| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Schmidt, J C Myskiw, C R G Furini, B E Schmidt, L E Cavalcante, I Izquierd. PACAP modulates the consolidation and extinction of the contextual fear conditioning through NMDA receptors. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25490058. |
the results indicated that in the ca1 region of hippocampus, pacap participates in the consolidation and extinction of the cfc, and in the bla, pacap participates only in the consolidation of the cfc. |
2015-11-10 |
2023-08-13 |
rat |
| Kazuhiro Takuma, Yuko Maeda, Yukio Ago, Toshihiro Ishihama, Kosuke Takemoto, Akira Nakagawa, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsud. An enriched environment ameliorates memory impairments in PACAP-deficient mice. Behavioural brain research. vol 272. 2015-07-16. PMID:25014004. |
in both wild-type and pacap(-/-) mice, ee increased the protein levels of the nmda receptor nr2b subunit, phospho-erk, phospho-camkii, and brain-derived neurotrophic factor (bdnf) in the hippocampus, and decreased neurotrophin-3 levels, whereas it did not affect nerve growth factor and glial cell-derived neurotrophic factor levels. |
2015-07-16 |
2023-08-13 |
mouse |
| Jennifer Strafford Stevens, Lynn M Almli, Negar Fani, David A Gutman, Bekh Bradley, Seth D Norrholm, Emily Reiser, Timothy D Ely, Rahim Dhanani, Ebony M Glover, Tanja Jovanovic, Kerry J Ressle. PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 8. 2014-04-22. PMID:24516127. |
pacap receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. |
2014-04-22 |
2023-08-12 |
Not clear |
| Jennifer Strafford Stevens, Lynn M Almli, Negar Fani, David A Gutman, Bekh Bradley, Seth D Norrholm, Emily Reiser, Timothy D Ely, Rahim Dhanani, Ebony M Glover, Tanja Jovanovic, Kerry J Ressle. PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 8. 2014-04-22. PMID:24516127. |
analyses focused on the amygdala and hippocampus, regions that play central roles in the pathophysiology of ptsd and are known to have high densities of pacap receptors. |
2014-04-22 |
2023-08-12 |
Not clear |
| Shan-Shan Mao, Rong Hua, Xiao-Ping Zhao, Xia Qin, Zhen-Quan Sun, Yang Zhang, Yu-Qing Wu, Meng-Xing Jia, Jun-Li Cao, Yong-Mei Zhan. Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-κB pathway. Journal of neurotrauma. vol 29. issue 10. 2013-05-22. PMID:22583372. |
pretreatment with pacap inhibited upregulation of tlr4 and its downstream signaling molecules myd88, p-iκb, and nf-κb, and suppressed increases in the levels of the downstream inflammatory agents interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α), in the brain tissue around the injured cortex and in the hippocampus. |
2013-05-22 |
2023-08-12 |
rat |
| Yuki Kambe, Atsuro Miyat. Role of mitochondrial activation in PACAP dependent neurite outgrowth. Journal of molecular neuroscience : MN. vol 48. issue 3. 2013-04-19. PMID:22460784. |
when mouse primary hippocampal neurons and neuro2a cells were exposed to pacap, neurite outgrowth and the mitochondrial membrane potential increased in both cell types. |
2013-04-19 |
2023-08-12 |
mouse |
| Tomoya Nakamachi, Masashi Tsuchida, Nobuyuki Kagami, Sachiko Yofu, Yoshihiro Wada, Motohide Hori, Daisuke Tsuchikawa, Akira Yoshikawa, Nori Imai, Keisuke Nakamura, Satoru Arata, Seiji Shiod. IL-6 and PACAP receptor expression and localization after global brain ischemia in mice. Journal of molecular neuroscience : MN. vol 48. issue 3. 2013-04-19. PMID:22669509. |
however, as the expression patterns of pacap receptors and il-6 following ischemia are not understood, we evaluated them in the mouse hippocampus in response to ischemia induced by bilateral common carotid artery occlusion. |
2013-04-19 |
2023-08-12 |
mouse |
| Lan-Run Gui, Wen-Bin Li, Bing-Lie Zhan. [Activation of PACAP receptor could protect cultured hippocampal neurons against beta amyloid peptide induced neurotoxicity]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 18. issue 2. 2012-12-03. PMID:21179800. |
[activation of pacap receptor could protect cultured hippocampal neurons against beta amyloid peptide induced neurotoxicity]. |
2012-12-03 |
2023-08-12 |
Not clear |
| Lan-Run Gui, Wen-Bin Li, Bing-Lie Zhan. [Activation of PACAP receptor could protect cultured hippocampal neurons against beta amyloid peptide induced neurotoxicity]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 18. issue 2. 2012-12-03. PMID:21179800. |
to observe the protective role of pituitary adenylate cyclase activating polypeptide (pacap) on hippocampal neuronal apoptosis induced by beta amyloid peptide in the culture. |
2012-12-03 |
2023-08-12 |
Not clear |
| Lisa Gasperini, Chiara Piubelli, Lucia Carbon. Proteomics of rat hypothalamus, hippocampus and pre-frontal/frontal cortex after central administration of the neuropeptide PACAP. Molecular biology reports. vol 39. issue 3. 2012-05-25. PMID:21687973. |
proteomics of rat hypothalamus, hippocampus and pre-frontal/frontal cortex after central administration of the neuropeptide pacap. |
2012-05-25 |
2023-08-12 |
rat |
