Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Paola C Bello-Medina, Mauricio Díaz-Muñoz, Sandra Teresita Martín Del Campo, Fermín Paul Pacheco-Moisés, Claudia Flores Miguel, Raquel Cobián Cervantes, Perla Belén García Solano, Mónica Navarro-Mez. A maternal low-protein diet results in sex-specific differences in synaptophysin expression and milk fatty acid profiles in neonatal rats. Journal of nutritional science. vol 13. 2024-10-29. PMID:39469193. |
significant decreases of hippocampal syn ratio in male offspring (decreases of 98% in hippocampal ca1 pyramidal and ca1 oriens, 83%, stratum pyramidal in ca3, 80%, stratum lucidum in ca3, and 81% stratum oriens in ca3). |
2024-10-29 |
2024-10-31 |
rat |
Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukaw. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Scientific reports. vol 12. issue 1. 2022-11-10. PMID:36357544. |
the results, in combination with our previous reports that show the reduction of hippocampal theta power through a decrease of a region-specific choline acetyltransferase in the stratum oriens of ca1 and the decrease of acetylcholine concentration in the hippocampus, may indicate the defined cholinergic dysfunction in hcnp-pp ko mice. |
2022-11-10 |
2023-08-14 |
mouse |
T A McCorkle, Z L Romm, R Raghupath. Repeated mild TBI in adolescent rats reveals sex differences in acute and chronic behavioral deficits. Neuroscience. 2022-04-26. PMID:35469970. |
histological analysis at 6 weeks after injury revealed that repeated mild tbi in male and female adolescent rats resulted in increased reactivity of astrocytes and microglia within the corpus callosum below the impact site and in the stratum oriens and stratum pyramidale of the ca2 region of the dorsal hippocampus. |
2022-04-26 |
2023-08-13 |
rat |
Meinrad Drexel, Sadegh Rahimi, Günther Sper. Silencing of hippocampal somatostatin interneurons induces recurrent spontaneous limbic seizures in mice. Neuroscience. 2022-02-15. PMID:35167940. |
the hippocampus proper and the subiculum contain two major populations of somatostatin (sst)-containing interneurons, oriens-lacunosum moleculare (o-lm) cells projecting from the stratum oriens to the stratum lacunosum moleculare and bistratified cells with their cell bodies close to the pyramidal cell layer and axons terminating in the strata radiatum and oriens. |
2022-02-15 |
2023-08-13 |
mouse |
Joaquín González Fuentes, Ricardo Insausti Serrano, Sandra Cebada Sánchez, Maria José Lagartos Donate, Eloy Rivas Infante, María Del Mar Arroyo Jiménez, María Del Pilar Marcos Raba. Neuropeptides in the developing human hippocampus under hypoxic-ischemic conditions. Journal of anatomy. vol 239. issue 4. 2021-11-23. PMID:34028021. |
two rostrocaudal sections of the body of the hippocampus were analysed, and the number of immunostained cells in the polymorphic layer of the dentate gyrus (dg) and the pyramidal cell layer and stratum oriens of the ca3, ca2 and ca1 fields of the hippocampus proper were quantified. |
2021-11-23 |
2023-08-13 |
human |
Elizabeth Nicholson, Dimitri M Kullman. Nicotinic receptor activation induces NMDA receptor independent long-term potentiation of glutamatergic signalling in hippocampal oriens interneurons. The Journal of physiology. vol 599. issue 2. 2021-04-12. PMID:33251594. |
long-term potentiation of glutamatergic transmission to hippocampal interneurons in stratum oriens does not require nmda receptors and the induction mechanisms are incompletely understood. |
2021-04-12 |
2023-08-13 |
Not clear |
Amanda Q Nguyen, Samantha Sutley, Jordan Koeppen, Karen Mina, Simone Woodruff, Sandy Hanna, Alekya Vengala, Peter W Hickmott, Andre Obenaus, Iryna M Ethel. Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32801156. |
lower numbers of parvalbumin-expressing cells and a reduction in the inhibitory vgat/gephyrin-positive synaptic sites on ca1 neurons in the stratum pyramidale and stratum oriens layers of ko hippocampus may contribute to reduced inhibition and higher excitation. |
2021-01-01 |
2023-08-13 |
mouse |
Lindsey N Friend, Ryan C Williamson, Collin B Merrill, Scott T Newton, Michael T Christensen, Jake Petersen, Bridget Wu, Isaac Ostlund, Jeffrey G Edward. Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes. Molecules (Basel, Switzerland). vol 24. issue 7. 2019-08-07. PMID:30987110. |
hippocampal stratum oriens somatostatin-positive cells undergo cb1-dependent long-term potentiation and express endocannabinoid biosynthetic enzymes. |
2019-08-07 |
2023-08-13 |
Not clear |
Inmaculada Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, Ancor Sanz-García, Berta Zamora, Raquel Rodríguez-Fernández, José Antonio Esteban, César Vener. Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. Neurobiology of aging. vol 78. 2019-07-08. PMID:30928883. |
moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (dg) and ca1, as well as a specific reduction in the volume of the stratum oriens and spine density in ca1. |
2019-07-08 |
2023-08-13 |
rat |
W Brad Ruzicka, Sivan Subburaju, Joseph T Coyle, Francine M Bene. Location matters: distinct DNA methylation patterns in GABAergic interneuronal populations from separate microcircuits within the human hippocampus. Human molecular genetics. vol 27. issue 2. 2019-01-03. PMID:29106556. |
