| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Ono, Yuichiro Izumi, Kosuke Maruyama, Yukiko Yasuoka, Akiko Hiramatsu, Jose Aramburu, Cristina López-Rodríguez, Hiroshi Nonoguchi, Yutaka Kakizoe, Masataka Adachi, Takashige Kuwabara, Masashi Mukoyam. Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice. American journal of physiology. Renal physiology. 2023-12-28. PMID:38153851. |
uuo significantly exacerbated renal fibrosis in the renal medulla in ko mice compared to wt mice, accompanied by enhanced activation of immune responses. |
2023-12-28 |
2023-12-31 |
mouse |
| Fabian Baalmann, Jana Brendler, Anne Butthof, Yulia Popkova, Kathrin M Engel, Jürgen Schiller, Karsten Winter, Vera Lede, Albert Ricken, Torsten Schöneberg, Angela Schul. Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250906. |
in contrast, the area of the outer stripe of the outer medulla was larger in wt compared to ko mice. |
2023-05-30 |
2023-08-14 |
mouse |
| Erkin Kurganov, Kaho Okamoto, Seiji Miyat. Distribution of TRPM 8-expressing trigeminal nerve fibers in the pons and medulla oblongata of the mouse brain. Journal of chemical neuroanatomy. 2022-05-13. PMID:35561876. |
the present study showed the distribution of trpm8-expressing fibers in the pons and medulla oblongata of the using trpm8 ko mice engineered by knocking in egfp at the frame of the start codon of trpm8. |
2022-05-13 |
2023-08-13 |
mouse |
| Ana Carolina Monteleone-Cassiano, Janaina A Dernowsek, Romario S Mascarenhas, Amanda Freire Assis, Dimitrius Pitol, Natalia Chermont Santos Moreira, Elza Tiemi Sakamoto-Hojo, João Paulo Mardegan Issa, Eduardo A Donadi, Geraldo Aleixo Passo. The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids. BMC molecular and cell biology. vol 23. issue 1. 2022-03-25. PMID:35331137. |
previous studies have shown that aire knockout (ko) mice have a small and disorganized thymic medulla; however, whether aire influences the mtec-mtec interaction in the maintenance of the 3d structure has been little explored. |
2022-03-25 |
2023-08-13 |
mouse |
| Bo Jiang, Guohao Liu, Jiashuo Zheng, Mengxia Chen, Zaitunamu Maimaitiming, Min Chen, Shunli Liu, Ruiwei Jiang, Brie K Fuqua, Joshua L Dunaief, Chris D Vulpe, Gregory J Anderson, Hongwei Wang, Huijun Che. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Scientific reports. vol 6. 2018-07-23. PMID:27991585. |
a significant increase in ferritin protein expression was also observed in the renal medulla and cortex of heph/cp ko mice. |
2018-07-23 |
2023-08-13 |
mouse |
| Bo Jiang, Guohao Liu, Jiashuo Zheng, Mengxia Chen, Zaitunamu Maimaitiming, Min Chen, Shunli Liu, Ruiwei Jiang, Brie K Fuqua, Joshua L Dunaief, Chris D Vulpe, Gregory J Anderson, Hongwei Wang, Huijun Che. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Scientific reports. vol 6. 2018-07-23. PMID:27991585. |
both dmt1 and tfr1 protein expression were significantly decreased in the renal medulla of heph/cp ko mice, while the expression of dmt1 protein was significantly increased in the renal cortex of these animals. |
2018-07-23 |
2023-08-13 |
mouse |
| Bo Jiang, Guohao Liu, Jiashuo Zheng, Mengxia Chen, Zaitunamu Maimaitiming, Min Chen, Shunli Liu, Ruiwei Jiang, Brie K Fuqua, Joshua L Dunaief, Chris D Vulpe, Gregory J Anderson, Hongwei Wang, Huijun Che. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Scientific reports. vol 6. 2018-07-23. PMID:27991585. |
the non-heme iron content both in the renal cortex and medulla of heph/cp ko mice was significantly increased. |
2018-07-23 |
2023-08-13 |
mouse |
| Emmanuel N Anyetei-Anum, Alissa Blum, Nabil G Seidah, Margery C Beinfel. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27923657. |
substantial decreases in brain levels of cck are found in the prefrontal, frontal, parietal-insular-pyriform, and temporal cortex, caudate-putamen, basal forebrain, thalamus, hippocampus, septum, and medulla of pc7 knock-out (ko) mice. |
2017-06-06 |
2023-08-13 |
mouse |
| Fuka Aizawa, Takashi Nishinaka, Takuya Yamashita, Kazuo Nakamoto, Takashi Kurihara, Akira Hirasawa, Fumiyo Kasuya, Atsuro Miyata, Shogo Tokuyam. GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior. Journal of pharmacological sciences. vol 132. issue 4. 2017-03-28. PMID:27979701. |
the level of noradrenaline was higher in the hippocampus, medulla oblongata, hypothalamus and midbrain of ko mice. |
2017-03-28 |
2023-08-13 |
mouse |
| Ravindra Boddu, Travis D Hull, Subhashini Bolisetty, Xianzhen Hu, Mark S Moehle, João Paulo Lima Daher, Ahmed Ibrahim Kamal, Reny Joseph, James F George, Anupam Agarwal, Lisa M Curtis, Andrew B Wes. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. Human molecular genetics. vol 24. issue 14. 2016-04-28. PMID:25904107. |
the cortex and medulla of lrrk2 ko rat kidneys become darkly pigmented in early adulthood, yet aged animals display no overt signs of kidney failure. |
2016-04-28 |
2023-08-13 |
mouse |
