the levels of pro-inflammatory markers, and enhanced the abundance of anti-inflammatory markers in the hippocampus of shrs. |
2023-11-20 |
2023-11-29 |
rat |
| Wen-Yuan Zhang, Cui-Mei Zhao, Chang-Shui Wang, Xin Xie, Yu-Qi Li, Bei-Bei Chen, Lei Feng, Pei Jian. Methylglyoxal accumulation contributes to accelerated brain aging in spontaneously hypertensive rats. Free radical biology & medicine. 2023-11-20. PMID:37984752. |
finally, nac was observed to inhibit apoptosis in the hippocampus of shrs. |
2023-11-20 |
2023-11-29 |
rat |
| Woonyen Wong, Youssef Sar. Effects of Chronic Hydrocodone Exposure and Ceftriaxone on the Expression of Astrocytic Glutamate Transporters in Mesocorticolimbic Brain Regions of C57/BL Mice. Toxics. vol 11. issue 10. 2023-10-27. PMID:37888720. |
our laboratory has shown that exposure to lower doses of hydrocodone reduced the expression of xct in the nucleus accumbens (nac) and the hippocampus. |
2023-10-27 |
2023-11-08 |
mouse |
| Pang-Ning Teng, Waleed Barakat, Sophie M Tran, Zoe M Tran, Nicholas W Bateman, Kelly A Conrads, Katlin N Wilson, Julie Oliver, Glenn Gist, Brian L Hood, Ming Zhou, G Larry Maxwell, Lorenzo Leggio, Thomas P Conrads, Mary R Le. Brain proteomic atlas of alcohol use disorder in adult males. Translational psychiatry. vol 13. issue 1. 2023-10-13. PMID:37833300. |
we performed a quantitative proteomic analysis using a liquid chromatography-tandem mass spectrometry (lc-ms/ms) analysis of human postmortem tissue from brain regions that play key roles in the development and maintenance of aud, the amygdala (amg), hippocampus (hipp), hypothalamus (hyp), nucleus accumbens (nac), prefrontal cortex (pfc) and ventral tegmental area (vta). |
2023-10-13 |
2023-10-15 |
human |
| Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Che. Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway. Neurobiology of stress. vol 26. 2023-09-04. PMID:37664874. |
concurrent with behavioral amelioration, the csds dbs-on group exhibited enhanced fc in the dopaminergic pathway with increased expression of bdnf- and neun-positive cells increased dopamine d1 receptor, dopamine d2 receptors, and th in the medial prefrontal cortex, nac, ventral hippocampus, ventral tegmental area, and amygdala. |
2023-09-04 |
2023-09-07 |
mouse |
| Courtney S Wilkinson, Harrison L Blount, Marek Schwendt, Lori A Knacksted. Brain Monoamine Dysfunction in Response to Predator Scent Stress Accompanies Stress-Susceptibility in Female Rats. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509091. |
using a predator scent stress (pss) rodent model of ptsd, we sought to determine if stress-susceptible female rats show altered monoamine concentrations in brain regions associated with ptsd: the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and dorsal (dhipp) and ventral (vhipp) hippocampus. |
2023-07-29 |
2023-08-14 |
rat |
| Debarpita Saha, Sangita Paul, Utkarsh Gaharwar, Anshu Priya, Anindita Neog, Archana Singh, Binukumar B. Cdk5-Mediated Brain Unfolded Protein Response Upregulation Associated with Cognitive Impairments in Type 2 Diabetes and Ameliorative Action of NAC. ACS chemical neuroscience. 2023-07-19. PMID:37468304. |
notably, we observed that oral treatment with nac decreased cdk5 kinase activity in the hippocampus, attenuated high levels of phospho-tau (ser396), and ameliorated memory and learning impairments in a type 2 diabetic (t2d) mouse model. |
2023-07-19 |
2023-08-14 |
mouse |
| Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-Xiang Liu, Cheng Lon. Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice. Stress (Amsterdam, Netherlands). vol 26. issue 1. 2023-07-03. PMID:37395260. |
here we report that cyld deficiency leads to an unexpected reaction to ars in mice, and is accompanied by significant neuronal activation of brain regions including the medial prefrontal cortex (mpfc), dorsal striatum (ds), nucleus accumbens (nac), and basal lateral amygdala (bla), but not ventral hippocampus (vhpc). |
2023-07-03 |
2023-08-14 |
mouse |
| Federica Lucantonio, Shuwen Li, Jaden Lu, Jacob Roeglin, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatell. Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333325. |
we found that ketamine rescues stress-induced reduction in excitatory strength at medial prefrontal cortex and ventral hippocampus inputs to nac d1-msns. |
2023-06-19 |
2023-08-14 |
mouse |
| Ihsan Serhatlioglu, Mete Ozcan, Emine Kacar, Tuncay Kuloglu, Nalan Kaya Tektemur, Funda Gulcu Bulmus, Ozgur Bulmus, Fatih Tan, Zubeyde Ercan, Nazife Ulker Ertugrul, Ahmet Yardımcı, Gokhan Zorlu, Haluk Kelestımu. TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300693. |
