| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiantian Zhao, Aiwen Chen, Danqing Dai, Zhen Li, Xiao-Fei Gao, Lize Xion. Role of the GRP/GRPR System in Regulating Brain Functions. ACS chemical neuroscience. 2023-09-13. PMID:37702025. |
gastrin-releasing peptide receptors (grprs) are gαq-coupling neuropeptide receptors and widely distributed in the brain, including hippocampus, amygdala, hypothalamus, nucleus tractus solitarius (nts), suprachiasmatic nucleus (scn), paraventricular nucleus of the hypothalamus (pvn), preoptic area of the hypothalamus (poa), prebötzinger complex (prebötc), etc., implying the grp/grpr system is involved in modulating multiple brain functions. |
2023-09-13 |
2023-10-07 |
Not clear |
| Natallia Makarava, Olga Mychko, Kara Molesworth, Jennifer Chen-Yu Chang, Rebecca J Henry, Natalya Tsymbalyuk, Volodymyr Gerzanich, J Marc Simard, David J Loane, Ilia V Baskako. Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults. Cells. vol 12. issue 17. 2023-09-08. PMID:37681904. |
to address this question, region-specific gene expression profiling was performed for four brain regions (cortex, hippocampus, thalamus, and hypothalamus) in mice using a custom nanostring panel consisting of selected sets of genes associated with astrocyte functions and their reactivity for five conditions: prion disease, traumatic brain injury, brain ischemia, 5xfad alzheimer's disease model and normal aging. |
2023-09-08 |
2023-10-07 |
mouse |
| Andreia Amaro, Diana Sousa, Mariana Sá-Rocha, Marcos Divino Ferreira-Junior, Daniela Rosendo-Silva, Lucas Paulo Jacinto Saavedra, Cátia Barra, Tamaeh Monteiro-Alfredo, Rodrigo Mello Gomes, Paulo Cezar de Freitas Mathias, Filipa I Baptista, Paulo Matafom. Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes. Nutrients. vol 15. issue 16. 2023-08-26. PMID:37630771. |
neurodevelopmental tests were conducted at infancy, whereas behavioural tests to assess locomotion, anxiety, and memory were performed at adolescence, together with molecular analysis of the hippocampus, hypothalamus, and prefrontal cortex. |
2023-08-26 |
2023-09-07 |
Not clear |
| Payman Raise-Abdullahi, Morvarid Meamar, Abbas Ali Vafaei, Maryam Alizadeh, Masoomeh Dadkhah, Sakineh Shafia, Mohadeseh Ghalandari-Shamami, Ramtin Naderian, Seyed Afshin Samaei, Ali Rashidy-Pou. Hypothalamus and Post-Traumatic Stress Disorder: A Review. Brain sciences. vol 13. issue 7. 2023-07-29. PMID:37508942. |
linked to the prefrontal cortex and limbic structures, especially the amygdala and hippocampus, the hypothalamus acts as a central hub, integrating physiological aspects of the stress response. |
2023-07-29 |
2023-08-14 |
Not clear |
| Ilaria Ottonelli, Aruna Sharma, Barbara Ruozi, Giovanni Tosi, Jason Thomas Duskey, Maria Angela Vandelli, José Vicente Lafuente, Ala Nozari, Dafin Fior Muresanu, Anca Dana Buzoianu, Z Ryan Tian, Zhiqiang Zhang, Cong Li, Lianyuan Feng, Lars Wiklund, Hari Shanker Sharm. Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor. Advances in neurobiology. vol 32. 2023-07-22. PMID:37480467. |
neurotoxicity is evident 4 h after its administration exhibiting breakdown of bbb to evans blue albumin in the cerebral cortex, hippocampus, cerebellum, thalamus and hypothalamus associated with vasogenic brain edema as seen measured using water content in all these regions. |
2023-07-22 |
2023-08-14 |
rat |
| Shuquan Zhao, Zihao Liu, Longda Ma, Min Yin, Yiwu Zho. Potential biomarkers in hypoglycemic brain injury. Forensic science, medicine, and pathology. 2023-07-19. PMID:37466819. |
the expressions of dj-1 and ndrg1 in the hippocampus, cortex, and hypothalamus of rats were increased (p < 0.05). |
2023-07-19 |
2023-08-14 |
rat |
| Diek Wheeler, Shaina Banduri, Sruthi Sankararaman, Samhita Vinay, Giorgio Ascol. Unsupervised classification of brain-wide axons reveals neuronal projection blueprint. Research square. 2023-07-18. PMID:37461601. |
