| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Morgan, Patricio Sáez-Briones, Rafael Barra, Andrea Reyes, Katherine Zepeda-Morales, Luis Constandil, Miguel Ríos, Paulina Ramírez, Héctor Burgos, Alejandro Hernánde. Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077493. |
a loss of neuroplastic control on nucleus accumbens (nac) neuronal activity exerted by the medial prefrontal cortex (mpfc) through long-term depression (ltd) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (nac) core. |
2022-09-09 |
2023-08-14 |
mouse |
| Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaned. A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice. Behavioural brain research. 2022-07-01. PMID:35777550. |
immunohistochemical analyses revealed that the number of c-fos (a neuronal activity marker)-positive cells increased in the medial prefrontal cortex (mpfc), core and shell of the nucleus accumbens (nac), dorsal striatum (str), and lateral septum (ls) at day 1, day 9, and days 20-24, in a time-dependent manner. |
2022-07-01 |
2023-08-14 |
mouse |
| Sophia C Levis, Matthew T Birnie, Jessica L Bolton, Christina R Perrone, Johanna S Montesinos, Tallie Z Baram, Stephen V Mahle. Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Translational psychiatry. vol 12. issue 1. 2022-06-15. PMID:35705547. |
we probe potential circuit mechanisms in males by assessing opioid-associated neuronal activation in stress and reward circuit nodes including nucleus accumbens (nac), amygdala, medial prefrontal cortex (mpfc), and paraventricular thalamus. |
2022-06-15 |
2023-08-14 |
rat |
| Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huan. Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683439. |
the c-fos expression analysis showed that the medial prefrontal cortex (i.e., cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), nucleus accumbens (nac), basolateral amygdala (bla), ventral tegmental area (vta), caudate-putamen (cpu), and hippocampus (i.e., ca1, ca3, and dentate gyrus (dg)) contributed to mamph-induced behavioral sensitization. |
2022-06-10 |
2023-08-14 |
mouse |
| Xiayun Wan, Akifumi Eguchi, Youge Qu, Yong Yang, Lijia Chang, Jiajing Shan, Chisato Mori, Kenji Hashimot. Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence. European archives of psychiatry and clinical neuroscience. 2022-06-06. PMID:35666299. |
repeated administration of win55,212-2 (2 mg/kg/day) during adolescence (p35-p45) significantly increased the expression of iba1 (ionized calcium-binding adapter molecule 1) in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) of adult mice after administration of lipopolysaccharide (lps: 0.5 mg/kg). |
2022-06-06 |
2023-08-14 |
mouse |
| Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Sumiyoshi Kiguch. Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside-induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission. Clinical and experimental pharmacology & physiology. 2022-05-31. PMID:35637550. |
moreover, rovatirelin significantly increased acetylcholine (ach) levels in the medial prefrontal cortex (mpfc) and dopamine (da) levels in the nucleus accumbens (nac) at ≥3 mg/kg and significantly increased da levels in the dorsal striatum at ≥10 mg/kg in normal rats. |
2022-05-31 |
2023-08-13 |
mouse |
| Kerri D Pryce, Aarthi Ramakrishnan, Hope Kronnman, Andrew Nicolais, Claire Polizu, Anne Ruiz, Randal Serafini, Sevasti Gaspari, Catherine J Pena, Angelica Torres-Berrio, Vassiliki Mitsi, Matthew Darpe, L I Shen, Eric J Nestler, Venetia Zachario. A novel HDAC1/2 inhibitor alleviates physical and emotional symptoms associated with spontaneous oxycodone withdrawal in neuropathic pain mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552957. |
