All Relations between matrix compartment and ko

Publication Sentence Publish Date Extraction Date Species
Yiming Zhong, Liang Zhou, Hui Wang, Sixiong Lin, Tiemin Liu, Xingxing Kong, Guozhi Xiao, Huanqing Ga. Kindlin-2 maintains liver homeostasis by regulating GSTP1-OPN-mediated oxidative stress and inflammation in mice. The Journal of biological chemistry. vol 300. issue 2. 2024-01-19. PMID:38159860. our recent study demonstrated that kindlin-2, a focal adhesion protein that activates integrins and regulates cell-extracellular matrix interactions, plays an important role in regulation of liver homeostasis by inhibiting inflammation pathway; however, the molecular mechanism of how kindlin-2 ko activates inflammation is unknown. 2024-01-19 2024-01-22 mouse
Zhaosu Chen, Jing Luo, Yunpeng Zhang, Shaoqi Zheng, Huifang Zhang, Yuanyong Huang, Jiemin Wong, Jiwen L. SUMOylation is enriched in the nuclear matrix and required for chromosome segregation. The Journal of biological chemistry. vol 300. issue 1. 2024-01-03. PMID:38072047. we demonstrated that inactivation of sumoylation by inhibiting sumo-activating e1 enzyme or ko of sumo-conjugating e2 enzyme ubc9 have only mild effect on nuclear matrix composition, indicating that sumoylation is neither required for nuclear matrix formation nor for targeting proteins to nuclear matrix. 2024-01-03 2024-01-10 Not clear
Xiaojian Shi, Marisa DeCiucis, Kariona A Grabinska, Jean Kanyo, Adam Liu, Tukiet T Lam, Hongying She. Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. Molecular cell. 2023-12-29. PMID:38157846. co-immunoprecipitation mass spectrometry and crispr knockout (ko) in mammalian cells identified that mitochondrial m-aaa protease afg3l2 is responsible for degrading slc25a39 through the matrix loop 1. 2023-12-29 2024-01-05 human
Jie Wu, Xi Ran, Tao Wang, Kun Xiong, Shuang Long, Yuhui Hao, Peng Wang, Aiping Wan. Enteric α-Defensin Contributes to Recovery of Radiation-Induced Intestinal Injury by Modulating Gut Microbiota and Fecal Metabolites. Radiation research. 2023-12-21. PMID:38124379. to address this, we utilized eαds-deficiency mice, in which the matrix metallopeptidase 7 to activate paneth cell α-defensins was knockout (ko) mice, and the complementary wild-type (wt) control mice for this study. 2023-12-21 2023-12-23 mouse
Y Tatarenko, M Li, P Pouletaut, M Kammoun, J R Hawse, V Joumaa, W Herzog, S Chatelin, S F Bensamou. Multiscale analysis of Klf10's impact on the passive mechanical properties of murine skeletal muscle. Journal of the mechanical behavior of biomedical materials. vol 150. 2023-12-14. PMID:38096609. at the submicron scale, no changes were observed between wt and klf10 ko myofibrils for either muscle; these results demonstrate that the passive property differences observed at the microscopic scale (fiber) are not caused by sarcomere intrinsic alterations but instead must originate outside the sarcomeres, likely in the collagen-based extracellular matrix. 2023-12-14 2023-12-17 mouse
Vaishaali Yogendran, Laura Mele, Oleksandra Prysyazhna, Vishwanie S Budhram-Mahade. Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways. Cell death & disease. vol 14. issue 11. 2023-11-25. PMID:38007517. male brn-3b knock-out (ko) aortas displayed extensive remodelling with increased extracellular matrix (ecm) deposition, elastin fibre disruption and small but consistent narrowing/coarctation in the descending aortas. 2023-11-25 2023-11-28 mouse
Connor James Robinson, Lalitha Thiagarajan, Rebecca Maynard, Maneesha Aruketty, Jeremy Herrera, Lewis Dingle, Adam Reid, Jason Wong, Heng Cao, James Dooley, Adrian Liston, Daniela Müllhaupt, Paul Hiebert, Hayley Hiebert, Svitlana Kurinn. Release of miR-29 target laminin C2 improves skin repair. The American journal of pathology. 2023-11-19. PMID:37981221. cutaneous wound healing model in mir29ab1 knockout (ko) mice was used to identify mir-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of mir-29. 2023-11-19 2023-11-29 mouse
