| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yulong Zhang, Chenxi Gao, Juncong Luo, Arsalan Khan, Mounir M Salem-Bekhit, Mohamed M Salem, Zeng Qi, Bo Jian. Deciphering the role of wound healing genes in skin cutaneous melanoma: Insights into expression, methylation, mutations, and therapeutic implications. International wound journal. vol 21. issue 4. 2024-04-09. PMID:38591163. |
in this comprehensive study, we investigated the intricate roles of two important wound healing genes in skcm, including matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9). |
2024-04-09 |
2024-04-11 |
Not clear |
| Caixian Song, Liping Che. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer. Open medicine (Warsaw, Poland). vol 19. issue 1. 2024-04-08. PMID:38584845. |
quantitative real-time polymerase chain reaction and western blotting analyses confirmed that circ_0051428 and matrix metalloprotein-2 (mmp2) were overexpressed in cc, whereas the microrna mir-885-3p was poorly expressed. |
2024-04-08 |
2024-04-10 |
Not clear |
| Huirong Li, Liang Ding, Jian Ding, Fudan Huan. The Influence of CD40/CD40L, MMP2/MMP9 on Uterine Artery Blood Flow and Their Expression in Recurrent Miscarriage. Alternative therapies in health and medicine. 2024-04-06. PMID:38581334. |
this study aims to investigate the expression levels of soluble cd40l (scd40l), matrix metalloproteinase 2 (mmp2), and matrix metalloproteinase 9 (mmp9) in the serum of patients experiencing recurrent abortion and their impact on uterine artery blood flow. |
2024-04-06 |
2024-04-10 |
Not clear |
| Kunlun Li, Dandan Li, Barbod Hafez, Mounir M Salem Bekhit, Yousef A Bin Jardan, Fars Kaed Alanazi, Ehab I Taha, Sayed H Auda, Faiqah Ramzan, Muhammad Jami. Identifying and validating MMP family members (MMP2, MMP9, MMP12, and MMP16) as therapeutic targets and biomarkers in kidney renal clear cell carcinoma (KIRC). Oncology research. vol 32. issue 4. 2024-04-01. PMID:38560573. |
by performing string and cytohubba analyses of the 24 mmp gene family members, mmp2 (matrix metallopeptidase 2), mmp9 (matrix metallopeptidase 9), mmp12 (matrix metallopeptidase 12), and mmp16 (matrix metallopeptidase 16) genes were denoted as hub genes having highest degree scores. |
2024-04-01 |
2024-04-04 |
Not clear |
| Linping Wang, Luyi Chen, Daniel Schlenk, Feixue Li, Jing Li. Parabens promotes invasive properties of multiple human cells: A potential cancer-associated adverse outcome pathway. The Science of the total environment. 2024-03-28. PMID:38547973. |
mp and pp up-regulated the expression levels and enzymatic activities of matrix metalloproteinase 2 and 9 (mmp2 and mmp9), as well as altered the expression of the tissue inhibitors of metalloproteinase 1 and 2 (timp1 and timp2) in four cell lines, suggesting mmps/timps as potential key events (kes) for paraben-induced cell invasion. |
2024-03-28 |
2024-03-31 |
human |
| Haotian Zheng, Linxin Yang, Huashang Huang, Yazhou Lin, Lin Che. Morroniside improves AngII-induced cardiac fibroblast proliferation, migration, and extracellular matrix deposition by blocking p38/JNK signaling pathway through the downregulation of KLF5. Naunyn-Schmiedeberg's archives of pharmacology. 2024-03-13. PMID:38472369. |
in this study, it was found that mor treatment inhibited angii-induced hyperproliferation, migration, and fibrosis of hcf cells, accompanied with decreased activities of matrix metalloproteinase 2 (mmp2), matrix metalloproteinase 9 (mmp9), connective tissue growth factor (ctgf), fibronectin, and α-sma, which were all reversed by klf5 overexpression. |
