| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward G Lakatt. Central arterial aging and the epidemic of systolic hypertension and atherosclerosis. Journal of the American Society of Hypertension : JASH. vol 1. issue 5. 2012-10-02. PMID:20409863. |
this profile is proinflammatory, and is manifested by intimal infiltration of fetal cells, increased production of angiotensin ii (ang ii)-signaling pathway molecules, eg, matrix metalloproteases (mmps), and monocyte chemoattractant protein (mcp-1), transforming growth factor b1 (tgf-beta1), enhanced activation of mmps, tgf-beta, and nadph oxidase, and reduced nitric oxide (no) bioavailability. |
2012-10-02 |
2023-08-12 |
human |
| Christopher Kaeding, Thomas M Bes. Tendinosis: pathophysiology and nonoperative treatment. Sports health. vol 1. issue 4. 2012-09-28. PMID:23015885. |
this article reviews recent evidence of the clinical efficacy of the following interventions: eccentric exercise, extracorporal shock wave treatment, corticosteroid and nonsteroidal anti-inflammatory medications, sclerosing injections, nitric oxide, platelet-rich plasma injections, and matrix metalloproteinase inhibitors. |
2012-09-28 |
2023-08-12 |
Not clear |
| D T Ngo, A L Sverdlov, J D Horowit. Prevention of aortic valve stenosis: a realistic therapeutic target? Pharmacology & therapeutics. vol 135. issue 1. 2012-09-17. PMID:22516738. |
recent insight into the pathophysiology of as has included central roles for angiotensin ii, for diminished nitric oxide effect at the level of valve endothelium and matrix, and for inflammatory activation/redox stress culminating in activation of pro-calcific stimuli. |
2012-09-17 |
2023-08-12 |
Not clear |
| R Higa, M Kurtz, M B Mazzucco, D Musikant, V White, A Jawerbau. Folic acid and safflower oil supplementation interacts and protects embryos from maternal diabetes-induced damage. Molecular human reproduction. vol 18. issue 5. 2012-09-10. PMID:22180326. |
in this study we here tested whether folic acid and safflower oil supplementations interact to prevent embryo malformations in diabetic rats, and analyzed whether they act through the regulation of matrix metalloproteinases (mmps), their endogenous inhibitors (timps), and nitric oxide (no) and reactive oxygen species production. |
2012-09-10 |
2023-08-12 |
rat |
| Lu Tie, Yilixiati Xiaokaiti, Xian Wang, Alex F Chen, Xue-Jun L. [Molecular mechanisms of diabetic wound healing]. Sheng li ke xue jin zhan [Progress in physiology]. vol 41. issue 6. 2012-09-06. PMID:21416956. |
various factors contribute to delayed diabetic wound healing, such as growth factor, nitric oxide (no), reactive oxygen species (ros), matrix metalloproteinases (mmps), microrna, endothelial progenitor cells (epcs), etc. |
2012-09-06 |
2023-08-12 |
Not clear |
| Minako Hara, Kuniko Tabata, Takahiro Suzuki, Mai-Khoi Q Do, Wataru Mizunoya, Mako Nakamura, Shotaro Nishimura, Shoji Tabata, Yoshihide Ikeuchi, Kenji Sunagawa, Judy E Anderson, Ronald E Allen, Ryuichi Tatsum. Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch. American journal of physiology. Cell physiology. vol 302. issue 12. 2012-08-23. PMID:22460715. |
this signaling pathway is a cascade of events including calcium-calmodulin formation, nitric oxide (no) radical production by no synthase, matrix metalloproteinase activation, release of hepatocyte growth factor (hgf) from the extracellular matrix, and presentation of hgf to the receptor c-met, as demonstrated by assays of primary cultures and in vivo experiments. |
2012-08-23 |
2023-08-12 |
Not clear |
| Sara L Dunn, J Mark Wilkinson, Aileen Crawford, Christine L Le Maitre, Rowena A D Bunnin. Cannabinoids: novel therapies for arthritis? Future medicinal chemistry. vol 4. issue 6. 2012-08-14. PMID:22530636. |
