| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryota Hashimoto, Hitoshi Hashimoto, Norihito Shintani, Kazutaka Ohi, Hiroaki Hori, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Nakao Iwata, Norio Ozaki, Kunitoshi Kamijima, Akemichi Baba, Masatoshi Takeda, Hiroshi Kunug. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19914336. |
the associations of the pacap gene with schizophrenia and hippocampal volume have been reported. |
2010-04-06 |
2023-08-12 |
mouse |
| Monika Riek-Burchardt, Angela Kolodziej, Petra Henrich-Noack, Klaus G Reymann, Volker Höllt, Ralf Stum. Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia. Neuropharmacology. vol 58. issue 1. 2010-02-25. PMID:19647005. |
here, we studied mrna patterns of pacap, sdf-1 and the cognate receptors pac1 and cxcr4 by in situ hybridization in the rat hippocampus after transient global ischemia, a rat model for programmed death of ca1 pyramidal neurons. |
2010-02-25 |
2023-08-12 |
rat |
| L Costa, F Santangelo, G Li Volsi, L Cirann. Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus. Hippocampus. vol 19. issue 1. 2009-02-27. PMID:18727050. |
modulation of ampa receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (pacap) in ca1 pyramidal neurons from rat hippocampus. |
2009-02-27 |
2023-08-12 |
rat |
| L Costa, F Santangelo, G Li Volsi, L Cirann. Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus. Hippocampus. vol 19. issue 1. 2009-02-27. PMID:18727050. |
pituitary adenylate cyclase-activating polypeptide (pacap), a neurotrophic and neuromodulatory peptide, was recently shown to enhance nmda receptor-mediated currents in the hippocampus (macdonald, et al. |
2009-02-27 |
2023-08-12 |
rat |
| L Costa, F Santangelo, G Li Volsi, L Cirann. Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus. Hippocampus. vol 19. issue 1. 2009-02-27. PMID:18727050. |
to check if pacap might also modulate ampa receptor function, we tested its effects on ampa receptor-mediated synaptic currents on ca1 pyramidal neurons, using the patch clamp technique on hippocampal slices. |
2009-02-27 |
2023-08-12 |
rat |
| Michal Reichenstein, Moshe Rehavi, Albert Pinhaso. Involvement of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the mechanism of antidepressant action. Journal of molecular neuroscience : MN. vol 36. issue 1-3. 2009-02-17. PMID:18592413. |
in rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated bdnf and pacap expression and down-regulated pacap receptor (pac1 and vpac2) expression; the tricyclic antidepressant imipramine had an opposite effect. |
2009-02-17 |
2023-08-12 |
rat |
| Paul J Kammermeie. Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 34. 2008-09-16. PMID:18716215. |
i examined the ability of endogenous homer 1a to alter mglur signaling in rat sympathetic neurons and hippocampal autapses using pituitary adenylate cyclase activating peptide (pacap) to induce native homer 1a expression. |
2008-09-16 |
2023-08-12 |
rat |
| Paul J Kammermeie. Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 34. 2008-09-16. PMID:18716215. |
in hippocampal autapses, pacap treatment uncoupled postsynaptic mglur5 from epsc inhibition, similar to the effect of homer 1a overexpression. |
2008-09-16 |
2023-08-12 |
rat |
| R Hashimoto, H Hashimoto, N Shintani, S Chiba, S Hattori, T Okada, M Nakajima, K Tanaka, N Kawagishi, K Nemoto, T Mori, T Ohnishi, H Noguchi, H Hori, T Suzuki, N Iwata, N Ozaki, T Nakabayashi, O Saitoh, A Kosuga, M Tatsumi, K Kamijima, D R Weinberger, H Kunugi, A Bab. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Molecular psychiatry. vol 12. issue 11. 2008-01-09. PMID:17387318. |
this allele of the pacap gene, which is overrepresented in schizophrenia patients, was associated with reduced hippocampal volume and poorer memory performance. |
2008-01-09 |
2023-08-12 |
mouse |
| Akemichi Bab. [Molecular pharmacologic approaches to functional analysis of new biological target molecules for drug discovery]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 127. issue 10. 2008-01-07. PMID:17917422. |
based on these experimental findings, a genetic association study in schizophrenia patients revealed that the single-nucleotide polymorphisms of the pacap gene are significantly associated with the hypofunction of the hippocampus. |
2008-01-07 |
2023-08-12 |
mouse |
| Frank K H van Landeghem, Thorsten Weiss, Andreas von Deimlin. Expression of PACAP and glutamate transporter proteins in satellite oligodendrocytes of the human CNS. Regulatory peptides. vol 142. issue 1-2. 2007-08-20. PMID:17346813. |
