All Relations between matrix compartment and mmp2

Publication Sentence Publish Date Extraction Date Species
Lori M Roberts, Jenny A Visser, Holly A Ingraha. Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development. Development (Cambridge, England). vol 129. issue 6. 2002-04-19. PMID:11880357. we have identified a member of the matrix metalloproteinase gene family, mmp2, as one of the first candidate target genes downstream of the mis cascade to function as a paracrine death factor in müllerian duct regression. 2002-04-19 2023-08-12 mouse
T Kubo, T Saito, H Fukuzawa, Y Matsud. Two tandemly-located matrix metalloprotease genes with different expression patterns in the chlamydomonas sexual cell cycle. Current genetics. vol 40. issue 2. 2002-03-13. PMID:11680823. the mmp2 gene has ten introns and the deduced amino acid sequence has the hallmark motif characteristics of metzincin-type matrix metalloproteases. 2002-03-13 2023-08-12 Not clear
Bruno Legallicier, Germain Trugnan, Gillian Murphy, Brigitte Lelongt, Pierre Ronc. Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. Journal of the American Society of Nephrology : JASN. vol 12. issue 11. 2002-02-15. PMID:11675412. type iv collagenases matrix metalloproteinase-2 (mmp2) and mmp9 and their related proteins, mt1-mmp, tissue inhibitor of metalloproteinases 1 (timp1), timp2, and timp3, are expressed during kidney morphogenesis and nephrogenesis, but the renal ontogeny of these proteins is only partially known, and their persistence in the adult remains controversial. 2002-02-15 2023-08-12 mouse
Bruno Legallicier, Germain Trugnan, Gillian Murphy, Brigitte Lelongt, Pierre Ronc. Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. Journal of the American Society of Nephrology : JASN. vol 12. issue 11. 2002-02-15. PMID:11675412. all components persisted in specific segments of the adult renal tubule, where mmp9, mmp2, and mt1-mmp showed an apical expression, suggesting that substrates for these enzymes should be in the tubule lumen or in the apical cell domain and not in the extracellular matrix. 2002-02-15 2023-08-12 mouse
A S Rigg, N R Lemoin. Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo. Cancer gene therapy. vol 8. issue 11. 2002-02-14. PMID:11773977. pancreatic carcinomas overexpress several matrix metalloproteinases (mmps), in particular mmp2 and mmp9. 2002-02-14 2023-08-12 mouse
D J MacPhee, H Mostachfi, R Han, S J Lye, M Post, I Caniggi. Focal adhesion kinase is a key mediator of human trophoblast development. Laboratory investigation; a journal of technical methods and pathology. vol 81. issue 11. 2001-12-07. PMID:11706056. activated fak, phosphorylated on tyr-397, colocalized with alpha5 integrin and matrix metalloproteinase-2 (mmp2) expression in evt cells within a previously characterized intermediate, invasive-restrained region. 2001-12-07 2023-08-12 human
W R English, B Holtz, G Vogt, V Knäuper, G Murph. Characterization of the role of the "MT-loop": an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases. The Journal of biological chemistry. vol 276. issue 45. 2001-12-05. PMID:11555661. characterization of the role of the "mt-loop": an eight-amino acid insertion specific to progelatinase a (mmp2) activating membrane-type matrix metalloproteinases. 2001-12-05 2023-08-12 Not clear
T R Kyriakides, Y H Zhu, Z Yang, G Huynh, P Bornstei. Altered extracellular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice. The American journal of pathology. vol 159. issue 4. 2001-12-04. PMID:11583953. the alterations in neovascularization, dense tissue invasion, and mmp2 in tsp2-null mice coincided with the deposition of tsp2 in the extracellular matrix of wild-type animals. 2001-12-04 2023-08-12 mouse
S W Lin, M T Lee, F C Ke, P P Lee, C J Huang, M M Ip, L Chen, J J Hwan. TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103. Clinical & experimental metastasis. vol 18. issue 6. 2001-10-25. PMID:11592306. tgfbeta1 stimulates the secretion of matrix metalloproteinase 2 (mmp2) and the invasive behavior in human ovarian cancer cells, which is suppressed by mmp inhibitor bb3103. 2001-10-25 2023-08-12 human
