| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
in the frontal cortex, hippocampus, striatum, hypothalamus, and midbrain the concentrations of 5-ht and its main metabolite, 5-hydroxyindole acetic acid (5-hiaa), and tph activity were assayed using hplc, while tph1 and tph2 mrna were quantified using quantitative real-time rt-pcr. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
the highest concentration of tph2 gene mrna was observed in the midbrain in 5-ht neuron bodies, while this gene mrna level was lower in 5-ht endings (cortex, hippocampus, striatum, and hypothalamus). |
2023-03-31 |
2023-08-14 |
mouse |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| Xiaoju Liu, Haijuan Wang, Xiaoyu Wang, Yinxia Ning, Wei Liu, Jie Ga. Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1-mediated GABA can regulate 5-HT levels in multiple brain regions. Aging. vol 15. 2023-03-29. PMID:36988497. |
the improvement way is as follows: decreased abnormal increase of gaba and gb1 in the drn further mediated synaptic inhibition and increased 5-ht level in the drn, leading to increased 5-ht levels in the pfc, hypothalamus, and hippocampus. |
2023-03-29 |
2023-08-14 |
rat |
| Arseniy E Izyurov, Alexandra V Plyusnina, Elizabeth A Kulikova, Alexander V Kulikov, Nikita V Khotski. Lethal yellow mutation causes anxiety, obsessive-compulsive behavior and affects the brain melanocortin system in males and females of mice. Current protein & peptide science. 2023-03-21. PMID:36941814. |
positive correlation between agouti and raly genes mrna levels were shown in the hypothalamus, hippocampus, and frontal cortex in ay/a mice. |
2023-03-21 |
2023-08-14 |
mouse |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
our results show that the dorsomedial hypothalamus and hippocampal ca2 region of adult male mice undergo increased microglia volume, territory, and endpoints following social isolation, whereas females exhibit this increase in the hypothalamus only. |
2023-03-15 |
2023-08-14 |
mouse |
| Helin Chen, Qibin Kan, Ling Zhao, Gang Ye, Xiaoli He, Huaqiao Tang, Fei Shi, Yuanfeng Zou, Xiaoxia Liang, Xu Song, Rui Liu, Jie Luo, Yinglun L. Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-03-15. PMID:36921537. |
rt-qpcr was used to detect the gene expression of crhr1, nr3c1, and nr3c2 in the hypothalamus and hippocampus and the gene expression of glutamic acid and γ-aminobutyric acid-related receptors in the hippocampus. |
2023-03-15 |
2023-08-14 |
mouse |
| Jacqueline M Anderson, Amber A Boardman, Rhiannon Bates, Xunchang Zou, Wei Huang, Lei Ca. Hypothalamic TrkB.FL overexpression improves metabolic outcomes in the BTBR mouse model of autism. PloS one. vol 18. issue 3. 2023-03-09. PMID:36893171. |
brain-derived neurotrophic factor (bdnf) and its receptor tropomyosin kinase receptor b (ntrk2) were upregulated in the hypothalamus, hippocampus, and amygdala by implementing ee in btbr mice, suggesting that bdnf-trkb signaling plays a role in the ee-btbr phenotype. |
2023-03-09 |
2023-08-14 |
mouse |
| Yajie Jiang, Manshu Zou, Yeqing Wang, Yuhong Wan. Nucleus Accumbens in the Pathogenesis of Major Depressive Disorder: A Brief Review. Brain research bulletin. 2023-03-08. PMID:36889362. |
extensive studies have demonstrated the involvement of nuclei such as the prefrontal cortex (pfc), hippocampus (hip), nucleus accumbens (nac), hypothalamus, etc., in mdd. |
2023-03-08 |
2023-08-14 |
Not clear |
| Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.). vol 165. 2023-03-04. PMID:36869551. |
in hypothalamus and hippocampus, clock (bmal1 and clock) and tight junction (ocln and tjp2) genes were improved by prebiotics, and corticotropin-releasing hormone receptor genes, crf1 and crf2, were also significantly regulated for mitigation of depression and anxiety caused by sleep deprivation. |
2023-03-04 |
2023-08-14 |
mouse |
| Elisa Giunti, Roberto Collu, Simona Dedoni, M Paola Castelli, Maria Scherma, Paola Fadd. Food restriction and hyperactivity induce changes in corticolimbic brain dopamine and serotonin levels in female rats. Behavioural brain research. 2023-03-02. PMID:36863461. |
