| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saptarsi Mitra, Sumela Basu, Omprakash Singh, Ronald M Lechan, Praful S Singr. Cocaine- and amphetamine-regulated transcript peptide- and dopamine-containing systems interact in the ventral tegmental area of the zebra finch, Taeniopygia guttata, during dynamic changes in energy status. Brain structure & function. vol 226. issue 8. 2021-09-20. PMID:34392422. |
in the midbrain, tyrosine hydroxylase-immunoreactive (th-i) neurons were seen in the substantia nigra (sn) and vta [anterior (vtaa), mid (vtam) and caudal (vtac)]; those in vta were smaller. |
2021-09-20 |
2023-08-13 |
Not clear |
| Vito S Hernández, Mario A Zetter, Enrique C Guerra, Ileana Hernández-Araiza, Nikita Karuzin, Oscar R Hernández-Pérez, Lee E Eiden, Limei Zhan. ACE2 expression in rat brain: Implications for COVID-19 associated neurological manifestations. Experimental neurology. vol 345. 2021-09-16. PMID:34400158. |
ace2 is ubiquitously present in brain vasculature, with the highest density of ace2 expressing capillaries found in the olfactory bulb, the hypothalamic paraventricular, supraoptic, and mammillary nuclei, the midbrain substantia nigra and ventral tegmental area, and the hindbrain pontine nucleus, the pre-bötzinger complex, and nucleus of tractus solitarius. |
2021-09-16 |
2023-08-13 |
rat |
| Blake L Elliott, Kimberlee D'Ardenne, Prerona Mukherjee, Julie B Schweitzer, Samuel M McClur. Limbic and Executive Meso- and Nigrostriatal Tracts Predict Impulsivity Differences in Attention-Deficit/Hyperactivity Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-08-26. PMID:34051394. |
we tested whether human midbrain pathways (where dopaminergic cell bodies originate) between the substantia nigra (sn) and ventral tegmental area (vta) and the striatum differed between participants with adhd and typically developing adolescent and young adult participants. |
2021-08-26 |
2023-08-13 |
human |
| Lauren Wills, Paul J Kenn. Addiction-related neuroadaptations following chronic nicotine exposure. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33742685. |
nachrs expressed by dopamine-containing neurons in the ventral midbrain, most notably in the ventral tegmental area (vta), contribute to the reward-enhancing properties of nicotine that motivate the use of tobacco products. |
2021-08-24 |
2023-08-13 |
Not clear |
| Rui Lin, Jingwen Liang, Minmin Lu. The Raphe Dopamine System: Roles in Salience Encoding, Memory Expression, and Addiction. Trends in neurosciences. vol 44. issue 5. 2021-08-18. PMID:33568331. |
while the vta da population is known to play important roles in reward processing, emerging evidence now supports the view that drn da neurons are a specialized midbrain da subsystem that performs distinct functions in parallel to the vta da population. |
2021-08-18 |
2023-08-13 |
mouse |
| Jun Wang, Jie Li, Qian Yang, Ya-Kai Xie, Ya-Lan Wen, Zhen-Zhong Xu, Yulong Li, Tianle Xu, Zhi-Ying Wu, Shumin Duan, Han X. Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 7. 2021-07-22. PMID:33563763. |
here we identify a causal role of the basal forebrain (bf) in the control of prosocial behavior via inhibitory projections that disinhibit the midbrain ventral tegmental area (vta) dopamine (da) neurons. |
2021-07-22 |
2023-08-13 |
Not clear |
| Gabriela Rodríguez-Manzo, Estefanía González-Morale. Endocannabinoids mediate long-lasting behavioural and physiological changes in male rats induced by the repeated activation of the mesolimbic system by copulation to satiety. Behavioural brain research. vol 383. 2021-05-25. PMID:31987931. |
copulation activates the mesolimbic circuit increasing dopamine (da) release in the nucleus accumbens (nacc) and, enhanced midbrain da neuron activity promotes endocannabinoid (ecb) release in the ventral tegmental area (vta). |
2021-05-25 |
2023-08-13 |
rat |
| Ewa Galaj, Zheng-Xiong X. Progress in opioid reward research: From a canonical two-neuron hypothesis to two neural circuits. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33227308. |
based on recent findings that activation of dopamine neurons in the ventral tegmental area (vta) and substantia nigra pars compacta (snc) is equally rewarding and that gaba neurons in the rostromedial tegmental nucleus (rmtg) and the substantia nigra pars reticula (snr) are rich in mu opioid receptors and directly synapse onto midbrain da neurons, we proposed that the rtmg→vta → ventrostriatal and snr → snc → dorsostriatal pathways may act as the two major neural substrates underlying opioid reward and abuse. |
2021-05-24 |
2023-08-13 |
Not clear |
| Smitha Bhaskar, Jeevan Gowda, Jyothi Prasanna, Anujith Kuma. Does altering proteasomal activity and trafficking reduce the arborization mediated specific vulnerability of SNpc dopaminergic neurons of Parkinson's disease? Medical hypotheses. vol 143. 2021-05-14. PMID:32652429. |
the disease originates majorly due to compromised function of the dopaminergic (da) neurons in the substantia nigra pars compacta (snpc), but not the ventral tegmental area (vta) region of the midbrain. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lynn D Selemon, Anita Begovi. Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure. Neuroscience. vol 442. 2021-05-14. PMID:32659340. |
