| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington\'s Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29526016.' |
first, we observed a hippocampal decline of all three pacap receptor expressions, i.e., pac1, vpac1, and vpac2, in two different hd mouse models, r6/1 and hdhq7/q111, from the onset of cognitive dysfunction. |
2018-12-17 |
2023-08-13 |
mouse |
| b' N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington\'s Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29526016.' |
we found that pacap treatment rescued pac1 level in r6/1 mice, promoted expression of the hippocampal brain-derived neurotrophic factor, and reduced the formation of mutant huntingtin aggregates. |
2018-12-17 |
2023-08-13 |
mouse |
| b' N Cabezas-Llobet, L Vidal-Sancho, M Masana, A Fournier, J Alberch, D Vaudry, X Xifr\\xc3\\xb. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington\'s Disease. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29526016.' |
importantly, the effect of pacap on cognitive performance was associated with an increase of vglut-1 and psd95 immunolabeling in hippocampus of r6/1 mice. |
2018-12-17 |
2023-08-13 |
mouse |
| J Huang, K A Waters, R Machaalan. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). Neurobiology of disease. vol 103. 2018-03-02. PMID:28392470. |
this study establishes a detailed interpretation of the neuroanatomical distribution and localization of both pacap and pac1 in the human infant brainstem and hippocampus, to determine whether any changes in expression are evident in infants who died of sudden infant death syndrome (sids) and any relationships to risk factors of sids including smoke exposure and sleep related parameters. |
2018-03-02 |
2023-08-13 |
mouse |
| J Huang, K A Waters, R Machaalan. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). Neurobiology of disease. vol 103. 2018-03-02. PMID:28392470. |
the highest expression of pacap was found in the hypoglossal (xii) of the brainstem medulla and lowest expression in the subiculum of the hippocampus. |
2018-03-02 |
2023-08-13 |
mouse |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience. vol 340. 2017-11-07. PMID:27816700. |
a subnanomolar concentration of pituitary adenylate cyclase-activating polypeptide (pacap) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. |
2017-11-07 |
2023-08-13 |
rat |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience. vol 340. 2017-11-07. PMID:27816700. |
the neuropeptide pacap modulates synaptic transmission in the hippocampus exerting multiple effects through different receptor subtypes: the underlying mechanisms have not yet been completely elucidated. |
2017-11-07 |
2023-08-13 |
rat |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience. vol 340. 2017-11-07. PMID:27816700. |
since pacap was shown to stimulate ach release in the hippocampus, we tested whether pacap acting through ach might indirectly modulate glutamate-mediated synaptic transmission at a pre- and/or at a post-synaptic level. |
2017-11-07 |
2023-08-13 |
rat |
| Valeria Pecoraro, Lara Maria Sardone, Mariangela Chisari, Flora Licata, Guido Li Volsi, Vincenzo Perciavalle, Lucia Ciranna, Lara Cost. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience. vol 340. 2017-11-07. PMID:27816700. |
using patch clamp on rat hippocampal slices, we tested pacap effects on stimulation-evoked ampa receptor-mediated excitatory post-synaptic currents (epscs |
2017-11-07 |
2023-08-13 |
rat |
| Minako Matsumoto, Tomoya Nakamachi, Jun Watanabe, Koichi Sugiyama, Hirokazu Ohtaki, Norimitsu Murai, Shun Sasaki, Zhifang Xu, Hitoshi Hashimoto, Tamotsu Seki, Akira Miyazaki, Seiji Shiod. Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke. Journal of molecular neuroscience : MN. vol 59. issue 2. 2017-03-09. PMID:26910758. |
pituitary adenylate cyclase-activating polypeptide (pacap) is involved in adult mouse hippocampal neurogenesis after stroke. |
2017-03-09 |
2023-08-13 |
mouse |
| R Marzagalli, G M Leggio, C Bucolo, E Pricoco, K A Keay, V Cardile, S Castorina, S Salomone, F Drago, A Castorin. Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution. Neuroscience. vol 316. 2016-10-18. PMID:26718601. |