cartilage breakdown is mediated by complex interactions of proinflammatory cytokines, such as il-1, inflammatory mediators, including nitric oxide and prostaglandin e(2), and proteases, including matrix metalloproteinases and aggrecanases, such as adamts-4 and -5. |
2012-08-14 |
2023-08-12 |
Not clear |
| Hyun-Ah Kim, Yunshin Yeo, Hyun A Jung, Young O Jung, Su J Park, Song J Ki. Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation. Rheumatology (Oxford, England). vol 51. issue 6. 2012-07-24. PMID:22332123. |
phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation. |
2012-07-24 |
2023-08-12 |
human |
| Camila Fernandes Moro, Sílvio Roberto Consonni, Renata Giardini Rosa, Maria Amália Cavinato Nascimento, Paulo Pinto Joazeir. High iNOS mRNA and protein localization during late pregnancy suggest a role for nitric oxide in mouse pubic symphysis relaxation. Molecular reproduction and development. vol 79. issue 4. 2012-07-19. PMID:22223460. |
it is recognized that nitric oxide synthase (nos) and consequently nitric oxide (no) generation play important roles in extracellular matrix modification, and may promote cytoskeleton changes that contribute to the remodeling of connective tissue, which precedes the onset of labor. |
2012-07-19 |
2023-08-12 |
mouse |
| Gayathri Acharya, Richard A Hopkins, Chi H Le. Advanced polymeric matrix for valvular complications. Journal of biomedical materials research. Part A. vol 100. issue 5. 2012-07-17. PMID:22337643. |
poly(l-lactic acid) (plla) matrix systems incorporated with poly(lactic-co-glycolic acid) (plga) nanoparticles (nps) containing nitric oxide (no) donors (deta nonoate) were developed for prevention of heart valve complications through sustained and controlled release of no. |
2012-07-17 |
2023-08-12 |
Not clear |
| Jun Wang, Shane O'Sullivan, Shona Harmon, Ray Keaveny, Marek W Radomski, Carlos Medina, John F Gilme. Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion. Journal of medicinal chemistry. vol 55. issue 5. 2012-07-09. PMID:22248361. |
we describe a new type of barbiturate-based matrix metalloproteinase (mmp) inhibitor incorporating a nitric oxide (no) donor/mimetic group (series 1). |
2012-07-09 |
2023-08-12 |
human |
| Ilhan Gecit, Mehmet Aslan, Mustafa Gunes, Necip Pirincci, Ramazan Esen, Halit Demir, Kadir Ceyla. Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer. Journal of cancer research and clinical oncology. vol 138. issue 5. 2012-06-18. PMID:22258852. |
nitric oxide (no) regulates many processes such as collagen synthesis and matrix remodeling. |
2012-06-18 |
2023-08-12 |
Not clear |
| Lashauna C Evans, Hongshan Liu, Gerard A Pinkas, Loren P Thompso. Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts. Pediatric research. vol 71. issue 1. 2012-05-15. PMID:22289847. |
excessive generation of nitric oxide (no) can induce nitrosative stress leading to the formation of peroxynitrite, which can upregulate the expression of matrix metalloproteinases (mmps). |
2012-05-15 |
2023-08-12 |
Not clear |
| Marta Skowrońska, Magdalena Zielińska, Luiza Wójcik-Stanaszek, Joanna Ruszkiewicz, Dejan Milatovic, Michael Aschner, Jan Albrech. Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22260250. |
concurrently, ammonia increased the activity of extracellular matrix metalloproteinases (mmp-2/mmp-9), increased cell permeability to fluorescein isothiocyanate-dextran (40 kda), and increased the expression of y+lat2, a transporter that mediates the uptake to the cells of the nitric oxide precursor, arginine. |
2012-05-03 |
2023-08-12 |
rat |