we exposed female rats to the aba paradigm and measured the levels of da, 5-ht, and the metabolites 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and dopaminergic type 2 (d2) receptors density in feeding- and reward-implicated brain regions (i.e., cerebral cortex, cx; prefrontal cortex, pfc; caudate putamen, cpu; nucleus accumbens, nacc; amygdala, amy; hypothalamus, hyp; hippocampus, hipp). |
2023-03-02 |
2023-08-14 |
rat |
| Caroline Woo. A Literature Review: Violence and Aggression in Neuroscience Nursing. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. 2023-03-01. PMID:36857134. |
an injury to the brain may not cause agitation; however, the effect on the frontal lobe, hypothalamus, and hippocampus may cause a lack of self-control, impulsivity, an inability to control emotions, and an uncontrolled release of hormones, leading to a heightened sympathetic response. |
2023-03-01 |
2023-08-14 |
Not clear |
| M Maetzi Estévez-Cabrera, Fausto Sánchez-Muñoz, Gilberto Pérez-Sánchez, Lenin Pavón, Adrian Hernández-Díazcouder, J Luis Córtes Altamirano, C Soria-Fregoso, Alfonso Alfaro-Rodríguez, Herlinda Bonilla-Jaim. Therapeutic treatment with fluoxetine using the chronic unpredictable stress model induces changes in neurotransmitters and circulating miRNAs in extracellular vesicles. Heliyon. vol 9. issue 2. 2023-02-28. PMID:36852042. |
after cums, the rats performed the fst, and serum levels of cort and six micrornas (mir-16, -21, -144, -155, -146a, -223) were analyzed, as were levels of dopamine, noradrenaline, and serotonin in the prefrontal cortex, hippocampus, and hypothalamus. |
2023-02-28 |
2023-08-14 |
rat |
| Chen-Chen Li, Fan Ye, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pa. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. Journal of affective disorders. 2023-02-06. PMID:36746244. |
after depression behavior tests, seven segments (cortex, hippocampus, striatum, hypothalamus, serum, cecum, and colon) along the gut-brain axis were collected to characterize their kp metabolism. |
2023-02-06 |
2023-08-14 |
rat |
| Yann Vanrobaeys, Zeru J Peterson, Emily N Walsh, Snehajyoti Chatterjee, Li-Chun Lin, Lisa C Lyons, Thomas Nickl-Jockschat, Ted Abe. Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36712009. |
we find that sleep deprivation induced pronounced differences in gene expression across the brain, with the greatest changes in the hippocampus, neocortex, hypothalamus, and thalamus. |
2023-01-30 |
2023-08-14 |
Not clear |
| Jesús Fernández-Felipe, Lucía L López, Victoria Cano, Enrique Sánchez-Hita, A Belén Sanz, Julie A Chowen, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merin. Regional specific effect of saturated vs unsaturated fat on leptin receptor signalling in mice brain areas regulating feeding. Neuroscience letters. 2022-12-08. PMID:36481371. |
leptin receptors (lepr) are expressed in brain areas controlling food intake homeostasis, such as the hypothalamus, the hippocampus and the prefrontal cortex. |
2022-12-08 |
2023-08-14 |
mouse |
| Elif Funda Sener, Halime Dana, Reyhan Tahtasakal, Zuhal Hamurcu, Ahsen Guler, Esra Tufan, Zuleyha Doganyigit, Minoo Rassoulzadega. Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous. Metabolic brain disease. 2022-12-01. PMID:36454503. |
partial changes in apoptotic pathways in hippocampus and hypothalamus of cc2d1a heterozygous. |
2022-12-01 |
2023-08-14 |
mouse |
| Elif Funda Sener, Halime Dana, Reyhan Tahtasakal, Zuhal Hamurcu, Ahsen Guler, Esra Tufan, Zuleyha Doganyigit, Minoo Rassoulzadega. Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous. Metabolic brain disease. 2022-12-01. PMID:36454503. |
the hippocampus and hypothalamus of cc2d1a ± mice were analyzed for the expression of apoptosis markers (caspase 3, 8 and 9). |
2022-12-01 |
2023-08-14 |
mouse |
| Lucia Carboni, Laura Rullo, Francesca Felicia Caputi, Serena Stamatakos, Sanzio Candeletti, Patrizia Romuald. Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430520. |
mrna expression of growth factor and circadian rhythm genes was evaluated by qpcr in the prefrontal cortex (pfcx), hippocampus, nucleus accumbens (nac), amygdala, and hypothalamus. |
2022-11-26 |
2023-08-14 |
rat |
| Lucia Carboni, Laura Rullo, Francesca Felicia Caputi, Serena Stamatakos, Sanzio Candeletti, Patrizia Romuald. Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430520. |
bdnf levels were significantly increased in pfcx and hippocampus by trazodone and in the nac and hypothalamus by citalopram. |
2022-11-26 |
2023-08-14 |
rat |