2024-03-13 |
2024-03-15 |
human |
| Suvendu Nandi, Soumyadeep Bhaduri, Debraj Das, Priya Ghosh, Mahitosh Mandal, Pralay Mitr. Deciphering the Lexicon of Protein Targets: A Review on Multifaceted Drug Discovery in the Era of Artificial Intelligence. Molecular pharmaceutics. 2024-03-11. PMID:38466810. |
we have also demonstrated the pathological conditions of heat shock protein 27 (hsp27) and matrix metallopoproteinases (mmp2 and mmp9) and designed inhibitors of these proteins using the drug discovery paradigm in a case study on the discovery of drug molecules for cancer treatment. |
2024-03-11 |
2024-03-14 |
Not clear |
| Jianfeng Zhang, Xiaocui Feng, Runling Yang, Jingya Bai, Feiyun Gao, Bangzhi Zhan. The Journal of pharmacology and experimental therapeutics. 2024-03-07. PMID:38453525. |
in this study, we discovered that the beclin-1-derived peptide mp1 significantly inhibits the abnormal expression of fibrosis and epithelial-mesenchymal transition (emt)-related markers, including α-smooth muscle actin (α-sma), fibronectin (fn), collagen i (col i), matrix metallopeptidase 2 (mmp2), snail1, and vimentin (vim) both in vitro and in vivo. |
2024-03-07 |
2024-03-10 |
mouse |
| Zhong-Qi Pang, Jian-She Wang, Jin-Feng Wang, Ya-Xuan Wang, Bo Ji, Yi-Dan Xu, Jia-Xin He, Lu Zhang, Li-Qiu Zhang, Bei-Chen Ding, Yang Liu, Ming-Hua Re. JAM3 is a potential risk biomarker for predicting prognosis and immune cell infiltration by regulating epithelial-mesenchymal transition in bladder cancer. Biomolecules & biomedicine. 2024-02-24. PMID:38400838. |
subsequently, we found that overexpression of jam3 promoted the migration and invasion abilities in bc cells, regulating the expression levels of n-cadherin, matrix metallopeptidase 2 (mmp2) and claudin-1 thereby promoting emt levels. |
2024-02-24 |
2024-02-27 |
Not clear |
| Ze Wu, Qian Zhang, Hailong Wang, Shenghui Zhou, Bingxin Fu, Lanlan Fang, Jung-Chien Cheng, Ying-Pu Su. Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells. Molecular and cellular endocrinology. 2024-02-18. PMID:38369181. |
it has been shown that gdf-11-indued matrix metalloproteinase 2 (mmp2) expression is required for evt cell invasion. |
2024-02-18 |
2024-02-21 |
human |
| Jaime Ibarrola, Rachel R Xiang, Zhe Sun, Qing Lu, Michael A Hill, Iris Zamir Jaff. Inhibition of the Histone Methyltransferase EZH2 Induces Vascular Stiffness. Clinical science (London, England : 1979). 2024-02-16. PMID:38362910. |
ezh2 inhibition enhanced elastin fiber degradation and matrix metalloprotease-2 (mmp2) expression. |
2024-02-16 |
2024-02-18 |
mouse |
| Baosheng Zeng, Elizabeth M Knapp, Ekaterina Skaritanov, Rebecca Oramas, Jianjun Su. ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila. Development (Cambridge, England). 2024-02-12. PMID:38345299. |
drosophila matrix metalloproteinase 2 (mmp2) is specifically expressed in posterior follicle cells of stage-14 egg chambers (mature follicles) and is crucial for the breakdown of the follicular wall during ovulation, a process highly conserved from flies to mammals. |
2024-02-12 |
2024-02-15 |
drosophila_melanogaster |
| Hanrui Liu, Weifeng Yan, Chengyong Ma, Kun Zhang, Kuan Li, Jin Rongrong, Huayan Xu, Rong Xu, Jiyu Tong, Zhigang Yang, Yingkun Gu. Early Detection of Cardiac Fibrosis in Diabetic Mice by Targeting Myocardiopathy and matrix metalloproteinase 2. Acta biomaterialia. 2024-01-20. PMID:38244659. |
in this study, we identified matrix metalloproteinase 2 (mmp2) as a potential biomarker for early fibrosis detection. |
