| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan-Dan Xu, Zhi-Qi Hou, Ya-Yun Xu, Jun Liang, Ye-Jun Gao, Chen Zhang, Fan Guo, Dan-Dan Huang, Jin-Fang Ge, Qing-Rong Xi. Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm". Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-02-02. PMID:38305948. |
furthermore, protein expression levels of the circadian locomotor output cycles kaput, cryptochrome 2, and period 2 was significantly reduced in the hippocampus of lps-challenged rats, whereas bmal1 expression was significantly increased in the hippocampus but decreased in the hypothalamus, where it was co-located with neurons, microglia, and astrocytes. |
2024-02-02 |
2024-02-04 |
rat |
| Jing Yin, Chun-Mei Tuo, Kai-Yue Yu, Xiao-Hong Hu, Yan-Ying Fan, Mei-Na W. Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice. Neuromolecular medicine. 2023-10-16. PMID:37843792. |
the results showed that the diurnal mrna expression profiles of ppo, ox1r, ox2r, bace2, bmal1, per1, per2 and cry1 in the hypothalamus, and gene expression of ox1r, ox2r, bace1, bmal1, per1 and cry2 in the hippocampus in 3xtg-ad mice were different from that in wt mice. |
2023-10-16 |
2023-11-08 |
mouse |
| Haotong Zhuang, Yuri Fujikura, Naoki Ohkura, Sayaka Higo-Yamamoto, Taiga Mishima, Katsutaka Oish. A ketogenic diet containing medium-chain triglycerides reduces REM sleep duration without significant influence on mouse circadian phenotypes. Food research international (Ottawa, Ont.). vol 169. 2023-05-31. PMID:37254426. |
the circadian expression of the core clock genes, per1, per2, bmal1, and dbp in the hypothalamus, heart, liver, epididymal adipose tissues, and skeletal muscle were almost identical between the ctrl and mct-kd mice, whereas the amplitude of hepatic per2 and adipose per1 expression was increased in mct-kd mice. |
2023-05-31 |
2023-08-14 |
mouse |
| Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.). vol 165. 2023-03-04. PMID:36869551. |
in hypothalamus and hippocampus, clock (bmal1 and clock) and tight junction (ocln and tjp2) genes were improved by prebiotics, and corticotropin-releasing hormone receptor genes, crf1 and crf2, were also significantly regulated for mitigation of depression and anxiety caused by sleep deprivation. |
2023-03-04 |
2023-08-14 |
mouse |
| Rong-Jin Lin, Xiao-Feng Da. Sleep deprivation affects sex hormones secretion by regulating the expression of the circadian clock gene in the hypothalamus and pituitary via the PI3K/Akt signaling pathway in pregnant rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 4. 2022-08-22. PMID:35993204. |
estradiol (e2) and progesterone (p4) levels were detected by enzyme-linked immunosorbent assay (elisa), and the expression of circadian clock genes, bmal1, clock and per2, in hypothalamus and pituitary gland tissues were evaluated by immunohistochemistry (ihc) and reverse transcription-quantitative polymerase chain reaction (rt-qpcr). |
2022-08-22 |
2023-08-14 |
rat |
| Matthew N Clemenzi, Alexandre Martchenko, Neruja Loganathan, Erika K Tse, Patricia L Brubaker, Denise D Belsha. Analysis of Western diet, palmitate and BMAL1 regulation of neuropeptide Y expression in the murine hypothalamus and BMAL1 knockout cell models. Molecular and cellular endocrinology. vol 507. 2021-04-30. PMID:32114021. |
analysis of western diet, palmitate and bmal1 regulation of neuropeptide y expression in the murine hypothalamus and bmal1 knockout cell models. |
2021-04-30 |
2023-08-13 |
mouse |
