| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huai-Dong Li, Qing-Xiang Zhang, Zhi Mao, Xing-Jie Xu, Nai-Yi Li, Hui Zhan. Exogenous interleukin-10 attenuates hyperoxia-induced acute lung injury in mice. Experimental physiology. vol 100. issue 3. 2015-11-16. PMID:25480159. |
in conclusion, our results show that exogenous il-10 treatment alleviates hyperoxia-induced acute lung injury in mice, possibly by regulating neutrophil recruitment and the subsequent generation of cytokines, nitric oxide and matrix metalloproteinases. |
2015-11-16 |
2023-08-13 |
mouse |
| Anat Elmann, Alona Telerman, Sharon Mordechay, Hilla Erlank, Miriam Rindner, Yoel Kashman, Rivka Ofi. Downregulation of microglial activation by achillolide A. Planta medica. vol 81. issue 3. 2015-11-03. PMID:25654405. |
in primary cultures of lipopolysaccharide-activated microglial cells, achillolide a inhibited the lipopolysaccharide-induced levels of proinflammatory and toxic mediators including glutamate, nitric oxide, matrix metalloproteinase-9, cyclooxygenase-2, induced nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α. |
2015-11-03 |
2023-08-13 |
Not clear |
| Thomas P Vacek, Shahnaz Rehman, Diana Neamtu, Shipeng Yu, Srikanth Givimani, Suresh C Tyag. Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms. Vascular health and risk management. vol 11. 2015-10-19. PMID:25767394. |
matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms. |
2015-10-19 |
2023-08-13 |
Not clear |
| Ali M Mutlag, Xuezhi Wang, Zhiqiang Yang, Jiaren Meng, Xurong Wang, Jingyan Zhang, Zhe Qin, Guibo Wang, Jianxi L. Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts. Animal reproduction science. vol 152. 2015-09-01. PMID:25496672. |
the objective of this study was to investigate how changes in total nitric oxide (no) and ovarian matrix metalloproteinase (mmp)-1 and mmp-2 correlated with luteinizing hormone (lh) and estradiol (e2) in infertile dairy cows with ovarian cysts. |
2015-09-01 |
2023-08-13 |
Not clear |
| Guanghong Jia, Annayya R Aroor, Vincent G DeMarco, Luis A Martinez-Lemus, Gerald A Meininger, James R Sower. Vascular stiffness in insulin resistance and obesity. Frontiers in physiology. vol 6. 2015-08-31. PMID:26321962. |
although the underlying mechanisms and mediators of vascular stiffness are not well understood, accumulating evidence supports the role of metabolic and immune dysregulation related to increased adiposity, activation of the renin angiotensin aldosterone system, reduced bioavailable nitric oxide, increased vascular extracellular matrix (ecm) and ecm remodeling in the pathogenesis of vascular stiffness. |
2015-08-31 |
2023-08-13 |
Not clear |
| G L Shyni, G Sindhu, A Hele. Downregulation of inflammatory mediators and pro-inflammatory cytokines by alkaloids of Jeevaneeya rasayana in adjuvant-induced arthritis. Immunological investigations. vol 44. issue 1. 2015-08-06. PMID:25058430. |
paw swelling, inflammatory mediators such as cyclooxygenase-2 (cox-2), matrix metalloproteinase-9 (mmp-9), level of prostaglandin e2 (pge2), expression of cytokines and serum nitric oxide (no) level were analyzed in experimental rats after an experimental period of 21 days. |
2015-08-06 |
2023-08-13 |
rat |
| Jong-Hau Hsu, Rei-Cheng Yang, Shih-Jen Lin, Shu-Fen Liou, Zen-Kong Dai, Jwu-Lai Yeh, Jiunn-Ren W. Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock. Shock (Augusta, Ga.). vol 42. issue 6. 2015-07-17. PMID:25243423. |
these results demonstrate that in lps-induced septic shock, extracellular hsc70 conveys pleiotropic protection on myocardial, hepatic, and systemic derangements, with associated inhibition of proinflammatory mediators including tumor necrosis factor α, nitric oxide, cyclooxygenase 2, and matrix metalloproteinase 9, through mitogen-activated protein kinase/nuclear factor κb signaling pathways. |