we thus report several findings: (1) individual classes target multiple subregions along defined functions, such as spatial representation vs. sensory integration and visual vs. auditory input; (2) all hypothalamic regions are exclusively targeted by the same class also invading midbrain, a sharp subset of thalamic nuclei, and agranular retrosplenial cortex; (3) cornu ammonis, in contrast, receives input from the same presubicular axons projecting to granular retrosplenial cortex, also the purview of a single class; (4) path distances from the presubiculum to the same targets differ significantly between classes, as do the path distances to distinct targets within most classes, suggesting fine temporal coordination in activating distant areas; (5) the identified classes have highly non-uniform abundances, with substantially more neurons projecting to midbrain and hypothalamus than to medial and lateral entorhinal cortex; (6) lastly, presubicular soma locations are segregated among classes, indicating topographic organization of projections. |
2023-07-18 |
2023-08-14 |
mouse |
| B Sienkiewicz-Oleszkiewicz, A Oleszkiewicz, M A Bock, T Humme. Intranasal insulin - effects on the sense of smell. Rhinology. 2023-07-15. PMID:37453136. |
in receptors are localized in the olfactory mucosa and the brain, mainly in the olfactory bulb, hypothalamus, hippocampus, amygdala, cerebral cortex, and cerebellum. |
2023-07-15 |
2023-08-14 |
Not clear |
| Dana Bakalar, Oksana Gavrilova, Sunny Z Jiang, Hai-Ying Zhang, Snehashis Roy, Sarah K Williams, Naili Liu, Stephen Wisser, Ted B Usdin, Lee E Eide. Constitutive and conditional deletion reveals distinct phenotypes driven by developmental versus neurotransmitter actions of the neuropeptide PACAP. Journal of neuroendocrinology. 2023-06-13. PMID:37309259. |
comparing constitutive pacap knockout mice to a variety of temporally and regionally specific pacap knockouts, we show that the prominent hyperlocomotor phenotype is a consequence of early loss of pacap expression, is associated with fos overexpression in hippocampus and basal ganglia, and that a thermoregulatory effect previously shown to be mediated by pacap-expressing neurons of medial preoptic hypothalamus is independent of pacap expression in those neurons in adult mice. |
2023-06-13 |
2023-08-14 |
mouse |
| Guillermo Iborra-Lázaro, Souhail Djebari, Irene Sánchez-Rodríguez, Esther Gratacòs-Batlle, Nuria Sánchez-Fernández, Marija Radošević, Núria Casals, Juan de Dios Navarro-López, David Soto Del Cerro, Lydia Jiménez-Día. CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative, and non-associative learning. The Journal of physiology. 2023-06-13. PMID:37309891. |
cpt1c (carnitine palmitoyltransferase 1c) is a neuron-specific protein widely distributed throughout the central nervous system and highly expressed in discrete brain areas including hypothalamus, hippocampus, amygdala and different motor regions. |
2023-06-13 |
2023-08-14 |
mouse |
| Emine Kacar, Ozgur Bulmus, Zubeyde Ercan, Ilay Buran Kavuran, Gokhan Zorlu, Fatih Tan, Ihsan Serhatlioglu, Haluk Kelestimu. Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300694. |
treadmill exercise caused a significant decrease in ef, ml, il, mf, if, iii, el, pei, ir1, mft, ift, irt sexual behavior parameters and kisspeptin and kiss1r gene expression in the hypothalamus, hippocampus, prefrontal cortex and corpus striatum in e group compared to c group (p<0.05), and a significant increase in ml, il, iii, el sexual behavior parameters (p<0.05). |
2023-06-11 |
2023-08-14 |
rat |
| Emine Kacar, Ozgur Bulmus, Zubeyde Ercan, Ilay Buran Kavuran, Gokhan Zorlu, Fatih Tan, Ihsan Serhatlioglu, Haluk Kelestimu. Treadmill exercise has healing effects on obesity-induced sexual behavior disorder through kisspeptin and kiss1R expression in male rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300694. |
based on this effect, we believe that it is caused by an increase in kisspeptin and kiss1r expression in the hypothalamus, hippocampus, prefrontal cortex and corpus striatum. |
2023-06-11 |
2023-08-14 |
rat |
| Sara Florén Lind, Frida Stam, Sofia Zelleroth, Evelina Meurling, Andreas Frick, Alfhild Grönblad. Acute caffeine differently affects risk-taking and the expression of BDNF and of adenosine and opioid receptors in rats with high or low anxiety-like behavior. Pharmacology, biochemistry, and behavior. 2023-06-11. PMID:37302662. |
thus, the aim of this study was to investigate general behavior, risk-taking, and anxiety-like behavior, as well as mrna expression (adenosine a2a and a1, dopamine d2, and, μ, κ, δ opioid, receptors, bdnf, c-fos, igf-1) in amygdala, caudate putamen, frontal cortex, hippocampus, hypothalamus, after an acute dose of caffeine. |
2023-06-11 |
2023-08-14 |
rat |