| Nirupama Ramkumar, Deborah Stuart, Matias Calquin, Syed Quadri, Shuping Wang, Alfred N Van Hoek, Helmy M Siragy, Atsuhiro Ichihara, Donald E Koha. Nephron-specific deletion of the prorenin receptor causes a urine concentration defect. American journal of physiology. Renal physiology. vol 309. issue 1. 2015-09-16. PMID:25995108. |
however, prr ko mice had reduced medullary aquaporin-2 levels and arginine vasopressin-stimulated camp accumulation in the isolated renal medulla compared with control mice. |
2015-09-16 |
2023-08-13 |
mouse |
| Juan-Antonio García-Carmona, Elena Martínez-Laorden, María-Victoria Milanés, María-Luisa Laorde. Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor. Toxicology and applied pharmacology. vol 283. issue 1. 2015-03-16. PMID:25582704. |
the experiments were performed in the hypothalamic paraventricular nucleus (pvn) ventrolateral medulla (vlm), brain regions involved in the regulation of cardiovascular activity, and in the right ventricle by using genetically engineered mice lacking functional crf1r levels (ko). |
2015-03-16 |
2023-08-13 |
mouse |
| Wararat Kittikulsuth, Deborah Stuart, Donald E Koha. Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling. Physiological reports. vol 2. issue 3. 2014-04-24. PMID:24760529. |
cd ac4 ko had no effect on vasopressin (avp)-stimulated camp generation in the inner medulla. |
2014-04-24 |
2023-08-13 |
mouse |
| Tomasz Andrzej Bonda, Andrzej Taranta, Karol Adam Kaminski, Magdalena Dziemidowicz, Sergey Litvinovich, Marcin Kozuch, Izabela Bialuk, Lech Chyczewski, Maria Malgorzata Winnick. CCN1 expression in interleukin-6 deficient mouse kidney in experimental model of heart failure. Folia histochemica et cytobiologica. vol 51. issue 1. 2014-01-17. PMID:23690222. |
the main difference in ccn1 distribution between the examined genotypes was lack of reaction in internal renal medulla and very weak reaction in proximal convoluted tubules in il-6 ko mice. |
2014-01-17 |
2023-08-12 |
mouse |
| Yue Zhang, Lijun Li, Donald E Kohan, Carolyn M Ecelbarger, Bellamkonda K Kishor. Attenuation of lithium-induced natriuresis and kaliuresis in P2Y₂ receptor knockout mice. American journal of physiology. Renal physiology. vol 305. issue 3. 2013-10-17. PMID:23739592. |
in addition, under control conditions, tissue osmolality of the inner medulla as well as furosemide sensitivity were significantly higher in ko mice versus wt mice. |
2013-10-17 |
2023-08-12 |
mouse |
| Apeksha A Gulvady, Eric J Murphy, Henry P Ciolino, Robert M Cabrera, Christopher A Joll. Glycerol-3-phosphate acyltransferase-1 gene ablation results in altered thymocyte lipid content and reduces thymic T cell production in mice. Lipids. vol 48. issue 1. 2013-06-10. PMID:23179391. |
these changes were associated with reduced glycerophospholipid mass while thymic cortex and medulla architecture was not altered by gpat-1 ko. |
2013-06-10 |
2023-08-12 |
mouse |
| Zhanjun Jia, Gang Liu, Ying Sun, Yutaka Kakizoe, Guangju Guan, Aihua Zhang, Shu-Feng Zhou, Tianxin Yan. mPGES-1-derived PGE2 mediates dehydration natriuresis. American journal of physiology. Renal physiology. vol 304. issue 2. 2013-03-06. PMID:23171554. |
by quantitative rt-pcr, wd increased the endothelial nitric oxide synthase (enos), inducible nos, and neuronal nos expressions in the renal medulla of wt mice by 3.9-, 1.48-, and 2.6-fold, respectively, all of which were significantly blocked in mpges-1 ko mice. |
2013-03-06 |
2023-08-12 |
mouse |
| Zhanjun Jia, Gang Liu, Maicy Downton, Zheng Dong, Aihua Zhang, Tianxin Yan. mPGES-1 deletion potentiates urine concentrating capability after water deprivation. American journal of physiology. Renal physiology. vol 302. issue 8. 2012-06-04. PMID:22237797. |
at baseline, the ko mice had a 20% increase in v(2) receptor mrna expression in the renal medulla but not the cortex compared with wt controls; the expression was unaffected by wd irrespective of the genotype. |
2012-06-04 |
2023-08-12 |
mouse |
| Yue Zhang, Ioana L Pop, Noel G Carlson, Bellamkonda K Kishor. Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling. American journal of physiology. Renal physiology. vol 302. issue 1. 2012-02-09. PMID:21975874. |
however, prostanoid ep(3) receptor (ep3-r) protein abundance in the renal medulla of ko mice was markedly lower vs. wt mice, irrespective of the dietary regimen. |
2012-02-09 |
2023-08-12 |
mouse |
| Yue Zhang, Raelene Listhrop, Carolyn M Ecelbarger, Bellamkonda K Kishor. Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NaCl diet with/without aldosterone infusion. American journal of physiology. Renal physiology. vol 300. issue 3. 2011-04-20. PMID:21190950. |
clamping aldosterone (with hsd) led to significantly impaired natriuresis with elevated na/h exchanger isoform 3 in the cortex, and nkcc2 in the medulla, and modest but significantly lower levels of nkcc2, and α- and β-enac in the cortex of ko vs. wt mice. |
2011-04-20 |
2023-08-12 |
mouse |