2015-07-17 |
2023-08-13 |
rat |
| Sarah R Amend, Ozge Uluckan, Michelle Hurchla, Daniel Leib, Deborah Veis Novack, Matthew Silva, William Frazier, Katherine N Weilbaeche. Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 1. 2015-07-14. PMID:25042340. |
thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts. |
2015-07-14 |
2023-08-13 |
mouse |
| Gian Mario Tiboni, Adalisa Ponzan. Nitric oxide and teratogenesis: an update. Current pharmaceutical design. vol 20. issue 34. 2015-06-22. PMID:24502594. |
nitric oxide (no), generated by no synthase (nos) enzymes, is an important bioactive molecule involved in the regulation of several biological phenomena that are crucial for organogenesis, including gene expression, cell growth, matrix remolding, proliferation, differentiation and apoptosis. |
2015-06-22 |
2023-08-12 |
mouse |
| Refah Sayın, Mehmet Aslan, Mehmet Emin Kucukoglu, Arda Luleci, Murat Atmaca, Ramazan Esen, Halit Demi. Serum prolidase enzyme activity and oxidative stress levels in patients with diabetic neuropathy. Endocrine. vol 47. issue 1. 2015-06-08. PMID:24347244. |
previous studies have suggested that prolidase and nitric oxide (no) regulate many processes, such as collagen synthesis and matrix remodeling. |
2015-06-08 |
2023-08-12 |
Not clear |
| In-Soo Oh, Dong-Whan Suh, Sung-Ryeoll Park, Kee-Yong H. Fractalkine receptor chemokine (CX3CR1) influences on cervical and lumbar disc herniation. Indian journal of orthopaedics. vol 49. issue 2. 2015-05-27. PMID:26015616. |
herniation of nuclear or disc material along with, inflammatory chemokines such as prostaglandin e2, interleukin-6, matrix metalloproteinase and nitric oxide has definite correlation, possibly they are over produced. |
2015-05-27 |
2023-08-13 |
Not clear |
| Michael Craig Larson, Cheryl A Hillery, Neil Hog. Circulating membrane-derived microvesicles in redox biology. Free radical biology & medicine. vol 73. 2015-05-11. PMID:24751526. |
notably, recent studies have shown that circulating mvs from platelets and endothelial cells drive reactive species-dependent angiogenesis; circulating mvs in cancer alter the microenvironment and enhance invasion through horizontal transfer of mutated proteins and nucleic acids and harbor redox-regulated matrix metalloproteinases and procoagulative surface molecules; and circulating mvs from red blood cells and other cells modulate cell-cell interactions through scavenging or production of nitric oxide and other free radicals. |
2015-05-11 |
2023-08-13 |
Not clear |
| Zoltán V Varga, Zoltán Giricz, Lucas Liaudet, György Haskó, Peter Ferdinandy, Pál Pache. Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochimica et biophysica acta. vol 1852. issue 2. 2015-04-17. PMID:24997452. |
superoxide anion interacts with nitric oxide forming the potent toxin peroxynitrite via diffusion limited reaction, which in concert with other oxidants triggers activation of stress kinases, endoplasmic reticulum stress, mitochondrial and poly(adp-ribose) polymerase 1-dependent cell death, dysregulates autophagy/mitophagy, inactivates key proteins involved in myocardial calcium handling/contractility and antioxidant defense, activates matrix metalloproteinases and redox-dependent pro-inflammatory transcription factors (e.g. |
2015-04-17 |
2023-08-13 |
Not clear |
| L Zhang, J Sun, Z Liu, Y Dai, Z Luo, X Jiang, Z Li, Y Li, P Cao, Y Zhou, Z Zeng, A Tang, X Li, X Li, J Xiang, G L. Mesenchymal stem cells regulate cytoskeletal dynamics and promote cancer cell invasion through low dose nitric oxide. Current molecular medicine. vol 14. issue 6. 2015-04-13. PMID:24894170. |