| Ingrid F Metzger, Valéria C Sandrim, Jose E Tanus-Santo. Endogenous nitric oxide formation correlates negatively with circulating matrix metalloproteinase (MMP)-2 and MMP-9 levels in black subjects. Molecular and cellular biochemistry. vol 360. issue 1-2. 2012-03-22. PMID:21956669. |
endogenous nitric oxide formation correlates negatively with circulating matrix metalloproteinase (mmp)-2 and mmp-9 levels in black subjects. |
2012-03-22 |
2023-08-12 |
human |
| Ingrid F Metzger, Valéria C Sandrim, Jose E Tanus-Santo. Endogenous nitric oxide formation correlates negatively with circulating matrix metalloproteinase (MMP)-2 and MMP-9 levels in black subjects. Molecular and cellular biochemistry. vol 360. issue 1-2. 2012-03-22. PMID:21956669. |
deficient formation of endogenous nitric oxide (no) contributes to cardiovascular diseases, and this may be associated with increased circulating levels of matrix metalloproteinase-9 (mmp-9), as previously shown in white subjects. |
2012-03-22 |
2023-08-12 |
human |
| Lachlan J Smith, Joseph A Chiaro, Nandan L Nerurkar, Daniel H Cortes, Sarena D Horava, Nader M Hebela, Robert L Mauck, George R Dodge, Dawn M Elliot. Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture. European cells & materials. vol 22. 2012-03-07. PMID:22102324. |
il-1β treatment resulted in upregulation of a disintegrin and metalloproteinase with thrombospondin motifs 4, matrix metalloproteinase-13 and inducible nitric oxide sythase, decreased gag and modulus, and increased permeability. |
2012-03-07 |
2023-08-12 |
cattle |
| Amteshwar Singh Jaggi, Nirmal Sing. Therapeutic targets for the management of peripheral nerve injury-induced neuropathic pain. CNS & neurological disorders drug targets. vol 10. issue 5. 2012-02-03. PMID:21631400. |
the present review discusses these therapeutic targets including noradrenaline and 5-ht reuptake inhibitors; sodium, calcium and potassium channels; inhibitory and excitatory neurotransmitters; neuropeptides including bradykinin, tachykinin, cholecystokinin, neuropeptide y, vasoactive intestinal peptide, and cgrp; pro-inflammatory cytokines; map kinases; ppar γ; na(+)/ca(2+) exchanger; nitric oxide; purinergic receptors; neuronal nicotinic receptors; cation-dependent chloride transporters; oxidative stress; matrix metalloproteinase and plasminogen activators; growth factors; transient receptor potential (trp) channels; endocannabinoids; histamine receptors; dopamine; sigma receptors, beta adrenergic receptors, endothelins, and d-amino acid oxidase. |
2012-02-03 |
2023-08-12 |
Not clear |
| Mariella Mannino, Anthony J Chalmer. Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit'? Molecular oncology. vol 5. issue 4. 2012-02-01. PMID:21659010. |
the paper, therefore, focuses on the interaction between tumour stem cells and the microenvironment, analyzing how its various elements (endothelial cells, extracellular matrix, cytokines, nitric oxide, oxygen levels) are affected by radiation and how these might influence the response of tumour stem cells to radiation. |
2012-02-01 |
2023-08-12 |
Not clear |
| Kiyoshi Kikuchi, Hisaaki Uchikado, Naohisa Miyagi, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Naoki Miura, Kei Miyata, Rokudai Sakamoto, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Ko-Ichi Kawahar. Beyond neurological disease: new targets for edaravone (Review). International journal of molecular medicine. vol 28. issue 6. 2012-01-26. PMID:21922128. |
it has since been shown that edaravone can diffuse into many organs and, in addition to its effects on hydroxyl radical removal, edaravone modulates inflammatory processes, matrix metalloproteinase levels, nitric oxide production, apoptotic cell death, and necrotic cell death. |
2012-01-26 |
2023-08-12 |
Not clear |