Connor James Robinson, Lalitha Thiagarajan, Rebecca Maynard, Maneesha Aruketty, Jeremy Herrera, Lewis Dingle, Adam Reid, Jason Wong, Heng Cao, James Dooley, Adrian Liston, Daniela Müllhaupt, Paul Hiebert, Hayley Hiebert, Svitlana Kurinn. Release of miR-29 target laminin C2 improves skin repair. The American journal of pathology. 2023-11-19. PMID:37981221. one of them, laminin c2 (also known as laminin γ2), was strongly upregulated during skin repair in the wound matrix of ko mice. 2023-11-19 2023-11-29 mouse
Yan Liu, Yi-Hui Shao, Jun-Meng Zhang, Ying Wang, Mei Zhou, Hui-Qin Li, Cong-Cong Zhang, Pei-Jie Yu, Shi-Juan Gao, Xue-Rui Wang, Li-Xin Jia, Chun-Mei Piao, Jie Du, Yu-Lin L. Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-12. PMID:37828006. additionally, card9 ko suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase (mmp) expression. 2023-10-12 2023-10-15 mouse
Byung Chul Jung, Dongjoo You, Ikjun Lee, Daofeng Li, Rebecca L Schill, Katherine Ma, Anna Pi, Zehan Song, Wei-Chieh Mu, Ting Wang, Ormond A MacDougald, Alexander S Banks, Sona Kan. TET3 plays a critical role in white adipose development and diet-induced remodeling. Cell reports. vol 42. issue 10. 2023-10-01. PMID:37777963. transcriptomic analysis of wild-type and tet3 knockout (ko) apcs unveiled tet3 target genes, including pparg and several genes linked to the extracellular matrix, pivotal for adipogenesis and remodeling. 2023-10-01 2023-10-07 Not clear
Santhanam Shanmughapriya, Thiruvelselvan Ponnusamy, Prema Velusamy, Amrendra Kumar, Daniel Morris, Xueqian Zhang, Gang Ning, Marianne Klinger, Jean Copper, Sudarsan Rajan, Joseph Cheung, Natarajaseenivasan Kalimuthusamy, Nelli Mnatsakanya. Mitochondrial Magnesium is the cationic rheostat for MCU-mediated mitochondrial Ca2+ uptake. Research square. 2023-07-28. PMID:37502932. using a liver-specific mrs2 ko mouse model, we showed that decreased matrix [mg2+] is associated with increased mcu activity and matrix ca2+ overload. 2023-07-28 2023-08-14 mouse
Meisong Zhu, Zhiyou Cao, Fengbo Mo, Shoujie Shi, Jiawei Hu, Qiang Xu, Kun Quan, Jianhui Liang, Wei Li, Xin Hong, Bin Zhang, Xuqiang Liu, Min Da. ADRM1/RPN13 attenuates cartilage extracellular matrix degradation via enhancing UCH37-mediated ALK5 deubiquitination. International journal of biological macromolecules. 2023-07-05. PMID:37406898. global knockout (ko) adrm1 in cartilage or adrm1 inhibitor (ra190) could accelerate the disorders of extracellular matrix (ecm) homeostasis, thereby accelerated dmm-induced cartilage degeneration, whereas overexpression of adrm1 protected mice from dmm-induced oa development by maintaining the homeostasis of articular cartilage. 2023-07-05 2023-08-14 mouse
Ilaria Bernabei, Uwe Hansen, Driss Ehirchiou, Jürgen Brinckmann, Veronique Chobaz, Nathalie Busso, Sonia Nas. CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298730. moreover, we revealed by tem that cd11b ko cartilage had increased expression of lysyl oxidase (lox), the enzyme that catalyzes matrix crosslinks. 2023-06-11 2023-08-14 mouse
Fabian Baalmann, Jana Brendler, Anne Butthof, Yulia Popkova, Kathrin M Engel, Jürgen Schiller, Karsten Winter, Vera Lede, Albert Ricken, Torsten Schöneberg, Angela Schul. Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250906. transcriptome comparison of the papilla region of wt and ko mice revealed differences in the gene expression of extracellular matrix proteins (e.g., decorin, fibulin-1, fibulin-7) and proteins involved in sphingolipid metabolism (e.g., small subunit b of the serine palmitoyltransferase) and other related gpcrs (e.g., gpr171). 2023-05-30 2023-08-14 mouse
