| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin vol issue 2023 36870621 |
investigation of the memory-associated gene pacap and its receptor pac1r revealed differential effects of hfd on their expression in the hippocampus and amygdala. |
2023-03-04 |
2023-03-06 |
rat |
| Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin vol issue 2023 36870621 |
specifically, hfd induced increased expression of pacap and pac1r in the hippocampus, whereas decreased pacap was observed in the amygdala. |
2023-03-04 |
2023-03-06 |
rat |
| Tam\\xc3\\xa1s Gaszner, J\\xc3\\xb3zsef Farkas, D\\xc3\\xa1niel Kun, Bal\\xc3\\xa1zs Ujv\\xc3\\xa1ri, N\\xc3\\xb3ra F\\xc3\\xbcredi, L\\xc3\\xa1szl\\xc3\\xb3 \\xc3\\x81kos Kov\\xc3\\xa1cs, Hitoshi Hashimoto, D\\xc3\\xb3ra Regl\\xc5\\x91di, Vikt\\xc3\\xb3ria Kormos, Bal\\xc3\\xa1zs Gaszne. Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice. International journal of molecular sciences vol 23 issue 19 2022 36233039 |
epigenetic and neuronal activity markers suggest the recruitment of the prefrontal cortex and hippocampus in the three-hit model of depression in male pacap heterozygous mice. |
2022-10-14 |
2023-01-30 |
mouse |
| Hailou Zhang, Yan Sun, Suk-Yu Yau, Yanmeng Zhou, Xinxin Song, Han-Ting Zhang, Boran Zhu, Haoxin Wu, Gang Che. Synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal PACAP signaling. British journal of pharmacology vol issue 2022 35362097 |
synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal pacap signaling. |
2022-04-01 |
2023-01-27 |
Not clear |
| Melissa N Boucher, Victor May, Karen M Braas, Sayamwong E Hammac. PACAP orchestration of stress-related responses in neural circuits. Peptides vol 142 issue 2021 33865930 |
pacap can also influence both the consolidation and expression of fear memories, as demonstrated by studies in several fear-related areas, such as the amygdala, hippocampus, and prefrontal cortex. |
2021-11-17 |
2023-01-26 |
human |
| Scheila Daiane Schmidt, Carolina Garrido Zinn, Jonny Anderson Kielbovicz Behling, Ana Fl\\xc3\\xa1via Furian, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Ivan Izquierd. Inhibition of PACAP/PAC1/VPAC2 signaling impairs the consolidation of social recognition memory and nitric oxide prevents this deficit. Neurobiology of learning and memory vol 180 issue 2021 33705861 |
in the present work, we investigate the effect of the infusion of pacap-38 (endogenous neuropeptide and potent stimulator of adenylyl cyclase), pacap 6-38 (pac1/vpac2 receptors antagonist) and s-nitroso-n-acetyl-dl-penicillamine (snap, no donor) in the ca1 region of the hippocampus and in the basolateral amygdala (bla) on the consolidation of srm. |
2021-06-18 |
2023-01-26 |
rat |
| Lucia Ciranna, Lara Cost. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Frontiers in cellular neuroscience vol 13 issue 2020 31827422 |
pituitary adenylate cyclase-activating polypeptide (pacap) modulates glutamatergic synaptic transmission and plasticity in the hippocampus, a brain area with a key role in learning and memory. |
2020-10-01 |
2023-01-26 |
Not clear |
| Lucia Ciranna, Lara Cost. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Frontiers in cellular neuroscience vol 13 issue 2020 31827422 |
in this context, results from our laboratory demonstrate that pacap rescued metabotropic glutamate receptor-mediated synaptic plasticity in the hippocampus of a mouse model of fragile x syndrome (fxs), a genetic form of intellectual disability. |
2020-10-01 |
2023-01-26 |
Not clear |
| Gregory C Johnson, Rodney Parsons, Victor May, Sayamwong E Hammac. The Role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signaling in the Hippocampal Dentate Gyrus. Frontiers in cellular neuroscience vol 14 issue 2020 32425759 |
the role of pituitary adenylate cyclase-activating polypeptide (pacap) signaling in the hippocampal dentate gyrus. |
2020-09-28 |
2023-01-26 |
Not clear |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory vol 157 issue 2019 30458282 |