this study examined the impact of curtailing neurogenesis in early gestation on neuron number in the midbrain dopamine group, i.e., the substantia nigra and contiguous ventral tegmental area. |
2021-05-14 |
2023-08-13 |
monkey |
| Yanfei Sun, Jing Cao, Chunpeng Xu, Xiaofeng Liu, Zicheng Wang, Hua Zha. Rostromedial tegmental nucleus-substantia nigra pars compacta circuit mediates aversive and despair behavior in mice. Experimental neurology. vol 333. 2021-03-05. PMID:32791155. |
gabaergic neurons in the rostromedial tegmental nucleus (rmtg) receive major input from the lateral habenula (lhb), which conveys negative reward and motivation related information, and project intensively to midbrain dopamine neurons, including those in the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-03-05 |
2023-08-13 |
mouse |
| Elina Nagaeva, Ivan Zubarev, Carolina Bengtsson Gonzales, Mikko Forss, Kasra Nikouei, Elena de Miguel, Lauri Elsilä, Anni-Maija Linden, Jens Hjerling-Leffler, George J Augustine, Esa R Korp. Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area. eLife. vol 9. 2021-02-18. PMID:32749220. |
overall, our results demonstrate the remarkable complexity and heterogeneity of vta sst neurons and suggest that these cells are multifunctional players in the midbrain reward circuitry. |
2021-02-18 |
2023-08-13 |
mouse |
| Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo Horg. Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses. NeuroImage. vol 208. 2021-02-17. PMID:31841683. |
furthermore, a voxelwise-analysis approach has been validated to resolve substructures, such as the ventral tegmental area (vta), within midbrain dopaminergic nuclei thought to have distinct anatomical targets and functional roles. |
2021-02-17 |
2023-08-13 |
Not clear |
| Taylor Joel Woodward, Vesna Tesic, Tamara Timic Stamenic, Vesna Jevtovic-Todorovic, Slobodan M Todorovi. Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for α-Lipoic Acid. Frontiers in pharmacology. vol 10. 2021-02-11. PMID:31849661. |
the ventral tegmental area (vta) is a midbrain region highly involved in motivation and reward. |
2021-02-11 |
2023-08-13 |
rat |
| F M Corrigan, J Christie-Sand. An innate brainstem self-other system involving orienting, affective responding, and polyvalent relational seeking: Some clinical implications for a "Deep Brain Reorienting" trauma psychotherapy approach. Medical hypotheses. vol 136. 2021-01-25. PMID:31794877. |
the hypothesis set out here is that this most basic urge to connect is dependent on circuits based in three main components: the midbrain superior colliculi (sc), the midbrain periaqueductal gray (pag), and the mesolimbic and mesocortical dopamine systems originating in the midbrain ventral tegmental area. |
2021-01-25 |
2023-08-13 |
Not clear |
| Tingting Di, Ya Wang, Yajie Zhang, Sha Sha, Yanying Zeng, Ling Che. Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin-releasing hormone in paraventricular nucleus. Journal of neurochemistry. vol 154. issue 2. 2020-12-10. PMID:32096869. |
dopaminergic (daergic) neurons of the midbrain ventral tegmental area (vta) are known to regulate the hypothalamic-pituitary-adrenal (hpa) axis but have no direct projections to the paraventricular nucleus (pvn) of the hypothalamus. |
2020-12-10 |
2023-08-13 |
mouse |
| Lindsey M Schuette, Christopher C Gray, Paul J Curri. Microinjection of Ghrelin into the Ventral Tegmental Area Potentiates Cocaine-Induced Conditioned Place Preference. Journal of behavioral and brain science. vol 3. issue 8. 2020-10-01. PMID:28989815. |
in order to further investigate ghrelin's role in dopamine-mediated reward, the present report examined whether pretreament with ghrelin, administered directly into the ventral tegmental area (vta) of the midbrain, would potentiate the rewarding properties of cocaine as measured by cpp. |
2020-10-01 |
2023-08-13 |
rat |
| Zachary Freyberg, Ryan W Loga. The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction. Current opinion in physiology. vol 5. 2020-10-01. PMID:30631826. |
midbrain dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens play crucial roles in substance-induced neural and behavioral plasticity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kelly H MacNiven, Josiah K Leong, Brian Knutso. Medial forebrain bundle structure is linked to human impulsivity. Science advances. vol 6. issue 38. 2020-10-01. PMID:32938676. |
comparative research indicates that projections from midbrain dopamine nuclei [including the ventral tegmental area (vta)] to the ventral striatum [including the nucleus accumbens (nacc)] critically support motivated behavior. |
2020-10-01 |
2023-08-13 |
human |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
considering that the ventral tegmental area (vta) and substantia nigra (sn) in the midbrain are the primary dopamine producers, creating reliable anatomical templates of the vta and sn through neuroimaging studies would be useful for achieving a detailed understanding of this dopaminergic system. |
2020-09-30 |
2023-08-13 |
Not clear |