| Lisa Gasperini, Chiara Piubelli, Lucia Carbon. Proteomics of rat hypothalamus, hippocampus and pre-frontal/frontal cortex after central administration of the neuropeptide PACAP. Molecular biology reports. vol 39. issue 3. 2012-05-25. PMID:21687973. |
a proteomics investigation was carried out in hypothalamus, hippocampus and pre-frontal/frontal cortex (p/fc) using 2-dimensional gel electrophoresis at 120 min, the end-point suggested by studies on pacap hypophysiotropic activities. |
2012-05-25 |
2023-08-12 |
rat |
| P Du, C H Lee, J H Choi, K-Y Yoo, Y L Lee, I-J Kang, I K Hwang, J-D Kim, M-H Wo. Pituitary adenylate cyclase-activating polypeptide-immunoreactive cells in the ageing gerbil hippocampus. Anatomia, histologia, embryologia. vol 40. issue 5. 2012-01-18. PMID:21545645. |
in the present study, we investigated age-related changes in pituitary adenylate cyclase-activating polypeptide (pacap) immunoreactivity and its protein levels in the gerbil hippocampus at various ages using immunohistochemistry and western blot analysis. |
2012-01-18 |
2023-08-12 |
Not clear |
| P Du, C H Lee, J H Choi, K-Y Yoo, Y L Lee, I-J Kang, I K Hwang, J-D Kim, M-H Wo. Pituitary adenylate cyclase-activating polypeptide-immunoreactive cells in the ageing gerbil hippocampus. Anatomia, histologia, embryologia. vol 40. issue 5. 2012-01-18. PMID:21545645. |
however, pacap immunoreactivity in the mossy fibre zone and pacap protein level in the hippocampus are highest in the adult stage. |
2012-01-18 |
2023-08-12 |
Not clear |
| Y Ago, M Yoneyama, T Ishihama, S Kataoka, K Kawada, T Tanaka, K Ogita, N Shintani, H Hashimoto, A Baba, K Takuma, T Matsud. Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis. Neuroscience. vol 172. 2011-12-05. PMID:20974227. |
the present study investigated the role of pituitary adenylate cyclase-activating polypeptide (pacap) in adult hippocampal neurogenesis under standard or enriched rearing conditions. |
2011-12-05 |
2023-08-12 |
mouse |
| Y Ago, M Yoneyama, T Ishihama, S Kataoka, K Kawada, T Tanaka, K Ogita, N Shintani, H Hashimoto, A Baba, K Takuma, T Matsud. Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis. Neuroscience. vol 172. 2011-12-05. PMID:20974227. |
these findings suggest that endogenous pacap is partly involved in the survival of the enriched environment-induced generation, but not in the basal rate, of newborn cells in the dentate gyrus of the adult hippocampus. |
2011-12-05 |
2023-08-12 |
mouse |
| Raita Tamaki, Masanobu Yoshikawa, Takashi Shinomiya, Hidehiro Andoh, Mitsuru Kawaguchi, Atsushi Hashimoto, Daniel W Byrne, Hiroyuki Kobayash. Chronic administration of methamphetamine increases the mRNA expression of diazepam binding inhibitor in rat brain. The Tokai journal of experimental and clinical medicine. vol 33. issue 1. 2011-08-05. PMID:21318965. |
we examined the effect of chronic administration of map on the mrna expression of dbi and dbi-related proteins, such as alpha 2 subunit of gabaa receptor (gaba-α2), peripheral-type benzodiazepine receptor (pbr), and pituitary adenylate cyclase-activating polypeptide (pacap) in seven regions (diencephalon, cerebral cortex, cerebellum, striatum, hippocampus, midbrain, and pons-medulla) of the rat brain. |
2011-08-05 |
2023-08-12 |
rat |
| Melissa M J Farnham, Paul M Pilowsk. The role of PACAP in central cardiorespiratory regulation. Respiratory physiology & neurobiology. vol 174. issue 1-2. 2011-03-02. PMID:20470908. |
pituitary adenylate cyclase activating polypeptide (pacap) plays a role in almost every biological process from reproduction to hippocampal function. |
2011-03-02 |
2023-08-12 |
mouse |
| Leslayann C Schecterson, Mark P Hudson, Mabel Ko, Polyxeni Philippidou, Wendy Akmentin, Jesse Wiley, Elise Rosenblum, Moses V Chao, Simon Halegoua, Mark Bothwel. Trk activation in the secretory pathway promotes Golgi fragmentation. Molecular and cellular neurosciences. vol 43. issue 4. 2010-06-15. PMID:20123019. |
transactivation of nascent trkb in hippocampal neurons resulting from exposure to the neuropeptide pacap caused golgi fragmentation, whereas bdnf-dependent activation of trkb did not. |
2010-06-15 |
2023-08-12 |
Not clear |
| Kohei Yamada, Shinsuke Matsuzaki, Tsuyoshi Hattori, Ryusuke Kuwahara, Manabu Taniguchi, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Natsuko Kumamoto, Kazuo Yamada, Takeo Yoshikawa, Taiichi Katayama, Masaya Tohyam. Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations. PloS one. vol 5. issue 1. 2010-05-20. PMID:20062533. |
pacap stimulation inhibited stathmin1 expression in pc12 cells, while increased stathmin1expression in neurons of the subgranular zone and in primary cultured hippocampal neurons induced abnormal arborization of axons. |
2010-05-20 |
2023-08-12 |
mouse |
| R Anne Stetler, Yanqin Gao, R Suzanne Zukin, Peter S Vosler, Lili Zhang, Feng Zhang, Guodong Cao, Michael V L Bennett, Jun Che. Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 7. 2010-05-10. PMID:20133634. |
here we show that intracerebral administration of pituitary adenylate cyclase-activating polypeptide (pacap), an endogenously occurring small neuropeptide, induces expression of ape1 in hippocampal neurons. |
2010-05-10 |
2023-08-12 |
Not clear |