| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanna Molas, Rubing Zhao-Shea, Timothy G Freels, Andrew R Tappe. Viral tracing confirms paranigral ventral tegmental area dopaminergic inputs to the interpeduncular nucleus where dopamine release encodes motivated exploration. eNeuro. 2023-01-04. PMID:36599671. |
midbrain dopaminergic (daergic) neurons of the ventral tegmental area (vta) are engaged by rewarding stimuli and encode reward prediction error to update goal-directed learning. |
2023-01-04 |
2023-08-14 |
mouse |
| Susanna Molas, Rubing Zhao-Shea, Timothy G Freels, Andrew R Tappe. Viral tracing confirms paranigral ventral tegmental area dopaminergic inputs to the interpeduncular nucleus where dopamine release encodes motivated exploration. eNeuro. 2023-01-04. PMID:36599671. |
previous work identifying a mesointerpeduncular circuit consisting of vta daergic neurons projecting to the interpeduncular nucleus (ipn), a midbrain area implicated in aversion, anxiety-like behavior, and familiarity, has recently come into question. |
2023-01-04 |
2023-08-14 |
mouse |
| Matthew T C Manion, Erica R Glasper, Kuan Hong Wan. A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala. Biology of sex differences. vol 13. issue 1. 2022-12-30. PMID:36585727. |
previous anatomical tracing studies in mammalian species have revealed a prominent circuit projection connecting the dopaminergic midbrain ventral tegmental area (vta) to the basolateral amygdala (bla), which is involved in emotional processing and associative learning. |
2022-12-30 |
2023-08-14 |
mouse |
| Hongyan Zhang, Lulu Xu, Junwei Xiong, Xinxin Li, Yindong Yang, Yong Liu, Chunfeng Zhang, Qiyu Wang, Jiajia Wang, Pengyu Wang, Xiaobin Wu, Xue Wang, Xiaofeng Zhu, Yanzhong Gua. Role of KCC2 in the Regulation of Brain-Derived Neurotrophic Factor on Ethanol Consumption in Rats. Molecular neurobiology. 2022-11-18. PMID:36401060. |
the mesocorticolimbic dopamine (da) system, originating from the ventral tegmental area (vta) in the midbrain, is involved in the rewarding effect of ethanol. |
2022-11-18 |
2023-08-14 |
rat |
| Junichi Yoshida, Maritza Oñate, Leila Khatami, Jorge Vera, Farzan Nadim, Kamran Khodakha. Cerebellar Contributions to the Basal Ganglia Influence Motor Coordination, Reward Processing, and Movement Vigor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 42. issue 45. 2022-11-09. PMID:36351826. |
we review two sets of such connections: disynaptic projections through the thalamus and direct monosynaptic projections to the midbrain dopaminergic nuclei, the vta and the snc. |
2022-11-09 |
2023-08-14 |
Not clear |
| Margarida Martins-Oliveira, Simon Akerman, Philip R Holland, Isaura Tavares, Peter J Goadsb. Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine. Cephalalgia : an international journal of headache. 2022-10-19. PMID:36259130. |
imaging migraine premonitory studies show increased midbrain activation consistent with the ventral tegmental area, an area involved in pain modulation and hedonic feeding. |
2022-10-19 |
2023-08-14 |
Not clear |
| Michal Rafal Zareba, Wiktoria Furman, Marek Binde. Influence of age and cognitive performance on resting-state functional connectivity of dopaminergic and noradrenergic centers. Brain research. 2022-09-17. PMID:36115586. |
in turn, older age was associated with greater local synchronization within vta, its lower fc with caudate, mediodorsal thalamus, and snc, as well as higher fc of both midbrain dopaminergic seeds with red nuclei. |
2022-09-17 |
2023-08-14 |
Not clear |
| Fabian M P Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M Zopf, Virgil A S H Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D Katsikis, Joyce H G Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I De Zeeuw, Aleksandra Badura, Meinrad Busslinge. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder. The Journal of experimental medicine. vol 219. issue 9. 2022-08-10. PMID:35947077. |
pax5 deficiency also caused profound hypoplasia of the substantia nigra and ventral tegmental area due to loss of gabaergic neurons, thus affecting two midbrain hubs, controlling motor function and reward processing, respectively. |
2022-08-10 |
2023-08-14 |
mouse |
| Jaron T Colas, Neil M Dundon, Raphael T Gerraty, Natalie M Saragosa-Harris, Karol P Szymula, Koranis Tanwisuth, J Michael Tyszka, Camilla van Geen, Harang Ju, Arthur W Toga, Joshua I Gold, Dani S Bassett, Catherine A Hartley, Daphna Shohamy, Scott T Grafton, John P O'Dohert. Reinforcement learning with associative or discriminative generalization across states and actions: fMRI at 3 T and 7 T. Human brain mapping. 2022-07-21. PMID:35860954. |
with high-resolution high-field fmri targeting the dopaminergic midbrain, the grl model's rpe signals (alongside value and decision signals) were localized within not only the striatum but also the substantia nigra and the ventral tegmental area, including specific effects of generalization that also extend to the hippocampus. |
