Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Yuan Wu, Haixiang Zhu, Qijin Xu, Yan Li, Leiwen Tan. Effect of exercise training in patients with angina with nonobstructive coronary arteries: a systematic review and meta-analysis. Coronary artery disease. 2024-10-29. PMID:39470145. |
nitric oxide (wmd = 20.18, 95% ci: 19.16 to 21.21) and peripheral arterial tonometry (wmd = 0.16, 95% ci: 0.11 to 0.21) were higher, and matrix metalloproteinase-9 (wmd = -8.02, 95% ci: -9.21 to -6.84) was lower in et group. |
2024-10-29 |
2024-10-31 |
Not clear |
Apurva Jaiswal, Neha Kaushik, Tirtha Raj Acharya, Han Sup Uhm, Eun Ha Choi, Nagendra Kumar Kaushi. Antiaging in a Bottle: Bioactive Competency of Plasma-Generated Nitric Oxide Water for Modulation of Aging-Related Signature in Human Dermal Cells. ACS applied materials & interfaces. 2024-10-22. PMID:39437326. |
herein, we examine the potential of plasma-generated nitric oxide water (now) as a bioactive agent in human dermal fibroblasts, emphasizing gene expression patterns linked to extracellular matrix (ecm) breakdown and cellular senescence. |
2024-10-22 |
2024-10-25 |
human |
G Priyadarshini, Sreejith Parameswaran, Jayaprakash Sahoo, Sandhiya Selvarajan, Ananthakrishnan Ramesh, Medha Rajapp. Matrix Gla Protein and Nitric Oxide Synthase-3 Genetic Variants in Chronic Kidney Disease and Their Relation with Cardiovascular Risk. International journal of nephrology. vol 2024. 2024-09-09. PMID:39246453. |
matrix gla protein and nitric oxide synthase-3 genetic variants in chronic kidney disease and their relation with cardiovascular risk. |
2024-09-09 |
2024-09-11 |
Not clear |
Rizki Rahmadi Pratama, Riza Ambar Sari, Irawati Sholikhah, Hakiman Mansor, Hsin-I Chang, Sukardiman, Retno Widyowat. Inhibition of nitric oxide production in RAW 264.7 cells and cytokines IL-1β in osteoarthritis rat models of 70 % ethanol extract of Heliyon. vol 10. issue 15. 2024-08-22. PMID:39170555. |
interleukin-1β (il-1β) and nitric oxide (no) are essential factors in the pain response; il-1β and no are responsible for increasing the production of matrix metalloproteinases (mmp) and a disintegrin-like and metalloproteinases with thrombospondin motifs (adams) in chondrocytes. |
2024-08-22 |
2024-08-24 |
rat |
Yu-Chen Hu, Tzu-Ching Huang, Li-Wen Huang, Hsiao-Ling Cheng, Bau-Shan Hsieh, Kee-Lung Chan. S-Equol Ameliorates Menopausal Osteoarthritis in Rats through Reducing Oxidative Stress and Cartilage Degradation. Nutrients. vol 16. issue 14. 2024-07-27. PMID:39064807. |
knee joint histopathological change; serum biomarkers of bone turnover, including n-terminal propeptide of type i procollagen (pinp), c-terminal telopeptide of type i collagen (ctx-i) and n-terminal telopeptide of type i collagen (ntx-i); the cartilage degradation biomarkers hyaluronic acid (ha) and n-terminal propeptide of type ii procollagen (piinp); and the matrix-degrading enzymes matrix metalloproteinases (mmp)-1, mmp-3 and mmp-13, as well as the oxidative stress-inducing molecules nitric oxide (no) and hydrogen peroxide (h |
2024-07-27 |
2024-07-29 |
mouse |
Samina Malik, Sulayman Waquar, Nimra Idrees, Arif Mali. Impending role of inflammatory markers and their specificity and sensitivity in breast cancer patients. Scientific reports. vol 14. issue 1. 2024-07-02. PMID:38956273. |
serum samples were obtained, and the levels of stress and inflammatory markers, including matrix metalloproteases (mmps), interleukins (ils), heat shock proteins (hsps), malondialdehyde (mda), nitric oxide (no), inducible nitric oxide synthase (inos) and tumour necrosis factor-alpha (tnf-α), were determined. |
2024-07-02 |
2024-07-06 |
cat |
Jiangtao Fu, Pingping Zhang, Zhiguo Sun, Guodong Lu, Qi Cao, Yiting Chen, Wenbin Wu, Jiabao Zhang, Chunlin Zhuang, Chunquan Sheng, Jiajun Xu, Ying Lu, Pei Wan. A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment. Acta pharmaceutica Sinica. B. vol 14. issue 5. 2024-05-27. PMID:38799646. |