rna-sequencing (rna-seq) and bioinformatic analyses revealed that oxycodone withdrawal alone triggers robust gene expression adaptations in the nucleus accumbens (nac), medial prefrontal cortex (mpfc), and ventral tegmental area (vta), with numerous genes and pathways selectively affected by oxycodone withdrawal under peripheral nerve injury states. |
2022-05-13 |
2023-08-13 |
mouse |
| Troy D Fort, Mary E Cai. The Role of Astroglial xCT in Mitigating Cue-Induced Amphetamine-Seeking. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555299. |
following testing, all rats were perfused and brains were extracted for immunofluorescence (if) analysis of astrocyte and xct transporter expression within the acb and medial prefrontal cortex using a simultaneous immunofluorescence (if) method. |
2022-05-13 |
2023-08-13 |
rat |
| Yanmei Chen, Xuebing Wang, Mei Xiao, Na Kang, Wanli Zeng, Jichuan Zhan. Prenatal morphine exposure increases gamma oscillation and theta coherence in the rat reward system. Neurotoxicology. 2022-04-24. PMID:35461814. |
we recorded local field potentials (lfp) simultaneously in the vta, nac (nucleus accumbens), bla (basolateral amygdala) and mpfc (medial prefrontal cortex) in male adult rats prenatally treated with saline or morphine. |
2022-04-24 |
2023-08-13 |
rat |
| Laurie Hamel, Bilgehan Cavdaroglu, Dylan Yeates, David Nguyen, Sadia Riaz, Dylan Patterson, Nisma Khan, Nardin Kirolos, Katherine Roper, Quynh An Ha, Rutsuko It. Cortico-striatal control over adaptive goal-directed responding elicited by cues signaling sucrose reward or punishment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-03-30. PMID:35351827. |
the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) have been associated with the expression of adaptive and maladaptive behavior elicited by fear-related and drug-associated cues. |
2022-03-30 |
2023-08-13 |
Not clear |
| Mariusz Papp, Piotr Gruca, Magdalena Lason, Ewa Litwa, Wojciech Solecki, Paul Willne. Optogenetic stimulation of medial prefrontal cortex excites GABAergic cells in the nucleus accumbens and hippocampus of Wistar-Kyoto rats exposed to chronic mild stress. Psychopharmacology. 2022-03-16. PMID:35292832. |
optogenetic stimulation of medial prefrontal cortex excites gabaergic cells in the nucleus accumbens and hippocampus of wistar-kyoto rats exposed to chronic mild stress. |
2022-03-16 |
2023-08-13 |
rat |
| Michaela R Breach, Courtney N Dye, Anabel Galan, Kathryn M Len. Prenatal allergic inflammation in rats programs the developmental trajectory of dendritic spine patterning in brain regions associated with cognitive and social behavior. Brain, behavior, and immunity. 2022-03-04. PMID:35245680. |
mean dendritic spine density was calculated for neurons in brain regions associated with cognition and social behavior, including the medial prefrontal cortex (mpfc), basal ganglia, septum, nucleus accumbens (nac), and amygdala. |
2022-03-04 |
2023-08-13 |
rat |
| Rodolpho Pereira de Oliveira, José Simões de Andrade, Marianna Spina, João Vítor Chamon, Paulo Henrique Dias Silva, Ana Keyla Werder, Daniela Ortolani, Lucas de Santana Cardoso Thomaz, Simone Romariz, Daniel Araki Ribeiro, Beatriz Monteiro Longo, Regina Célia Spadari, Milena de Barros Viana, Liana Melo-Thomas, Isabel Cristina Céspedes, Regina Cláudia Barbosa da Silv. Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress. PloS one. vol 17. issue 3. 2022-03-03. PMID:35239670. |
in the present study, we evaluate the effect of acute restraint stress (15 min) of male wistar rats on social interaction measurements and c-fos immunoreactivity (c-fos-ir) expression, a marker of neuronal activity, in areas involved with the modulation of acute physical restraint in rats, i.e., the paraventricular nucleus of the hypothalamus (pvn), median raphe nucleus (mnr), medial prefrontal cortex (mpfc), cingulate prefrontal cortex (cpfc), nucleus accumbens (nac), hippocampus (ca3), lateral septum (ls) and medial amygdala (mea). |
