| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arman Ahmadzade, Leila Simani, Mehrdad Roozbeh, Farane Farsad, Mehdi Sheibani, Omid Negaresh, Mohammad Mehdi Emam, Alireza Rajaei, Muhanna Kazempour, Mahtab Ramezani, Samad Nazarpoo. Correlation between neurofilament, HMGB1, MMP9, ds DNA blood levels and cognitive impairment in patients with neuropsychiatric systemic lupus erythematosus. Caspian journal of internal medicine. vol 15. issue 1. 2024-03-11. PMID:38463908. |
high serum levels of neurofilament protein light subunit (nfl), high mobility group box 1 (hmgb1), matrix metalloproteinase-9 (mmp-9) and have been reported in several autoimmune diseases. |
2024-03-11 |
2024-03-14 |
Not clear |
| Jianying Zhang, Roshawn Brown, MaCalus V Hogan, James H-C Wan. Mitigating Scar Tissue Formation in Tendon Injuries: Targeting HMGB1, AMPK Activation, and Myofibroblast Migration All at Once. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139865. |
our findings revealed that intraperitoneal (ip) injections of met, administered before or after injury, as well as both, effectively prevented the release of hmgb1 into the tendon matrix and reduced circulating levels of hmgb1. |
2023-12-23 |
2023-12-25 |
mouse |
| Xiangjing Meng, Sumei Guo, Xiaoxia Zhang, Bo Jiao, Xiaohan Yang, Ming Li, Chao Li, Jin He, Shangya Chen, Cheng Peng, Hua Shao, Qiang Ji. HMGB1 inhibition reduces TDI-induced occupational asthma through ROS/AMPK/autophagy pathway. Ecotoxicology and environmental safety. vol 266. 2023-10-15. PMID:37839183. |
at the molecular level, inhibition of hmgb1 decreased the expressions of hmgb1, toll-like receptor 4, vimentin and matrix metalloproteinase-9 proteins, activated nf-κb and nod-like receptor protein 3 (nlrp3) inflammasome, and increased e-cadherin expression. |
2023-10-15 |
2023-11-08 |
mouse |
| Xiangqi Chen, Qian Liu, Enqing Wu, Zhiyuan Ma, Biguang Tuo, Shuji Terai, Taolang Li, Xuemei Li. The role of HMGB1 in digestive cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-27. PMID:37757495. |
in the context of digestive inflammation and tumors, hmgb1 readily migrates into the extracellular matrix and binds to immune cell receptors to affect their function and differentiation, further promoting digestive tract tissue injury and tumor development. |
2023-09-27 |
2023-10-07 |
Not clear |
| Qin Zhao, Zifan Zhao, Jing Zhang, Yueqi Ni, Simin Ouyang, Haoning Qi, Yiqian Yu, Richard J Miron, Hua Tang, Yufeng Zhan. Fn-HMGB1 Adsorption Behavior Initiates Early Immune Recognition and Subsequent Osteoinduction of Biomaterials. Advanced healthcare materials. 2023-08-21. PMID:37602504. |
dominanted by the highly expressed extracellular matrix protein fibronectin (fn) and the high mobility group box 1 (hmgb1). |
2023-08-21 |
2023-09-07 |
Not clear |
| Wenlan Ma, Jiarui Zhu, Ling Bai, Peipei Zhao, Feifei Li, Sigong Zhan. The role of neutrophil extracellular traps and proinflammatory damage-associated molecular patterns in idiopathic inflammatory myopathies. Clinical and experimental immunology. 2023-06-08. PMID:37289984. |
important components of nets, including high-mobility group box 1 (hmgb1), dna, histones, extracellular matrix (ecm), serum amyloid a (saa), and s100a8/a9, act as damage-associated molecular patterns (damps) to promote inflammation in iims. |
2023-06-08 |
2023-08-14 |
Not clear |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
the effects of ast were examined on the motor function, spinal cord edema, integrity of blood-spinal cord barrier (bscb), and expression of high mobility group box 1 (hmgb1), toll-like receptor 4 (tlr4), nuclear factor-kappa b (nf-κb), glial fibrillary acidic protein (gfap), and aquaporin-4 (aqp4), and matrix metallopeptidase- 9 (mmp-9) post-sci. |
2023-05-05 |
2023-08-14 |
rat |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
after spinal cord injury, hmgb1 is rapidly expressed by neurons, microglia and ependymal cells, and it is either actively or passively released into the extracellular matrix and blood circulation; furthermore, it also participates in the pathophysiological process of spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yingying Xie, Kang Zhang, Jingyan Zhang, Kai Zhang, Xuequan Hu, Lei Wang, Xuezhi Wang, Jianxi L. High mobility group box-1 regulates expression of EGFR, VEGF, StAR and TIMP1/2 in bovine granulosa cells through a mechanism involving TLR2/NF-κB. Animal reproduction science. vol 247. 2022-12-04. PMID:36463708. |
the mrna levels of tlr2, epidermal growth factor receptor (egfr), vascular endothelial growth factor (vegf), the steroidogenic acute regulatory protein (star), tissue inhibitors of matrix (timp1/2) of ovarian granulosa cells were upregulated by hmgb1(p < 0.05). |
2022-12-04 |
2023-08-14 |
cattle |
| Ramona Clemen, Kevin Arlt, Lea Miebach, Thomas von Woedtke, Sander Bekeschu. Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells. Cells. vol 11. issue 22. 2022-11-26. PMID:36429087. |
seventeen proteins were analyzed, including viral proteins (e.g., cmv and hbv), inflammation-related proteins (e.g., ho1 and hmgb1), matrix proteins (e.g., vim and coll), and vastly in the laboratory used proteins (e.g., bsa and ova). |