2022-07-21 |
2023-08-14 |
human |
| Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Den. Effects of Risperidone and Prenatal Poly I:C Exposure on GABA Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625659. |
effects of risperidone and prenatal poly i:c exposure on gaba the ventral tegmental area (vta) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. |
2022-05-28 |
2023-08-13 |
Not clear |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
in the midbrain, dopaminergic neurons are mainly situated in the substantia nigra (sn) and the ventral tegmental area (vta). |
2022-04-22 |
2023-08-13 |
Not clear |
| María-José Sánchez-Catalán, Michel Barro. Fos response of the tail of the ventral tegmental area to food restriction entails a prediction error processing. Behavioural brain research. 2022-03-05. PMID:35247487. |
the tail of the ventral tegmental area (tvta) or rostromedial tegmental nucleus (rmtg) receives lateral habenula inputs and projects heavily to midbrain dopamine neurons. |
2022-03-05 |
2023-08-13 |
rat |
| Ian M O'Shea, Haroon S Popal, Ingrid R Olson, Vishnu P Murty, David V Smit. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-03-01. PMID:35228561. |
in parkinson's disease (pd), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (sn), while leaving the ventral tegmental area (vta) relatively spared in early phases of the disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Dmitry Troshev, Dmitry Voronkov, Anastasia Pavlova, Denis Abaimov, Alexander Latanov, Tatiana Fedorova, Daniil Berezhno. Time Course of Neurobehavioral Disruptions and Regional Brain Metabolism Changes in the Rotenone Mice Model of Parkinson's Disease. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203675. |
neuropathological changes in this model include a general decrease in cox activity in different areas of the brain (acute effect of rotenone) and a more specific decrease in midbrain (chronic effect), followed by significant neurodegeneration in snpc but not vta by the 5th week of rotenone exposure. |
2022-02-25 |
2023-08-13 |
mouse |
| Pieter Derdeyn, May Hui, Desiree Macchia, Kevin T Beie. Uncovering the Connectivity Logic of the Ventral Tegmental Area. Frontiers in neural circuits. vol 15. 2022-02-14. PMID:35153681. |
decades of research have revealed the remarkable complexity of the midbrain dopamine (da) system, which comprises cells principally located in the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2022-02-14 |
2023-08-13 |
Not clear |
| Imre Kalló, Azar Omrani, Frank J Meye, Han de Jong, Zsolt Liposits, Roger A H Ada. Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens. Brain structure & function. 2022-01-14. PMID:35029758. |
orexin neurons are involved in homeostatic regulatory processes, including arousal and feeding, and provide a major input from the hypothalamus to the ventral tegmental area (vta) of the midbrain. |
2022-01-14 |
2023-08-13 |
Not clear |
| Isao Nagata, Mika Sasaki, Tomoyuki Miyazaki, Kensuke Saeki, Ken-Ichi Ogawa, Yoshinori Kamiy. Subanesthetic Dose of Propofol Activates the Reward System in Rats. Anesthesia and analgesia. 2021-12-27. PMID:34958308. |
activation of the dopaminergic circuits of the midbrain reward system, including the ventral tegmental area (vta) and nac, plays a crucial role in addiction. |
2021-12-27 |
2023-08-13 |
rat |
| Lianwei Mu, Xiaojie Liu, Hao Yu, Mengming Hu, Vladislav Friedman, Thomas J Kelly, Li Zhao, Qing-Song Li. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. vol 201. 2021-12-11. PMID:34626665. |
to investigate potential mechanisms for ibudilast-induced attenuation of cocaine self-administration, we recorded from ventral tegmental area (vta) dopamine neurons in ex vivo midbrain slices prepared from rats that had undergone saline and cocaine self-administration. |
2021-12-11 |
2023-08-13 |
rat |
| Yan Xu, Shicong Wang, Longmao Chen, Ziqiang Shao, Min Zhang, Shuang Liu, Xinwen Wen, Yangding Li, Wenhan Yang, Fei Tang, Jing Luo, Li Fan, Cui Yan, Jun Liu, Kai Yua. Reduced midbrain functional connectivity and recovery in abstinent heroin users. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34662755. |
the resting-state functional connectivity (rsfc) patterns of midbrain (i.e., the ventral tegmental area (vta) and substantia nigra (sn)) were compared between 40 abstinent heroin users with opioid use disorder (hus) and 35 healthy controls (hcs). |
2021-12-07 |
2023-08-13 |
human |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
we identify a population of midbrain dopaminergic neurons near the border of the substantia nigra pars compacta and the lateral ventral tegmental area that sends direct projections to the dorsal hippocampus. |
2021-12-06 |
2023-08-13 |
mouse |