2024-01-20 |
2024-01-23 |
mouse |
| Xiaoxi Wang, Yan Wang, Wenyan Zhang, Xueqin Zhu, Zimai Liu, Meiyi Liu, Sijia Liu, Bingyu Li, Yalan Chen, Ziyan Wang, Pingping Zhu, Wenshan Zhao, Yongchao Wang, Zhenzhen Che. Biomimetic-gasdermin-protein-expressing nanoplatform mediates tumor-specific pyroptosis for cancer immunotherapy. Journal of controlled release : official journal of the Controlled Release Society. 2024-01-19. PMID:38242210. |
in this study, inspired by the tumor-specific expression of sry-box transcription factor 4 (sox4) and matrix metalloproteinase 2 (mmp2), we constructed a doubly regulated plasmid, pgmd, that expresses a biomimetic gasdermin d (gsdmd) protein to induce the caspase-independent pyroptosis of tumor cells. |
2024-01-19 |
2024-01-22 |
Not clear |
| Yixia Li, Xiaorong Zhong, Feng Yan. Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-29. PMID:38157023. |
western blotting was used to determine the levels of c3, he4, matrix metalloproteinase-2 (mmp2), mmp9, p-p65, prss23, and prss35 in renal tissues. |
2023-12-29 |
2024-01-05 |
mouse |
| Mengzhe Zhang, Fenfen Xiang, Yipeng Sun, Rongrong Liu, Qian Li, Qing Gu, Xiangdong Kang, Rong W. Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression. Oncology reports. vol 51. issue 2. 2023-12-22. PMID:38131251. |
the expression levels of proteins including arl4c, matrix metallopeptidase 2 (mmp2), phosphorylated (p)‑akt and p‑mtor were measured using western blot analysis. |
2023-12-22 |
2023-12-24 |
mouse |
| Min Chen, Shanjiao Huang, Shuoyun Weng, Junting Weng, Rongjie Guo, Bingbing Shi, Danjuan Li. Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-22. PMID:38133657. |
and sgr activated the mitochondrial biosynthesis-related peroxisome proliferator-activated receptor-γ coactivator-1α (pgc-1α), β-catenin, and matrix metallopeptidase 2 (mmp2) proteins. |
2023-12-22 |
2023-12-24 |
mouse |
| Shokoofeh Jamshidi, Ali Rostami, Setareh Shojaei, Amir Taherkhani, Heshmatollah Taherkhan. Exploring natural anthraquinones as potential MMP2 inhibitors: A computational study. Bio Systems. 2023-12-20. PMID:38123060. |
matrix metalloproteinase-2 (mmp2) plays a significant role in cleaving extracellular matrix components, leading to many cancer cells' progression and invasion behavior. |
2023-12-20 |
2023-12-23 |
Not clear |
| Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot analysis was performed to detect key proteins involved in ventricular remodeling, including transforming growth factor-β1(tgf-β1), α-smooth muscle actin(α-sma), wingless-type mmtv integration site family member 3a(wnt3a), β-catenin, matrix metallopeptidase 2(mmp2), matrix metallopeptidase 3(mmp3), timp metallopeptidase inhibitor 1(timp1), and timp metallopeptidase inhibitor 2(timp2). |
2023-12-19 |
2023-12-23 |
mouse |
| Xin-Yi Fan, Xiao-Qi Wei, Yun-Yang Zhang, Hai-Yin Pu, Fang-He Li, Kuo Gao, Xue Yu, Shu-Zhen Gu. [Effect and mechanism of Jiming Powder on myocardial fibrosis in mice with myocardial infarction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114180. |
western blot results showed that jiming powder reduced the expression of tgf-β1, α-sma, wnt3a, and β-catenin, decreased the levels of mmp2, mmp3, and timp2, and increased the level of timp1, suggesting its role in inhibiting cardiac fibroblast transformation, reducing extracellular matrix metabolism in myocardial cells, and lowering collagen Ⅰ and α-sma content, thus exerting an anti-myocardial fibrosis effect after myocardial infarction. |
2023-12-19 |
2023-12-23 |
mouse |