pacap can alter synaptic plasticity and has direct actions on neurons in the amygdala and hippocampus that could contribute to its acute and persistent effects on the consolidation and expression of conditioned fear. |
2019-11-25 |
2023-01-26 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory vol 157 issue 2019 30458282 |
we recently demonstrated that intracerebroventricular (icv) infusion of pacap prior to fear conditioning (fc) results in initial amnestic-like effects followed by hyper-expression of conditioned freezing with repeated testing, and analyses of immediate-early gene c-fos expression suggested that the central nucleus of the amygdala (cea), but not the lateral/basolateral amygdala (la/bla) or hippocampus, are involved in these pacap effects. |
2019-11-25 |
2023-01-26 |
rat |
| N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease. Molecular neurobiology vol 55 issue 11 2018 29526016 |
pituitary adenylate cyclase-activating polypeptide (pacap) enhances hippocampal synaptic plasticity and improves memory performance in huntington's disease. |
2018-12-17 |
2023-01-26 |
mouse |
| N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease. Molecular neurobiology vol 55 issue 11 2018 29526016 |
first, we observed a hippocampal decline of all three pacap receptor expressions, i.e., pac1, vpac1, and vpac2, in two different hd mouse models, r6/1 and hdhq7/q111, from the onset of cognitive dysfunction. |
2018-12-17 |
2023-01-26 |
mouse |
| N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease. Molecular neurobiology vol 55 issue 11 2018 29526016 |
we found that pacap treatment rescued pac1 level in r6/1 mice, promoted expression of the hippocampal brain-derived neurotrophic factor, and reduced the formation of mutant huntingtin aggregates. |
2018-12-17 |
2023-01-26 |
mouse |
| N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease. Molecular neurobiology vol 55 issue 11 2018 29526016 |
importantly, the effect of pacap on cognitive performance was associated with an increase of vglut-1 and psd95 immunolabeling in hippocampus of r6/1 mice. |
2018-12-17 |
2023-01-26 |
mouse |
| J Huang, K A Waters, R Machaalan. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). Neurobiology of disease vol 103 issue 2018 28392470 |
this study establishes a detailed interpretation of the neuroanatomical distribution and localization of both pacap and pac1 in the human infant brainstem and hippocampus, to determine whether any changes in expression are evident in infants who died of sudden infant death syndrome (sids) and any relationships to risk factors of sids including smoke exposure and sleep related parameters. |
2018-03-02 |
2023-01-26 |
mouse |
| J Huang, K A Waters, R Machaalan. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). Neurobiology of disease vol 103 issue 2018 28392470 |
the highest expression of pacap was found in the hypoglossal (xii) of the brainstem medulla and lowest expression in the subiculum of the hippocampus. |
2018-03-02 |
2023-01-26 |
mouse |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience vol 340 issue 2017 27816700 |
a subnanomolar concentration of pituitary adenylate cyclase-activating polypeptide (pacap) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. |
2017-11-07 |
2023-01-26 |
rat |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience vol 340 issue 2017 27816700 |
the neuropeptide pacap modulates synaptic transmission in the hippocampus exerting multiple effects through different receptor subtypes: the underlying mechanisms have not yet been completely elucidated. |
2017-11-07 |
2023-01-26 |
rat |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience vol 340 issue 2017 27816700 |
since pacap was shown to stimulate ach release in the hippocampus, we tested whether pacap acting through ach might indirectly modulate glutamate-mediated synaptic transmission at a pre- and/or at a post-synaptic level. |
2017-11-07 |
2023-01-26 |
rat |