nitric oxide (no) is a versatile biological molecule that can degrade extracellular matrix. |
2024-05-27 |
2024-05-31 |
Not clear |
Sree Samanvitha Kuppa, Ju Yeon Kang, Hong Yeol Yang, Seok Cheol Lee, Jaishree Sankaranarayanan, Hyung Keun Kim, Jong Keun Seo. Hyaluronic Acid Viscosupplement Modulates Inflammatory Mediators in Chondrocyte and Macrophage Coculture via MAPK and NF-κB Signaling Pathways. ACS omega. vol 9. issue 19. 2024-05-21. PMID:38764654. |
the viscosupplement attenuated inflammation, showing an inhibitory effect on nitric oxide production, downregulating proinflammatory cytokines such as matrix metalloproteinases (mmp13 and mmp3), and upregulating the expression levels of type ii collagen and aggrecan in chondrocytes. |
2024-05-21 |
2024-05-27 |
Not clear |
Carolina Rosa Rodrigues Souza, Edileia Souza Paula Caetano, Serginara David Rodrigues, Matheus Cleto Lopes, Bruna Rahal Mattos, Mariana Landenberger Santos, Elen Rizzi, Carlos A Dias-Junio. Isoflurane increases the activity of the vascular matrix metalloproteinase-2 in non-pregnant rats and increases the nitric oxide metabolites in pregnancy. Bioscience reports. 2024-05-17. PMID:38757914. |
isoflurane increases the activity of the vascular matrix metalloproteinase-2 in non-pregnant rats and increases the nitric oxide metabolites in pregnancy. |
2024-05-17 |
2024-05-27 |
rat |
Danmeng Bai, Haoxin Cheng, Junmin Mei, Guangqi Tian, Qingqing Wang, Simin Yu, Jie Gao, Yanhua Zhong, Hongbo Xin, Xiaolei Wan. Rapid formed temperature-sensitive hydrogel for the multi-effective wound healing of deep second-degree burn with shikonin based scar prevention. Biomaterials advances. vol 160. 2024-04-20. PMID:38642517. |
in this study, snp/mcns-skn-chitosan-β-glycerophosphate hydrogel (mssh), a hydrogel composed of a temperature-sensitive chitosan-β-glycerophosphate hydrogel matrix (cgh), mesoporous carbon nanospheres (mcns), nitric oxide (no) donor sodium nitroprusside (snp) and anti-scarring substance shikonin (skn), is intended for use as a biomedical material. |
2024-04-20 |
2024-04-23 |
Not clear |
Samia Mahmoud Manawy, Eman Mohamed Faruk, Rabab Fawzy Hindawy, Mahmoud M Hassan, Diaa M G Farrag, Mansour A E Bashar, Hanan Fouad, Rania Abubaker Bagabir, Dina Allam Abdelmaksoud Hassan, Ahmed Mohammed Zaazaa, Mohamed Ghazy Attia Hablas, K Mostafa Kama. Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone). Tissue & cell. vol 87. 2024-02-27. PMID:38412579. |
renal tissue was collected to assess matrix metalloproteinase-9 (mmp9), inflammatory and apoptotic markers: tumor necrosis factor-alpha (tnf- β, caspase-3, cyclo-oxygenase-2 (cox-2), and oxidative stress markers: nitric oxide (no), glutathione (gsh), malondialdehyde (mda), and superoxide dismutase (sod). |
2024-02-27 |
2024-03-01 |
rat |
Sung Un Kang, Haeng Jun Kim, Sukhwal Ma, Doo-Yi Oh, Jeon Yeob Jang, Chorong Seo, Yun Sang Lee, Chul-Ho Ki. Liquid plasma promotes angiogenesis through upregulation of endothelial nitric oxide synthase-induced extracellular matrix metabolism: potential applications of liquid plasma for vascular injuries. Cell communication and signaling : CCS. vol 22. issue 1. 2024-02-19. PMID:38374138. |
liquid plasma promotes angiogenesis through upregulation of endothelial nitric oxide synthase-induced extracellular matrix metabolism: potential applications of liquid plasma for vascular injuries. |
2024-02-19 |
2024-02-22 |
Not clear |
Hannah Youngblood, Patricia V Schoenlein, Louis R Pasquale, W Daniel Stamer, Yutao Li. Estrogen dysregulation, intraocular pressure, and glaucoma risk. Experimental eye research. 2023-11-16. PMID:37956940. |
based upon its known activities, estrogen signaling may promote iop homeostasis by affecting extracellular matrix turnover, focal adhesion assembly, actin stress fiber formation, mechanosensation, and nitric oxide production. |
