| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seiji Shioda, Hirokazu Ohtaki, Ryusuke Suzuki, Tomoya Nakamachi, Fumiko Takenoya, Kenji Dohi, Shigeo Nakaj. [Prevention of delayed neuronal cell death by PACAP and its molecular mechanism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 123. issue 4. 2004-06-10. PMID:15056939. |
ischemic delayed neuronal cell death (apoptosis) in the hippocampus is prevented by pacap. |
2004-06-10 |
2023-08-12 |
mouse |
| Alex Mercer, Harriet Rönnholm, Johan Holmberg, Hanna Lundh, Jessica Heidrich, Olof Zachrisson, Amina Ossoinak, Jonas Frisén, Cesare Patron. PACAP promotes neural stem cell proliferation in adult mouse brain. Journal of neuroscience research. vol 76. issue 2. 2004-05-17. PMID:15048918. |
finally, intracerebroventricular infusion of pacap increases cell proliferation in the ventricular zone of the lateral ventricle and the dentate gyrus of the hippocampus. |
2004-05-17 |
2023-08-12 |
mouse |
| Lucia Ciranna, Sebastiano Cavallar. Opposing effects by pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide on hippocampal synaptic transmission. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769370. |
pituitary adenylate cyclase-activating polypeptide (pacap), vasoactive intestinal peptide (vip), and their receptors have been localized within the hippocampus but their physiological function on synaptic transmission is still unclear. |
2004-04-02 |
2023-08-12 |
rat |
| Lucia Ciranna, Sebastiano Cavallar. Opposing effects by pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide on hippocampal synaptic transmission. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769370. |
we investigated the effects of pacap and vip on evoked excitatory postsynaptic currents (epscs) recorded with patch clamp from ca1 pyramidal neurons in rat hippocampal slices. |
2004-04-02 |
2023-08-12 |
rat |
| Zhijun Liu, Lin Geng, Ruxin Li, Xiangping He, James Q Zheng, Zuoping Xi. Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through G-protein-coupled receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764103. |
here we report that synchronized ca2+ spikes among cultured hippocampal neurons can be modulated by two small factors that act on g-protein-coupled receptors (gpcrs): the neuropeptide pacap (pituitary adenylate cyclase-activating polypeptide) and the chemokine sdf-1 (stromal cell-derived factor-1). |
2003-06-25 |
2023-08-12 |
Not clear |
| Kenji Dohi, Hidekatsu Mizushima, Shigeo Nakajo, Hirokazu Ohtaki, Seiji Matsunaga, Tohru Aruga, Seiji Shiod. Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways. Regulatory peptides. vol 109. issue 1-3. 2003-06-24. PMID:12409219. |
pituitary adenylate cyclase-activating polypeptide (pacap) prevents hippocampal neurons from apoptosis by inhibiting jnk/sapk and p38 signal transduction pathways. |
2003-06-24 |
2023-08-12 |
rat |
| Kenji Dohi, Hidekatsu Mizushima, Shigeo Nakajo, Hirokazu Ohtaki, Seiji Matsunaga, Tohru Aruga, Seiji Shiod. Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways. Regulatory peptides. vol 109. issue 1-3. 2003-06-24. PMID:12409219. |
we have demonstrated that ischemic neuronal death (apoptosis) of rat ca1 region of the hippocampus was prevented by infusing pituitary adenylate cyclase-activating polypeptide (pacap) either intracerebroventricularly or intravenously. |
2003-06-24 |
2023-08-12 |
rat |
| M Di Mauro, S Cavallaro, L Cirann. Pituitary adenylate cyclase-activating polypeptide modifies the electrical activity of CA1 hippocampal neurons in the rat. Neuroscience letters. vol 337. issue 2. 2003-03-28. PMID:12527397. |
the effects of pituitary adenylate cyclase-activating polypeptide (pacap) on neuronal excitability in the ca1 region of rat hippocampus were studied using in vivo and in vitro electrophysiological techniques. |
2003-03-28 |
2023-08-12 |
rat |
| M Di Mauro, S Cavallaro, L Cirann. Pituitary adenylate cyclase-activating polypeptide modifies the electrical activity of CA1 hippocampal neurons in the rat. Neuroscience letters. vol 337. issue 2. 2003-03-28. PMID:12527397. |
these results indicate that pacap induces depolarizing effects on ca1 hippocampal neurons. |
2003-03-28 |
2023-08-12 |
rat |
| Jens Hanniba. Pituitary adenylate cyclase-activating peptide in the rat central nervous system: an immunohistochemical and in situ hybridization study. The Journal of comparative neurology. vol 453. issue 4. 2002-12-13. PMID:12389210. |
pacap was also present in cell bodies in the olfactory areas, in neocortical areas, in the hippocampus, in the vestibulo- and cochlear nuclei, in cell bodies of the intermediolateral cell column of the spinal cord and in purkinje cells of the cerebellum, in the subfornical organ, and in the organum vasculosum of the lamina terminalis. |