2022-11-26 |
2023-08-14 |
human |
| Jonathan Lozano, Alin Rai, Jarmon G Lees, Haoyun Fang, Bethany Claridge, Shiang Y Lim, David W Greenin. Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430812. |
nvs captured the dynamic proteome of parental cells and include pluripotency markers (lin28a, oct4) and regulators of cardiac repair processes, including tissue repair (gja1, hsp20/27/70, hmgb1), wound healing (flna, myh9, actc1, ilk), stress response/translation initiation (eif2s1/s2/s3/b4), hypoxia response (hmox2, hsp90, gnb1), and extracellular matrix organization (itga6, mfge8, itgb1). |
2022-11-26 |
2023-08-14 |
human |
| Hui Miao, Hao Ouyang, Qian Guo, Mengjuan Wei, Bin Lu, Guoyin Kai, Lili J. Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism. The Journal of nutritional biochemistry. 2022-04-26. PMID:35472433. |
cga reduced the enhanced hepatic extracellular matrix (ecm) expression and the elevated serum high-mobility group box 1 (hmgb1) content in mice fed with mcd diet. |
2022-04-26 |
2023-08-13 |
mouse |
| Marat Airapetov, Sergei Eresko, Andrei Lebedev, Evgenii Bychkov, Petr Shabano. The role of Toll-like receptors in neurobiology of alcoholism. Bioscience trends. vol 15. issue 2. 2021-11-29. PMID:33716257. |
ethanol consumption leads to the activation of neuroimmune signaling in the central nervous system through many subtypes of toll-like receptors (tlrs), as well as release of their endogenous agonists (high-mobility group protein b1 (hmgb1), s100 protein, heat shock proteins (hsps), and extracellular matrix degradation proteins). |
2021-11-29 |
2023-08-13 |
Not clear |
| Milad Shirvalilo. The blood-gas barrier in COVID-19: an overview of the effects of SARS-CoV-2 infection on the alveolar epithelial and endothelial cells of the lung. Tissue barriers. vol 9. issue 4. 2021-11-12. PMID:34232823. |
the infection of aecs and ecs with severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the pathogen behind covid-19, triggers an inflammatory response at the bgb, inducing the release of interleukin 1 (il-1), il-6, tumor necrosis factor alpha (tnf-α), transforming growth factor beta (tgf-β), high mobility group box 1 (hmgb1), matrix metalloproteinases (mmps), intercellular adhesion molecule-1 (icam-1) and platelet activating factor (paf). |
2021-11-12 |
2023-08-13 |
Not clear |
| Aishwarya Devaraj, Laura A Novotny, Frank H Robledo-Avila, John R Buzzo, Lauren Mashburn-Warren, Joseph A Jurcisek, Natalia O Tjokro, Santiago Partida-Sanchez, Lauren O Bakaletz, Steven D Goodma. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. The Journal of clinical investigation. vol 131. issue 16. 2021-11-08. PMID:34396989. |
extracellularly, hmgb1 induces a proinflammatory immune response, whereas the dnabii proteins stabilize the extracellular dna-dependent matrix that maintains bacterial biofilms. |
2021-11-08 |
2023-08-13 |
Not clear |
| Viktoria Anselm, Cornelia Sommersdorf, Montserrat Carrasco-Triguero, Paula Katavolos, Hannes Planatscher, Andreas Steinhilber, Thomas Joos, Oliver Poet. Matrix and Sampling Effects on Quantification of Protein Biomarkers of Drug-Induced Liver Injury. Journal of proteome research. vol 20. issue 11. 2021-11-05. PMID:34554759. |
matrix effects were observed particularly for hmgb1 and mcsf1r. |
2021-11-05 |
2023-08-13 |
Not clear |
| Can Yu, Zhao Lei, Xia Li, Li-Hua Huang, Zhi-Qiang Li, Hong-Wei Zhu, Duo Han, Hui Huang, Xiao Y. Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis. Biochemical genetics. 2021-09-29. PMID:34327615. |
our study demonstrated that hmgb1 migrated from the nucleus to the cytoplasm at the onset of necroptosis and was subsequently released passively to the extracellular matrix. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jiaming Xue, Joelle S Suarez, Michael Minaai, Shuangjing Li, Giovanni Gaudino, Harvey I Pass, Michele Carbone, Haining Yan. HMGB1 as a therapeutic target in disease. Journal of cellular physiology. vol 236. issue 5. 2021-09-28. PMID:33107103. |
hmgb1 can be released into the extracellular matrix (ecm) by either granulocytes or necrotic cells to serve as a chemotaxis/cytokine during infection, endotoxemia, hypoxia, ischemia-reperfusion events, and cancer. |
2021-09-28 |
2023-08-13 |
Not clear |
| R Guzmán-Ruiz, C Tercero-Alcázar, J López-Alcalá, J Sánchez-Ceinos, M M Malagón, A Gordo. The potential role of the adipokine HMGB1 in obesity and insulin resistance. Novel effects on adipose tissue biology. Molecular and cellular endocrinology. vol 536. 2021-09-16. PMID:34339826. |
this review summarizes the current evidence on the mechanisms controlling hmgb1 release, as well as its role as a regulator of adipocyte function and extracellular matrix remodeling, with special emphasis on the potential of this novel adipokine as a target in the obesity treatment. |
2021-09-16 |
2023-08-13 |
Not clear |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
dual luciferase reporter assays were executed for determining the correlation between mir-449b-5p and tug1, high mobility group box 1 (hmgb1), or matrix metalloproteinase 2 (mmp2). |
2021-06-10 |
2023-08-13 |
Not clear |