nitric oxide produced by bmscs in tumor environment could translocate caldesmon to podosome in ca2+/calmodulin manner and promoted metastatic ability of npc cells through invadopodia formation, with which the npc cells degrade the extracellular matrix. |
2015-04-13 |
2023-08-13 |
Not clear |
| L Zhang, J Liu, X Wang, Z Li, X Zhang, P Cao, X She, Q Dai, J Tang, Z Li. Upregulation of cytoskeleton protein and extracellular matrix protein induced by stromal-derived nitric oxide promotes lung cancer invasion and metastasis. Current molecular medicine. vol 14. issue 6. 2015-04-13. PMID:25056538. |
upregulation of cytoskeleton protein and extracellular matrix protein induced by stromal-derived nitric oxide promotes lung cancer invasion and metastasis. |
2015-04-13 |
2023-08-13 |
Not clear |
| Cathy Q Fan, James M Crawfor. Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). Journal of clinical and experimental hepatology. vol 4. issue 4. 2015-03-10. PMID:25755580. |
contributing factors are sec glutathione depletion, nitric oxide depletion, increased intrahepatic expression of matrix metalloproteinases and vascular endothelial growth factor (vegf), and activation of clotting factors. |
2015-03-10 |
2023-08-13 |
Not clear |
| Hui Su Lee, Purum Kang, Ka Young Kim, Geun Hee Seo. Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 2. 2015-03-02. PMID:25729281. |
fennel also significantly and dose-dependently reduced the activity of the proinflammatory mediator matrix metalloproteinase 9 and the immune modulator nitric oxide (no). |
2015-03-02 |
2023-08-13 |
mouse |
| Linlong Wang, Yunpeng Wu, Yang Tan, Xi Fei, Yu Deng, Hong Cao, Biao Chen, Hui Wang, Jacques Magdalou, Liaobin Che. Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells. Journal of applied toxicology : JAT. vol 34. issue 8. 2015-02-26. PMID:23813946. |
the mrna expression levels of matrix metalloproteinase (mmp)-1, mmp-3, mmp-13, tissue inhibitors of metalloproteinase (timp)-1, timp-3, col1a1, bcl-2, caspase-3 and inducible nitric oxide were analyzed by real-time polymerase chain reaction. |
2015-02-26 |
2023-08-12 |
rabbit |
| Jacqueline Chor-Wing Tam, Chun-Hay Ko, Kit-Man Lau, Ming-Ho To, Hin-Fai Kwok, Yuet-Wa Chan, Wing-Sum Siu, Nelly Etienne-Selloum, Ching-Po Lau, Wai-Yee Chan, Ping-Chung Leung, Kwok-Pui Fung, Valérie B Schini-Kerth, Clara Bik-San La. A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats. Journal of diabetes and its complications. vol 28. issue 4. 2015-02-13. PMID:24731763. |
enhancement of tissue oxidative stress, reduction of nitric oxide (no) and angiogenic growth factors, and abnormal matrix metalloproteinase (mmp) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. |
2015-02-13 |
2023-08-13 |
rat |
| ShaoYi She, WeiJuan Liu, Tong Li, YingKai Hon. Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. Food & function. vol 5. issue 5. 2014-12-19. PMID:24595557. |
rats were studied 30 days after the stz treatment, and the diabetes untreated model group presented significantly higher kidney index, blood glucose, triglyceride (tg), total cholesterol (tc), malondialdehyde (mda), interferon-γ (ifn-γ), and ifn-γ/il-4 levels, lower body weight, fasting blood insulin (fpi), il-4, superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gsh-px) and nitric oxide (no) levels and worse renal function (higher blood urea nitrogen (bun), serum creatinine (scr), urine protein (up) levels and glomerular extracellular matrix (relative area)) compared with the normal control group (p < 0.05). |
2014-12-19 |
2023-08-12 |
rat |