2002-12-13 |
2023-08-12 |
rat |
| Y Dong, T S Tang, C L Lu, C He, J B Dong, X Y Huang, F Z Sun, X Ba. [Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate]. Sheng li xue bao : [Acta physiologica Sinica]. vol 52. issue 5. 2002-12-10. PMID:11941395. |
treatment of glutamate for 24 h greatly decreased neuronal survival and pretreatment with pituitary adenylate cyclase activating polypeptide (pacap) significantly attenuated hippocampal neuron death induced by glutamate. |
2002-12-10 |
2023-08-12 |
Not clear |
| Y Dong, T S Tang, C L Lu, C He, J B Dong, X Y Huang, F Z Sun, X Ba. [Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate]. Sheng li xue bao : [Acta physiologica Sinica]. vol 52. issue 5. 2002-12-10. PMID:11941395. |
moreover, glutamate dose-dependently increased the intracellular calcium concentration in cultured hippocampal neurons, while pacap inhibited the increase of intracellular calcium concentration induced by glutamate. |
2002-12-10 |
2023-08-12 |
Not clear |
| Y Dong, T S Tang, C L Lu, C He, J B Dong, X Y Huang, F Z Sun, X Ba. [Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate]. Sheng li xue bao : [Acta physiologica Sinica]. vol 52. issue 5. 2002-12-10. PMID:11941395. |
pacap 6-38, a specific pacap type i receptor antagonist, completely inhibited the amelioration of glutamate induced death and the decrease of intracellular calcium concentration induced by pacap in cultured hippocampal neurons. |
2002-12-10 |
2023-08-12 |
Not clear |
| Y Dong, T S Tang, C L Lu, C He, J B Dong, X Y Huang, F Z Sun, X Ba. [Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate]. Sheng li xue bao : [Acta physiologica Sinica]. vol 52. issue 5. 2002-12-10. PMID:11941395. |
the data suggest that pacap has a neuroprotective effect on the hippocampal neuronal damage induced by glutamate, which is related to an inhibition of glutamate-induced increase of intracellular calcium concentration and mediated by pacap type i receptor. |
2002-12-10 |
2023-08-12 |
Not clear |
| Francis S Lee, Rithwick Rajagopal, Albert H Kim, Paul C Chang, Moses V Cha. Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. The Journal of biological chemistry. vol 277. issue 11. 2002-04-05. PMID:11784714. |
we have found that pacap treatment resulted in an increase in trka tyrosine kinase activity in pc12 cells and trkb activity in hippocampal neurons. |
2002-04-05 |
2023-08-12 |
Not clear |
| A Yuhara, C Nishio, Y Abiru, H Hatanaka, N Take. PACAP has a neurotrophic effect on cultured basal forebrain cholinergic neurons from adult rats. Brain research. Developmental brain research. vol 131. issue 1-2. 2002-02-04. PMID:11718834. |
hippocampus, a targeting area of basal forebrain cholinergic neurons, contains pacap. |
2002-02-04 |
2023-08-12 |
rat |
| M Roberto, M Brunell. PACAP-38 enhances excitatory synaptic transmission in the rat hippocampal CA1 region. Learning & memory (Cold Spring Harbor, N.Y.). vol 7. issue 5. 2000-11-21. PMID:11040262. |
specific receptors for pituitary adenylate cyclase-activating polypeptide (pacap), a novel peptide with neuroregulatory and neurotrophic functions, have been identified recently in different brain regions, including the hippocampus. |
2000-11-21 |
2023-08-12 |
rat |
| N Takei, E Torres, A Yuhara, H Jongsma, C Otto, L Korhonen, Y Abiru, Y Skoglösa, G Schütz, H Hatanaka, M V Sofroniew, D Lindhol. Pituitary adenylate cyclase-activating polypeptide promotes the survival of basal forebrain cholinergic neurons in vitro and in vivo: comparison with effects of nerve growth factor. The European journal of neuroscience. vol 12. issue 7. 2000-09-19. PMID:10947806. |
pacap mrna is expressed in the developing and adult hippocampus, which is the principal target region of septal cholinergic neurons. |
2000-09-19 |
2023-08-12 |
rat |
| K Peeters, H H Gerets, L Arckens, F Vandesand. Distribution of pituitary adenylate cyclase-activating polypeptide and pituitary adenylate cyclase-activating polypeptide type I receptor mRNA in the chicken brain. The Journal of comparative neurology. vol 423. issue 1. 2000-08-07. PMID:10861537. |
the telencephalic areas where the most intense signals for pacap mrna were found included the hyperstriatum accessorium, the hippocampus, and the archistriatum. |
2000-08-07 |
2023-08-12 |
chicken |
| D Reglodi, A Somogyvari-Vigh, S Vigh, T Kozicz, A Arimur. Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat. Stroke. vol 31. issue 6. 2000-06-27. PMID:10835464. |
delayed systemic administration of pituitary adenylate cyclase-activating polypeptide (pacap) has been shown to attenuate the neuronal damage in the hippocampus in a model of global ischemia in rats. |
2000-06-27 |
2023-08-12 |
rat |