the illumina humanmethylation450 beadchip was used to assess genome-wide dna methylation in stratum oriens gabaergic interneurons sampled by laser-microdissection from two discrete microcircuits along the trisynaptic pathway in postmortem human hippocampus from eight control, eight schizophrenia, and eight bipolar disorder subjects. |
2019-01-03 |
2023-08-13 |
human |
Marta Pérez-Rando, Esther Castillo-Gómez, María Bellés, Héctor Carceller, Juan Náche. The activation of NMDA receptors alters the structural dynamics of the spines of hippocampal interneurons. Neuroscience letters. vol 658. 2018-07-26. PMID:28838810. |
among hippocampal interneurons, the somatostatin expressing cells in the ca1 stratum oriens are of special interest because of their functional importance and structural characteristics: they display dendritic spines, which change their density in response to different stimuli. |
2018-07-26 |
2023-08-13 |
mouse |
Stefan L Leber, Ida C Llenos, Christine L Miller, Jeannette R Dulay, Johannes Haybaeck, Serge Wei. Homer1a protein expression in schizophrenia, bipolar disorder, and major depression. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 10. 2018-06-29. PMID:28815330. |
stratum oriens glial cells of the hippocampus showed decreased homer1a levels in bipolar disorder when compared to controls and major depression. |
2018-06-29 |
2023-08-13 |
Not clear |
Sivan Subburaju, Andrew J Coleman, Miles G Cunningham, W Brad Ruzicka, Francine M Bene. Epigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 11. 2018-06-20. PMID:27733539. |
in stratum oriens (so) of sector ca3/2 of the human hippocampus, a network of genes involved in the regulation of glutamic acid decarboxylase gad67 has been identified. |
2018-06-20 |
2023-08-13 |
human |
S Subburaju, A J Coleman, W B Ruzicka, F M Bene. Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. Translational psychiatry. vol 6. 2016-10-17. PMID:26812044. |
schizophrenia (sz) is associated with gaba neuron dysfunction in the hippocampus, particularly the stratum oriens of sector ca3/2. |
2016-10-17 |
2023-08-13 |
human |
Francine M Bene. Building models for postmortem abnormalities in hippocampus of schizophrenics. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25749020. |
in micro-dissected human hippocampal slices, a loss of interneurons and a compensatory upregulation of gabaa receptor binding activity on interneurons, but not pns, has suggested that disinhibitory gaba-to-gaba connections are abnormal in stratum oriens (so) of ca3/2, but not ca1, in schizophrenia. |
2016-06-27 |
2023-08-13 |
human |
Sarah R Hulme, Owen D Jones, Clarke R Raymond, Pankaj Sah, Wickliffe C Abraha. Mechanisms of heterosynaptic metaplasticity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298150. |
of particular interest is our previously reported finding that priming stimulation in stratum oriens of area ca1 in the hippocampal slice heterosynaptically inhibits subsequent long-term potentiation and facilitates long-term depression in stratum radiatum. |
2014-08-11 |
2023-08-12 |
Not clear |
Guilherme Neves, Mala M Shah, Petros Liodis, Angeliki Achimastou, Myrto Denaxa, Grant Roalfe, Abdul Sesay, Matthew C Walker, Vassilis Pachni. The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 8. 2014-02-26. PMID:22710612. |
consistent with a selective deficit in the differentiation of sst(+) interneurons in the ca1 subfield of the hippocampus, we observed reduced expression of metabotropic glutamate receptor 1 in the stratum oriens and characteristic changes in dendritic inhibition, but normal inhibitory input onto the somatic compartment of ca1 pyramidal cells. |
2014-02-26 |
2023-08-12 |
mouse |
Osnat Hadad-Ophir, Anne Albrecht, Oliver Stork, Gal Richter-Levi. Amygdala activation and GABAergic gene expression in hippocampal sub-regions at the interplay of stress and spatial learning. Frontiers in behavioral neuroscience. vol 8. 2014-01-30. PMID:24478650. |
spatial learning resulted in highly selective pattern of changes in hippocampal subregions: gene expression levels of neuropeptide y (npy) were reduced in the hilus of the dentate gyrus (dg), whereas somatostatin (sst) was increased in the stratum oriens (so) of ca3. |
2014-01-30 |
2023-08-12 |
rat |
Gergő A Nagy, Gergő Botond, Zsolt Borhegyi, Nicholas W Plummer, Tamás F Freund, Norbert Hájo. DAG-sensitive and Ca(2+) permeable TRPC6 channels are expressed in dentate granule cells and interneurons in the hippocampal formation. Hippocampus. vol 23. issue 3. 2013-08-12. PMID:23193081. |
double immunofluorescent staining showed that trpc6 channels were present in the dendrites of hilar interneurons and hippocampal interneurons with horizontal dendrites in the stratum oriens expressing mglu1a receptors, whereas parvalbumin immunoreactivity was revealed in trpc6-expressing dendrites with radial appearance in the stratum radiatum. |
2013-08-12 |
2023-08-12 |
mouse |
Le Zhang, Kalavathi Dasuri, Sun-Ok Fernandez-Kim, Annadora J Bruce-Keller, Linnea R Freeman, Jennifer K Pepping, Tina L Beckett, M Paul Murphy, Jeffrey N Kelle. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochimica et biophysica acta. vol 1832. issue 9. 2013-08-08. PMID:23313575. |
however, within the hippocampal gyri a localized increase in reactive microglia were increased in the ca1 and stratum oriens relative to caa mice on a control diet. |
2013-08-08 |
2023-08-12 |
mouse |