genetic blockade of the dopamine d3 receptor enhances hippocampal expression of pacap and receptors and alters their cortical distribution. |
2016-10-18 |
2023-08-13 |
mouse |
| R Marzagalli, G M Leggio, C Bucolo, E Pricoco, K A Keay, V Cardile, S Castorina, S Salomone, F Drago, A Castorin. Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution. Neuroscience. vol 316. 2016-10-18. PMID:26718601. |
to address this issue, levels of pacap and its receptors were compared in the hippocampus and cerebral cortex (cx) of mice devoid of functional d3rs (d3r(-/-)) and wild-types (wts) using a series of comparative immunohistochemical and biochemical analyses. |
2016-10-18 |
2023-08-13 |
mouse |
| R Marzagalli, G M Leggio, C Bucolo, E Pricoco, K A Keay, V Cardile, S Castorina, S Salomone, F Drago, A Castorin. Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution. Neuroscience. vol 316. 2016-10-18. PMID:26718601. |
pacap levels were increased in the hippocampus of d3r(-/-) mice. |
2016-10-18 |
2023-08-13 |
mouse |
| Raeesa P Gupte, Suraj Kadunganattil, Andrew J Shepherd, Ronald Merrill, William Planer, Michael R Bruchas, Stefan Strack, Durga P Mohapatr. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology. vol 101. 2016-10-05. PMID:26456351. |
we identified, cloned and characterized the downstream signaling originating from the activation of three pacap receptor (pac1) isoforms that are expressed in rodent hippocampal neurons that also exhibit abundant expression of kv4.2 protein. |
2016-10-05 |
2023-08-13 |
Not clear |
| Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimot. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PloS one. vol 10. issue 3. 2016-02-17. PMID:25807538. |
pacap enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as bdnf. |
2016-02-17 |
2023-08-13 |
Not clear |
| Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimot. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PloS one. vol 10. issue 3. 2016-02-17. PMID:25807538. |
pituitary adenylate cyclase-activating polypeptide (pacap) exerts neurotrophic activities including modulation of synaptic plasticity and memory, hippocampal neurogenesis, and neuroprotection, most of which are shared with brain-derived neurotrophic factor (bdnf). |
2016-02-17 |
2023-08-13 |
Not clear |
| Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimot. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PloS one. vol 10. issue 3. 2016-02-17. PMID:25807538. |
therefore, the aim of this study was to compare morphological effects of pacap and bdnf on primary cultured hippocampal neurons. |
2016-02-17 |
2023-08-13 |
Not clear |
| Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimot. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PloS one. vol 10. issue 3. 2016-02-17. PMID:25807538. |
these results indicate that in primary cultured hippocampal neurons, pacap shows morphological actions via its cognate receptor pac1, stimulating neurite length and number, and soma size to a comparable extent as bdnf, and that the increase in total neurite length is ascribed to axon outgrowth. |
2016-02-17 |
2023-08-13 |
Not clear |
| S D Schmidt, J C Myskiw, C R G Furini, B E Schmidt, L E Cavalcante, I Izquierd. PACAP modulates the consolidation and extinction of the contextual fear conditioning through NMDA receptors. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25490058. |
thus, in the current study we investigated in the ca1 region of hippocampus and in the basolateral amygdala (bla) the role of pacap in the consolidation and extinction of contextual fear conditioning (cfc) and the interaction between pacap and nmda receptors. |
2015-11-10 |
2023-08-13 |
rat |
| S D Schmidt, J C Myskiw, C R G Furini, B E Schmidt, L E Cavalcante, I Izquierd. PACAP modulates the consolidation and extinction of the contextual fear conditioning through NMDA receptors. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25490058. |
male rats with cannulae implanted in the ca1 region of the hippocampus or in the bla received immediately after the training or extinction training of the cfc infusions of the vehicle, pacap-38 (40 pg/side), pacap 6-38 (40 pg/side) or pacap 6-38 plus d-serine (50 μg/side). |
2015-11-10 |
2023-08-13 |
rat |