2022-03-03 |
2023-08-13 |
rat |
| Matthew J Muelbl, Breanna L Glaeser, Alok S Shah, Rachel A Chiariello, Natalie N Nawarawong, Brian D Stemper, Matthew D Budde, Christopher M Olse. Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes. Addiction biology. vol 27. issue 2. 2022-03-01. PMID:35229952. |
we found interactive effects of rbtbi and oxycodone on fractional anisotropy (fa) in the nucleus accumbens (nac) and that fa in the medial prefrontal cortex (mpfc) was correlated with drug seeking. |
2022-03-01 |
2023-08-13 |
rat |
| Ying Hao Yu, Yeou San Lim, Chen Yin Ou, Kai Chieh Chang, Arthur C Tsai, Fang Chih Chang, Andrew Chih Wei Huan. The Medial Prefrontal Cortex, Nucleus Accumbens, Basolateral Amygdala, and Hippocampus Regulate the Amelioration of Environmental Enrichment and Cue in Fear Behavior in the Animal Model of PTSD. Behavioural neurology. vol 2022. 2022-02-18. PMID:35178125. |
the present study addressed this issue and examined whether the medial prefrontal cortex (mpfc, including the cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), the nucleus accumbens (nac), the basolateral amygdala (bla), and the hippocampus (e.g., ca1, ca3, and dentate gyrus (dg)) regulated the amelioration of the ee, cue, or the combination of ee and cue. |
2022-02-18 |
2023-08-13 |
Not clear |
| Imre Kalló, Azar Omrani, Frank J Meye, Han de Jong, Zsolt Liposits, Roger A H Ada. Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens. Brain structure & function. 2022-01-14. PMID:35029758. |
vta neurons are a central hub processing reward and motivation and target the medial prefrontal cortex (mpfc) and the shell part of nucleus accumbens (nacs). |
2022-01-14 |
2023-08-13 |
Not clear |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
here, we investigated changes in the total neuronal density and relative concentration of d2r-expressing neurons in the medial prefrontal cortex (mpfc), dorsal striatum (dstr), nucleus accumbens (nac), and ventral tegmental area (vta) in both male and female mice passively exposed to cocaine for two weeks. |
2021-12-12 |
2023-08-13 |
mouse |
| Alexander K Zinsmaier, Yan Dong, Yanhua H Huan. Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens. Molecular psychiatry. 2021-11-26. PMID:33963288. |
the nucleus accumbens (nac) integrates and prioritizes different emotional and motivational inputs to the reward system by processing convergent glutamatergic projections from the medial prefrontal cortex, basolateral amygdala, ventral hippocampus, and other limbic and paralimbic brain regions. |
2021-11-26 |
2023-08-13 |
Not clear |
| Kensuke Hirose, Yuka Nakaya, Kohei Kitano, Yasuhiko Saito, Ryosuke Kaneko, Yuchio Yanagawa, Kiyofumi Yamamoto, Tetsuo Shirakawa, Masayuki Kobayash. Differential regulation of medium spiny and cholinergic neurons in the nucleus accumbens core by the insular and medial prefrontal cortices in the rat. Pflugers Archiv : European journal of physiology. vol 473. issue 12. 2021-11-25. PMID:34724104. |
the nucleus accumbens (nac) receives cortical projections principally from the insular cortex (ic) and medial prefrontal cortex (mpfc). |
2021-11-25 |
2023-08-13 |
rat |
| Jacques P Flores-Dourojeanni, Coby van Rijt, Marleen H van den Munkhof, Linde Boekhoudt, Mieneke C M Luijendijk, Louk J M J Vanderschuren, Roger A H Ada. Temporally Specific Roles of Ventral Tegmental Area Projections to the Nucleus Accumbens and Prefrontal Cortex in Attention and Impulse Control. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 19. 2021-11-22. PMID:33837050. |
frontostriatal structures, such as the nucleus accumbens (nacb), the medial prefrontal cortex (mpfc), and their dopaminergic innervation from the ventral tegmental area (vta) have been implicated in impulse control and attention. |
2021-11-22 |
2023-08-13 |
rat |