| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Coope. A perspective on the use of minocycline for rheumatoid arthritis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. vol 5. issue 4. 2009-12-14. PMID:19078393. |
laboratory investigations that support a possible anti-arthritic action of tetracyclines through their effect on nitric oxide generation, matrix metalloprotease inhibition, and chondrocyte apoptosis are discussed. |
2009-12-14 |
2023-08-12 |
Not clear |
| Martina Vokurkova, Shaoping Xu, Rhian M Touy. Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension. Future cardiology. vol 3. issue 1. 2009-12-14. PMID:19804207. |
oxidative stress causes vascular injury by reducing nitric oxide bioavailability, altering endothelial function and vascular contraction/dilation, promoting vascular smooth muscle cell proliferation and hypertrophy, and increasing extracellular matrix deposition and inflammation. |
2009-12-14 |
2023-08-12 |
Not clear |
| Tania R Lizarbe, Carlos Tarín, Mónica Gómez, Begoña Lavin, Enrique Aracil, Luis M Orte, Carlos Zaragoz. Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN. The American journal of pathology. vol 175. issue 4. 2009-12-09. PMID:19779140. |
nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer emmprin. |
2009-12-09 |
2023-08-12 |
mouse |
| Dilek Telci, Russell John Collighan, Huveyda Basaga, Martin Griffi. Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide. The Journal of biological chemistry. vol 284. issue 43. 2009-11-23. PMID:19657147. |
increased tg2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide. |
2009-11-23 |
2023-08-12 |
Not clear |
| Kyle B Walsh, Alexander H Toledo, Fernando A Rivera-Chavez, Fernando Lopez-Neblina, Luis H Toledo-Pereyr. Inflammatory mediators of liver ischemia-reperfusion injury. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. vol 7. issue 2. 2009-10-22. PMID:19715511. |
specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, t cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines. |
2009-10-22 |
2023-08-12 |
Not clear |
| An-Cheng Huang, Shu-Chun Hsu, Chao-Lin Kuo, Ching-Lung Liao, Kuang-Chi Lai, Tsung-Ping Lin, Shin-Hwar Wu, Hsu-Feng Lu, Nou-Ying Tang, Jai-Sing Yang, Jing-Gung Chun. Involvement of matrix metalloproteinases in the inhibition of cell invasion and migration through the inhibition of NF-[kappa]B by the new synthesized ethyl 2-[N-p-chlorobenzyl-(2'-methyl)]anilino-4-oxo-4,5-dihydrofuran-3-carboxylate (JOTO1007) in human cervical cancer Ca ski cells. In vivo (Athens, Greece). vol 23. issue 4. 2009-09-24. PMID:19567397. |
the results indicated that joto1007 inhibited the levels of son of sevenless homolog 1 (sos-1), growth factor receptor-bound protein 2 (grb2), ras homolog gene family, member a (rhoa), rho-associated, coiled-coil containing protein kinase 1 (rock-1), focal adhesion kinase (fak), phosphorylated-c-jun (p-c-jun), nuclear factor kappa b (nf-kappab) p65, cyclooxygenase-2 (cox-2), extracellular signal-regulated kinases 1/2 (erk1/2), matrix metalloproteinase-2 (mmp-2), mmp-7 and mmp-9 but promoted the levels of protein kinase c (pkc), phosphoinositide 3-kinases (pi3k), map kinase kinase kinase 3 (mekk3), mitogen-activated protein kinase kinase 7 (mkk7), c-jun and inducible nitric oxide synthases (inos), while not affecting ras, phosphorylated-erk (p-erk), p38 and c-jun n-terminal kinase 1/2 (jnk1/2), which finally led to the inhibition of migration and invasion of the ca ski cells in vitro. |
2009-09-24 |
2023-08-12 |
human |
| Ll Uranga-Piña, A Martínez-Mesa, L García-Reyes, J Rubayo-Soneir. Effective temperature representation of quantum delocalization effects on the dynamics of NO(A(2)Sigma(+) <--X(2)Pi(+)) photoexcitation in Ne matrices. Physical chemistry chemical physics : PCCP. vol 11. issue 26. 2009-09-17. PMID:19551203. |
the energetics of the optical excitation of the lowest rydberg state of a nitric oxide molecule embedded in a neon matrix and the subsequent rearrangement of the solid host are investigated by classical molecular dynamics simulations. |
2009-09-17 |
2023-08-12 |
Not clear |
| L Arnaud, J Haroche, P Duhaut, J-C Piette, Z Amour. [Pathogenesis of primary large vessel arteritis]. La Revue de medecine interne. vol 30. issue 7. 2009-09-15. PMID:18804314. |
macrophages located in the media differentiate into giant cells and/or produce reactive oxygen species, nitric oxide and matrix metallo-proteinases. |
2009-09-15 |
2023-08-12 |
Not clear |
| Laura Spencer, Christopher Mann, Matthew Metcalfe, M'Balu Webb, Cristina Pollard, Daniel Spencer, David Berry, William Steward, Ashley Denniso. The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. European journal of cancer (Oxford, England : 1990). vol 45. issue 12. 2009-09-11. PMID:19493674. |
the conclusions drawn from this review suggest that omega-3 fas in particular eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) found principally in oily fish have potent anti-angiogenic effects inhibiting production of many important angiogenic mediators namely; vascular endothelial growth factor (vegf), platelet-derived growth factor (pdgf), platelet-derived endothelial cell growth factor (pdecgf), cyclo-oxygenase 2 (cox-2), prostaglandin-e2 (pge2), nitric oxide, nuclear factor kappa beta (nfkb), matrix metalloproteinases and beta-catenin. |
2009-09-11 |
2023-08-12 |
human |
