All Relations between hippocampus and pacap

Publication Sentence Publish Date Extraction Date Species
Steven J Granger, Victor May, Sayamwong E Hammack, Eylül Akman, Sydney A Jobson, Elizabeth A Olson, Cameron D Pernia, Nikos P Daskalakis, Caitlin Ravichandran, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. medRxiv : the preprint server for health sciences. 2023-09-11. PMID:37693514. research in animal models suggests that pacap modulates entorhinal cortex (ec) input to the hippocampus, contributing to impaired contextual fear conditioning. 2023-09-11 2023-10-07 Not clear
Steven J Granger, Victor May, Sayamwong E Hammack, Eylül Akman, Sydney A Jobson, Elizabeth A Olson, Cameron D Pernia, Nikos P Daskalakis, Caitlin Ravichandran, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. medRxiv : the preprint server for health sciences. 2023-09-11. PMID:37693514. in ptsd, pacap is associated with higher activity of the amygdala to threat stimuli and lower functional connectivity of the amygdala and hippocampus. 2023-09-11 2023-10-07 Not clear
Steven J Granger, Victor May, Sayamwong E Hammack, Eylül Akman, Sydney A Jobson, Elizabeth A Olson, Cameron D Pernia, Nikos P Daskalakis, Caitlin Ravichandran, William A Carlezon, Kerry J Ressler, Scott L Rauch, Isabelle M Ross. Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. medRxiv : the preprint server for health sciences. 2023-09-11. PMID:37693514. here, we examined whether peripheral pacap levels were associated with neuronal morphology of the amygdala and hippocampus (primary analysis), and ec (secondary analysis) using neurite orientation dispersion and density imaging. 2023-09-11 2023-10-07 Not clear
Dana Bakalar, Oksana Gavrilova, Sunny Z Jiang, Hai-Ying Zhang, Snehashis Roy, Sarah K Williams, Naili Liu, Stephen Wisser, Ted B Usdin, Lee E Eide. Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP. Journal of neuroendocrinology. 2023-06-13. PMID:37309259. comparing constitutive pacap knockout mice to a variety of temporally and regionally specific pacap knockouts, we show that the prominent hyperlocomotor phenotype is a consequence of early loss of pacap expression, is associated with fos overexpression in hippocampus and basal ganglia, and that a thermoregulatory effect previously shown to be mediated by pacap-expressing neurons of medial preoptic hypothalamus is independent of pacap expression in those neurons in adult mice. 2023-06-13 2023-08-14 mouse
Li Ren, Hailou Zhang, Weiwei Tao, Wenda Xue, Yin Chen, Zhilu Zou, Xiaoyan Guo, Qinqin Shen, Wei Wang, Haitang Jiang, Juanjuan Tang, Quansheng Feng, Gang Che. Hippocampal pituitary adenylate cyclase-activating polypeptide mediates rapid antidepressant-like effects of Yueju pill. Neuropeptides. vol 101. 2023-06-07. PMID:37285664. mice with hippocampal pacap knockdown via viral-mediated rnai displayed depression-like behavior. 2023-06-07 2023-08-14 mouse
Li Ren, Hailou Zhang, Weiwei Tao, Wenda Xue, Yin Chen, Zhilu Zou, Xiaoyan Guo, Qinqin Shen, Wei Wang, Haitang Jiang, Juanjuan Tang, Quansheng Feng, Gang Che. Hippocampal pituitary adenylate cyclase-activating polypeptide mediates rapid antidepressant-like effects of Yueju pill. Neuropeptides. vol 101. 2023-06-07. PMID:37285664. we also identified iridoids fraction of gardenia jasminoides ellis (gj-if), a vital component of the yueju pill, was identified to recapitulate rapid antidepressant-like behavior through increased hippocampal pacap expression of the yueju pill. 2023-06-07 2023-08-14 mouse
Li Ren, Hailou Zhang, Weiwei Tao, Wenda Xue, Yin Chen, Zhilu Zou, Xiaoyan Guo, Qinqin Shen, Wei Wang, Haitang Jiang, Juanjuan Tang, Quansheng Feng, Gang Che. Hippocampal pituitary adenylate cyclase-activating polypeptide mediates rapid antidepressant-like effects of Yueju pill. Neuropeptides. vol 101. 2023-06-07. PMID:37285664. the promotion of hippocampal pacap may collectively represent a novel mechanism of rapid antidepressant-like effect. 2023-06-07 2023-08-14 mouse
Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin. 2023-03-04. PMID:36870621. investigation of the memory-associated gene pacap and its receptor pac1r revealed differential effects of hfd on their expression in the hippocampus and amygdala. 2023-03-04 2023-08-14 rat
Stephanie M Muscat, Michael J Butler, Sabrina E Mackey-Alfonso, Ruth M Barriento. Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet. Brain research bulletin. 2023-03-04. PMID:36870621. specifically, hfd induced increased expression of pacap and pac1r in the hippocampus, whereas decreased pacap was observed in the amygdala. 2023-03-04 2023-08-14 rat
Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszne. Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233039. epigenetic and neuronal activity markers suggest the recruitment of the prefrontal cortex and hippocampus in the three-hit model of depression in male pacap heterozygous mice. 2022-10-14 2023-08-14 mouse
Hailou Zhang, Yan Sun, Suk-Yu Yau, Yanmeng Zhou, Xinxin Song, Han-Ting Zhang, Boran Zhu, Haoxin Wu, Gang Che. Synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal PACAP signaling. British journal of pharmacology. 2022-04-01. PMID:35362097. synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal pacap signaling. 2022-04-01 2023-08-13 Not clear
Melissa N Boucher, Victor May, Karen M Braas, Sayamwong E Hammac. PACAP orchestration of stress-related responses in neural circuits. Peptides. vol 142. 2021-11-17. PMID:33865930. pacap can also influence both the consolidation and expression of fear memories, as demonstrated by studies in several fear-related areas, such as the amygdala, hippocampus, and prefrontal cortex. 2021-11-17 2023-08-13 human
Scheila Daiane Schmidt, Carolina Garrido Zinn, Jonny Anderson Kielbovicz Behling, Ana Flávia Furian, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, Ivan Izquierd. Inhibition of PACAP/PAC1/VPAC2 signaling impairs the consolidation of social recognition memory and nitric oxide prevents this deficit. Neurobiology of learning and memory. vol 180. 2021-06-18. PMID:33705861. in the present work, we investigate the effect of the infusion of pacap-38 (endogenous neuropeptide and potent stimulator of adenylyl cyclase), pacap 6-38 (pac1/vpac2 receptors antagonist) and s-nitroso-n-acetyl-dl-penicillamine (snap, no donor) in the ca1 region of the hippocampus and in the basolateral amygdala (bla) on the consolidation of srm. 2021-06-18 2023-08-13 rat
Lucia Ciranna, Lara Cost. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31827422. pituitary adenylate cyclase-activating polypeptide (pacap) modulates glutamatergic synaptic transmission and plasticity in the hippocampus, a brain area with a key role in learning and memory. 2020-10-01 2023-08-13 mouse
Lucia Ciranna, Lara Cost. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31827422. in this context, results from our laboratory demonstrate that pacap rescued metabotropic glutamate receptor-mediated synaptic plasticity in the hippocampus of a mouse model of fragile x syndrome (fxs), a genetic form of intellectual disability. 2020-10-01 2023-08-13 mouse
Gregory C Johnson, Rodney Parsons, Victor May, Sayamwong E Hammac. The Role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signaling in the Hippocampal Dentate Gyrus. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32425759. the role of pituitary adenylate cyclase-activating polypeptide (pacap) signaling in the hippocampal dentate gyrus. 2020-09-28 2023-08-13 Not clear
Atsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A Waschek, Hitoshi Hashimot. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 22. 2020-06-12. PMID:30886013. pacap modified the density and morphology of psd-95-positive spines in primary cultured hippocampal neurons. 2020-06-12 2023-08-13 human
Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. pacap can alter synaptic plasticity and has direct actions on neurons in the amygdala and hippocampus that could contribute to its acute and persistent effects on the consolidation and expression of conditioned fear. 2019-11-25 2023-08-13 rat
Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. we recently demonstrated that intracerebroventricular (icv) infusion of pacap prior to fear conditioning (fc) results in initial amnestic-like effects followed by hyper-expression of conditioned freezing with repeated testing, and analyses of immediate-early gene c-fos expression suggested that the central nucleus of the amygdala (cea), but not the lateral/basolateral amygdala (la/bla) or hippocampus, are involved in these pacap effects. 2019-11-25 2023-08-13 rat
b' N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington\'s Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29526016.' pituitary adenylate cyclase-activating polypeptide (pacap) enhances hippocampal synaptic plasticity and improves memory performance in huntington's disease. 2018-12-17 2023-08-13 mouse