trpm2 immunoreactivity significantly increased in the hippocampus, prefrontal cortex (pfc), nucleus accumbens (nac), and amygdala regions by hfcs and cis treatments. |
2023-06-11 |
2023-08-14 |
rat |
| Madalyn Hafenbreidel, Sherri B Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D Cameron, Gavin Rumbaugh, Courtney A Mille. Basolateral Amygdala Corticotrophin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292925. |
dorsal hippocampus [dphc], nucleus accumbens [nac]), nor does it interfere with associations for other aversive or appetitive stimuli, including cocaine (coc). |
2023-06-09 |
2023-08-14 |
Not clear |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
evidence from previous literature suggests that the nucleus accumbens (nac), hippocampus, and amygdala play critical roles in the reward circuit. |
2023-06-04 |
2023-08-14 |
human |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
however, few studies have investigated the structural alterations of the nac, hippocampus, and amygdala in depression with anhedonia as the main clinical manifestation. |
2023-06-04 |
2023-08-14 |
human |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
thus, the current study aimed to explore the structural changes of the subcortical regions among melancholic depression (md) patients, especially in the nac, hippocampus, and amygdala, to provide a theoretical basis for understanding the pathological mechanisms of md. |
2023-06-04 |
2023-08-14 |
human |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
the reduced hippocampal volume may be related to the pathogenesis of major depressive disorder (mdd), and the reduced volume of the nac may be the unique neural mechanism of md. |
2023-06-04 |
2023-08-14 |
human |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
silent information regulator 1 (sirt1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa b (nf-κb), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β)), gene expression in the nucleus accumben (nac) and ca1 region of the hippocampus (e.g., nescient helix-loop-helix2 (nhlh2), monoamine oxidase (mao-a), and 5-hydroxyindole-3-acetic acid (5-hiaa)), and neuronal regeneration in the ca3 region of the hippocampus. |
2023-05-27 |
2023-08-14 |
Not clear |
| Diego Romero-Miguel, Marta Casquero-Veiga, Javier Fernández, Nicolás Lamanna-Rama, Vanessa Gómez-Rangel, Carlos Gálvez-Robleño, Cristina Santa-Marta, Claudio J Villar, Felipe Lombó, Raquel Abalo, Manuel Desco, María Luisa Soto-Montenegr. Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia. Antioxidants (Basel, Switzerland). vol 12. issue 4. 2023-04-28. PMID:37107344. |
nac treatment prevented hippocampal volume reduction and long-term memory deficits in mis-offspring. |
2023-04-28 |
2023-08-14 |
rat |
| Paola Brivio, Maria Teresa Gallo, Piotr Gruca, Magdalena Lason, Ewa Litwa, Fabio Fumagalli, Mariusz Papp, Francesca Calabres. Chronic N-Acetyl-Cysteine Treatment Enhances the Expression of the Immediate Early Gene International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108481. |
we found that nac enhanced the expression of several immediate early genes, markers of neuronal plasticity in the ventral and dorsal hippocampus, prefrontal cortex and amygdala, and in particular it mediated the acute-stress-induced upregulation of |
2023-04-28 |
2023-08-14 |
rat |
| Liang Wang, Qingfan Wei, Rui Xu, Yaxing Chen, Shu Li, Qian Bu, Ying Zhao, Hongchun Li, Yue Zhao, Linhong Jiang, Yuanyuan Chen, Yanping Dai, Yinglan Zhao, Xiaobo Ce. Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice. ACS chemical neuroscience. 2023-04-12. PMID:37043723. |
the results showed that meth remodeled the mitochondrial lipidome of the hippocampus, nucleus accumbens (nac), and striatum in both models. |
2023-04-12 |
2023-08-14 |
mouse |
| Linxuan Zhang, Zehao Zeng, Xiaoyu Lu, Mengqing Li, Jiayu Yao, Guangjing Zou, Zhaorong Chen, Qian Li, Changqi Li, Fang L. CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice. Neurotoxicity research. 2023-04-04. PMID:37014368. |
therefore, in the present study, we established mouse models of single and repeated meth exposure and subsequently determined that cntn1 expression in the nucleus accumbens (nac) was upregulated in mice following single or repeated meth exposure, whereas cntn1 expression in the hippocampus was not significantly altered. |
2023-04-04 |
2023-08-14 |
mouse |