| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justyna Gogola-Mruk, Weronika Marynowicz, Kinga Krawczyk, Anna Pta. Visfatin increases the invasive potential of ovarian granulosa tumor spheroids by reprogramming glucose metabolism. Reproduction (Cambridge, England). 2023-03-07. PMID:36880885. |
moreover, visfatin increased the potential invasiveness of kgn spheroid cells by upregulating mmp2 (matrix metalloproteinase 2) and downregulating cldn3 and cldn4 (claudin 3 and 4) gene expression. |
2023-03-07 |
2023-08-14 |
Not clear |
| Shiyang Li, Xiaobin Zeng, Shihai Wang, Xiaoshuang Xie, Jianjun La. Association between MMP2 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population. ESC heart failure. 2023-03-03. PMID:36866790. |
mmp2 is a zinc-dependent and calcium-containing secreted endoproteinases, which could cleave a broad spectrum of substrates including extracellular matrix components and cytokines. |
2023-03-03 |
2023-08-14 |
Not clear |
| Stefan Harmansa, Alexander Erlich, Christophe Eloy, Giuseppe Zurlo, Thomas Lecui. Growth anisotropy of the extracellular matrix shapes a developing organ. Nature communications. vol 14. issue 1. 2023-03-03. PMID:36869053. |
moreover, differential expression of the matrix metalloproteinase mmp2 controls growth anisotropy of the ecm envelope. |
2023-03-03 |
2023-08-14 |
drosophila_melanogaster |
| Bin Zhang, Kuan Zeng, Rui-Cong Guan, Hui-Qi Jiang, Yong-Jia Qiang, Qing Zhang, Mo Yang, Bao-Ping Deng, Yan-Qi Yan. Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic Dissection. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830768. |
finally, immunohistochemistry, immunofluorescence, and western blot experiments confirmed the overexpression of macrophage marker genes (cd68 and cd163) and matrix metalloproteinases (mmp9 and mmp2) in ataad tissue. |
2023-02-25 |
2023-08-14 |
human |
| Dieter Blottner, Manuela Moriggi, Gabor Trautmann, Maria Hastermann, Daniele Capitanio, Enrica Torretta, Katharina Block, Joern Rittweger, Ulrich Limper, Cecilia Gelfi, Michele Salanov. Space Omics and Tissue Response in Astronaut Skeletal Muscle after Short and Long Duration Missions. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835504. |
immunoexpression signals of extracellular matrix (ecm) molecules, collagen 4 and 6, col4 and 6, and perlecan were reduced while matrix-metalloproteinase, mmp2, biomarker remained unchanged in ldm post vs. preflight suggesting connective tissue remodeling. |
2023-02-25 |
2023-08-14 |
human |
| Qingshuang Tang, Suhui Sun, Ping Wang, Lihong Sun, Yuan Wang, Lulu Zhang, Menghong Xu, Jing Chen, Ruiqi Wu, Jinxia Zhang, Ming Gong, Qingfeng Chen, Xiaolong Lian. Genetically Engineering Cell Membrane-Coated BTO Nanoparticles for MMP2-activated Piezocatalysis-immunotherapy. Advanced materials (Deerfield Beach, Fla.). 2023-02-22. PMID:36809650. |
herein, cellular membrane stably expressing matrix metallopeptidase 2 (mmp2)-activated pd-l1 blockades was engineered to coat ultrasmall barium titanate (bto) nanoparticle for overcoming the immunosuppressive microenvironment of tumors. |
2023-02-22 |
2023-08-14 |
Not clear |
| Zongang Liu, Mengnan Zhao, Xizi Jiang, Yao Zhang, Suning Zhang, Yitong Xu, Hongjiu Ren, Hongbo Su, Huanxi Wang, Xueshan Qi. Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway. Laboratory investigation; a journal of technical methods and pathology. vol 102. issue 12. 2023-02-15. PMID:36792299. |
overexpression of klhl17 in the cell lines of nsclc with klhl17-flag plasmid promoted the proliferation and migration of tumor cells, which was associated with elevated activation of rat sarcoma/mitogen-activated protein kinases (ras/mapk) signaling and increased expression of cyclin d1, cyclin d-dependent kinases 4 (cdk4), matrix metalloproteinase 2 (mmp2) and ras homolog gene family member a (rhoa). |
2023-02-15 |
2023-08-14 |
human |
| Xishuang Wang, Zengtao Wei, Zhongyun Tang, Chenyue Xue, Huayun Yu, Derui Zhang, Yulan Li, Xihong Liu, Yongyu Shi, Lining Zhang, Guoling Chen, Huaiyu Zhou, Jianing Wang, Xiaoyan Wan. IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 6. 2023-02-12. PMID:36775395. |
a mature form of il-37b (il-37bΔ1-45) effectively suppressed the migration and invasion of endometrial cancer cells by decreasing the expression of matrix metalloproteinase 2 (mmp2) via rac1/nf-κb signal pathway. |
2023-02-12 |
2023-08-14 |
Not clear |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| L Sari, X Castro-González, R Zampini, S Apichela, M Ratto, M Argañara. Characterization of proteases in the seminal plasma and spermatozoa of llama. Theriogenology. vol 199. 2023-01-22. PMID:36682266. |
matrix metalloproteinase 2 (mmp2) was the most prominent metallo-protease of llama seminal plasma characterized under the exposure of different inhibitors (edta and benzamidine) and by a specific immunodetection. |