| Abhilash Prabhat, Indu Malik, Neelu Anand Jha, Sanjay Kumar Bhardwaj, Vinod Kuma. Developmental effects of constant light on circadian behaviour and gene expressions in zebra finches: Insights into mechanisms of metabolic adaptation to aperiodic environment in diurnal animals. Journal of photochemistry and photobiology. B, Biology. vol 211. 2021-04-30. PMID:32836050. |
intriguingly, at the end of the experiment, the majority (4/5th) of birds under ll were rhythmic in activity despite arrhythmic expression in the hypothalamus of c-fos (neuronal activity), rhodopsin and mel1-a genes (light perception), and clock genes (bmal1, per2 and rev-erb β). |
2021-04-30 |
2023-08-13 |
Not clear |
| Jason R Gerstner, Georgios K Pascho. Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO mice. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32093736. |
here we examined the circadian expression of fabp7 mrna in the hypothalamus of core clock gene bmal1 knock-out (ko) mice. |
2021-02-03 |
2023-08-13 |
mouse |
| Xiao Wu, Xuguang Liu, Zhongkun Jing, Yang Chen, Huahui Liu, Wenbin M. Moxibustion benignantly regulates circadian rhythm of REV-ERBα in RA rats. American journal of translational research. vol 12. issue 5. 2020-09-28. PMID:32509155. |
rt-pcr was used to measure the relatively expression quantity of rev-erbα, clock, bmal1, and per2 in hypothalamus, hippocampus, and adrenal gland. |
2020-09-28 |
2023-08-13 |
rat |
| Zothanmawii Renthlei, Tennison Gurumayum, Bijoy Krishna Borah, Amit Kumar Trived. Daily expression of clock genes in central and peripheral tissues of tree sparrow (Passer montanus). Chronobiology international. vol 36. issue 1. 2020-03-16. PMID:30365349. |
bmal1, clock, per2, per3, cry1, cry2 and npas2 showed daily oscillation in all tissues except cry2 in hypothalamus, pineal and intestine. |
2020-03-16 |
2023-08-13 |
Not clear |
| Zothanmawii Renthlei, Tennison Gurumayum, Bijoy Krishna Borah, Amit Kumar Trived. Daily expression of clock genes in central and peripheral tissues of tree sparrow (Passer montanus). Chronobiology international. vol 36. issue 1. 2020-03-16. PMID:30365349. |
here, we studied daily expression of canonical clock genes (bmal1, clock, per2, per3, cry1 and cry2) and clock-controlled gene (npas2) in all three central tissues (hypothalamus, pineal and retina) and in peripheral tissues (liver, intestine and muscle). |
2020-03-16 |
2023-08-13 |
Not clear |
| Neha Agarwal, Ila Mishra, Sangeeta Rani, Vinod Kuma. Temporal expression of clock genes in central and peripheral tissues of spotted munia under varying light conditions: Evidence for circadian regulation of daily physiology in a non-photoperiodic circannual songbird species. Chronobiology international. vol 35. issue 5. 2019-06-10. PMID:29370529. |
we monitored activity-rest pattern and measured 24-h mrna oscillation of core clock (bmal1, clock, per2, cry1 and cry2) and clock-controlled (e4bp4, rorα and rev-erbα) genes in the hypothalamus, retina, liver and gut of spotted munia subjected to an aberrant light-dark (ld) cycle (3.5l:3.5d; t7, t = period length of ld cycle) and continuous light (ll, 24l:0d), with controls on 24-h ld cycle (t24, 12l:12d). |
2019-06-10 |
2023-08-13 |
Not clear |
| Neha Agarwal, Ila Mishra, Sangeeta Rani, Vinod Kuma. Temporal expression of clock genes in central and peripheral tissues of spotted munia under varying light conditions: Evidence for circadian regulation of daily physiology in a non-photoperiodic circannual songbird species. Chronobiology international. vol 35. issue 5. 2019-06-10. PMID:29370529. |
an exposure to 3.5l:3.5d or ll induced arrhythmicity in transcriptional oscillation of all eight genes in the hypothalamus (except rev-erbα) and liver (except bmal1 and rev-erbα under t7 and cry1 under ll). |
2019-06-10 |
2023-08-13 |
Not clear |
| Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiu. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PloS one. vol 12. issue 11. 2017-11-28. PMID:29108016. |
finally, modifications to expression of 12 genes (adora2a, app, aqp4, bdnf, bmal1, clock, cry, gfap, orx1, orx2, per, tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed. |
2017-11-28 |
2023-08-13 |
rat |
| Devraj Singh, Vinod Kuma. Extra-hypothalamic brain clocks in songbirds: Photoperiodic state dependent clock gene oscillations in night-migratory blackheaded buntings, Emberiza melanocephala. Journal of photochemistry and photobiology. B, Biology. vol 169. 2017-04-26. PMID:28254568. |
the avian circadian pacemaker system is comprised of independent clocks in the retina, pineal and hypothalamus, as shown by daily and circadian oscillations of core clock genes (per2, cry1, bmal1 and clock) in several birds including migratory blackheaded buntings (emberiza melanocephala). |
2017-04-26 |
2023-08-13 |
Not clear |
| Edith Grosbellet, Stephanie Dumont, Carole Schuster-Klein, Beatrice Guardiola-Lemaitre, Paul Pevet, François Criscuolo, Etienne Challe. Circadian phenotyping of obese and diabetic db/db mice. Biochimie. vol 124. 2016-12-16. PMID:26144489. |
compared with db/+ mice, very subtle or no difference in oscillations of per1 and bmal1 is found in the medial hypothalamus. |
2016-12-16 |
2023-08-13 |
mouse |
| Amit Kumar Trivedi, Shalie Malik, Sangeeta Rani, Vinod Kuma. Pinealectomy abolishes circadian behavior and interferes with circadian clock gene oscillations in brain and liver but not retina in a migratory songbird. Physiology & behavior. vol 156. 2016-12-13. PMID:26801391. |
whereas activity-rest pattern was monitored continuously, the mrna expressions of clock genes (bmal1, clock, npas2, per2, cry1, rorα, reverα) were measured in the retina, hypothalamus, telencephalon, optic tectum and liver tissues at circadian times, ct, 1, 6, 13, 17 and 21 (ct 0, activity onset) on day 11 of the lldim. |
2016-12-13 |
2023-08-13 |
Not clear |
| b' Lucie Olejn\\xc3\\xadkov\\xc3\\xa1, Lenka Polidarov\\xc3\\xa1, Lucia Pau\\xc5\\xa1lyov\\xc3\\xa1, Martin Sl\\xc3\\xa1dek, Alena Sumov\\xc3\\xa. Diverse development and higher sensitivity of the circadian clocks to changes in maternal-feeding regime in a rat model of cardio-metabolic disease. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25839096.' |
in the suprachiasmatic nuclei of the hypothalamus (scn) and liver, the development of a high-amplitude expression rhythm selectively for bmal1 was delayed compared with wistar rat. |
2016-02-16 |
2023-08-13 |
rat |
| M Akiyama, S Takino, Y Sugano, T Yamada, A Nakata, T Miura, M Fukumoto, H Yamashir. EFFECT OF SEASONAL CHANGES ON TESTICULAR MORPHOLOGY AND THE EXPRESSION OF CIRCADIAN CLOCK GENES IN JAPANESE WOOD MICE (APODEMUS SPECIOSUS). Journal of biological regulators and homeostatic agents. vol 29. issue 3. 2015-11-16. PMID:26403397. |
the expression of bmal1 was significantly lower in the hypothalamus and testes during the transitional season compared to the reproductive and non-reproductive seasons. |
2015-11-16 |
2023-08-13 |
mouse |
| M Akiyama, S Takino, Y Sugano, T Yamada, A Nakata, T Miura, M Fukumoto, H Yamashir. EFFECT OF SEASONAL CHANGES ON TESTICULAR MORPHOLOGY AND THE EXPRESSION OF CIRCADIAN CLOCK GENES IN JAPANESE WOOD MICE (APODEMUS SPECIOSUS). Journal of biological regulators and homeostatic agents. vol 29. issue 3. 2015-11-16. PMID:26403397. |
in addition, rt-pcr analysis was carried out with mrna extracted from the hypothalamus and testes to evaluate the expression of the circadian clock genes clock, bmal1, per1, and cry1. |
2015-11-16 |
2023-08-13 |
mouse |