| Kenia L O Cruz, Daniele H Salla, Mariana P Oliveira, Larissa E Silva, Larissa M D Vedova, Talita F Mendes, Catarina B C Bressan, Mariella R Silva, Sheila M L Santos, Hevylin J Soares, Rayane L Mendes, Camila N Vernke, Marina G Silva, Ana O M Laurentino, Fabiana D Medeiros, Thais C Vilela, Isabela Lemos, Rafael M Bitencourt, Gislaine Z Réus, Emilio L Streck, Aline H Mello, Gislaine T Rezi. Energy metabolism and behavioral parameters in female mice subjected to obesity and offspring deprivation stress. Behavioural brain research. 2023-06-04. PMID:37271313. |
thus, it is concluded that obesity and od lead to anhedonia in animals and to mitochondrial dysfunction in the hypothalamus and hippocampus, which may lead to losses in feeding control and cognition of the dams. |
2023-06-04 |
2023-08-14 |
mouse |
| Cristina Dettori, Francesca Ronca, Marco Scalese, Federica Saponar. Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System. Journal of personalized medicine. vol 13. issue 5. 2023-05-27. PMID:37240884. |
the pth/pthrp/pth1r system has been found to be expressed in many areas of the brain (hippocampus, amygdala, hypothalamus, caudate nucleus, corpus callosum, subthalamic nucleus, thalamus, substantia nigra, cerebellum), and literature data suggest the system exercises a protective action against neuroinflammation and neurodegeneration, with positive effects on memory and hyperalgesia. |
2023-05-27 |
2023-08-14 |
Not clear |
| Jacqueline Alves Leite, Ana Maria Orellana, Diana Zukas Andreotti, Amanda Midori Matumoto, Natacha Medeiros de Souza Ports, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Carolina Demarchi Munhoz, Cristoforo Scavon. Ouabain Reverts CUS-Induced Disruption of the HPA Axis and Avoids Long-Term Spatial Memory Deficits. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189795. |
these changes in both the hypothalamus and hippocampus may reflect in the rapid extinction of aversive memory. |
2023-05-16 |
2023-08-14 |
human |
| Arash Kamali, Sofia Milosavljevic, Anusha Gandhi, Kinsey R Lano, Parnian Shobeiri, Farzaneh Ghazi Sherbaf, Haris I Sair, Roy F Riascos, Khader M Hasa. The Cortico-Limbo-Thalamo-Cortical Circuits: An Update to the Original Papez Circuit of the Human Limbic System. Brain topography. vol 36. issue 3. 2023-05-06. PMID:37148369. |
the papez circuit, first proposed by james papez in 1937, is a circuit believed to control memory and emotions, composed of the cingulate cortex, entorhinal cortex, parahippocampal gyrus, hippocampus, hypothalamus, and thalamus. |
2023-05-06 |
2023-08-14 |
human |
| Darya V Bazovkina, Dariya V Fursenko, Vladimir S Naumenko, Aleksandr V Kuliko. The Role of C1473G Polymorphism in Mouse Triptophan Hydroxylase 2 Gene in the Acute Effects of Ethanol on the c-fos Gene Expression and Metabolism of Biogenic Amines in the Brain. Biochemistry. Biokhimiia. vol 88. issue 3. 2023-04-19. PMID:37076278. |
acute alcoholization led to a significant upregulation of the c-fos gene expression in the frontal cortex and striatum of b6-1473g mice and in the hippocampus of b6-1473c mice and caused a decrease in the index of serotonin metabolism in the nucleus accumbens in b6-1473c mice and in the hippocampus and striatum of b6-1473g mice, as well as to the decrease in the norepinephrine level in the hypothalamus of b6-1473c mice. |
2023-04-19 |
2023-08-14 |
mouse |
| Karen Lin, Daniel Sunko, Junying Wang, Jie Yang, Ramin Parsey, Christine DeLorenz. Investigating The Relationship Between Hippocampus:Dentate Gyrus Volume and Hypothalamus Metabolism in Participants with Major Depressive Disorder. Research square. 2023-04-17. PMID:37066238. |
investigating the relationship between hippocampus:dentate gyrus volume and hypothalamus metabolism in participants with major depressive disorder. |
2023-04-17 |
2023-08-14 |
human |
| Tamara Dakic, Tanja Jevdjovic, Iva Lakic, Aleksandra Ruzicic, Nebojsa Jasnic, Sinisa Djurasevic, Jelena Djordjevic, Predrag Vujovi. The Expression of Insulin in the Central Nervous System: What Have We Learned So Far? International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047558. |
considering that both insulin mrna and insulin were detected in the central nervous system (cns), it is now known that this hormone is also synthesized in several brain regions, including the hypothalamus, hippocampus, cerebral and cerebellar cortex, and olfactory bulb. |
2023-04-13 |
2023-08-14 |
Not clear |