2023-01-22 |
2023-08-14 |
Not clear |
| Guangrui Chen, Jian Li, Huimeng Liu, Huiyu Zhou, Mingqiu Liu, Di Liang, Zhiyun Meng, Hui Gan, Zhuona Wu, Xiaoxia Zhu, Peng Han, Taoyun Liu, Ruolan Gu, Shuchen Liu, Guifang Do. Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677811. |
the expression levels of myofibroblast markers, including col1a1, vimentin, α-sma, and matrix metallopeptidase 2 (mmp2), were also suppressed by cep. |
2023-01-21 |
2023-08-14 |
rat |
| Goutham V Ganesh, Kunka Mohanram Ramkuma. Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia. Inflammopharmacology. 2023-01-20. PMID:36662400. |
gelatin zymography of matrix metalloproteinase2 (mmp2) expression revealed that hemin under hyperglycemic condition significantly elevated mmp2 expression, which was reversed by pts treatment. |
2023-01-20 |
2023-08-14 |
Not clear |
| Qing Han, Shuran Tan, Lanqing Gong, Guoqing Li, Qiulei Wu, Le Chen, Shi Du, Wenhan Li, Xiaoli Liu, Jing Cai, Zehua Wan. Omental cancer-associated fibroblast-derived exosomes with low miR-29c-3p promote ovarian cancer peritoneal metastasis. Cancer science. 2023-01-16. PMID:36644823. |
based on rna-sequencing, expression assays, and luciferase assays, matrix metalloproteinase 2 (mmp2) was identified as a direct target of mir-29c-3p. |
2023-01-16 |
2023-08-14 |
mouse |
| Suraj Bastola, Chandrasekhar R Kothapalli, Anand Ramamurth. Sodium Nitroprusside-Stimulation of Elastic Matrix Regeneration by Aneurysmal Smooth Muscle Cells. Tissue engineering. Part A. 2023-01-04. PMID:36597287. |
snp treatment (100 nm) upregulated elastic matrix regeneration at both gene (p <0.05) and protein levels (p<0.01) without affecting cell proliferation, improved gene and protein expression of cross-linking enzyme, lysyl oxidase (lox) (p<0.05), inhibited the expression of mmp2 significantly (p<0.05) and promoted contractile smc phenotypes in ahasmc culture. |
2023-01-04 |
2023-08-14 |
human |
| Tomoki Takeuchi, Yusaku Nomura, Tomoko Tamita, Rie Nishikawa, Hiroyuki Kakinuma, Naoki Kojima, Kosuke Hitaka, Yunoshin Tamura, Masafumi Kamitani, Masashi Mima, Akiko Nozoe, Masato Hayash. Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold. Journal of medicinal chemistry. 2023-01-03. PMID:36595440. |
matrix metalloproteinase-2 (mmp2) is a zinc-dependent endopeptidase and a promising target for various diseases, including cancer and fibrosis. |
2023-01-03 |
2023-08-14 |
Not clear |
| Cuihua Liu, Fangxin Zhao, Peng Sun, Wenjie Han, Mei Hong, Jianqiang Wu, Xuan Zhan. [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 12. 2022-12-30. PMID:36585230. |
after transfection, the real-time quantitative pcr was used to detect the relative expressions of mir-181c and reck mrna, and western blot analysis was used to detect the expression levels of reck, matrix metalloproteinase 2 (mmp2) and mmp9 proteins. |
2022-12-30 |
2023-08-14 |
human |
| Yi-Kai Wang, Shi-Jie Li, Lu-Lu Zhou, Duan Li, Li-Wei Gu. GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells. European journal of pharmacology. vol 939. 2022-12-16. PMID:36473594. |
moreover, overexpression of galnt3 significantly down-regulated the expression of the oxidative stress markers nox2 and nox4, up-regulated total antioxidant capacity, decreased the expression of pro-inflammatory factors il-1β, tnf-α and il-8, matrix metalloproteinases mmp2 and mmp9, as well as reduced the apoptosis of cells in phosphate induced hasmcs. |
2022-12-16 |
2023-08-14 |
mouse |
| Zhencheng Yu, Yun Li, Rao Fu, Yaxin Xue, Danyang Zhao, Dong Ha. Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway. Archives of dermatological research. 2022-12-16. PMID:36526799. |
finally, western blot analysis showed that pd reduced tgf-β ri expression (p < 0.05) and affected matrix metalloproteinase 2 (mmp2) protein levels (p < 0.05). |
2022-12-16 |
2023-08-14 |
human |
| Hongcan Huang, Jing Xie, Jieya Wei, Siqun Xu, Demao Zhang, Xuedong Zho. Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65. Journal of bone and mineral metabolism. 2022-12-13. PMID:36512085. |
gelatinases, namely mmp2 and mmp9, are involved in the natural turnover of articular cartilage, as well as the loss of the cartilage matrix in osteoarthritis (oa). |
2022-12-13 |
2023-08-14 |
Not clear |
| Yongbin Jing, Mingkun Jia, Jinpeng Zhuang, Dong Han, Changlong Zhou, Jinglong Ya. TLR9 Exerts an Oncogenic Role in Promoting Osteosarcoma Progression Depending on the Regulation of NF-κB Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 12. 2022-11-30. PMID:36450527. |
furthermore, tlr9 overexpression could enhance the migration and invasion activities of the os cells by the upregulation of matrix metalloproteinases 2 (mmp2) and mmp9, and the opposite result was observed in tlr9-silenced cells. |
2022-11-30 |
2023-08-14 |
Not clear |