Lushen Li, Long Wu, Allison Kensiski, Jing Zhao, Marina W Shirkey, Yang Song, Wenji Piao, Tianshu Zhang, Zhongcheng Mei, Samuel J Gavzy, Bing Ma, Vikas Saxena, Young S Lee, Yanbao Xiong, Xiaofei Li, Xiaoxuan Fan, Reza Abdi, Jonathan S Bromber. FRC transplantation restores lymph node conduit defects in laminin α4-deficient mice. JCI insight. vol 8. issue 8. 2023-04-24. PMID:37092548. the present study revealed the specific roles of extracellular matrix lama4 in regulating ln conduits using frc-specific ko mouse strains. 2023-04-24 2023-08-14 mouse
Yuhang Liu, Xudong Zhang, Xiaodong Chen, Bingjun Zhang, Liming Dai, Chenglong Wang, Yang Li, Xiaoling Zhan. MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression. American journal of physiology. Cell physiology. 2023-03-20. PMID:36939200. mir146a knockout (ko) led to the increased chondrogenesis of mscs compared to that in wild-type (wt) mscs, whereas the overexpression of mir146a by mimics resulted in the decreased chondrogenesis of mscs, as determined by the mrna expression of collagen, type ii, alpha 1 (col2a1), aggrecan, cartilage oligomeric matrix protein (comp), and matrix metallopeptidase 13 (mmp13). 2023-03-20 2023-08-14 Not clear
Ying Sun, Buqu Hu, Gail Stanley, Zachary M Harris, Samir Gautam, Robert Homer, Jonathan L Koff, Govindarajan Rajagopala. IFN- American journal of respiratory cell and molecular biology. vol 68. issue 1. 2023-01-03. PMID:36125351. systemic t-cell activation with staphylococcal enterotoxin b resulted in robust upregulation of several chemokines, s100a8/a9, matrix metalloproteases, and other molecules implicated in tissue damage, granulocyte as well as agranulocyte adhesion, and diapedesis in the lungs as early as 4 hours, which was accompanied by subsequent neutrophil/eosinophil lung infiltration and severe ali in ifn-γ ko mice. 2023-01-03 2023-10-07 mouse
Dominika Czaplinska, Renata Ialchina, Henriette Berg Andersen, Jiayi Yao, Arnaud Stigliani, Johs Dannesboe, Mette Flinck, Xiaoming Chen, Jakub Mitrega, Sebastian Peter Gnosa, Oksana Dmytriyeva, Frauke Alves, Joanna Napp, Albin Sandelin, Stine Falsig Pederse. Crosstalk between tumor acidosis, p53, and extracellular matrix regulates pancreatic cancer aggressiveness. International journal of cancer. 2022-11-21. PMID:36408933. acid-adaptation-induced gain of cancerous traits was further increased p53 knockout (ko), but only in specific extracellular matrix (ecm) compositions. 2022-11-21 2023-08-14 Not clear
Yan Yang, Haiming Xiao, Zeyuan Lin, Rui Chen, Shanshan Li, Chuting Li, Xiaohong Sun, Ziqing Hei, Wenyan Gong, Heqing Huan. The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article). Biochemical pharmacology. 2022-11-08. PMID:36347273. here, we identified ckip-1 expression was down-regulated in diabetic kidneys and knockout (ko) of ckip-1 increased c-jun expression and extra cellular matrix (ecm) in kidneys of normal mice, and knockout (ko) of ckip-1 further exacerbated renal inflammatory fibrosis in diabetic mice. 2022-11-08 2023-08-14 mouse
De-Wei Peng, Chun-Lin Lan, Ling-Qin Dong, Meng-Xi Jiang, Huan Xiao, Robert J D'Amato, Zai-Long Ch. Anti-angiogenic properties of microRNA-29a in preclinical ocular models. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 45. 2022-11-02. PMID:36322719. rna sequencing analysis of retinas from mir-29a ko mice and rna interference experiments identified platelet-derived growth factor c and several extracellular matrix genes as downstream targets of mir-29a involved in regulating ocular angiogenesis. 2022-11-02 2023-08-14 mouse