following transient global ischemia, the total number of satellite oligodendrocytes expressing pacap or glutamate transporter proteins was significantly decreased in cerebral neocortex and hippocampus. |
2007-08-20 |
2023-08-12 |
human |
| T Hattori, K Baba, S Matsuzaki, A Honda, K Miyoshi, K Inoue, M Taniguchi, H Hashimoto, N Shintani, A Baba, S Shimizu, F Yukioka, N Kumamoto, A Yamaguchi, M Tohyama, T Katayam. A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth. Molecular psychiatry. vol 12. issue 4. 2007-06-01. PMID:17389905. |
a disc1-binding domain of dbz reduced the neurite length in pc12 cells after pacap stimulation and in primary cultured hippocampal neurons. |
2007-06-01 |
2023-08-12 |
human |
| Shigeki Ohta, Christopher Gregg, Samuel Weis. Pituitary adenylate cyclase-activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo. Journal of neuroscience research. vol 84. issue 6. 2007-01-04. PMID:16941483. |
finally, we determined that the intracerebroventricular infusion of pacap into the adult forebrain was sufficient to increase neurogenesis significantly in both the hippocampus and the subventricular zone. |
2007-01-04 |
2023-08-12 |
Not clear |
| Tamas Atlasz, Zsombor Koszegi, Norbert Babai, Andrea Tamás, Dora Reglodi, Peter Kovács, Istvan Hernádi, Robert Gábrie. Microiontophoretically applied PACAP blocks excitatory effects of kainic acid in vivo. Annals of the New York Academy of Sciences. vol 1070. 2006-09-25. PMID:16888156. |
we found that pacap could block the excitatory effects of ka in several brain areas (cortex: 89%, hippocampus: 36%, and thalamus: 50%). |
2006-09-25 |
2023-08-12 |
Not clear |
| Seiji Shioda, Hirokazu Ohtaki, Tomoya Nakamachi, Kenji Dohi, Jun Watanabe, Shigeo Nakajo, Satoru Arata, Shinji Kitamura, Hiromi Okuda, Fumiko Takenoya, Yoshitaka Kitamur. Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Annals of the New York Academy of Sciences. vol 1070. 2006-09-25. PMID:16888224. |
pacap prevents ischemic delayed neuronal cell death (apoptosis) in the hippocampus. |
2006-09-25 |
2023-08-12 |
mouse |
| Seiji Shioda, Hirokazu Ohtaki, Tomoya Nakamachi, Kenji Dohi, Jun Watanabe, Shigeo Nakajo, Satoru Arata, Shinji Kitamura, Hiromi Okuda, Fumiko Takenoya, Yoshitaka Kitamur. Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Annals of the New York Academy of Sciences. vol 1070. 2006-09-25. PMID:16888224. |
these results suggest that pacap itself and pacap-stimulated secretion of il-6 synergistically inhibit apoptotic cell death in the hippocampus. |
2006-09-25 |
2023-08-12 |
mouse |
| Aurélia Ravni, Steve Bourgault, Alexis Lebon, Philippe Chan, Ludovic Galas, Alain Fournier, Hubert Vaudry, Bruno Gonzalez, Lee E Eiden, David Vaudr. The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. Journal of neurochemistry. vol 98. issue 2. 2006-08-18. PMID:16805827. |
induction of neuritogenesis, growth arrest, and promotion of cell survival are effects of pacap that occur in developing cerebellar, hippocampal and cortical neurons, as well as in the more tractable pc12 cell model. |
2006-08-18 |
2023-08-12 |
human |
| Kazuhiro Tanaka, Hitoshi Hashimoto, Norihito Shintani, Akiko Yamamoto, Akemichi Bab. Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice. Regulatory peptides. vol 123. issue 1-3. 2005-03-31. PMID:15518898. |
in mice, pacap deficiency is associated with impaired memory performance and hippocampal long-term potentiation (ltp), however, sensitivity to ethanol has not been well investigated. |
2005-03-31 |
2023-08-12 |
mouse |
| Beatrice M Girard, Emily T Keller, Kristin C Schutz, Victor May, Karen M Braa. Pituitary adenylate cyclase activating polypeptide and PAC1 receptor signaling increase Homer 1a expression in central and peripheral neurons. Regulatory peptides. vol 123. issue 1-3. 2005-03-31. PMID:15518900. |
given the prominent roles of homer in synaptogenesis, synaptic protein complex assembly and receptor/channel signaling, we have examined the ability for pacap to induce h1a expression in sympathetic, cortical and hippocampal neurons to evaluate more comprehensively the roles of pacap in synaptic function. |
2005-03-31 |
2023-08-12 |
Not clear |
| Norihito Shintan. [Mice lacking PACAP: a mini-review focussing on brain function]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 124. issue 10. 2004-12-15. PMID:15467274. |
in this paper, phenotypic changes in several brain functions in pacap(-/-) mice, including light-induced phase-resetting of the circadian activity rhythm, hippocampal long-term potentiation, and psychomotor behaviors, are reviewed based on the results obtained in our laboratory. |
2004-12-15 |
2023-08-12 |
mouse |