2023-11-16 |
2023-11-20 |
Not clear |
Fang-Fang Xu, Fan Zheng, Ye Chen, Yang Wang, Shao-Bo Ma, Weng Ding, Le-Sha Zhang, Ji-Zheng Guo, Chang-Bo Zheng, Bing She. Role of thrombospondin-1 in high-salt-induced mesenteric artery endothelial impairment in rats. Acta pharmacologica Sinica. 2023-11-06. PMID:37932403. |
the matrix glycoprotein thrombospondin-1 (thbs1) modulates nitric oxide (no) signaling in endothelial cells. |
2023-11-06 |
2023-11-08 |
rat |
Xiaosha Wang, Maoren Wang, Hanhan Liu, Karl Mercieca, Julia Prinz, Yuan Feng, Verena Prokosc. The Association between Vascular Abnormalities and Glaucoma-What Comes First? International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686017. |
in this study, several biomarkers of glaucoma progression from a vascular perspective, including endothelin-1 (et-1), nitric oxide, vascular endothelial growth factor (vegf), and matrix metalloproteinases (mmps), were identified and subsequently assessed for their potential as pharmacological intervention targets. |
2023-09-09 |
2023-10-07 |
chicken |
Gisela Soledad Gualdoni, Camila Barril, Patricia Verónica Jacobo, Liliana Nazareth Pacheco Rodríguez, Elisa Cebra. Involvement of metalloproteinase and nitric oxide synthase/nitric oxide mechanisms in early decidual angiogenesis-vascularization of normal and experimental pathological mouse placenta related to maternal alcohol exposure. Frontiers in cell and developmental biology. vol 11. 2023-09-06. PMID:37670932. |
these placental angiogenic events are highly dependent on the coordination of several mechanisms at the early maternal-fetal interface, and one of them is the expression and activity of matrix metalloproteinases (mmps) and endothelial nitric oxide synthases (noss). |
2023-09-06 |
2023-10-07 |
mouse |
Zhifang Tang, Hanzhen Feng, Xusheng Chen, Shuiyan Shao, Chuan L. SNORC knockdown alleviates inflammation, autophagy defect and matrix degradation of chondrocytes in osteoarthritis development. Molecular and cellular biochemistry. 2023-09-02. PMID:37659033. |
knocking down snorc in il-1β-induced chondrocytes obviously suppressed the production of nitric oxide (no), il-6, tumor necrosis factor (tnf)-α and prostaglandin e2 (pge2) to alleviate inflammation, and reduced the protein levels of a disintegrin and metalloproteinase with thrombospondin 5 (adamts5) and matrix metallopeptidase (mmp)13 and elevated collagen type 2 alpha 1 (col2a1) level to improve matrix degradation. |
2023-09-02 |
2023-09-07 |
rat |
Laisla Zanetoni Martins, Maria Luiza Santos da Silva, Serginara David Rodrigues, Sáskia Estela Biasotti Gomes, Laura Molezini, Elen Rizzi, Marcelo Freitas Montenegro, Carlos Alan Dias-Junio. Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628999. |
placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (no) and the vascular activity of extracellular matrix metalloproteinase-2 (mmp-2). |
2023-08-26 |
2023-09-07 |
rat |
Bingqing Wang, Yuqing Yang, Yichen Wang, Yanxin Yang, Yi Li, Chenxi Hu, Changyue Xu. Matrix stiffness regulates neovascular homeostasis through autophagy in nude mice. Journal of cellular physiology. 2023-08-11. PMID:37565586. |
endothelial function markers, such as endothelial nitric oxide synthase and e-selectin, were downregulated as the matrix stiffness increased. |
2023-08-11 |
2023-08-16 |
mouse |
Judit Hodrea, Minh Ngoc Tran, Balazs Besztercei, Timea Medveczki, Attila J Szabo, Laszlo Őrfi, Illes Kovacs, Andrea Feket. Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511406. |
furthermore, flu demonstrated its protective effects by increasing the production of nitric oxide and facilitating the degradation of the extracellular matrix through the elevation of cathepsin k. these findings suggest that the s1r could be a novel target for the development of anti-fibrotic drugs and offer a new therapeutic approach for glaucoma. |
2023-07-29 |
2023-08-14 |
mouse |