| Chanhung Z Lee, Zheng Xue, Qi Hao, Guo-Yuan Yang, William L Youn. Nitric oxide in vascular endothelial growth factor-induced focal angiogenesis and matrix metalloproteinase-9 activity in the mouse brain. Stroke. vol 40. issue 8. 2009-08-19. PMID:19498186. |
nitric oxide in vascular endothelial growth factor-induced focal angiogenesis and matrix metalloproteinase-9 activity in the mouse brain. |
2009-08-19 |
2023-08-12 |
mouse |
| Stuart Egginto. Invited review: activity-induced angiogenesis. Pflugers Archiv : European journal of physiology. vol 457. issue 5. 2009-07-24. PMID:18704490. |
exercise hyperaemia leads to an increase in microvascular shear stress, which stimulates endothelial release of nitric oxide, whilst proteolytic modification of the extracellular matrix is induced by mechanical deformation during cyclical contractions or muscle overload. |
2009-07-24 |
2023-08-12 |
Not clear |
| Adrian Boswoo. Biomarkers in cardiovascular disease: beyond natriuretic peptides. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. vol 11 Suppl 1. 2009-06-25. PMID:19395333. |
there are markers of myocyte injury typified by troponins i and t; markers of myocyte stress including adrenomedullin and st2; markers of remodeling including matrix metalloproteinases, tissue inhibitors of metalloproteinases and collagen molecules (piiinp); markers of endothelial function including dimethylarginines and nitric oxide metabolites; markers of inflammation including c-reactive protein, several interleukins and tumor necrosis factor alpha; and finally neurohormonal markers. |
2009-06-25 |
2023-08-12 |
human |
| Tien-Yu Huang, Heng-Cheng Chu, Yi-Ling Lin, Chih-Kung Lin, Tsai-Yuan Hsieh, Wei-Kuo Chang, You-Chen Chao, Ching-Len Lia. Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases. Toxicology and applied pharmacology. vol 237. issue 1. 2009-06-09. PMID:19285099. |
mechanistically, minocycline administration suppressed inducible nitric oxide synthase (inos) expression and nitrotyrosine production, inhibited proinflammatory cytokine expression, repressed the elevated mrna expression of matrix metalloproteinases (mmps) 2, 3, 9, and 13, diminished the apoptotic index in colonic tissues, and inhibited nitric oxide production in the serum of mice with dss-induced acute colitis. |
2009-06-09 |
2023-08-12 |
mouse |
| Ryuichi Tatsumi, Adam L Wuollet, Kuniko Tabata, Shotaro Nishimura, Shoji Tabata, Wataru Mizunoya, Yoshihide Ikeuchi, Ronald E Alle. A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation. American journal of physiology. Cell physiology. vol 296. issue 4. 2009-06-02. PMID:19158401. |
this process depends on nitric oxide (no) production by no synthase (nos), matrix metalloproteinase activation, release of hepatocyte growth factor (hgf) from the extracellular matrix, and presentation of hgf to the c-met receptor as demonstrated by a primary culture and in vivo assays. |
2009-06-02 |
2023-08-12 |
Not clear |
| Martin Feelisc. The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis. Osteoarthritis and cartilage. vol 16 Suppl 2. 2009-05-15. PMID:18794015. |
excess formation of nitric oxide (no) has been invoked in the development of osteoarthritis and blamed for triggering chondrocyte apoptosis and matrix destruction. |
2009-05-15 |
2023-08-12 |
Not clear |
| Thomas Waldow, Wolfgang Witt, Anne Buzin, André Ulmer, Klaus Matschk. Prevention of ischemia/reperfusion-induced accumulation of matrix metalloproteinases in rat lung by preconditioning with nitric oxide. The Journal of surgical research. vol 152. issue 2. 2009-05-14. PMID:18694576. |
prevention of ischemia/reperfusion-induced accumulation of matrix metalloproteinases in rat lung by preconditioning with nitric oxide. |
2009-05-14 |
2023-08-12 |
rat |
| Angela Satie Nishikaku, Raphael Fagnani Sanchez Molina, Luciana Cristina Ribeiro, Renata Scavone, Bernardo Paulo Albe, Cláudia Silva Cunha, Eva Burge. Nitric oxide participation in granulomatous response induced by Paracoccidioides brasiliensis infection in mice. Medical microbiology and immunology. vol 198. issue 2. 2009-05-06. PMID:19360439. |
the role of nitric oxide (no) in granulomas of paracoccidioides brasiliensis-infected inducible no synthase-deficient c57bl/6 mice (inos ko) and their wild-type counterparts and its association with osteopontin (opn) and matrix metalloproteinases (mmps) was studied. |
2009-05-06 |
2023-08-12 |
mouse |
| Idalis Villanueva, Brenda J Klement, Daniel von Deutsch, Stephanie J Bryan. Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel. Biotechnology and bioengineering. vol 102. issue 4. 2009-02-20. PMID:18949761. |
chondrocyte response was measured through total dna content, total nitric oxide (no) production, and matrix deposition for glycosaminoglycans (gag). |
2009-02-20 |
2023-08-12 |
Not clear |
| Krassimira Ivanova, Britta Lambers, Rene van den Wijngaard, I Caroline Le Poole, Olga Grigorieva, Rupert Gerzer, Pranab K Da. Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP. In vitro cellular & developmental biology. Animal. vol 44. issue 8-9. 2009-01-29. PMID:18594937. |
immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cgmp. |
2009-01-29 |
2023-08-12 |
human |
| Abhijit Ghosh, Ji Young Park, Christopher Fenno, Yvonne L Kapil. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infection and immunity. vol 76. issue 12. 2008-12-30. PMID:18838522. |
porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-jun n-terminal kinase 1-mediated nitric oxide generation and cell death. |
2008-12-30 |
2023-08-12 |
Not clear |