F Kratz, J Drevs, G Bing, C Stockmar, K Scheuermann, P Lazar, C Unge. Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates. Bioorganic & medicinal chemistry letters. vol 11. issue 15. 2001-10-04. PMID:11454467. two doxorubicin albumin conjugates (a-dp1 and a-dp2), which differ in their substrate specificity for the matrix metalloproteinases mmp2 and mmp9, were prepared by binding maleimide doxorubicin peptide derivatives to the cysteine-34 position of human serum albumin. 2001-10-04 2023-08-12 human
D L Boger, J Goldberg, S Silletti, T Kessler, D A Cheres. Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3). Journal of the American Chemical Society. vol 123. issue 7. 2001-09-13. PMID:11456699. both mmp2, which degrades the extracellular matrix (ecm), and integrin alpha(v)beta(3), which contributes to endothelial cell attachment to the ecm, are critically involved in this process. 2001-09-13 2023-08-12 Not clear
D L Boger, J Goldberg, S Silletti, T Kessler, D A Cheres. Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3). Journal of the American Chemical Society. vol 123. issue 7. 2001-09-13. PMID:11456699. a prototypical inhibitor was further found to prevent the degradation of the protein matrix without directly inhibiting mmp2 activity or disrupting the binding of alpha(v)beta(3) to its classical ecm ligand, vitronectin. 2001-09-13 2023-08-12 Not clear
T Yano, H Kawano, H Mochizuki, O Doi, T Nakamura, Y Sait. Atherosclerotic plaques composed of a large core of foam cells covered with thin fibrous caps in twice-injured carotid arterial specimens obtained from high cholesterol diet-fed rabbits. Journal of atherosclerosis and thrombosis. vol 7. issue 2. 2001-08-09. PMID:11426587. gelatin proteolytic activities were found in homogenates containing either media or intima from the injured artery, and activated matrix metalloproteinase-2 (mmp2) was detected. 2001-08-09 2023-08-12 Not clear
J A Martignetti, A A Aqeel, W A Sewairi, C E Boumah, M Kambouris, S A Mayouf, K V Sheth, W A Eid, O Dowling, J Harris, M J Glucksman, S Bahabri, B F Meyer, R J Desnic. Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nature genetics. vol 28. issue 3. 2001-08-02. PMID:11431697. mutation of the matrix metalloproteinase 2 gene (mmp2) causes a multicentric osteolysis and arthritis syndrome. 2001-08-02 2023-08-12 Not clear
N Théret, O Musso, B Turlin, D Lotrian, P Bioulac-Sage, J P Campion, K Boudjéma, B Clémen. Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas. Hepatology (Baltimore, Md.). vol 34. issue 1. 2001-07-26. PMID:11431737. matrix metalloproteinase-2 (mmp2) is a key enzyme in the process of extracellular matrix remodeling involved in tumor invasion and metastasis. 2001-07-26 2023-08-12 human
Y Matsumoto, K Tanaka, K Harimaya, F Nakatani, S Matsuda, Y Iwamot. Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells. Japanese journal of cancer research : Gann. vol 92. issue 4. 2001-07-05. PMID:11346466. the disruption of extracellular matrix (ecm) by matrix metalloproteinase 2 (mmp2) is also critical for tumor cell invasion. 2001-07-05 2023-08-12 human
Z Yang, D K Strickland, P Bornstei. Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11113133. we have recently shown that the adhesive defect observed in dermal fibroblasts derived from thrombospondin 2 (tsp2)-null mice results from an increase in matrix metalloproteinase 2 (mmp2) levels (yang, z., kyriakides, t. r., and bornstein, p. (2000) mol. 2001-06-21 2023-08-12 mouse
Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. this study was undertaken to investigate the mrna synthesis of mmp2, mmp9, membrane-type 1 (mt1)-mmp, and matrix metalloproteinase inhibitors timp1 and timp2 by in situ hybridization in a set of heart mitral and aortic valves operatively removed due to degenerative or inflammatory valvular diseases. 2001-06-21 2023-08-12 Not clear
Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. the results show that matrix metalloproteinases mmp2 and mmp9, and matrix metalloproteinase inhibitors timp1 and timp2 mrnas are synthesized in diseased valves and suggest that they may contribute to matrix remodelling in valvular disease. 2001-06-21 2023-08-12 Not clear
John Martin, Lisa Eynstone, Malcolm Davies, Robert Steadma. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology : JASN. vol 12. issue 1. 2001-05-24. PMID:11134254. the present study, therefore, investigated the effect of different matrix components on the adherence of hmc and on their secretion and activation of the gelatinases mmp2 and mmp9. 2001-05-24 2023-08-12 human